LOCUS       NP_001268374              76 aa            linear   PRI 27-APR-2025
DEFINITION  cAMP-dependent protein kinase inhibitor gamma [Homo sapiens].
ACCESSION   NP_001268374
VERSION     NP_001268374.1
DBSOURCE    REFSEQ: accession NM_001281445.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 76)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 76)
  AUTHORS   Chen,X., Hausman,B.S., Luo,G., Zhou,G., Murakami,S., Rubin,J. and
            Greenfield,E.M.
  TITLE     Protein kinase inhibitor gamma reciprocally regulates osteoblast
            and adipocyte differentiation by downregulating leukemia inhibitory
            factor
  JOURNAL   Stem Cells 31 (12), 2789-2799 (2013)
   PUBMED   23963683
  REMARK    GeneRIF: Results show that endogenous levels of Pkig reciprocally
            regulate osteoblast and adipocyte differentiation and that this
            reciprocal regulation is mediated in part by LIF.
REFERENCE   3  (residues 1 to 76)
  AUTHORS   Zhao,L., Yang,S., Zhou,G.Q., Yang,J., Ji,D., Sabatakos,G. and
            Zhu,T.
  TITLE     Downregulation of cAMP-dependent protein kinase inhibitor gamma is
            required for BMP-2-induced osteoblastic differentiation
  JOURNAL   Int J Biochem Cell Biol 38 (12), 2064-2073 (2006)
   PUBMED   16870489
  REMARK    GeneRIF: These results indicate that the downregulation of PKIgamma
            may be prerequisite for the PKA activation during the osteoblastic
            differentiation of precursor cells.
REFERENCE   4  (residues 1 to 76)
  AUTHORS   Yu,J., Yu,L., Chen,Z., Zheng,L., Chen,X., Wang,X., Ren,D. and
            Zhao,S.
  TITLE     Protein inhibitor of neuronal nitric oxide synthase interacts with
            protein kinase A inhibitors
  JOURNAL   Brain Res Mol Brain Res 99 (2), 145-149 (2002)
   PUBMED   11978406
REFERENCE   5  (residues 1 to 76)
  AUTHORS   Lum,H., Hao,Z., Gayle,D., Kumar,P., Patterson,C.E. and Uhler,M.D.
  TITLE     Vascular endothelial cells express isoforms of protein kinase A
            inhibitor
  JOURNAL   Am J Physiol Cell Physiol 282 (1), C59-C66 (2002)
   PUBMED   11742798
  REMARK    GeneRIF: Functional studies of the mouse homolog
REFERENCE   6  (residues 1 to 76)
  AUTHORS   Zheng,L., Yu,L., Tu,Q., Zhang,M., He,H., Chen,W., Gao,J., Yu,J.,
            Wu,Q. and Zhao,S.
  TITLE     Cloning and mapping of human PKIB and PKIG, and comparison of
            tissue expression patterns of three members of the protein kinase
            inhibitor family, including PKIA
  JOURNAL   Biochem J 349 (Pt 2), 403-407 (2000)
   PUBMED   10880337
REFERENCE   7  (residues 1 to 76)
  AUTHORS   Collins,S.P. and Uhler,M.D.
  TITLE     Characterization of PKIgamma, a novel isoform of the protein kinase
            inhibitor of cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 272 (29), 18169-18178 (1997)
   PUBMED   9218452
  REMARK    GeneRIF: Functional studies of the mouse homolog
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA463287.1, DN994035.1 and
            BQ010165.1.
            
            Summary: This gene encodes a member of the protein kinase inhibitor
            family. Studies of a similar protein in mice suggest that this
            protein acts as a potent competitive cAMP-dependent protein kinase
            inhibitor, and is a predominant form of inhibitor in various
            tissues. The encoded protein may be involved in osteogenesis.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (5) differs in the 5' UTR,
            compared to variant 4. Variants 1-5 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.351591.1,
                                           SRR5189655.54449.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372886.6/ ENSP00000361977.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..76
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     Protein         1..76
                     /product="cAMP-dependent protein kinase inhibitor gamma"
                     /note="protein kinase (cAMP-dependent, catalytic)
                     inhibitor gamma"
                     /calculated_mol_wt=7779
     Region          1..25
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y2B9.1)"
     Region          2..70
                     /region_name="PKI"
                     /note="cAMP-dependent protein kinase inhibitor; pfam02827"
                     /db_xref="CDD:460716"
     Region          44..76
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y2B9.1)"
     CDS             1..76
                     /gene="PKIG"
                     /gene_synonym="PKI-gamma"
                     /coded_by="NM_001281445.2:247..477"
                     /db_xref="CCDS:CCDS13334.1"
                     /db_xref="GeneID:11142"
                     /db_xref="HGNC:HGNC:9019"
                     /db_xref="MIM:604932"
ORIGIN      
        1 mmevessysd fiscdrtgrr navpdiqgds eavsvrklag dmgelalega egqvegsapd
       61 keagnqpqss dgttss
//
