LOCUS       NM_032562               1564 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens phospholipase A2 group XIIB (PLA2G12B), transcript
            variant 1, mRNA.
ACCESSION   NM_032562
VERSION     NM_032562.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1564)
  AUTHORS   Liu,Q., Yang,M., Fu,X., Liu,R., Sun,C., Pan,H., Wong,C.W. and
            Guan,M.
  TITLE     Activation of farnesoid X receptor promotes triglycerides lowering
            by suppressing phospholipase A2 G12B expression
  JOURNAL   Mol Cell Endocrinol 436, 93-101 (2016)
   PUBMED   27471003
  REMARK    GeneRIF: FXR regulates serum triglyceride level in part through
            PLA2G12B.
REFERENCE   2  (bases 1 to 1564)
  AUTHORS   Golan,S., Entin-Meer,M., Semo,Y., Maysel-Auslender,S.,
            Mezad-Koursh,D., Keren,G., Loewenstein,A. and Barak,A.
  TITLE     Gene profiling of human VEGF signaling pathways in human
            endothelial and retinal pigment epithelial cells after anti VEGF
            treatment
  JOURNAL   BMC Res Notes 7, 617 (2014)
   PUBMED   25201034
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1564)
  AUTHORS   Li,X., Jiang,H., Qu,L., Yao,W., Cai,H., Chen,L. and Peng,T.
  TITLE     Hepatocyte nuclear factor 4alpha and downstream secreted
            phospholipase A2 GXIIB regulate production of infectious hepatitis
            C virus
  JOURNAL   J Virol 88 (1), 612-627 (2014)
   PUBMED   24173221
REFERENCE   4  (bases 1 to 1564)
  AUTHORS   Nevalainen,T.J. and Cardoso,J.C.
  TITLE     Conservation of group XII phospholipase A2 from bacteria to human
  JOURNAL   Comp Biochem Physiol Part D Genomics Proteomics 7 (4), 340-350
            (2012)
   PUBMED   22909802
REFERENCE   5  (bases 1 to 1564)
  AUTHORS   Guan,M., Qu,L., Tan,W., Chen,L. and Wong,C.W.
  TITLE     Hepatocyte nuclear factor-4 alpha regulates liver triglyceride
            metabolism in part through secreted phospholipase A GXIIB
  JOURNAL   Hepatology 53 (2), 458-466 (2011)
   PUBMED   21274867
REFERENCE   6  (bases 1 to 1564)
  AUTHORS   Triggiani,M., Giannattasio,G., Calabrese,C., Loffredo,S.,
            Granata,F., Fiorello,A., Santini,M., Gelb,M.H. and Marone,G.
  TITLE     Lung mast cells are a source of secreted phospholipases A2
  JOURNAL   J Allergy Clin Immunol 124 (3), 558-565 (2009)
   PUBMED   19541351
REFERENCE   7  (bases 1 to 1564)
  AUTHORS   Mounier,C.M., Wendum,D., Greenspan,E., Flejou,J.F., Rosenberg,D.W.
            and Lambeau,G.
  TITLE     Distinct expression pattern of the full set of secreted
            phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as
            a biomarker candidate
  JOURNAL   Br J Cancer 98 (3), 587-595 (2008)
   PUBMED   18212756
REFERENCE   8  (bases 1 to 1564)
  AUTHORS   Nevalainen,T.J., Eerola,L.I., Rintala,E., Laine,V.J., Lambeau,G.
            and Gelb,M.H.
  TITLE     Time-resolved fluoroimmunoassays of the complete set of secreted
            phospholipases A2 in human serum
  JOURNAL   Biochim Biophys Acta 1733 (2-3), 210-223 (2005)
   PUBMED   15863368
REFERENCE   9  (bases 1 to 1564)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   10 (bases 1 to 1564)
  AUTHORS   Rouault,M., Bollinger,J.G., Lazdunski,M., Gelb,M.H. and Lambeau,G.
  TITLE     Novel mammalian group XII secreted phospholipase A2 lacking
            enzymatic activity
  JOURNAL   Biochemistry 42 (39), 11494-11503 (2003)
   PUBMED   14516201
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP274516.1, DA536331.1,
            AY358032.1 and AK311349.1.
            
            On May 17, 2019 this sequence version replaced NM_032562.4.
            
            Summary: The protein encoded by this gene belongs to the
            phospholipase A2 (PLA2) group of enzymes, which function in
            glycolipid hydrolysis with the release of free fatty acids and
            lysophospholipids. This family member has altered
            phospholipid-binding properties and is catalytically inactive. The
            protein is secreted, and together with microsomal triglyceride
            transfer protein, it functions to regulate HNF4alpha-induced
            hepatitis C virus infectivity. The expression of this gene is
            down-regulated in various tumors, suggesting that it may function
            as a negative regulator of tumor progression. Alternative splicing
            of this gene results in multiple transcript variants. [provided by
            RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138522.814547.1, AF339053.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155590 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373032.4/ ENSP00000362123.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BP274516.1         14-30
            18-54               DA536331.1         18-54
            55-1123             AY358032.1         1-1069
            1124-1564           AK311349.1         1035-1475
FEATURES             Location/Qualifiers
     source          1..1564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..1564
                     /gene="PLA2G12B"
                     /gene_synonym="FKSG71; GXIIB; GXIIIsPLA2; PLA2G13;
                     sPLA2-GXIIB"
                     /note="phospholipase A2 group XIIB"
                     /db_xref="GeneID:84647"
                     /db_xref="HGNC:HGNC:18555"
                     /db_xref="MIM:611653"
     exon            1..332
                     /gene="PLA2G12B"
                     /gene_synonym="FKSG71; GXIIB; GXIIIsPLA2; PLA2G13;
                     sPLA2-GXIIB"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..709
                     /gene="PLA2G12B"
                     /gene_synonym="FKSG71; GXIIB; GXIIIsPLA2; PLA2G13;
                     sPLA2-GXIIB"
                     /EC_number="3.1.1.4"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; phospholipase A2, group XIII; group XIII
                     secreted phospholipase A2; group XIIB secretory
                     phospholipase A2-like protein"
                     /codon_start=1
                     /product="group XIIB secretory phospholipase A2-like
                     protein isoform a precursor"
                     /protein_id="NP_115951.2"
                     /db_xref="CCDS:CCDS7319.1"
                     /db_xref="GeneID:84647"
                     /db_xref="HGNC:HGNC:18555"
                     /db_xref="MIM:611653"
                     /translation="MKLASGFLVLWLSLGGGLAQSDTSPDTEESYSDWGLRHLRGSFE
                     SVNSYFDSFLELLGGKNGVCQYRCRYGKAPMPRPGYKPQEPNGCGSYFLGLKVPESMD
                     LGIPAMTKCCNQLDVCYDTCGANKYRCDAKFRWCLHSICSDLKRSLGFVSKVEAACDS
                     LVDTVFNTVWTLGCRPFMNSQRAACICAEEEKEEL"
     exon            333..421
                     /gene="PLA2G12B"
                     /gene_synonym="FKSG71; GXIIB; GXIIIsPLA2; PLA2G13;
                     sPLA2-GXIIB"
                     /inference="alignment:Splign:2.1.0"
     exon            422..587
                     /gene="PLA2G12B"
                     /gene_synonym="FKSG71; GXIIB; GXIIIsPLA2; PLA2G13;
                     sPLA2-GXIIB"
                     /inference="alignment:Splign:2.1.0"
     exon            588..1564
                     /gene="PLA2G12B"
                     /gene_synonym="FKSG71; GXIIB; GXIIIsPLA2; PLA2G13;
                     sPLA2-GXIIB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1122..1127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G12B"
                     /gene_synonym="FKSG71; GXIIB; GXIIIsPLA2; PLA2G13;
                     sPLA2-GXIIB"
                     /note="hexamer: AATAAA"
     polyA_site      1144
                     /gene="PLA2G12B"
                     /gene_synonym="FKSG71; GXIIB; GXIIIsPLA2; PLA2G13;
                     sPLA2-GXIIB"
                     /note="major polyA site"
ORIGIN      
        1 gaatgttcca gataatccct ttcccagtcc tgcctgacat ctgggtaggg ggtttgtccc
       61 tggaattctg ggacactggc tggggtttga ggagagaagc cagtacctac ctggctgcag
      121 gatgaagctg gccagtggct tcttggtttt gtggctcagc cttgggggtg gcctggctca
      181 gagcgacacg agccctgaca cggaggagtc ctattcagac tggggccttc ggcacctccg
      241 gggaagcttt gaatccgtca atagctactt cgattctttt ctggagctgc tgggagggaa
      301 gaatggagtc tgtcagtaca ggtgccgata tggaaaggca ccaatgccca gacctggcta
      361 caagccccaa gagcccaatg gctgcggctc ctatttcctg ggtctcaagg taccagaaag
      421 tatggacttg ggcattccag caatgacaaa gtgctgcaac cagctggatg tctgttatga
      481 cacttgcggt gccaacaaat atcgctgtga tgcaaaattc cgatggtgtc tccactcgat
      541 ctgctctgac cttaagcgga gtctgggctt tgtctccaaa gtggaagcag cctgtgattc
      601 cctggttgac actgtgttca acaccgtgtg gaccttgggc tgccgcccct ttatgaatag
      661 tcagcgggca gcttgcatct gtgcagagga ggagaaggaa gagttatgag gaagaagtga
      721 ttccttcctg gttttgagtg acaccacagc tgtcagcctt caagatgtca agtcttcgag
      781 tcagcgtgac tcattcgttc ttccaacagt ttggacacca caaagcagga gaaagggaac
      841 atttttctac agctggaaag tgagtcctat cctttgagga aatttgaaaa aagacatgga
      901 gtggtttgaa agctactctt catttaagac tgctctcccc aaccaagaca catttgcctg
      961 gaaattcagt tcttagctta aagactaaaa tgcaagcaaa ccctgcaatt cctggacctg
     1021 atagttatat tcatgagtga aattgtgggg agtccagcca tttgggaggc aatgactttc
     1081 tgctggccca tgtttcagtt gccagtaagc ttctcacatt taataaagtg tactttttag
     1141 aacatttgga aagagatgaa tgaattccat tatcaccaat gtgcttccat ttcacttaga
     1201 agagaccaaa actgaacctg gtaagttcca ccaatgacca cagttattcc cactgatgct
     1261 aaacagagaa aaacaggtgg gcaggctcag aggcttacct gattaaggcc aacggagggg
     1321 aaggtcagat ggaattaggt ctctgaggat tcatttttcc ctccggtgac ctaccccatt
     1381 ggtattccca gttactaaat ggtgttagag tcatgctaag atctgagatg tacttgctaa
     1441 gagttactga tggagctagc taggaaaagt ccctgcagcc tgtcgggagt gagagacaag
     1501 tggccattcc ctaacttgcg ggtctcaagc ctaactatgg attagaatca cctgaggatc
     1561 cttt
//
