LOCUS       XM_047432663            2469 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens pyruvate kinase M1/2 (PKM), transcript
            variant X2, mRNA.
ACCESSION   XM_047432663
VERSION     XM_047432663.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2469
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     gene            1..2469
                     /gene="PKM"
                     /gene_synonym="CTHBP; HEL-S-30; OIP3; p58; PK3; PKM2; TCB;
                     THBP1"
                     /note="pyruvate kinase M1/2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     mRNAs, 477 ESTs, 10409 long SRA reads, 10 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 6 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:5315"
                     /db_xref="HGNC:HGNC:9021"
                     /db_xref="MIM:179050"
     CDS             19..1848
                     /gene="PKM"
                     /gene_synonym="CTHBP; HEL-S-30; OIP3; p58; PK3; PKM2; TCB;
                     THBP1"
                     /codon_start=1
                     /product="pyruvate kinase PKM isoform X2"
                     /protein_id="XP_047288619.1"
                     /db_xref="GeneID:5315"
                     /db_xref="HGNC:HGNC:9021"
                     /db_xref="MIM:179050"
                     /translation="MRERSLSQKSALRNQGWAALLEPGESSECFTYNSSSPGHTVFSS
                     ERSLLVRPRSHPEPKGEHYVTGSPTPENQRTSAAMSKPHSEAGTAFIQTQQLHAAMAD
                     TFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHE
                     YHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATL
                     KITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVE
                     NGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRK
                     VLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMI
                     GRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPL
                     EAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIV
                     LTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDL
                     RVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP"
ORIGIN      
        1 actgtccagg cagctggcat gagggagagg agtctttccc agaagtccgc cctgagaaac
       61 caaggctggg ctgctctcct ggagccaggg gagtccagtg agtgttttac atacaactct
      121 agctctccag ggcacaccgt attcagctct gagcggtctt tgctagtgag gccaaggagc
      181 caccctgagc caaaagggga gcattatgtc accggaagcc caaccccaga gaaccaaagg
      241 acctcagcag ccatgtcgaa gccccatagt gaagccggga ctgccttcat tcagacccag
      301 cagctgcacg cagccatggc tgacacattc ctggagcaca tgtgccgcct ggacattgat
      361 tcaccaccca tcacagcccg gaacactggc atcatctgta ccattggccc agcttcccga
      421 tcagtggaga cgttgaagga gatgattaag tctggaatga atgtggctcg tctgaacttc
      481 tctcatggaa ctcatgagta ccatgcggag accatcaaga atgtgcgcac agccacggaa
      541 agctttgctt ctgaccccat cctctaccgg cccgttgctg tggctctaga cactaaagga
      601 cctgagatcc gaactgggct catcaagggc agcggcactg cagaggtgga gctgaagaag
      661 ggagccactc tcaaaatcac gctggataac gcctacatgg aaaagtgtga cgagaacatc
      721 ctgtggctgg actacaagaa catctgcaag gtggtggaag tgggcagcaa gatctacgtg
      781 gatgatgggc ttatttctct ccaggtgaag cagaaaggtg ccgacttcct ggtgacggag
      841 gtggaaaatg gtggctcctt gggcagcaag aagggtgtga accttcctgg ggctgctgtg
      901 gacttgcctg ctgtgtcgga gaaggacatc caggatctga agtttggggt cgagcaggat
      961 gttgatatgg tgtttgcgtc attcatccgc aaggcatctg atgtccatga agttaggaag
     1021 gtcctgggag agaagggaaa gaacatcaag attatcagca aaatcgagaa tcatgagggg
     1081 gttcggaggt ttgatgaaat cctggaggcc agtgatggga tcatggtggc tcgtggtgat
     1141 ctaggcattg agattcctgc agagaaggtc ttccttgctc agaagatgat gattggacgg
     1201 tgcaaccgag ctgggaagcc tgtcatctgt gctactcaga tgctggagag catgatcaag
     1261 aagccccgcc ccactcgggc tgaaggcagt gatgtggcca atgcagtcct ggatggagcc
     1321 gactgcatca tgctgtctgg agaaacagcc aaaggggact atcctctgga ggctgtgcgc
     1381 atgcagcacc tgatagctcg tgaggctgag gcagccatgt tccaccgcaa gctgtttgaa
     1441 gaacttgtgc gagcctcaag tcactccaca gacctcatgg aagccatggc catgggcagc
     1501 gtggaggctt cttataagtg tttagcagca gctttgatag ttctgacgga gtctggcagg
     1561 tctgctcacc aggtggccag ataccgccca cgtgccccca tcattgctgt gacccggaat
     1621 ccccagacag ctcgtcaggc ccacctgtac cgtggcatct tccctgtgct gtgcaaggac
     1681 ccagtccagg aggcctgggc tgaggacgtg gacctccggg tgaactttgc catgaatgtt
     1741 ggcaaggccc gaggcttctt caagaaggga gatgtggtca ttgtgctgac cggatggcgc
     1801 cctggctccg gcttcaccaa caccatgcgt gttgttcctg tgccgtgatg gaccccagag
     1861 cccctcctcc agcccctgtc ccaccccctt cccccagccc atccattagg ccagcaacgc
     1921 ttgtagaact cactctgggc tgtaacgtgg cactggtagg ttgggacacc agggaagaag
     1981 atcaacgcct cactgaaaca tggctgtgtt tgcagcctgc tctagtggga cagcccagag
     2041 cctggctgcc catcatgtgg ccccacccaa tcaagggaag aaggaggaat gctggactgg
     2101 aggcccctgg agccagatgg caagagggtg acagcttcct ttcctgtgtg tactctgtcc
     2161 agttccttta gaaaaaatgg atgcccagag gactcccaac cctggcttgg ggtcaagaaa
     2221 cagccagcaa gagttagggg ccttagggca ctgggctgtt gttccattga agccgactct
     2281 ggccctggcc cttacttgct tctctagctc tctaggcctc tccagtttgc acctgtcccc
     2341 accctccact cagctgtcct gcagcaaaca ctccaccctc caccttccat tttcccccac
     2401 tactgcagca cctccaggcc tgttgctata gagcctacct gtatgtcaat aaacaacagc
     2461 tgaagcacc
//
