LOCUS       NM_006823               3962 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens cAMP-dependent protein kinase inhibitor alpha (PKIA),
            transcript variant 1, mRNA.
ACCESSION   NM_006823
VERSION     NM_006823.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3962)
  AUTHORS   Xu,B., Zhang,J., Chen,W. and Cai,W.
  TITLE     Exploring the methylation status of CFTR and PKIA genes as
            potential biomarkers for lung adenocarcinoma
  JOURNAL   Orphanet J Rare Dis 18 (1), 246 (2023)
   PUBMED   37644544
  REMARK    GeneRIF: Exploring the methylation status of CFTR and PKIA genes as
            potential biomarkers for lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3962)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3962)
  AUTHORS   Fung,H.Y., Fu,S.C., Brautigam,C.A. and Chook,Y.M.
  TITLE     Structural determinants of nuclear export signal orientation in
            binding to exportin CRM1
  JOURNAL   Elife 4, e10034 (2015)
   PUBMED   26349033
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3962)
  AUTHORS   Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
            Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
            Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
            Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
            Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
            Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
            Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
            Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
            Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
            Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
            Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
            Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
            Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
            van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
            Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
            Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
            Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
            Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
            Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
            Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
            Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
            Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
            Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
            Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
            Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
            Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
            Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
            Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
            Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
            Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
            McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
            Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
            Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
            Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
            Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
            Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
            Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
            Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
            Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
  TITLE     Genome-wide meta-analysis identifies 56 bone mineral density loci
            and reveals 14 loci associated with risk of fracture
  JOURNAL   Nat Genet 44 (5), 491-501 (2012)
   PUBMED   22504420
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3962)
  AUTHORS   Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
            Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
  TITLE     A genome-wide search for loci interacting with known prostate
            cancer risk-associated genetic variants
  JOURNAL   Carcinogenesis 33 (3), 598-603 (2012)
   PUBMED   22219177
REFERENCE   6  (bases 1 to 3962)
  AUTHORS   Olsen,S.R. and Uhler,M.D.
  TITLE     Inhibition of protein kinase-A by overexpression of the cloned
            human protein kinase inhibitor
  JOURNAL   Mol Endocrinol 5 (9), 1246-1256 (1991)
   PUBMED   1770951
REFERENCE   7  (bases 1 to 3962)
  AUTHORS   Knighton,D.R., Zheng,J.H., Ten Eyck,L.F., Xuong,N.H., Taylor,S.S.
            and Sowadski,J.M.
  TITLE     Structure of a peptide inhibitor bound to the catalytic subunit of
            cyclic adenosine monophosphate-dependent protein kinase
  JOURNAL   Science 253 (5018), 414-420 (1991)
   PUBMED   1862343
REFERENCE   8  (bases 1 to 3962)
  AUTHORS   Olsen,S.R. and Uhler,M.D.
  TITLE     Isolation and characterization of cDNA clones for an inhibitor
            protein of cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 266 (17), 11158-11162 (1991)
   PUBMED   1710219
REFERENCE   9  (bases 1 to 3962)
  AUTHORS   Van Patten,S.M., Heisermann,G.J., Cheng,H.C. and Walsh,D.A.
  TITLE     Tyrosine kinase catalyzed phosphorylation and inactivation of the
            inhibitor protein of the cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 262 (7), 3398-3403 (1987)
   PUBMED   2434500
REFERENCE   10 (bases 1 to 3962)
  AUTHORS   Scott,J.D., Fischer,E.H., Demaille,J.G. and Krebs,E.G.
  TITLE     Identification of an inhibitory region of the heat-stable protein
            inhibitor of the cAMP-dependent protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 82 (13), 4379-4383 (1985)
   PUBMED   2989819
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI597731.1, BC022265.2,
            DR763580.1, BX419914.2 and CR744438.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006823.3.
            
            Summary: The protein encoded by this gene is a member of the
            cAMP-dependent protein kinase (PKA) inhibitor family. This protein
            was demonstrated to interact with and inhibit the activities of
            both C alpha and C beta catalytic subunits of the PKA.
            Alternatively spliced transcript variants encoding the same protein
            have been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs the in the 5' UTR, as
            compared to variant 2. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.274429.1,
                                           SRR1803616.154936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396418.7/ ENSP00000379696.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               BI597731.1         49-422
            375-1900            BC022265.2         116-1641
            1901-2781           DR763580.1         1-881
            2782-3638           BX419914.2         69-925
            3639-3962           CR744438.1         279-602
FEATURES             Location/Qualifiers
     source          1..3962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..3962
                     /gene="PKIA"
                     /gene_synonym="PRKACN1"
                     /note="cAMP-dependent protein kinase inhibitor alpha"
                     /db_xref="GeneID:5569"
                     /db_xref="HGNC:HGNC:9017"
                     /db_xref="MIM:606059"
     exon            1..129
                     /gene="PKIA"
                     /gene_synonym="PRKACN1"
                     /inference="alignment:Splign:2.1.0"
     exon            130..258
                     /gene="PKIA"
                     /gene_synonym="PRKACN1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..436
                     /gene="PKIA"
                     /gene_synonym="PRKACN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..516
                     /gene="PKIA"
                     /gene_synonym="PRKACN1"
                     /note="PKI-alpha; protein kinase (cAMP-dependent,
                     catalytic) inhibitor alpha"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase inhibitor alpha"
                     /protein_id="NP_006814.1"
                     /db_xref="CCDS:CCDS6222.1"
                     /db_xref="GeneID:5569"
                     /db_xref="HGNC:HGNC:9017"
                     /db_xref="MIM:606059"
                     /translation="MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAG
                     LDINKTEGEEDAQRSSTEQSGEAQGEAAKSES"
     exon            437..3962
                     /gene="PKIA"
                     /gene_synonym="PRKACN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1890..1895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PKIA"
                     /gene_synonym="PRKACN1"
                     /note="hexamer: AATAAA"
     regulatory      1894..1899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PKIA"
                     /gene_synonym="PRKACN1"
                     /note="hexamer: AATAAG"
     polyA_site      1909
                     /gene="PKIA"
                     /gene_synonym="PRKACN1"
                     /note="major polyA site"
     polyA_site      1917
                     /gene="PKIA"
                     /gene_synonym="PRKACN1"
     regulatory      3933..3938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PKIA"
                     /gene_synonym="PRKACN1"
                     /note="hexamer: ATTAAA"
     polyA_site      3962
                     /gene="PKIA"
                     /gene_synonym="PRKACN1"
ORIGIN      
        1 gggagcggag gctgctgctg gcaggtgggg cgcgggccgg cgcgagctga ccgagcactc
       61 ggcgggcgcg gcgggactgc ggcccgtggc ggcgtgcgcg gggacctgcg ctgactaggt
      121 ccggggaagt ttcctgactt tctgagaagc cctggtttcc ccaaagaagt gatttctgat
      181 agaaatctga aggtcatctc caagaaaaaa gagatctagt atagtcaatg aattaaagac
      241 aagaaggttt ccaatcagtc cctgctatgt ggatatttgg tagcaatgac tgatgtggaa
      301 actacatatg cagattttat tgcttcagga agaacaggta gaagaaatgc aatacatgat
      361 atcctggttt cctctgcaag tggcaacagc aatgaattag ccttgaaatt agcaggtctt
      421 gatatcaaca agacagaagg tgaagaagat gcacaacgaa gttctacaga acaaagtggg
      481 gaagcccagg gagaagcagc aaaatctgaa agctaacacc ccactttgac cctcgaccac
      541 acctgaaaat gtctcaaatc tccaggagta tctggaatgc atttgtttcc atgagtgaaa
      601 agaggaaaaa gaaaatggct gtgctgcatt gcaggaacct gctcattatc atgttaaaaa
      661 tgagggcaga ggctgtggct gcaggcagac ttttccctac ctctgtcatt agcaatggtt
      721 gaaatcatgt ggcttgtgtt tgggcgtcat ttttgtatgg atcctttcac ttgatcatat
      781 gacgaaatgc ttatagagag tagctccgac ctagatgatg attcttcctg tagcatctgg
      841 cccctcacaa tgtcagagga tttaattgtg tctaattgcg aagggttgat tgaaccccag
      901 agtttaaata tctctggctc aagtgttcac ccagtaaaag aaagatccag aaagcactgt
      961 ttttagcatt acgtatctgt gtgttactgc tgtgttattt acactgtttt gtattgtaca
     1021 atatatatgc tcagcactgc ccccttctct gattgcttat gaaaaacaaa atgatgtaca
     1081 ttactgtgaa tttttatacc actcattttt aaaagggctg tcttttcatt ttagttttcc
     1141 atactgtggt ggtgtacaca ggatagaaca ccctttttta aaacacagtc tttccccttg
     1201 ctcattgtat gttgatgagt tgattaagtc taacagattc atcaagactc cattgcttta
     1261 ttatagagac atttgaaaat atccattaat gtgaatatca cctgaattca gtctgtttgg
     1321 tgtctgcaca gactggaatt caatctgtca aatttgtttt attctcaagt ggagaacttc
     1381 tcccacataa tatatatata tatatatatt ttaatttatg agaattttgg acaattggaa
     1441 aggtagaaaa gaaaagccaa gatcatacta aggactggaa atattttgtt ctatggaatc
     1501 aaatttctca caatgctgta tgatactatt taaatttgga ggacaactta tcttcactaa
     1561 gctgaatcag gtggagaaag taatctcctt gcaatcatgt ggacaccaat cacaaaagta
     1621 aagccctggt gttgtgtttt catgtctttt ttcagccctc tcagatccaa atgttattat
     1681 gcacttttta atgtttgtaa acttttacta ataattagtg tgaattgcat tctgatacaa
     1741 taatgattat cattagaagc taacaaaatt ctcattaata ctgtgtttga tggcctctgc
     1801 tgtgttttaa catcgtgctt cttatatgga aagtttttgt gagctgtgta atccctctgg
     1861 tcagtattat gaaatcattt gtcagtggta ataaataagg aaccagtaat atgccaatgg
     1921 ttcatgaatt actggacaaa tagcagacaa tgggagtccc tttacaataa cgagcccact
     1981 tagctgtcct tgagggctta gataccttgc cacgtgaagt aggtagagca gcatttcaat
     2041 aggtaatttg tgtggttgtg ccagaaactc agcccttcta tgtaattaca tacaggataa
     2101 aaggtaagtc tgctcacttc tccttctaca gggcatttca actgactgga ataagggcat
     2161 ggttgcattt agtactcaat cagatattac tagaaaaaaa attaataatg tgagcctttc
     2221 cgagagcaga acgaggaaag attaaatttt agaatgcttc cttctgtcta atccatcagg
     2281 ggccaaaatg cccagtaaaa ttcaaacaca tcacctatta atagacttac aagtgagaaa
     2341 agaggttcct agggttattt taggcaatcc ctggtaaact gtttaaacca tcaaacccct
     2401 acagtcagtt ttcagtatcc tcatttaata ttttaatagg tttcttgtga atttaaactt
     2461 ctcttctttc ttaaggttgt gaaattccaa actgatttta tgtgattttg aaaagtttag
     2521 aaccagtgct gagtctatgt ggagggttta tattcctatg tgatatactg ttattaatgc
     2581 atgtggtgcc atgcttgtct ttaaatatat aaatagtgct aaattgcaaa gtcatatgga
     2641 gctttggatt tagtttgact tcttactact gctttgtctg ctatattcaa acccaaaggc
     2701 attcccaagc tagggagata aaaattaatt ttctaaaatg tccacatcct atacattttg
     2761 cttattcatg gcatctttca aattttattt tagtttcctt tatttgccaa gaatacatat
     2821 ggatttgaat ttttaaggag agaaggaaag ggtaggaaac cagggccttg ggtttagtaa
     2881 caggcattgg atgtctatta accaactatt cttacgctaa tggctttgca gctcctattc
     2941 tcccatttga tcctcaaaca attctattag agtggtattt ttatccaatt tcacagatta
     3001 aaatataagc actcaataaa atataacctt tagaagctta aaaagctagt aagtgatgaa
     3061 ctgaggattt gaacccatgt ttgtcaccaa ggagctttcc agggcacatg tcataaaatt
     3121 agagccaact gcagagctgt aagggaactt ttagagatga acttcttcag cctccatatt
     3181 ttacagaagg aaactgaatc ccagaaggag aaattgccgt tctcaaggct ccctggatgg
     3241 gtaataacac agatatgagt aggtcacata aagtatatct tttttaaaaa aaagaaattc
     3301 aattatgtct tatttggggg gtatatttcc cagaagatat ttttctggca tgtggtctgt
     3361 aaacacagca tgattcatat tttttatgtt tcatgctact cattttgttt aattaccaac
     3421 aaacatgggg actttggctt tttgacttat ttgcaacaag catgaaattg ttaaatttac
     3481 cttttatcaa ttgtaatcat cctatgccaa catattatca taaattcata gaaatatttt
     3541 taaaaataaa taacagacat tgaaatccaa ttcttagata atactcccag aacagccaat
     3601 ggtaaatgcc ctatacttga gtcttactta gatgctgtgg taatgcacca ttttagaaga
     3661 tgaatgatac tgctatttct cttcagggaa acaataatgg ataaagaaat gtaactgccg
     3721 ggcagcaaag cttctaagtg aaacctgtag tagcagtagt agtagggaga aaatgtgtag
     3781 tcatcaagtg aaaataggaa aggatctatg atttatgatg tcttaataga ccctaaattg
     3841 ttctttaatt acaagagtgg cagtctctga agtcatttgt gagcttgtat gacttttgta
     3901 tttagcaatg ttgcatgctc acataattga aaattaaaag taacacattt ttctgaaatg
     3961 ta
//
