LOCUS       NM_177531              19969 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens PKHD1 like 1 (PKHD1L1), mRNA.
ACCESSION   NM_177531
VERSION     NM_177531.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 19969)
  AUTHORS   Redfield,S.E., De-la-Torre,P., Zamani,M., Wang,H., Khan,H.,
            Morris,T., Shariati,G., Karimi,M., Kenna,M.A., Seo,G.H., Xu,H.,
            Lu,W., Naz,S., Galehdari,H., Indzhykulian,A.A., Shearer,A.E. and
            Vona,B.
  TITLE     PKHD1L1, a gene involved in the stereocilia coat, causes autosomal
            recessive nonsyndromic hearing loss
  JOURNAL   Hum Genet 143 (3), 311-329 (2024)
   PUBMED   38459354
  REMARK    GeneRIF: PKHD1L1, a gene involved in the stereocilia coat, causes
            autosomal recessive nonsyndromic hearing loss.
REFERENCE   2  (bases 1 to 19969)
  AUTHORS   Kang,J.Y., Yang,J., Lee,H., Park,S., Gil,M. and Kim,K.E.
  TITLE     Systematic Multiomic Analysis of PKHD1L1 Gene Expression and Its
            Role as a Predicting Biomarker for Immune Cell Infiltration in Skin
            Cutaneous Melanoma and Lung Adenocarcinoma
  JOURNAL   Int J Mol Sci 25 (1), 359 (2023)
   PUBMED   38203530
  REMARK    GeneRIF: Systematic Multiomic Analysis of PKHD1L1 Gene Expression
            and Its Role as a Predicting Biomarker for Immune Cell Infiltration
            in Skin Cutaneous Melanoma and Lung Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 19969)
  AUTHORS   Erdman,V.V., Karimov,D.D., Nasibullin,T.R., Timasheva,I.R.,
            Tuktarova,I.A. and Mustafina,O.E.
  TITLE     [Role of PLAT, PKHD1L1, STK38L and TEAD1 genes Alu-polymorphism for
            longevity]
  JOURNAL   Adv Gerontol 29 (5), 709-716 (2016)
   PUBMED   28556638
  REMARK    GeneRIF: High probability of detection of PKHD1L1*I/I had a
            Long-lived women and PKHD1L1*I/D genotype was a significant factor
            in providing of male longevity of the ethnically homogeneous group
            of Tatars from the Republic of Bashkortostan, Russia.
REFERENCE   4  (bases 1 to 19969)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 19969)
  AUTHORS   Lian,P.W., Fu,Y.L., Li,A., Dai,B.Z., Ding,Z.W., Li,L. and Wu,G.Q.
  TITLE     [Preparation and characterization of a polyclonal antibody against
            human Fibrocystin-L]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 27 (1), 78-81 (2011)
   PUBMED   21208571
REFERENCE   6  (bases 1 to 19969)
  AUTHORS   Hogan,M.C., Griffin,M.D., Rossetti,S., Torres,V.E., Ward,C.J. and
            Harris,P.C.
  TITLE     PKHDL1, a homolog of the autosomal recessive polycystic kidney
            disease gene, encodes a receptor with inducible T lymphocyte
            expression
  JOURNAL   Hum Mol Genet 12 (6), 685-698 (2003)
   PUBMED   12620974
  REMARK    GeneRIF: PKHDL1 may have a role in cellular immunity
REFERENCE   7  (bases 1 to 19969)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021237.5, AC021001.5, AP000427.3 and AI923283.1.
            
            On Nov 22, 2018 this sequence version replaced NM_177531.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY219181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378402.10/ ENSP00000367655.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AC021237.5         17261-17453         c
            194-283             AC021237.5         15278-15367         c
            284-428             AC021001.5         149633-149777       c
            429-537             AC021001.5         148576-148684       c
            538-595             AC021001.5         147020-147077       c
            596-689             AC021001.5         145517-145610       c
            690-743             AC021001.5         142597-142650       c
            744-817             AC021001.5         141995-142068       c
            818-860             AC021001.5         140653-140695       c
            861-931             AC021001.5         136662-136732       c
            932-1042            AC021001.5         135010-135120       c
            1043-1132           AC021001.5         132599-132688       c
            1133-1401           AC021001.5         130803-131071       c
            1402-1493           AC021001.5         129559-129650       c
            1494-1653           AC021001.5         126434-126593       c
            1654-1789           AC021001.5         126017-126152       c
            1790-1933           AC021001.5         124669-124812       c
            1934-2091           AC021001.5         122941-123098       c
            2092-2205           AC021001.5         121169-121282       c
            2206-2355           AC021001.5         118733-118882       c
            2356-2480           AC021001.5         117602-117726       c
            2481-2644           AC021001.5         111887-112050       c
            2645-2817           AC021001.5         110457-110629       c
            2818-2965           AC021001.5         105915-106062       c
            2966-3120           AC021001.5         103991-104145       c
            3121-3243           AC021001.5         101685-101807       c
            3244-3349           AC021001.5         101110-101215       c
            3350-3460           AC021001.5         97931-98041         c
            3461-3625           AC021001.5         95793-95957         c
            3626-3747           AC021001.5         94688-94809         c
            3748-3880           AC021001.5         92691-92823         c
            3881-4076           AC021001.5         92055-92250         c
            4077-4219           AC021001.5         90295-90437         c
            4220-4324           AC021001.5         89768-89872         c
            4325-4513           AC021001.5         88952-89140         c
            4514-4684           AC021001.5         88031-88201         c
            4685-4911           AC021001.5         87245-87471         c
            4912-5896           AC021001.5         85502-86486         c
            5897-6145           AC021001.5         82756-83004         c
            6146-6295           AC021001.5         81660-81809         c
            6296-6470           AC021001.5         79998-80172         c
            6471-6627           AC021001.5         78867-79023         c
            6628-6784           AC021001.5         78273-78429         c
            6785-6864           AC021001.5         76901-76980         c
            6865-6994           AC021001.5         76295-76424         c
            6995-7124           AC021001.5         74756-74885         c
            7125-7366           AC021001.5         71311-71552         c
            7367-7503           AC021001.5         69239-69375         c
            7504-8533           AC021001.5         65902-66931         c
            8534-8725           AC021001.5         64378-64569         c
            8726-8877           AC021001.5         55878-56029         c
            8878-9037           AC021001.5         54480-54639         c
            9038-9209           AC021001.5         53751-53922         c
            9210-9298           AC021001.5         51508-51596         c
            9299-9447           AC021001.5         51008-51156         c
            9448-9577           AC021001.5         49585-49714         c
            9578-9696           AC021001.5         48042-48160         c
            9697-9826           AC021001.5         45974-46103         c
            9827-10000          AC021001.5         44326-44499         c
            10001-10104         AC021001.5         41092-41195         c
            10105-10234         AC021001.5         40046-40175         c
            10235-10356         AC021001.5         39153-39274         c
            10357-10447         AC021001.5         37396-37486         c
            10448-10596         AC021001.5         34080-34228         c
            10597-10719         AC021001.5         33875-33997         c
            10720-10831         AC021001.5         32574-32685         c
            10832-10948         AC021001.5         32376-32492         c
            10949-11114         AC021001.5         26655-26820         c
            11115-11347         AC021001.5         23252-23484         c
            11348-11515         AC021001.5         22883-23050         c
            11516-11673         AC021001.5         20213-20370         c
            11674-11809         AC021001.5         15842-15977         c
            11810-12151         AC021001.5         12639-12980         c
            12152-12303         AC021001.5         8810-8961           c
            12304-12450         AC021001.5         8257-8403           c
            12451-12604         AC021001.5         7761-7914           c
            12605-12841         AC021001.5         4127-4363           c
            12842-13908         AC021001.5         1-1067              c
            13909-19550         AP000427.3         95408-101049
            19551-19969         AI923283.1         17-435              c
FEATURES             Location/Qualifiers
     source          1..19969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.1-q23.2"
     gene            1..19969
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /note="PKHD1 like 1"
                     /db_xref="GeneID:93035"
                     /db_xref="HGNC:HGNC:20313"
                     /db_xref="MIM:607843"
     exon            1..193
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..12852
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /note="polycystic kidney and hepatic disease-like 1;
                     fibrocystin-L; PKHD1-like protein 1; polycystic kidney and
                     hepatic disease 1-like protein 1; polycystic kidney and
                     hepatic disease 1 (autosomal recessive)-like 1"
                     /codon_start=1
                     /product="fibrocystin-L precursor"
                     /protein_id="NP_803875.2"
                     /db_xref="CCDS:CCDS47911.1"
                     /db_xref="GeneID:93035"
                     /db_xref="HGNC:HGNC:20313"
                     /db_xref="MIM:607843"
                     /translation="MGHLWLLGIWGLCGLLLCAADPSTDGSQIIPKVTEIIPKYGSIN
                     GATRLTIRGEGFSQANQFNYGVDNAELGNSVQLISSFQSITCDVEKDASHSTQITCYT
                     RAMPEDSYTVRVSVDGVPVTENNTCKGHINSWECTFNAKSFRTPTIRSITPLSGTPGT
                     LITIQGRIFTDVYGSNIALSSNGKNVRILRVYIGGMPCELLIPQSDNLYGLKLDHPNG
                     DMGSMVCKTTGTFIGHHNVSFILDNDYGRSFPQKMAYFVSSLNKIAMFQTYAEVTMIF
                     PSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTPPKPHILKT
                     VYPGGRGLKLEVWNNSRPIRLEEILEYNEKTPGYMGASWVDSASYIWLMEQDTFVARF
                     SGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPEDKVRIAYHSANANSYFSSPTQRSDD
                     IHLQKGKEYYIEILLQEYRLSAFVDVGLYQYRNVYTEQQTGDAVNEEQVIKSQSTILQ
                     EVQVITLENWETTNAINEVQKIKVTSPCVEANSCSLYQYRLIYNMEKTVFLPADASEF
                     ILQSALNDLWSIKPDTVQVIRTQNPQSYVYMVTFISTRGDFDLLGYEVVEGNNVTLDI
                     TEQTKGKPNLETFTLNWDGIASKPLTLWSSEAEFQGAVEEMVSTKCPPQIANFEEGFV
                     VKYFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRRPYGDILL
                     FPYNQLCLAYKGFLANYIGLKFQYQDNSKITRSTDTQFTYNFAYGNNWTYTCIDLLDL
                     VRTKYTGTNVSLQRISLHKASESQSFYVDVVYIGHTSTISTLDEMPKRRLPALANKGI
                     FLEHFQVNQTKTNGPTMTNQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGN
                     NWPGESKIHIQRIQAASPPLSGSFDIQAYGHILKGLPAAVSAADLQFALQSLEGMGRI
                     SVTREGTCAGYAWNIKWRSTCGKQNLLQINDSNIIGEKANMTVTRIKEGGLFRQHVLG
                     DLLRTPSQQPQVEVYVNGIPAKCSGDCGFTWDSNITPLVLAISPSQGSYEEGTILTIV
                     GSGFSPSSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAQNVGG
                     EEFYFVYQSQISHIWPDSGSIAGGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRIT
                     CRTPKKTEGTVDISVTTNGFQATARDAFSYNCLQTPIITDFSPKVRTILGEVNLTIKG
                     YNFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLPKLSPGKHDIYVEVRNWGFASTRD
                     KLNSSIQYVLEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSE
                     NVIKCILHSTGNIFRITNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPFLRGIG
                     YRIFSVSSPGSVIYDGKGFTSGRQKSTSGSFSYQFTSPGIHYYSSGYVDEAHSIFLQG
                     VINVLPAETRHIPLHLFVGRSEATYAYGGPENLHLGSSVAGCLATEPLCSLNNTRVKN
                     SKRLLFEVSSCFSPSISNITPSTGTVNELITIIGHGFSNLPWANKVTIGSYPCVVEES
                     SEDSITCHIDPQNSMDVGIRETVTLTVYNLGTAINTLSNEFDRRFVLLPNIDLVLPNA
                     GSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDL
                     LIHGVPAQCQGNCTFSYLESITPYITGVFPNSVIGSVKVLIEGEGLGTVLEDIAVFIG
                     NQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKGLALGNLTVSSPPVASLSPTSGS
                     IGGGTTLVITGNGFYPGNTTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNT
                     IAYPPLLFTYALEDTPFLRGIIPSRGPPGTEIEITGSNFGFEILEISVMINNIQCNVT
                     MANDSVVQCIVGDHAGGTFPVMMHHKTKGSAMSTVVFEYPLNIQNINPSQGSFGGGQT
                     MTVTGTGFNPQNSIILVCGSECAIDRLRSDYTTLLCEIPSNNGTGAEQACEVSVVNGK
                     DLSQSMTPFTYAVSLTPLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKC
                     DVEYSNKTHIICMTDAHTLSGWAPVCVHIRGVGMAKLDNADFLYVDAWSSNFSWGGKS
                     PPEEGSLVVITKGQTILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGVLQ
                     IGTETSPFQHKAVITLHGHLRSPELPVYGAKTLAVREGILDLHGVPVPVTWTRLAHTA
                     KAGERILILQEAVTWKPGDNIVIASTGHRHSQGENEKMTIASVSADGINITLSNPLNY
                     THLGITVTLPDGTLFEARAEVGILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQT
                     CLQGKFGEEIGSDQFGGCVMFHAPVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHL
                     LGDLQFKSYVRGCAIHQAYNRAVTIHNTHHLLVERNIIYDIKGGAFFIEDGIEHGNIL
                     QYNLAVFVQQSTSLLNDDVTPAAFWVTNPNNTIRHNAVAGGTHFGFWYRMNNHPDGPS
                     YDRNICQKRVPLGEFFNNTVHSQGWFGMWIFEEYFPMQTGSCTSTVPAPAIFNSLTTW
                     NCQKGAEWVNGGALQFHNFVMVNNYEAGIETKRILAPYVGGWGETNGAVIKNAKIVGH
                     LDELGMGSAFCTAKGLVLPFSEGLTVSSVHFMNFDRPNCVALGVTSISGVCNDRCGGW
                     SAKFVDVQYSHTPNKAGFRWEHEMVMIDVDGSLTGHKGHTVIPHSSLLDPSHCTQEAE
                     WSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLSDSFGTSIIPFQKKRLTHMSGW
                     MALIPNANHINWYFKGVDHITNISYTSTFYGFKEEDYVIISHNFTQNPDMFNIIDMRN
                     GSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQLISGNLDPDVKDVVINFQA
                     YCCILQDCFPVHPPSRKPIPKKRPATYNLWSNDSFWQSSRENNYTVPHPGANVIIPEG
                     TWIVADIDMPSMERLIIWGVLELEDKYNVGAAESSYREVVLNATYISLQGGRLIGGWE
                     DNPFKGDLKIVLRGNHTTQDWALPEGPNQGAKVLGVFGELDLHGIPHSIYKTKLSETA
                     FAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKILILNDSLSYTH
                     FAEKYHVPGTGESYTLAADVGILSRNIKIVGEDYPGWSEDSFGARVLVGSFTENMMTF
                     KGNARISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYIRGCAFHHGFSPAI
                     GVFGTDGLDIDDNIIHFTVGEGIRIWGNANRVRGNLIALSVWPGTYQNRKDLSSTLWH
                     AAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLYGIYMN
                     QDGLPGCSLIQGFTIWTCWDYGIYFQTTESVHIYNVTLVDNGMAIFPMIYMPAAISHK
                     ISSKNVQIKSSLIVGSSPGFNCSDVLTNDDPNIELTAAHRSPRSPSGGRSGICWPTFA
                     SAHNMAPRKPHAGIMSYNAISGLLDISGSTFVGFKNVCSGETNVIFITNPLNEDLQHP
                     IHVKNIKLVDTTEQSKIFIHRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGNAGS
                     VIPQAEYEWDGNSQVGIGDYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYLPEW
                     QSYQCFGMEYAMMVIESLDPDTETRRLSPVAIMGNGYVDLINGPQDHGWCAGYTCQRR
                     LSLFHSIVALNKSYEVYFTGTSPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNL
                     LVCPKTTIWNAQQKHCELNNHLYKDQFLPNLDSTVLGENYFDGTYQMLYLLVKGTIPV
                     EIHTATVIFVSFQLSVATEDDFYTSHNLVKNLALFLKIPSDKIRISKIRGKSLRRKRS
                     MGFIIEIEIGDPPIQFISNGTTGQMQLSELQEIAGSLGQAVILGNISSILGFNISSMS
                     ITNPLPSPSDSGWIKVTAQPVERSAFPVHHVAFVSSLLVITQPVAAQPGQPFPQQPSV
                     KATDSDGNCVSVGITALTLRAILKDSNNNQVNGLSGNTTIPFSSCWANYTDLTPLRTG
                     KNYKIEFILDNVVGVESRTFSLLAESVSSSGSSSSSNSKASTVGTYAQIMTVVISCLV
                     GRMWLLEIFMAAVSTLNITLRSY"
     exon            194..283
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..428
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..537
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..595
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..689
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..743
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..817
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..860
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..931
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1042
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1132
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1401
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1493
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1653
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1789
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1933
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2091
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2205
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2355
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2480
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2644
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2817
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2965
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3120
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3243
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3349
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3460
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3625
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3626..3747
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3748..3880
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3881..4076
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4219
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4220..4324
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4325..4513
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4514..4684
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4685..4911
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4912..5896
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5897..6145
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6146..6295
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6296..6470
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6471..6627
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6628..6784
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6785..6864
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6865..6994
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            6995..7124
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7125..7366
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7367..7503
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            7504..8533
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            8534..8725
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            8726..8877
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            8878..9037
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            9038..9209
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            9210..9298
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            9299..9447
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            9448..9577
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            9578..9696
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            9697..9826
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            9827..10000
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            10001..10104
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            10105..10234
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            10235..10356
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            10357..10447
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            10448..10596
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            10597..10719
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            10720..10831
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            10832..10948
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            10949..11114
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            11115..11347
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            11348..11515
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            11516..11673
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            11674..11809
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            11810..12151
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            12152..12303
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            12304..12450
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            12451..12604
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            12605..12841
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     exon            12842..19969
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15428..15433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /note="hexamer: AATAAA"
     polyA_site      15446
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /note="major polyA site"
     regulatory      19947..19952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /note="hexamer: AATAAA"
     polyA_site      19969
                     /gene="PKHD1L1"
                     /gene_synonym="DFNB124; PKHDL1"
                     /note="major polyA site"
ORIGIN      
        1 gttccccagc tctcccggga cgaagcgggc ccgccagcga gtcgcagtcc caggagccga
       61 gctccagcac tagagccagc tgcgagcgga gggcaccaac tccgcagaac tggcttttca
      121 atgggacacc tgtggctcct gggtatttgg ggcctctgtg ggctgctcct gtgtgccgcg
      181 gatcccagca cagatggctc tcaaataatc cccaaagtca cagaaataat acctaaatat
      241 ggcagtataa atggagcaac aaggctgact ataagagggg aaggtttttc tcaagcaaac
      301 cagtttaact atggagttga taacgctgag ttgggaaaca gtgtgcaatt aatttcttct
      361 ttccagtcaa ttacttgtga tgtagaaaaa gatgcaagtc attcaactca aattacatgc
      421 tatactagag caatgccgga agattcctac actgttagag tcagtgtgga cggggttcct
      481 gttacggaaa ataacacctg caaaggtcac atcaacagct gggaatgtac cttcaacgca
      541 aaaagtttta gaaccccaac aataagaagc atcacacctt tatctggaac tccaggtaca
      601 ctaataacaa tccaaggcag aatcttcact gatgtctatg gaagtaatat tgcactaagc
      661 tcaaatggga aaaatgttag gattttgaga gtttacattg gaggaatgcc ctgtgagctt
      721 ctcataccac aatctgataa tttatatggt ctaaaactgg atcatccaaa tggagatatg
      781 ggttctatgg tttgtaagac gactggaact tttattggtc atcacaatgt cagcttcatc
      841 ttagataatg attatggaag gagttttcca cagaaaatgg catattttgt ttcttctctc
      901 aataaaattg caatgtttca aacatatgca gaggtcacca tgattttccc ttcacaagga
      961 agcattcgag gtggcaccac gctgacaata agtgggcgtt tctttgatca gacagatttc
     1021 cccgtcagag ttctagttgg aggtgaacct tgtgatattt tgaatgtcac agaaaatagt
     1081 atatgttgca agacaccccc caaacctcat attctcaaaa ctgtatatcc aggagggaga
     1141 ggcctgaagc ttgaggtgtg gaataatagc cgtccaatac gtttggaaga gatactggaa
     1201 tacaatgaaa aaacgcctgg gtacatgggt gccagttggg tagattcagc ttcctatatt
     1261 tggctcatgg aacaagacac atttgttgca cgctttagtg gatttttggt ggctccagat
     1321 tctgatgttt atagattcta catcaagggt gatgaccgtt atgctattta ttttagccag
     1381 actggacttc cagaagataa ggtgaggatt gcatatcatt ctgctaatgc caacagttat
     1441 ttttccagtc caacacaaag atcagatgat attcatctgc agaaaggaaa agaatactat
     1501 attgaaatct tgctgcagga gtacagatta agtgcatttg ttgatgttgg actgtaccag
     1561 tatcgaaatg tttatactga acaacaaaca ggagatgcag tgaatgaaga acaagttatc
     1621 aaatcccagt cgacaatcct ccaggaagta caggttataa cattggaaaa ctgggaaaca
     1681 actaatgcaa ttaatgaggt tcagaagatc aaggtaacca gcccatgtgt ggaagctaat
     1741 tcatgttcac tttaccaata tagattaatc tataatatgg aaaaaactgt cttcctacct
     1801 gctgatgctt ctgaattcat actgcaatca gccttgaatg acctctggtc tataaaaccg
     1861 gacacagttc aagtaataag aacacaaaat ccccagagct atgtctacat ggtaacattc
     1921 atatcaacta gaggagactt tgatctgctt ggttatgaag tagttgaagg gaataatgtc
     1981 acactggata ttacagaaca aaccaaagga aaacccaact tggagacatt cacactgaat
     2041 tgggatggga tcgcttctaa gccactcact ctatggtcat cagaagctga atttcaggga
     2101 gcagtggaag aaatggttag cactaagtgt ccaccacaaa ttgcaaattt tgaagaagga
     2161 tttgttgtga aatatttcag agactatgaa actgatttta atctggaaca tattaacaga
     2221 gggcagaaga cagctgaaac cgatgcttac tgtggtcgtt attccctgaa aaacccagct
     2281 gttctttttg actcagcaga tgttaaacca aacagacgac catatggaga tattttattg
     2341 tttccttata atcagttatg tttagcatac aaaggattcc tggcaaatta tattggtcta
     2401 aaatttcagt accaagacaa tagcaagatt actagaagca ctgatacaca gtttacatac
     2461 aactttgctt atggaaacaa ctggacttac acttgcatag accttctgga tctcgtaaga
     2521 acgaaataca ctgggacaaa tgtttctctt cagaggatta gcttacataa agcatcagaa
     2581 tcacagtcct tctatgtgga tgtagtgtac attggacaca catctacaat ctcaacattg
     2641 gatgaaatgc ccaagagaag acttcctgca ttagcaaata aaggaatatt cttagagcac
     2701 tttcaggtga atcagaccaa aacaaatggg ccaactatga caaaccaata ttctgttacc
     2761 atgacttcat acaattgcag ttacaatata cccatgatgg ctgtgagctt tgggcagata
     2821 atcacacatg agacagagaa cgagtttgtc tacagaggaa ataattggcc aggcgagtca
     2881 aaaattcata ttcaaagaat tcaagctgca tctccacctc taagtggcag ctttgacatt
     2941 caagcttatg gacatattct taaaggcctc cccgctgctg tgtcagctgc agatctgcag
     3001 tttgcactcc agagtctgga gggaatggga agaatctcag ttacacgaga gggaacctgt
     3061 gctggctacg cgtggaacat caaatggaga agcacctgcg gaaagcagaa tcttctacag
     3121 attaatgatt ccaacattat tggagaaaag gctaatatga cagttacaag gataaaggaa
     3181 ggtggcttat tcagacaaca tgtacttgga gacctacttc gtacacccag tcaacagcca
     3241 caggttgaag tctatgtcaa tggaattcca gctaaatgtt caggtgactg tggatttaca
     3301 tgggattcca acattactcc cctagtcttg gcgataagcc cttctcaagg gtcctatgaa
     3361 gaaggcacaa ttctaaccat agtgggttct ggattttctc ctagttcagc tgtaacagtc
     3421 tcagttggac cagtaggttg ttctcttctt tctgtggatg aaaaagagct caagtgccag
     3481 attctgaatg gaagtgctgg acatgccccc gttgctgtgt ccatggctga tgttggacta
     3541 gcacagaatg tagggggtga agagttctac tttgtttatc agagtcagat ctcacatatc
     3601 tggcctgatt ctggaagcat agcaggtggt actctactga ctttatctgg atttggcttt
     3661 aatgaaaatt caaaggtatt agttggaaat gaaacctgca atgtgattga aggggatttg
     3721 aataggataa cctgcaggac accaaaaaaa actgagggta cagttgatat ttcagttact
     3781 accaatggat ttcaagccac agcaagggat gcttttagtt ataattgttt acagacacca
     3841 attataactg attttagtcc aaaagtacga acaatactag gagaagttaa tttaacaatt
     3901 aagggctata attttggaaa tgaactcaca caaaacatgg cggtgtatgt tggaggaaaa
     3961 acctgccaga ttcttcactg gaacttcaca gatattagat gccttttgcc caagttgtct
     4021 cctggaaaac atgatatcta tgtagaagtc agaaactggg gttttgcatc aacaagagac
     4081 aaattaaatt cttcaataca gtatgtttta gaagtgacca gcatgtttcc acaaagaggc
     4141 tccttgtttg gtggaactga aatcaccata aggggttttg gattcagcac aataccagct
     4201 gagaataccg tgctgttagg gtccatccct tgcaatgtta catcatcatc agaaaatgtc
     4261 ataaaatgta ttcttcattc aactgggaat atattcagga ttaccaacaa tgggaaagat
     4321 tcagtacatg gattaggtta tgcctggtca ccaccagtcc taaatgtgtc tgtgggggac
     4381 acagtggcat ggcattggca aacacatccg tttcttagag ggataggata taggattttt
     4441 tctgtctcca gtcctggaag tgtaatttat gatggcaaag gattcacaag tggaagacaa
     4501 aaatctacat caggttcatt ttcttaccaa tttacttctc ctggaatcca ttattatagc
     4561 agcgggtatg ttgatgaggc tcactccatt tttctccaag gagtcattaa tgttttacca
     4621 gctgaaacca gacacattcc cttgcacctg tttgtgggtc gctctgaagc cacatatgct
     4681 tatggaggac ctgagaattt gcacttggga agctctgtgg caggctgcct agcaacagaa
     4741 cccctgtgca gcctgaacaa taccagggtt aaaaattcaa aaagattgct atttgaggtt
     4801 tcaagttgtt tttcaccatc tataagcaac attactccgt ccactggaac agtaaatgaa
     4861 ctaataacaa ttattggaca tggctttagt aatctcccat gggctaataa ggttacaatt
     4921 ggtagctacc cctgtgtcgt agaagaaagt agtgaggatt caattacatg tcatattgac
     4981 cctcaaaact caatggatgt tggtatcagg gaaactgtca ctttgactgt ctacaacctg
     5041 ggcactgcta tcaatacgtt gtccaatgaa tttgataggc gatttgtact tttgccaaac
     5101 attgacctgg tgttgccaaa tgcaggatca actacaggaa tgacaagcgt gaccataaaa
     5161 ggctctggat ttgccgtttc ttctgcaggt gtaaaagtcc ttatgggtca tttcccatgt
     5221 aaagttctat cagtgaatta tacggccatt gaatgtgaaa catcccctgc tgcccaacag
     5281 cttgtggatg tagatcttct aatacatgga gtgcctgccc agtgccaggg aaactgcacc
     5341 ttttcatact tagaaagcat cactccttac ataacaggag tcttcccaaa ctctgtcata
     5401 ggatctgtaa aagttcttat tgaaggagaa ggtttgggga ctgttttgga ggacattgct
     5461 gttttcattg gaaatcaaca gttcagagca atagaggtta atgaaaacaa catcactgct
     5521 cttgtgactc ctctcccagt tggacatcat tctgttagtg ttgtggtggg aagtaaaggc
     5581 ttggctctgg gaaacctgac tgtcagcagc cccccagtag catctctatc accaacttct
     5641 ggaagcattg gtggtggaac tacactggtg atcacaggaa atggcttcta tccaggcaac
     5701 actacagtca ctattgggga tgaaccttgt caaattattt ccatcaaccc caatgaagtc
     5761 tactgccgca ctcccgctgg gaccactgga atggtcgatg ttaaaatctt tgttaataca
     5821 attgcttatc cacctttgct ttttacatat gccctggagg atactccatt tctcagagga
     5881 attatcccaa gcagaggtcc accaggaact gaaattgaga tcactggatc caactttggc
     5941 tttgagatct tggaaatctc cgtgatgata aataacattc agtgtaatgt aaccatggcc
     6001 aatgatagtg tggtgcagtg catcgtggga gatcatgctg ggggcacatt tcctgttatg
     6061 atgcatcata agacaaaagg ctcagccatg tccacagttg tatttgagta cccgcttaat
     6121 attcaaaata ttaatccaag ccaagggagc tttggtgggg gtcaaaccat gactgtgaca
     6181 ggcaccggat ttaatccaca aaattcaatt atattagttt gtggctcaga atgtgcaatt
     6241 gacaggctta gatctgatta cacaacacta ttatgtgaaa ttccatctaa taatggcacg
     6301 ggagctgagc aagcctgtga agtgagtgtg gttaatggga aagatttgtc acagtccatg
     6361 actccgttta cgtacgcagt gtcactgact ccactcatca ctgcagtatc tcctaagaga
     6421 ggcagtacag cagggggcac cagactgaca gtcgtgggat caggattcag tgaaaatatg
     6481 gaggatgttc atatcaccat agctgaagcc aaatgtgatg ttgagtattc caacaagaca
     6541 cacatcatct gcatgacaga tgcccatact ctatcagggt gggctccagt ttgtgtccac
     6601 atcagaggtg tcggcatggc caaactggat aatgctgact ttctttatgt tgatgcctgg
     6661 tcctccaatt tctcatgggg gggaaaatct cccccagaag aaggatctct tgttgttatt
     6721 acaaaaggac agaccattct gctggatcaa agcaccccta ttttgaaaat gttgcttatt
     6781 cagggtggga ctctaatatt tgatgaagct gacattgaac tccaggcaga aaatattcta
     6841 attacagatg gaggtgttct tcagattgga acagagacat ccccattcca acacaaggct
     6901 gtcattacct tgcatggtca cctgcgatct cctgagctcc ctgtctatgg tgccaaaaca
     6961 ctggctgtgc gggagggaat cctggatctg cacggtgtgc ctgttcctgt gacctggact
     7021 cgcttggctc atactgcaaa ggcaggggaa agaattttaa ttttacaaga agcagtaaca
     7081 tggaaaccag gagataacat tgtaattgca agcacaggac acagacacag tcaaggagag
     7141 aatgaaaaaa tgaccattgc atctgtgtct gctgatggca taaacataac actaagtaac
     7201 ccactaaatt acacacactt aggaattacg gtcacactcc ctgatggaac tctgtttgaa
     7261 gcaagagcag aagttggaat tcttacaaga aatattttaa taagaggatc tgataatgtt
     7321 gagtggaata acaaaattcc tgcatgtcct gatggatttg acacaggaga atttgctaca
     7381 cagacctgtc tccaaggaaa gtttggagaa gaaataggaa gtgaccaatt tggaggctgc
     7441 gttatgtttc atgctcctgt acctggtgct aacatggtaa ctgggagaat agaatatgta
     7501 gaggtattcc atgctggcca ggctttccgg ttggggcgat atccaataca ttggcacctg
     7561 cttggagact tacagtttaa atcttatgta agaggctgtg caattcacca ggcctataac
     7621 agagctgtta ctattcataa cacacaccat cttctggttg agaggaatat tatatatgat
     7681 attaagggag gagcattttt tatagaagat ggtattgaac atggcaatat cctccagtat
     7741 aacttggcag tatttgtaca gcaaagtacc agtcttctga atgatgatgt gaccccggct
     7801 gcattttggg tcaccaaccc gaacaatacc atacgacaca atgctgttgc tggtggcact
     7861 cactttggct tttggtaccg gatgaacaac caccctgatg ggccatccta tgacagaaac
     7921 atttgtcaaa aaagagttcc ccttggcgaa ttttttaaca atactgtcca ttctcaaggt
     7981 tggtttggaa tgtggatctt tgaggaatat ttccccatgc aaacgggatc ttgtacatct
     8041 acagtgcctg cacctgcaat atttaactca cttactactt ggaattgtca aaaaggagct
     8101 gaatgggtca atggaggtgc ccttcagttc cataactttg tgatggtgaa taactatgag
     8161 gctggaattg agactaagag gatcctggct ccttatgttg gagggtgggg tgaaaccaat
     8221 ggagcggtga ttaaaaatgc caaaatagtc ggccatcttg atgaactggg aatggggtct
     8281 gcattttgca cagcaaaagg cctggttctc ccatttagtg aaggcttgac tgtctcttct
     8341 gtgcacttta tgaactttga ccgtcccaac tgtgtagctt tgggagtgac atccatctct
     8401 ggagtttgta atgacagatg tgggggttgg agtgcaaagt ttgttgacgt ccagtattct
     8461 cacacaccga acaaggctgg ctttcgctgg gaacatgaaa tggtaatgat tgatgttgat
     8521 ggctcactta cagggcacaa aggacatacc gtcattccac acagctcatt gctagaccct
     8581 tctcattgta ctcaggaagc tgagtggagc attgggttcc ctggatcagt ctgtgatgct
     8641 tcagtcagct ttcaccgttt agcgttcaac cagccttctc cagtatctct gcttgaaaag
     8701 gatgtggttc tttcagactc ttttggcaca agcattattc catttcagaa gaaacgactg
     8761 actcatatgt ctggatggat ggctctgatt ccaaatgcaa atcacattaa ctggtatttt
     8821 aaaggtgtgg atcacataac caacatttca tatacatcga cattctatgg attcaaggaa
     8881 gaagactatg taattatatc acataacttc actcaaaatc ctgacatgtt taatattatt
     8941 gatatgagga atggttcctc aaatccattg aattggaata ctagcaagaa tggggactgg
     9001 caccttgaag caaacactag tactctatat tacttggtgt caggaagaaa tgaccttcat
     9061 cagagtcagc tcatttctgg gaacctggat cctgatgtga aagacgttgt tattaatttc
     9121 caagcttact gttgtattct ccaggattgc tttcctgtac atccgccatc aagaaaacca
     9181 attcccaaga agcgaccagc cacatataat ttatggtcaa atgattcttt ttggcaatca
     9241 tcacgagaaa ataattatac tgtacctcac ccaggggcaa atgtgattat acctgaagga
     9301 acatggattg tagctgacat agatatgcca tcaatggaaa gactcattat ttggggggtt
     9361 ctagaactgg aagataaata caatgtagga gctgcagaat cttcttacag agaagttgtt
     9421 ttgaatgcta cctacatatc actgcaggga ggtagattaa tcggtggctg ggaagataac
     9481 ccttttaaag gagacttaaa gattgttctt agaggaaatc atactacaca agactgggct
     9541 cttccagaag gaccaaatca aggggcaaag gtcttagggg tgtttggtga gctggatctt
     9601 catggaattc cacattcaat atataaaact aagctctcag aaactgcatt tgcaggttcc
     9661 aaagtcctgt ctctgatgga tgctgtggat tggcaggagg gagaagagat tgtgataaca
     9721 accacaagct acgatttcca ccagacagaa acaagaagta tcgttaaaat cctgcatgat
     9781 cataaaattc tcattcttaa tgatagcctt tcctatactc actttgctga aaaataccat
     9841 gtccctggaa ctggtgagag ctacacgtta gcagctgatg ttgggatact gagtaggaac
     9901 atcaaaatag ttggtgaaga ttaccccggt tggtctgagg actcttttgg agcacgcgta
     9961 ctggttggct cattcactga aaatatgatg acatttaaag gaaatgcaag aataagtaat
    10021 gtggaatttt atcacagtgg tcaagaaggc ttcagggata gcacagatcc aagatatgct
    10081 gtaacgtttc ttaacctagg acagattcaa gaacatggct catcttatat tcgaggctgt
    10141 gcttttcacc atggcttctc tccagcaatt ggtgtatttg ggacagatgg attggacata
    10201 gatgacaaca tcattcactt tacagtgggg gaaggcataa gaatatgggg gaatgccaac
    10261 cgagtccgag ggaatttgat tgcactttcg gtttggccag gaacctatca gaacagaaaa
    10321 gatttaagtt caactctctg gcatgcagca attgagataa atagagggac caatacagtt
    10381 ttacagaata atgtagtggc tggatttgga agagcaggat accgcattga tggtgaacct
    10441 tgcccaggcc agtttaatcc tgtggaaaag tggtttgaca atgaagccca tggaggttta
    10501 tatgggatct atatgaacca agatggcctt cctggatgtt ctcttataca aggatttacc
    10561 atttggacat gctgggatta tggaatttat tttcagacca cagagagtgt gcacatttat
    10621 aatgtgaccc tggttgacaa tggaatggcc atttttccaa tgatttacat gccagctgct
    10681 atatcacaca aaatttccag taaaaatgta caaattaaga gctcattaat tgttggaagt
    10741 agccctgggt ttaattgctc tgatgtccta actaatgatg atcctaatat tgaactcact
    10801 gctgctcatc ggagtcctag atctccatca ggtgggagaa gtgggatttg ttggcctacc
    10861 tttgcttcag ctcataacat ggcaccccga aagccccatg caggaatcat gagttacaat
    10921 gccatcagtg gccttttgga catctcaggt tcaacatttg ttggatttaa gaatgtttgt
    10981 tcaggggaaa ctaatgttat attcattact aaccctttaa atgaggattt acagcatcca
    11041 atccatgtga agaatataaa actggttgat accactgaac aatcaaaaat atttatacat
    11101 aggcctgata taagtaaggt caatccatct gattgtgtag acatggtttg tgatgccaag
    11161 aggaaatctt ttcttagaga catagatggc tcctttctgg ggaatgctgg ttctgtgata
    11221 cctcaagcag aatatgaatg ggacggaaac agccaagtag gaattggaga ctacagaatt
    11281 cctaaggcga tgctcacatt cttgaatgga agtagaattc ctgtcactga gaaagcacct
    11341 cataaaggaa ttattagaga ttcaacctgt aagtaccttc cagagtggca gagctatcag
    11401 tgctttggga tggaatatgc aatgatggtt attgaaagtc tggatcctga cacagaaact
    11461 cgaagacttt ccccagtggc tataatgggc aacggttatg ttgatcttat taatggccca
    11521 caggatcatg gctggtgtgc tggatataca tgccagagaa ggctgtccct gtttcacagc
    11581 attgtggctc tgaacaaatc ttatgaagtt tacttcactg gcaccagtcc tcagaatctt
    11641 cgactgatgt tgcttaatgt tgatcataac aaggctgttc tagtaggaat tttcttttcc
    11701 acacttcaac gtttggatgt ctatgtgaac aacttattgg tctgtccaaa aactacaata
    11761 tggaatgccc agcagaaaca ctgtgaactt aataaccatc tgtacaaaga ccaattcctt
    11821 cctaacctgg attccactgt ccttggtgaa aactactttg atggaaccta ccagatgctt
    11881 tatcttttgg ttaaaggaac tatacctgtt gaaattcaca ctgccacagt gatatttgtt
    11941 tctttccaat tatctgttgc aacagaagat gacttttata cctctcacaa tctggttaaa
    12001 aatcttgcct tgttcctaaa gataccaagt gacaaaatcc gtatcagcaa aataagaggg
    12061 aagagtctga ggaggaagag atccatggga ttcataattg aaatagagat tggagaccct
    12121 cctattcagt tcataagcaa tggcaccaca ggtcagatgc agttatctga actccaggaa
    12181 attgctggtt ctcttggaca agctgtaatt ttaggaaaca tcagtagtat ccttggattt
    12241 aacatttcgt ccatgtctat tactaatccc ctccccagcc caagtgactc tgggtggatt
    12301 aaggtgactg cccagccagt tgaaaggtct gcatttcctg ttcatcacgt ggccttcgtg
    12361 tcctcactct tagtgatcac tcagccggtg gcagcacagc caggacagcc atttcctcag
    12421 cagccttcgg taaaggcaac agattctgac ggtaactgtg tatcagttgg aattactgca
    12481 ctaactttga gggccatact caaggactcc aataataacc aagtcaatgg ccttagtgga
    12541 aatacaacaa ttccgtttag cagctgttgg gccaactaca cagaccttac tccccttaga
    12601 acaggaaaaa attataagat tgaatttata ctggataatg ttgttggggt agaatccaga
    12661 actttcagcc tgctggcaga gtctgtctct agcagtggca gcagcagcag cagcaacagc
    12721 aaagcatcaa ctgtgggtac atatgcccag ataatgactg tagtaattag ctgtctggtt
    12781 ggaagaatgt ggctcttgga aatatttatg gctgcagttt caactttgaa tataacttta
    12841 agaagctact aaagtgctgt tccgaagaat aggctgaaac aaaaatataa gaattattag
    12901 ctactttgtt gggcaatagg caaaagtcta tagcattttc atgaaaatat actaaaaata
    12961 tttttatgat atataaaatg tactaattag ctttaaacac taaaatcaga tttcttcaaa
    13021 atataaattt gttttgattc tttatattta tatgttttta tttcatttca ataaacttcc
    13081 agaaatttgt catttggaag tagatatgac acctctaagt tattgtacca acaaatcata
    13141 gaatccttta aataatggaa agagcttgtc tagttccgac ttaagctctt tacatcagat
    13201 tggaagcatt ttaagtattc tttttaatac ttgagggggg gggttcttat tttctctatc
    13261 catttacaag gttttgattt ccaataatct aagccattct agtttctaag gattttggag
    13321 agacgagatt gtcttcacac aatctgagat gacaatctca tctcagattt ttcacactga
    13381 gttcctgtct ttcagattca cagtaatccc aggaattcta gactgtcctg tatttctgga
    13441 tctgcccaac tctggccaat attgggaaaa gttttcttgt ccttggaatg aacttttgga
    13501 acaagtccaa actccttctc tgcctacccc tccttcccac tcaaaactgc cactactaag
    13561 agcaggactc ccctcaaccc cgggcatgag ttgagggttg aggggttccc ttaactggtg
    13621 gatgcttatt cactgtttac tggatgaatg aagtataaag tgtgggaagt caacaacaga
    13681 acagaactta ttttcaagaa gataaattag agaatgcaaa aaagctacag actaaggtag
    13741 ctaagttaac cgaactctct aacagtattg aaaatagcaa ttctttactc agaaaattct
    13801 aaagggaata cttaatttga cagaactcct aataaagaca ttgtagccag atccagagcc
    13861 ttccagcaag tgacactcag caaacatttg ggacagctga gagaattcaa caaagcccat
    13921 accgttgtct cttgtataac atctcctagt acattcacct cagatcattg ttagtcttac
    13981 ttagcagaaa atgtataaac acttaccagg tagtaaaatc aaatatcttg gtataaatgt
    14041 ggcatttcat tcacttgagc agtatctgtt gggtgttcta gtaagtagga aggctacaag
    14101 aaataagatg ctatgccttc cctcgaagag ttttcaggat atttggggaa agaatggaaa
    14161 cagaccattt caatacaaca tgatcactgt ctcagggaga gagagacaga gaaagacaga
    14221 gagatagaga cagagacaga gagggagggg gagagagaga tagatagaga gagagagaaa
    14281 gcatgaggtt gctagcaata tggaggcctt aagccttgtt caggagggct acctagaaga
    14341 gcagtggaag aaaactggga gaggaccact gaaggcctag gggctacaga aaaaattcaa
    14401 atgaacagct ggaatggaaa tagtcacaat tttaagggaa ttgcaggtaa gaggtccctg
    14461 acaaggtagt cttcaaagta tacatgaaag ccccttcatg aggaacattt gccatgtcca
    14521 gagagcattg atacttcatt gtacagcacc aggtaacaga gcacttttat actcccctca
    14581 gttccaaccc tggtggggtg aaaaacctct gttcctggga tagggagggg gaaagagacc
    14641 caacatgggc catttcacgc tgagacttaa aaatcagtct tcctaaggca aatctagttt
    14701 actgttcatt ccgtgatact tcctttctgt tggaaaacta aattccaaaa actgcaattc
    14761 cagcatctat ggaacaaatt cctacatttg ggttctggaa gagatacaaa aatattcttc
    14821 acaccagaac attgtaaaag ccataaaatt gtccaccatc tgtattcttt tcttacctaa
    14881 aggtttaatt cagcccactg gagttttttg tcaagatttt ttctgtcagt ttttaataag
    14941 gaaattttct aatacaagtt atatggcagt aaaaggaatt tctaaaaatt gcttcttagc
    15001 cacacagact ttgttaaaaa gttcctgttt taactgcttt aggcttctgg ctgtctgctt
    15061 tttaagaaca ttctagaatt atcataataa ttccttattc cagataaatt acaatttaat
    15121 tactactttt aaaaatgctt gaattattgg aatccatggg caatacatct tcacatgtcc
    15181 cttattcata tgctaagcaa gttttatttt tgcttttttt ttgcatttaa ataatatttc
    15241 tctgaacatt ctgtctcaga aattgatgtt taaattctta aaaataattt gtattgtaag
    15301 aagtggctat ctagctcttg aacaagtcat aaaaatcctt tgatgtgtga atattcttct
    15361 acctaagacc tgaaatgttg gcgaagtaaa tatgttgttc caattttggt caaagtaaga
    15421 aacagagaat aaaaagttaa taagaatagc ttcttgtatt tctcatagta agtgaaatgt
    15481 ttatatcttg tactactgtc tctactcatt cctaaattcc atcaccttgt gatcattgca
    15541 atgacttcta gatggtccat ctgtttttac cttttatcca ttttatcccc aaaagtgcta
    15601 tttaaaatat ccctagcact aataataaca ataatcaata ataaagtaaa ggtttatcac
    15661 atgttcacta catgccagac actatgctgt gtgttctaca tggacccttt ccttacagca
    15721 atcctatgag gataacctta ttcccttctc caaatgagga aacttgaaat gttgaagggt
    15781 taggttaaat tcccaagttc acagagctac taatggtaaa gctgggattc aaacacagac
    15841 aatttaactc cagagcccaa attccaacat ttaattgctt cccacttttc ctcaagcatg
    15901 ggcaagtgct tcattgggaa gagtttttaa tccaaattcc tgttcaaatt cttggtttct
    15961 actttaccac ttctatgccc tcaggcaagt tcttagtttc cattattctc agtttcttca
    16021 actgtaaaat gtggaaagtg tgacatctga agactgatgg tatcatatat atgacatgta
    16081 acacagtgcc taacaggcgg taaaatgata gccactcttg tttttatttc cataatgtgg
    16141 cctatatcat gtcaatccct ggcccagtaa accattaggc ttcttattac actggaacag
    16201 tgcctggcat gtaataagca ccatgtgagt gctaattatt agaattattg gctgggcact
    16261 gggccaccta gaacaaagac aatttcccag cttcacttgc agtgagactg atcaatttct
    16321 gtgcagtggg ttacaaaaac agacattatc tcgtggcata ttctagaaac tgaccttaaa
    16381 acatagctat tatgcatccc tttgcctttt cttcatccct ttctgttttt ccagctacat
    16441 ggagcaagat ggctcctgag acctggagga taaaggccag tgccttttat tgctccataa
    16501 cttgtgttag aaaatctcct tactaaaaat ctacagaaaa atcttgacaa aaaaaaaatt
    16561 ccagtggatt gaattaaaac tttaggtaag aaaagactaa gatggtggac aattttatgg
    16621 cttttacaat gtccttgtgt gaagaatatt tttatacctc ttccagaacc cagagagctc
    16681 agctgaaagg agtttgggtt cctgacattg tggtgcccta taccagccct tgctccttta
    16741 gggtttcatt gttatttggt ggttatccta aatctcctgc tttcatcaga tgtctgagat
    16801 ggcaaaattt ggaaggatca agagaacaga gagttaatcc ttcctaatgg gaaaggtgga
    16861 caatgccaag gttaaaatac cacatgcatc tttgagttac tactataccc tcccgaatgg
    16921 aaatgcttca actttaatct gaggctaggc gcagtggctc acgcctgtaa tcccagcact
    16981 ctgggaggcc aaggcaggcg gatcacgagg tcaggagatc gagactatcc tggctaacac
    17041 agtgaaatcc tgtctctact aaaaatacaa aaaaattagc caggcatggt ggcgggcacc
    17101 tgtagtctca gctagtcggg aggctgaggc aggagaatgg tgtgaaccca ggaggcggag
    17161 cttgcagtga gctgagatct cgccactgca ctccagcctg ggtgacagag cgagacacat
    17221 ctcaaaaaaa aaaacccaaa aaactttaat ctgaatccat tatgtgttgg gttgggttgg
    17281 ggaacctacc aaaacagtgg gagagtcttg ccctttttct aagatcatca gtgggcattt
    17341 tcagcttccc cattatggta gtagctgcaa ggagtgttca gtctccagtg aaagaaatat
    17401 taagatttat tcccccaatt tcccctcccc agagagtagc tacagacaca ctgtgtaaga
    17461 ccaaatagga aaagtctgcc acaggggaca cagtaggtac ttgaatactt gtgggcagtc
    17521 taaccagcta caaacctctt gttgccgtac ttgcaagtcc taatacagta ctgtagttat
    17581 tataattcca tcattctgaa attagaaaga tggtcatgga gaaactgttc taagaacgcc
    17641 attcacccat gaatgtgact ttattagagg tttttttttt aggttaagga ctatgtattc
    17701 tttcaatttc tctaaagtgc ttagcacaca ctctgcccat ggtaagtgtt aaataaactt
    17761 tctgataaac caatgattgg gtagcatgat gaaacttttc ctatcctgct ttttgagatt
    17821 aagaaatctt ttaaaaatat tacagaaact gcactttatc ctgacttaca gccttaatgt
    17881 ttgaagtagc agtgtataaa attcacaccc agttatagac tgagtaatta tagttgctat
    17941 ggtaatgggc tctgtgccta tgagcaaaaa aaaaaaattc cttttgtgca agatatttat
    18001 gactgtgcct ggctacatgg caatagtatt ttcctttggt ttttcattac agtaacttat
    18061 gcatttaggc agatgatcct ttatatatgt aaacgctata aattcttagg aagaaaataa
    18121 atttattaag tttttcacat caaaaatttc tagtatgatt atgagttcaa ttttcaagtg
    18181 aaagtaatcc ttaaaggatt taatttcaaa taagaactac gtacaaaata tagatttaaa
    18241 ttaattttca ctgtatgaaa tgtacagtat acatagacca actcctttaa caagaatttc
    18301 tggtatgtct taaagggcat gggtggttag agggagatcc ccaaacaaac aattcaaaat
    18361 taagagttta aaaagcaaca atcaagacac atatcctcct aagtgaattt gaattagaca
    18421 ctggaaaatt taaaaaggtc agttactatg aagaaggtgt aacaatattt atattaatca
    18481 gacagcaaag taacaaactg acttagagga aggaaaatag taaaatacaa aagactaagt
    18541 tagcagatca ttttgatatc cagatgtgct gaaatgatgg acactgagaa gaaagaatag
    18601 acaaaacttg gcaacagatc ttggtatgaa ataaatatcc catgagtagt acataaaagc
    18661 ctggagagag aggggaagga ttgtaagtgt catagttctg acagctgctc tttcatccta
    18721 tgcctttaaa acaaagggaa caaagaaggg aacaaagaag gtagaagcgg gggtatggag
    18781 ggttgacttc tggctgtccc tccctgtttc cctttgttaa tatattgcta gtagacatgt
    18841 ctacttctgg ttgctgatga cataaaattc acctctattt cttggaagca ctattccatg
    18901 ttgtgagcta aaggggattg tactgatctt gaagataaca aatctgcctg cttcaaaggt
    18961 ttcaccgatt ttattgctgt gtttccaaca catttccaca tatggtatga tatttaattt
    19021 gcaaaataaa tccgtaaagc aggaattact aacctaattt tgcagatgag aaaactgagg
    19081 cttaaagttg ttcaaggtca aagtcacgat gtccatcatg ctgtagctca atgaatgagt
    19141 ctcacattgt ttcatgttgt tttatttcta ctttctcaat ccatgtacaa gatagattta
    19201 caaactactg ttttatgttg gttgtatgaa tttcaataca tttactgtta gaaataacaa
    19261 aaggtcttag actgccagat gctgttccca tcaactctac ttaattcata atatagctga
    19321 actctgtcat aaatctaata acgatgtgga cattagccag aagtatgatg tggctgaacc
    19381 tcaccactga acacaaaatg agaattcacc tcatcttttc atttgaattt atttctacta
    19441 aaatatatgt attatttttc ttgatttcta accaggcccc ttctgaagaa aactggttaa
    19501 ctctaaattg ttactaaatt ttgaatcttc ctgtatttag caataaaagt tactgctaat
    19561 tgtaataaca attatgagga aaaatttatt taaatgcttc atagaaagtt aattttcatt
    19621 taatagaaaa gaaataaaaa atctgcttca gactgtttga tttctctatt aggcaattga
    19681 ccctaactag tatatggtga ttttgagtat taaaaaagaa gttataattt tccagaatat
    19741 taatgtttat tattttgaaa gcaagtaaaa ttctccagta ggaagattaa taaaacaatt
    19801 cattaaaatt ctcatcagaa aatcctatgc tttcaaatgt atctgctcaa agatgtcact
    19861 ctatgtgcgg caaagctttg ttttacttga tcaagaaatg aatgtgactt tatgatcttg
    19921 tattcaactg tgaacagctg ctcattaata aaaagccatt aaagtccaa
//
