LOCUS       NM_003561                636 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens phospholipase A2 group X (PLA2G10), transcript variant
            1, mRNA.
ACCESSION   NM_003561 NM_001031688
VERSION     NM_003561.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 636)
  AUTHORS   Zhang,T., Yu,W., Cheng,X., Yeung,J., Ahumada,V., Norris,P.C.,
            Pearson,M.J., Yang,X., van Deursen,W., Halcovich,C., Nassar,A.,
            Vesely,M.D., Zhang,Y., Zhang,J.P., Ji,L., Flies,D.B., Liu,L.,
            Langermann,S., LaRochelle,W.J., Humphrey,R., Zhao,D., Zhang,Q.,
            Zhang,J., Gu,R., Schalper,K.A., Sanmamed,M.F. and Chen,L.
  TITLE     Up-regulated PLA2G10 in cancer impairs T cell infiltration to
            dampen immunity
  JOURNAL   Sci Immunol 9 (94), eadh2334 (2024)
   PUBMED   38669316
  REMARK    GeneRIF: Up-regulated PLA2G10 in cancer impairs T cell infiltration
            to dampen immunity.
REFERENCE   2  (bases 1 to 636)
  AUTHORS   Chen,Y., Ma,X., Lou,C., Zhou,C., Zhao,X., Li,N., Tian,H. and
            Meng,X.
  TITLE     PLA2G10 incorporated in exosomes could be diagnostic and prognostic
            biomarker for non-small cell lung cancer
  JOURNAL   Clin Chim Acta 530, 55-65 (2022)
   PUBMED   35231479
  REMARK    GeneRIF: PLA2G10 incorporated in exosomes could be diagnostic and
            prognostic biomarker for non-small cell lung cancer.
REFERENCE   3  (bases 1 to 636)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 636)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 636)
  AUTHORS   Brglez,V., Lambeau,G. and Petan,T.
  TITLE     Secreted phospholipases A2 in cancer: diverse mechanisms of action
  JOURNAL   Biochimie 107 Pt A, 114-123 (2014)
   PUBMED   25286228
  REMARK    GeneRIF: Studies indicate that the expression of secreted
            phospholipases A2 (sPLA2s), most notably the group IIA, III and X
            enzymes, is dysregulated in various malignant tissues.
REFERENCE   6  (bases 1 to 636)
  AUTHORS   Degousee,N., Ghomashchi,F., Stefanski,E., Singer,A., Smart,B.P.,
            Borregaard,N., Reithmeier,R., Lindsay,T.F., Lichtenberger,C.,
            Reinisch,W., Lambeau,G., Arm,J., Tischfield,J., Gelb,M.H. and
            Rubin,B.B.
  TITLE     Groups IV, V, and X phospholipases A2s in human neutrophils: role
            in eicosanoid production and gram-negative bacterial phospholipid
            hydrolysis
  JOURNAL   J Biol Chem 277 (7), 5061-5073 (2002)
   PUBMED   11741884
  REMARK    GeneRIF: circulating human neutrophils express groups V and X
            sPLA(2) (GV and GX sPLA(2)) mRNA and contain GV and GX sPLA(2)
            proteins, whereas GIB, GIIA, GIID, GIIE, GIIF, GIII, and GXII
            sPLA(2)s are undetectable
REFERENCE   7  (bases 1 to 636)
  AUTHORS   Morioka,Y., Saiga,A., Yokota,Y., Suzuki,N., Ikeda,M., Ono,T.,
            Nakano,K., Fujii,N., Ishizaki,J., Arita,H. and Hanasaki,K.
  TITLE     Mouse group X secretory phospholipase A2 induces a potent release
            of arachidonic acid from spleen cells and acts as a ligand for the
            phospholipase A2 receptor
  JOURNAL   Arch Biochem Biophys 381 (1), 31-42 (2000)
   PUBMED   11019817
REFERENCE   8  (bases 1 to 636)
  AUTHORS   Yokota,Y., Higashino,K., Nakano,K., Arita,H. and Hanasaki,K.
  TITLE     Identification of group X secretory phospholipase A(2) as a natural
            ligand for mouse phospholipase A(2) receptor
  JOURNAL   FEBS Lett 478 (1-2), 187-191 (2000)
   PUBMED   10922494
REFERENCE   9  (bases 1 to 636)
  AUTHORS   Cupillard,L., Koumanov,K., Mattei,M.G., Lazdunski,M. and Lambeau,G.
  TITLE     Cloning, chromosomal mapping, and expression of a novel human
            secretory phospholipase A2
  JOURNAL   J Biol Chem 272 (25), 15745-15752 (1997)
   PUBMED   9188469
REFERENCE   10 (bases 1 to 636)
  AUTHORS   Lennon,G., Auffray,C., Polymeropoulos,M. and Soares,M.B.
  TITLE     The I.M.A.G.E. Consortium: an integrated molecular analysis of
            genomes and their expression
  JOURNAL   Genomics 33 (1), 151-152 (1996)
   PUBMED   8617505
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U95301.1.
            
            On Nov 26, 2019 this sequence version replaced NM_003561.2.
            
            Summary: This gene encodes a member of the phospholipase A2 family
            of proteins. Alternative splicing results in multiple transcript
            variants, at least one of which encodes a preproprotein that is
            proteolytically processed to generate the mature enzyme. This
            calcium-dependent enzyme hydrolyzes glycerophospholipids to produce
            free fatty acids and lysophospholipids. In one example, this enzyme
            catalyzes the release of arachidonic acid from cell membrane
            phospholipids, thus playing a role in the production of various
            inflammatory lipid mediators, such as prostaglandins. The encoded
            protein may promote the survival of breast cancer cells through its
            role in lipid metabolism. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U95301.1, AW292929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152798 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438167.8/ ENSP00000393847.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-636               U95301.1           362-997
FEATURES             Location/Qualifiers
     source          1..636
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.12-p13.11"
     gene            1..636
                     /gene="PLA2G10"
                     /gene_synonym="GXPLA2; GXSPLA2; SPLA2; sPLA2-X"
                     /note="phospholipase A2 group X"
                     /db_xref="GeneID:8399"
                     /db_xref="HGNC:HGNC:9029"
                     /db_xref="MIM:603603"
     exon            1..176
                     /gene="PLA2G10"
                     /gene_synonym="GXPLA2; GXSPLA2; SPLA2; sPLA2-X"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..577
                     /gene="PLA2G10"
                     /gene_synonym="GXPLA2; GXSPLA2; SPLA2; sPLA2-X"
                     /EC_number="3.1.1.4"
                     /note="group 10 secretory phospholipase A2; group X
                     secretory phospholipase A2; phosphatidylcholine
                     2-acylhydrolase 10"
                     /codon_start=1
                     /product="group 10 secretory phospholipase A2
                     preproprotein"
                     /protein_id="NP_003552.1"
                     /db_xref="CCDS:CCDS10555.1"
                     /db_xref="GeneID:8399"
                     /db_xref="HGNC:HGNC:9029"
                     /db_xref="MIM:603603"
                     /translation="MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGI
                     LELAGTVGCVGPRTPIAYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSP
                     KTERYSWQCVNQSVLCGPAENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPD
                     SPKCD"
     exon            177..327
                     /gene="PLA2G10"
                     /gene_synonym="GXPLA2; GXSPLA2; SPLA2; sPLA2-X"
                     /inference="alignment:Splign:2.1.0"
     exon            328..434
                     /gene="PLA2G10"
                     /gene_synonym="GXPLA2; GXSPLA2; SPLA2; sPLA2-X"
                     /inference="alignment:Splign:2.1.0"
     exon            435..636
                     /gene="PLA2G10"
                     /gene_synonym="GXPLA2; GXSPLA2; SPLA2; sPLA2-X"
                     /inference="alignment:Splign:2.1.0"
     regulatory      612..617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA2G10"
                     /gene_synonym="GXPLA2; GXSPLA2; SPLA2; sPLA2-X"
                     /note="hexamer: AATAAA"
     polyA_site      636
                     /gene="PLA2G10"
                     /gene_synonym="GXPLA2; GXSPLA2; SPLA2; sPLA2-X"
                     /note="major polyA site"
ORIGIN      
        1 gtgacagccg gggtgtgtgt ccgccgggct tggtgcctcc ggtggccctg cagcaccgtc
       61 ccacctctgc caccctccga tggggccgct acctgtgtgc ctgccaatca tgctgctcct
      121 gctactgccg tcgctgctgc tgctgctgct tctacctggc cccgggtccg gcgaggcctc
      181 caggatatta cgtgtgcacc ggcgtgggat cctggaactg gcaggaactg tgggttgtgt
      241 tggtccccga acccccatcg cctatatgaa atatggttgc ttttgtggct tgggaggcca
      301 tggccagccc cgcgatgcca ttgactggtg ctgccatggc cacgactgtt gttacactcg
      361 agctgaggag gccggctgca gccccaagac agagcgctac tcctggcagt gcgtcaatca
      421 gagcgtcctg tgcggaccgg cagagaacaa atgccaagaa ctgttgtgca agtgtgacca
      481 ggagattgct aactgcttag cccaaactga gtacaactta aagtacctct tctaccccca
      541 gttcctatgt gagccggact cgcccaagtg tgactgacta ccttgacttg aaatgctctt
      601 ttgcacaagg aaataaagcg tcctctcagt aatgaa
//
