LOCUS       NM_015900               1743 bp    mRNA    linear   PRI 26-JUN-2022
DEFINITION  Homo sapiens phospholipase A1 member A (PLA1A), transcript variant
            1, mRNA.
ACCESSION   NM_015900
VERSION     NM_015900.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1743)
  AUTHORS   Zhou Y, Chang M, Wang N, Zhuang Y, Wang F, Zhang X, Guo M, Lin N,
            Li JZ and Wang Q.
  TITLE     Phosphatidylserine-Specific Phospholipase A1 Limits Aggressiveness
            of Lung Adenocarcinoma by Lysophosphatidylserine and Protein Kinase
            A-Dependent Pathway
  JOURNAL   Am J Pathol 192 (6), 970-983 (2022)
   PUBMED   35358472
  REMARK    GeneRIF: Phosphatidylserine-Specific Phospholipase A1 Limits
            Aggressiveness of Lung Adenocarcinoma by Lysophosphatidylserine and
            Protein Kinase A-Dependent Pathway.
REFERENCE   2  (bases 1 to 1743)
  AUTHORS   Zhao Y, Hasse S, Vaillancourt M, Zhao C, Davis L, Boilard E, Fortin
            P, Di Battista J, Poubelle PE and Bourgoin SG.
  TITLE     Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes
            through the Autotaxin-Lysophosphatidic Acid Receptor Axis
  JOURNAL   Int J Mol Sci 22 (23), 12685 (2021)
   PUBMED   34884486
  REMARK    GeneRIF: Phospholipase A1 Member A Activates Fibroblast-like
            Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor
            Axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1743)
  AUTHORS   Yang G, Liu S, Maghsoudloo M, Shasaltaneh MD, Kaboli PJ, Zhang C,
            Deng Y, Heidari H, Entezari M, Fu S, Wen Q and Imani S.
  TITLE     PLA1A expression as a diagnostic marker of BRAF-mutant metastasis
            in melanoma cancer
  JOURNAL   Sci Rep 11 (1), 6056 (2021)
   PUBMED   33723350
  REMARK    GeneRIF: PLA1A expression as a diagnostic marker of BRAF-mutant
            metastasis in melanoma cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1743)
  AUTHORS   Nakawatari K, Kurano M, Araki O, Nishikawa M, Shimamoto S, Igarashi
            K, Aoki J, Murakami M and Yatomi Y.
  TITLE     Elevated phosphatidylserine-specific phospholipase A1 level in
            hyperthyroidism
  JOURNAL   Clin Chim Acta 503, 99-106 (2020)
   PUBMED   31978406
  REMARK    GeneRIF: Elevated phosphatidylserine-specific phospholipase A1
            level in hyperthyroidism.
REFERENCE   5  (bases 1 to 1743)
  AUTHORS   Uranbileg B, Kurano M, Sato M, Ikeda H, Ishizawa T, Hasegawa K,
            Kokudo N and Yatomi Y.
  TITLE     Possible involvement of PS-PLA1 and lysophosphatidylserine receptor
            (LPS1) in hepatocellular carcinoma
  JOURNAL   Sci Rep 10 (1), 2659 (2020)
   PUBMED   32060356
  REMARK    GeneRIF: Possible involvement of PS-PLA1 and lysophosphatidylserine
            receptor (LPS1) in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1743)
  AUTHORS   Aoki J, Nagai Y, Hosono H, Inoue K and Arai H.
  TITLE     Structure and function of phosphatidylserine-specific phospholipase
            A1
  JOURNAL   Biochim Biophys Acta 1582 (1-3), 26-32 (2002)
   PUBMED   12069807
  REMARK    Review article
REFERENCE   7  (bases 1 to 1743)
  AUTHORS   Nagai Y, Aoki J, Sato T, Amano K, Matsuda Y, Arai H and Inoue K.
  TITLE     An alternative splicing form of phosphatidylserine-specific
            phospholipase A1 that exhibits lysophosphatidylserine-specific
            lysophospholipase activity in humans
  JOURNAL   J Biol Chem 274 (16), 11053-11059 (1999)
   PUBMED   10196188
REFERENCE   8  (bases 1 to 1743)
  AUTHORS   van Groningen JJ, Egmond MR, Bloemers HP and Swart GW.
  TITLE     nmd, a novel gene differentially expressed in human melanoma cell
            lines, encodes a new atypical member of the enzyme family of
            lipases
  JOURNAL   FEBS Lett 404 (1), 82-86 (1997)
   PUBMED   9074642
REFERENCE   9  (bases 1 to 1743)
  AUTHORS   Sato T, Aoki J, Nagai Y, Dohmae N, Takio K, Doi T, Arai H and Inoue
            K.
  TITLE     Serine phospholipid-specific phospholipase A that is secreted from
            activated platelets. A new member of the lipase family
  JOURNAL   J Biol Chem 272 (4), 2192-2198 (1997)
   PUBMED   8999922
REFERENCE   10 (bases 1 to 1743)
  AUTHORS   Bohn E, Gerke V, Kresse H, Loffler BM and Kunze H.
  TITLE     Annexin II inhibits calcium-dependent phospholipase A1 and
            lysophospholipase but not triacyl glycerol lipase activities of rat
            liver hepatic lipase
  JOURNAL   FEBS Lett 296 (3), 237-240 (1992)
   PUBMED   1531641
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313519.1 and BC035347.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015900.3.
            
            Summary: The protein encoded by this gene is a phospholipase that
            hydrolyzes fatty acids at the sn-1 position of phosphatidylserine
            and 1-acyl-2-lysophosphatidylserine. This secreted protein
            hydrolyzes phosphatidylserine in liposomes. Three transcript
            variants encoding different isoforms have been found for this
            gene.[provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.301755.1,
                                           SRR3476690.914462.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273371.9/ ENSP00000273371.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1400              AK313519.1         1-1400
            1401-1446           BC035347.1         1390-1435
            1447-1743           BC035347.1         1441-1737
FEATURES             Location/Qualifiers
     source          1..1743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..1743
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /note="phospholipase A1 member A"
                     /db_xref="GeneID:51365"
                     /db_xref="HGNC:HGNC:17661"
                     /db_xref="MIM:607460"
     exon            1..102
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1400
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /EC_number="3.1.1.111"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; phosphatidylserine-specific phospholipase
                     A1alpha"
                     /codon_start=1
                     /product="phospholipase A1 member A isoform 1 precursor"
                     /protein_id="NP_056984.1"
                     /db_xref="CCDS:CCDS2991.1"
                     /db_xref="GeneID:51365"
                     /db_xref="HGNC:HGNC:17661"
                     /db_xref="MIM:607460"
                     /translation="MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLF
                     EGTDLKVQFLLFVPSNPSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWID
                     TFIRTLLRATNANVIAVDWIYGSTGVYFSAVKNVIKLSLEISLFLNKLLVLGVSESSI
                     HIIGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHT
                     DTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCP
                     LMAFPCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSA
                     PYCMHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIPKQQRYGKGIIAHATPQC
                     QINQVKFKFQSSNRVWKKDRTTIIGKFCTALLPVNDREKMVCLPEPVNLQASVTVSCD
                     LKIACV"
     exon            103..304
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..482
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..591
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..693
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..783
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..951
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1041
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1150
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1315
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1743
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1719..1724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /note="hexamer: AATAAA"
     polyA_site      1743
                     /gene="PLA1A"
                     /gene_synonym="PS-PLA1; PSPLA1"
                     /note="major polyA site"
ORIGIN      
        1 ataccagctc tgagatttcc agctcagcga tgcccccagg tccctgggag agctgcttct
       61 gggtgggggg cctcattttg tggctcagcg ttggaagttc aggggatgca cctcctaccc
      121 cacagccaaa gtgcgctgac ttccagagcg ccaacctttt tgaaggcacc gatctcaaag
      181 tccagtttct cctctttgtc ccttcgaatc ctagctgtgg gcagctagta gaaggaagca
      241 gtgacctcca aaactctggg ttcaatgcca ctctgggaac caaactaatt atccatggat
      301 tcagggtttt aggaacaaag ccttcctgga ttgacacatt tattagaacc cttctgcgtg
      361 caacgaatgc taatgtgatt gccgtggact ggatttatgg gtctacagga gtctacttct
      421 cagctgtgaa aaatgtgatt aagttgagcc tcgagatctc ccttttcctc aataaactcc
      481 tggtgctggg tgtgtcggaa tcctcaatcc acatcattgg tgttagcctg ggggcccacg
      541 ttgggggcat ggtgggacag ctcttcggag gccagctggg acagatcaca ggcctggacc
      601 ccgctggacc tgagtacacc agggccagtg tggaagagcg cttggatgct ggagatgccc
      661 tcttcgtgga agccatccac acagacaccg acaatttggg tattcggatt cccgttggac
      721 atgtggacta cttcgtcaac ggaggccaag accaacctgg ctgccccacc ttcttttacg
      781 caggttatag ttatctgatc tgtgatcaca tgagggctgt gcacctctac atcagcgccc
      841 tggagaattc ctgtccactg atggcctttc cctgtgccag ctacaaggcc ttccttgctg
      901 gacgctgtct ggattgcttt aacccttttc tgctttcctg cccaaggata ggactggtgg
      961 aacaaggtgg tgtcaagata gagccgctcc ccaaggaagt gaaagtctac ctcctgacta
     1021 cttccagtgc tccgtactgc atgcatcaca gcctcgtgga gtttcacttg aaggaactga
     1081 gaaacaagga caccaacatc gaggttacct tccttagcag taacatcacc tcttcatcta
     1141 agatcaccat acctaagcag caacgctatg ggaaaggaat catagcccat gccaccccac
     1201 aatgccagat aaaccaagtg aaattcaagt ttcagtcttc caaccgagtt tggaaaaaag
     1261 accggactac cattattggg aagttctgca ctgccctttt gcctgtcaat gacagagaaa
     1321 agatggtctg cttacctgaa ccagtgaact tacaagcaag tgtgactgtt tcctgtgacc
     1381 tgaagatagc ctgtgtgtag tttaacctgg gcaggacaca tctccctgca tttttttttt
     1441 ttttttgaga gagaggtgtg atgagggatg tgtgtgtgca gcttattgta gaccattact
     1501 actaaggaga aaagcaaagc tctttcttat tttcctcata atcagctacc ctggagggga
     1561 gggagaactc attttacaga acttggtttc ctttgccgat cttatgtaca tacccatttt
     1621 agctttccca tgcatactta actgcacttg ctttatctcc ttgggcattc gtacttagga
     1681 ttcaatagaa acatgtacag ggtaaacaat tttttaaaaa taaaacttca tggagtatct
     1741 gaa
//
