LOCUS       NM_030821               5219 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens phospholipase A2 group XIIA (PLA2G12A), mRNA.
ACCESSION   NM_030821
VERSION     NM_030821.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5219)
  AUTHORS   Wu,M., Wang,Q., Li,H., Tao,J., Wang,Z., Zhang,S., Chen,L., Li,P.,
            Chen,L. and Qu,L.
  TITLE     PLA2G12A protects against diet-induced obesity and insulin
            resistance by enhancing energy expenditure and clearance of
            circulating triglycerides
  JOURNAL   FASEB J 38 (9), e23643 (2024)
   PUBMED   38703030
  REMARK    GeneRIF: PLA2G12A protects against diet-induced obesity and insulin
            resistance by enhancing energy expenditure and clearance of
            circulating triglycerides.
REFERENCE   2  (bases 1 to 5219)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5219)
  AUTHORS   Hui,L., Yin,X.L., Chen,J., Zhu,H.L., Zhang,G.Y., Wang,X.Q.,
            Liu,J.H., Zhu,C., Xu,D.W., Yu,X. and Yin,G.Z.
  TITLE     Association between PLA2G12A polymorphism and patients with
            schizophrenia in a southern Chinese Han population
  JOURNAL   Hum Psychopharmacol 33 (2), e2654 (2018)
   PUBMED   29527719
  REMARK    GeneRIF: The results of this study revealed that PLA2G12A rs3087494
            polymorphism did not influence age at onset in patients with
            schizophrenia.
REFERENCE   4  (bases 1 to 5219)
  AUTHORS   Yang,G., Xu,H., Zhang,H., Yu,Q., Wu,Y., Shi,J., Rao,W., You,Y.,
            Kou,C. and Yu,Y.
  TITLE     Association between PLA2G12A Polymorphisms and Schizophrenia in a
            Han Chinese Population from Northeast China
  JOURNAL   PLoS One 11 (7), e0159584 (2016)
   PUBMED   27434078
  REMARK    GeneRIF: The study demonstrated that PLA2G12A SNPs or haplotypes
            might influence the susceptibility to schizophrenia in the Han
            Chinese population from Northeast China.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5219)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 5219)
  AUTHORS   Rouault,M., Bollinger,J.G., Lazdunski,M., Gelb,M.H. and Lambeau,G.
  TITLE     Novel mammalian group XII secreted phospholipase A2 lacking
            enzymatic activity
  JOURNAL   Biochemistry 42 (39), 11494-11503 (2003)
   PUBMED   14516201
REFERENCE   7  (bases 1 to 5219)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 5219)
  AUTHORS   Murakami,M., Masuda,S., Shimbara,S., Bezzine,S., Lazdunski,M.,
            Lambeau,G., Gelb,M.H., Matsukura,S., Kokubu,F., Adachi,M. and
            Kudo,I.
  TITLE     Cellular arachidonate-releasing function of novel classes of
            secretory phospholipase A2s (groups III and XII)
  JOURNAL   J Biol Chem 278 (12), 10657-10667 (2003)
   PUBMED   12522102
  REMARK    GeneRIF: cellular arachidonate (AA) release and prostaglandin (PG)
            production are regulated by novel classes of secretory
            phospholipase A(2)s (sPLA(2)s), groups III and XII
REFERENCE   9  (bases 1 to 5219)
  AUTHORS   Ho,I.C., Arm,J.P., Bingham,C.O. 3rd, Choi,A., Austen,K.F. and
            Glimcher,L.H.
  TITLE     A novel group of phospholipase A2s preferentially expressed in type
            2 helper T cells
  JOURNAL   J Biol Chem 276 (21), 18321-18326 (2001)
   PUBMED   11278438
REFERENCE   10 (bases 1 to 5219)
  AUTHORS   Gelb,M.H., Valentin,E., Ghomashchi,F., Lazdunski,M. and Lambeau,G.
  TITLE     Cloning and recombinant expression of a structurally novel human
            secreted phospholipase A2
  JOURNAL   J Biol Chem 275 (51), 39823-39826 (2000)
   PUBMED   11031251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI667755.1, BC017218.2 and AC004067.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030821.4.
            
            Summary: Secreted phospholipase A2 (sPLA2) enzymes liberate
            arachidonic acid from phospholipids for production of eicosanoids
            and exert a variety of physiologic and pathologic effects. Group
            XII sPLA2s, such as PLA2G12A, have relatively low specific activity
            and are structurally and functionally distinct from other sPLA2s
            (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence data to make the sequence
            consistent with the reference genome assembly. The extent of this
            RefSeq transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.179690.1,
                                           SRR3476690.862979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467150, SAMN03267778
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243501.10/ ENSP00000243501.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BI667755.1         22-36
            16-1141             BC017218.2         1-1126
            1142-5219           AC004067.1         137513-141590       c
FEATURES             Location/Qualifiers
     source          1..5219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..5219
                     /gene="PLA2G12A"
                     /gene_synonym="GXII; PLA2G12; ROSSY"
                     /note="phospholipase A2 group XIIA"
                     /db_xref="GeneID:81579"
                     /db_xref="HGNC:HGNC:18554"
                     /db_xref="MIM:611652"
     exon            1..469
                     /gene="PLA2G12A"
                     /gene_synonym="GXII; PLA2G12; ROSSY"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..831
                     /gene="PLA2G12A"
                     /gene_synonym="GXII; PLA2G12; ROSSY"
                     /EC_number="3.1.1.4"
                     /note="group XII secreted phospholipase A2; group XIIA
                     secreted phospholipase A2; group XIIA secretory
                     phospholipase A2; sPLA2-XII; GXII sPLA2;
                     phosphatidylcholine 2-acylhydrolase 12A; phospholipase A2,
                     group XII"
                     /codon_start=1
                     /product="group XIIA secretory phospholipase A2 precursor"
                     /protein_id="NP_110448.2"
                     /db_xref="CCDS:CCDS3686.1"
                     /db_xref="GeneID:81579"
                     /db_xref="HGNC:HGNC:18554"
                     /db_xref="MIM:611652"
                     /translation="MALLSRPALTLLLLLMAAVVRCQEQAQTTDWRATLKTIRNGVHK
                     IDTYLNAALDLLGGEDGLCQYKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGIPS
                     LTKCCNQHDRCYETCGKSKNDCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVELLF
                     DSVIHLGCKPYLDSQRAACRCHYEEKTDL"
     exon            470..546
                     /gene="PLA2G12A"
                     /gene_synonym="GXII; PLA2G12; ROSSY"
                     /inference="alignment:Splign:2.1.0"
     exon            547..712
                     /gene="PLA2G12A"
                     /gene_synonym="GXII; PLA2G12; ROSSY"
                     /inference="alignment:Splign:2.1.0"
     exon            713..5219
                     /gene="PLA2G12A"
                     /gene_synonym="GXII; PLA2G12; ROSSY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1271..1276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G12A"
                     /gene_synonym="GXII; PLA2G12; ROSSY"
                     /note="hexamer: AATACA"
     polyA_site      1291
                     /gene="PLA2G12A"
                     /gene_synonym="GXII; PLA2G12; ROSSY"
                     /note="major polyA site"
     regulatory      5202..5207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G12A"
                     /gene_synonym="GXII; PLA2G12; ROSSY"
                     /note="hexamer: AATAAA"
     polyA_site      5219
                     /gene="PLA2G12A"
                     /gene_synonym="GXII; PLA2G12; ROSSY"
                     /note="major polyA site"
ORIGIN      
        1 gcacagggga cggttgctgg cccaggtgag cgggcgcgct ggtccaggtg agcgggcgcg
       61 tccccgcgac ggcgctgcct gcccgaggcg gttcacgtaa agacagcgag atcctgaggg
      121 ccagccggga aggaggcgtg gatatggagc tggctgctgc caagtccggg gcccgcgccg
      181 ctgcctagcg cgtcctgggg actctgtggg gacgcgcccc gcgccgcggc tcggggaccc
      241 gtagagcccg gcgctgcgcg catggccctg ctctcgcgcc ccgcgctcac cctcctgctc
      301 ctcctcatgg ccgctgttgt caggtgccag gagcaggccc agaccaccga ctggagagcc
      361 accctgaaga ccatccggaa cggcgttcat aagatagaca cgtacctgaa cgccgccttg
      421 gacctcctgg gaggcgagga cggtctctgc cagtataaat gcagtgacgg atctaagcct
      481 ttcccacgtt atggttataa accctcccca ccgaatggat gtggctctcc actgtttggt
      541 gttcatctta acattggtat cccttccctg acaaagtgtt gcaaccaaca cgacaggtgc
      601 tatgagacct gtggcaaaag caagaatgac tgtgatgaag aattccagta ttgcctctcc
      661 aagatctgcc gagatgtaca gaaaacacta ggactaactc agcatgttca ggcatgtgaa
      721 acaacagtgg agctcttgtt tgacagtgtt atacatttag gttgtaaacc atatctggac
      781 agccaacgag ccgcatgcag gtgtcattat gaagaaaaaa ctgatcttta aaggagatgc
      841 cgacagctag tgacagatga agatggaaga acataccttt gacaaataac taatgttttt
      901 acaacataaa actgtcttat ttttgtgaaa ggattatttt gagaccttaa aataatttat
      961 atcttgatgt taaaacctca aagcaaaaaa agtgagggag atagtgaggg gagggcacgc
     1021 ttgtcttctc aggtatcttc cccagcattg ctcccttact tagtatgcca aatgtcttga
     1081 ccaatatcaa aaacaagtgc ttgtttagcg gagaattttg aaaagaggaa tatataactc
     1141 aattttcaca accacattta ccaaaaaaag agatcaaata taaaattcat cataatgtct
     1201 gttcaacatt atcttatttg gaaaatgggg aaattatcac ttacaagtat ttgtttacta
     1261 tgaaatttta aatacacatt tatgcctaga aggaacggac tttttttttc tattttaatt
     1321 acacataata tgtaattaaa gtacaacata atatgttgtt tctctgtagc ccgttgagca
     1381 tatgagtaag tcacatttct attaggacta cttacaagga caaggtttcc atttttccag
     1441 ttgtaaaatt ggaaccatca gctgataacc tcgtagggag caaccccagg atagctaagt
     1501 gttatgtaat atgcctagaa ggtgatgtga atgcgattca gaagcatagc cactcccatt
     1561 ttatgagcta ctcacatgac aaatgtcatc ttttgctata acctttgcca agttagagaa
     1621 aagatggatt taatgagata aatgaaaaga tatttaacct aatatatcaa ggcactattt
     1681 gctgttatgc tttgttattt atttcccagc acttgttcct tattgtagat tttttaaaga
     1741 ctgtaacctt ttactaactg tggtcttact aaaatttgtg cttgatactg cttttcaaaa
     1801 agcctttaat tagagccaaa aggatggaaa aggcaagata taaatgcctt ttatagatct
     1861 cttatttaca ttgaaaatta ttaccatatg tttagagcaa atccaagaaa acttcaacag
     1921 cttctgaaga tgtctatgaa tgttgaaaac ttttcaatct cttggaatgc tcagttatgt
     1981 tcctagaccg gtctttgctg actactggtt gttaaccttt ccctagcctg ggacctcaag
     2041 ccatatatat cctttgggtg acccatggcc aaagttatta agatgaactg actttcaaag
     2101 tcagagaagg acagcatagg gagaggcggt tatttgtaag tcattacagg tagaacaggg
     2161 cagaaggaaa agtatgttct ggagaaaggg ccatgttcct aactttggag atatgtcatt
     2221 gccgggaacc tagtatcttc caacttgaat tggtggcagc tgttccagtg agacaaggca
     2281 catgtatgcc ttgtggctaa gtgagcaaac tgggtttcca cttaaatgtt tgggaccctc
     2341 aattgattct ttatttcaaa cctttataaa aggtacagtt ttgtaagcca ttattaataa
     2401 ttaatgctta tcggctgggc acagtggctc acacctataa tcccagcact ttgggaggct
     2461 gaggcggttg gatcacttga ggtcaggagt ttgagaccag ctggccaaca tggtgaaaca
     2521 gcgtctctac taaaaataca aaaatttgcc gggcgtggtg gcgcatgctt atagtctcag
     2581 ctactcagga agctgaggta cgagaatcac ttgaacccag gaggtggagg ttgcagtgag
     2641 ctgagattgt gccactgcac tgcagcctgg gcaacagagc aagactctaa aaaaaaaatg
     2701 gtttatcaat atttactatt gaaatatttg tccaggtaac tttacactta caatgaattc
     2761 atggattttg ttagcagcat tggctttctc aaaaggacaa actcaatatc gttataaaat
     2821 ataattcgtg atcacaaatt atacaaaaat cagtagaaac agttttttat gttcagatta
     2881 aaaaaaaaaa cttgggataa ttttagattt acagaaaagt tgcaaagata catggagagc
     2941 ttctgtgacc actcacccag ttcccccagt gttaaccttt tatttaacca tgaagcattt
     3001 gtcagaagct aagtaaccag caatggcaat tactattaac ggaactttga ctttattttt
     3061 cagattgtac tagtttttta attaatgtca tttttctttt ccaggatcca atctaggata
     3121 ccacactgaa ttagtcgtca tgcctaatta gcctctggtc tgtgatagtt ccacagtctt
     3181 tctttttcat aaccttgaca gttttgagga gtactggtca ggtgttttgt agaatattcc
     3241 tcaatttggg tttgtctgat gttttcctca tggttagagt ggggttatag atttttagga
     3301 agaataccag aggtgaaggt ccttctcact gcatcatgtc aggagttaca tgctatcagc
     3361 ttgatggtgt attaactttg gacacttggt taaggtagtg tgtgttggtt ttttgctgct
     3421 gaaaattact gttattttcc ctttccatac ttctgttctt tggaaaacag tcactaagtc
     3481 cagtcatggg aggtggtggg tgggaaagat tacattcaac cccctggaag tgggaatatc
     3541 catatgtagt atttggaatt tttctatatg gaaaatttgt ttctccctcc caccctaatt
     3601 tgtttacatc agtatggact catgtatatt ttgtattttg ggtaacacag tatttatttt
     3661 gttgcttaag ttgtccagct tggctattag gagttctgcc aggttggcta ctatgtccct
     3721 ttgatgtgcc catccttttg atttttgagc acttcttact ttctggcact acaagatgct
     3781 ccaggttcat cttggatatt ccctgcccca accctagaat ccctagaatc aacccctgct
     3841 ccaaagagcc ctggttcctt ttgttggaga atcatactta gaaaccaaga tctgggcatt
     3901 agatgtgctt gttgctactg ggatgtcact gtttgtagca gagttgagaa atatgtatgt
     3961 atattaatcc atgcatatgt acacatctat aattatttat gtgtgtacaa agctaaacat
     4021 gagtttgtac tgccgtcttc aactcaaaat ttgtcccaaa attttgtggc atatgtttag
     4081 attttaaagt tgatattttc cctattgaca gaataaactc attaaaagag caaaaaaaaa
     4141 aaaaaaaaaa aaaaggcaag aactaactgt cagcagctct ttgcaagaaa tgtaatattg
     4201 atactttaaa ataatactgc cttcaaatga tgcctgtctc tttaaaatct tttgacatag
     4261 ttcttccagg gacagatatg gctgtattta tttcatagat ggagaaactg agcacagagc
     4321 tgtaatgaag acagaattga gatataaggg caaaagctaa ttaaacgcat cctcacaggt
     4381 agcctttctt tcagtgaacc tgtagactag tccagtaata cttattaaaa ttagttgtta
     4441 gaggctgggc atggtggttc aagcctgtaa tctcagcact gtgggaggcc aaggcggaca
     4501 gatcactcaa agtcagaagt tcgagaccag cttggccaac atggcaaaac cctgtctcta
     4561 ctaaaaatac aaaaattagt tgggtgtggt ggcacatgcc tgtaatccca gccactcggg
     4621 aggtgaaggc acaagaattg gttgaacctg ggaagcagag gttgcagtga gctgagattg
     4681 cactgctgca ctccagcata ggcgtcagaa taagactctg tcttggaaag aagaaaaaaa
     4741 attgttagcc taaaaccaac tctctctaaa tttaaaagag tgattattta tcttagtatt
     4801 tatagaagta tgagattatc agaaggtgcg atgcacaatg ctcattattt tatcctagta
     4861 caagacacgt ataacatcta acagtaaaga agatggaatc tttctataaa aacaattctg
     4921 ttattaatag ttgactgact tcagtaactt tgaggagtag aatgaaactt attaggcaag
     4981 atctttccac atacactaca ttgtattgtt caaaattcat agaaattact tgcaatatat
     5041 tgatttaagc cttatgtagt gactgttgct atatttgaag tagcattttt agtttgctgt
     5101 ttttcctcac tgcttaatcc tacaaaaacc agccatctgc ctaaaaaata aaagagcaaa
     5161 aatgaatcag tgcaaccggt atacgaaaaa taataattat taataaaact gtaaaggga
//
