LOCUS       XM_017010944           16109 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens PKHD1 ciliary IPT domain containing
            fibrocystin/polyductin (PKHD1), transcript variant X2, mRNA.
ACCESSION   XM_017010944
VERSION     XM_017010944.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017010944.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16109
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..16109
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /note="PKHD1 ciliary IPT domain containing
                     fibrocystin/polyductin; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 3 mRNAs, 8 ESTs, 31 long
                     SRA reads, 5 Proteins, and 99% coverage of the annotated
                     genomic feature by RNAseq alignments, including 4 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:5314"
                     /db_xref="HGNC:HGNC:9016"
                     /db_xref="MIM:606702"
     CDS             103..12327
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /codon_start=1
                     /product="fibrocystin isoform X1"
                     /protein_id="XP_016866433.1"
                     /db_xref="GeneID:5314"
                     /db_xref="HGNC:HGNC:9016"
                     /db_xref="MIM:606702"
                     /translation="MTAWLISLMSIEVLLLAVRHLSLHIEPEEGSLAGGTWITVIFDG
                     LELGVLYPNNGSQLEIHLVNVNMVVPALRSVPCDVFPVFLDLPVVTCRTRSVLSEAHE
                     GLYFLEAYFGGQLVSSPNPGPRDSCTFKFSKAQTPIVHQVYPPSGVPGKLIHVYGWII
                     TGRLETFDFDAEYIDSPVILEAQGDKWVTPCSLINRQMGSCYPIQEDHGLGTLQCHVE
                     GDYIGSQNVSFSVFNKGKSMVHKKAWLISAKQDLFLYQTHSEILSVFPETGSLGGRTN
                     ITITGDFFDNSAQVTIAGIPCDIRHVSPRKIECTTRAPGKDVRLTTPQPGNRGLLFEV
                     GDAVEGLELTEATPGYRWQIVPNASSPFGFWSQEGQPFRARLSGFFVAPETNNYTFWI
                     QADSQASLHFSWSEEPRTKVKVASISVGTADWFDSWEQNRDEGTWQQKTPKLELLGGA
                     MYYLEAEHHGIAPSRGMRIGVQIHNTWLNPDVVTTYLREKHQIRVRAQRLPEVQVLNV
                     SGRGNFFLTWDNVSSQPIPANATAHLIQTTIEELLAVKCKLEPLWSNILLRLGFERGP
                     EVSNSDGDLTSGTEPFCGRFSLRQPRHLVLTPPAAQKGYRLDQYTHLCLAYKGHMNKI
                     LKMIVSFTIGFQNMVKNTTCDWSLTRTSPESWQFDCTDLWETCVRCFGDLQPPPANSP
                     VLVHQINLLPLAQETGLFYVDEIIIADTNVTVSQADSGTARPGGNLVESVSVVGSPPV
                     YSVTSWLAGCGTELPLITARSVPTEGTEEGSGLVLVTTQRRQRTSPPLGGHFRIQLPN
                     TVISDVPVQISAHHLHQLLQNNADDFTSRYLNASDFTVKEDLYTCYEHVWTLSWSTQI
                     GDLPNFIRVSDENLTGVNPAAATRVVYDGGVFLGPIFGDMLATANQHTQVVVRVNDVP
                     AHCPGSCSFQYLQGSTPCVHSVWYSIDGDINLMIYITGTGFSGDSQFLQVTVNKTSCK
                     VIFSNQTNVVCQTDLLPVGMHRILMLVRPSGLAISATGEDLFLNVKPRLDMVEPSRAA
                     DIGGLWATIRGSSLEGVSLILFGSYSCAINVATSNSSRIQCKVPPRGKDGRIVNVTVI
                     RGDYSAVLPRAFTYVSSLNPVIVTLSRNISNIAGGETLVIGVARLMNYTDLDVEVHVQ
                     DALAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQGVDLHIQYLTEVFSIEPC
                     CGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQIPDAGA
                     PTVPAAVEVWAGNRFFARGPSPSLVGKGFTFMYEAAATPVVTAMQGEITNSSLSLHVG
                     GSNLSNSVILLGNLNCDVETQSFQGNVSLSGCSIPLHSLEAGIYPLQVRQKQMGFANM
                     SVVLQQFAVMPRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGPFTCVILSL
                     GDHTILCQVSLEGDPLPGASFSLNVTVLVNGLTSECQGNCTLFIREEASPVMDALSTN
                     TSGSLTTVLIRGQRLATTADEPMVFVDDQLPCNVTFFNASHVVCQTRDLAPGPHYLSV
                     FYTRNGYACSGNVSRHFYIMPQVFHYFPKNFSLHGGSLLTIEGTGLRGQNTTSVYIDQ
                     QTCLTVNIGAELIRCIVPTGNGSVALEIEVDGLWYHIGVIGYNKAFTPELISISQSDD
                     ILTFAVAQISGAANIDIFIGMSPCVGVSGNHTVLQCVVPSLPAGEYHVRGYDCIRGWA
                     SSALVFTSRVIITAVTENFGCLGGRLVHVFGAGFSPGNVSAAVCGAPCRVLANATVSA
                     FSCLVLPLDVSLAFLCGLKREEDSCEAARHTYVQCDLTVAMATEQLLESWPYLYICEE
                     SSQCLFVPDHWAESMFPSFSGLFISPKLERDEVLIYNSSCNITMETEAEMECETPNQP
                     ITVKITEIRKRWGQNTQGNFSLQFCRRWSRTHSWFPERLPQDGDNVTVENGQLLLLDT
                     NTSILNLLHIKGGKLIFMAPGPIELRAHAILVSDGGELRIGSEDKPFQGRAQITLYGS
                     SYSTPFFPYGVKFLAVRNGTLSLHGSLPEVIVTCLRATAHALDTVLALEDAVDWNPGD
                     EVVIISGTGVKGAKPMEEIVTVETVQDTDLYLKSPLRYSHNFTENWVAGEHHILKATV
                     ALLSRSITIQGNLTNEREKLLVSCQEANAPEGNLQHCLYSMSEKMLGSRDMGARVIVQ
                     SFPEEPSQVQLKGVQFQVLGQAFHKHLSSLTLVGAMRESFIQGCTVRNSFSRGLSMCG
                     TLGLKVDSNVFYNILGHALLVGTCTEMRYISWEAIHGRKDDWSGHGNIIRNNVIIQVS
                     GAEGLSNPEMLTPSGIYICSPTNVIEGNRVCGAGYGYFFHLMTNQTSQAPLLSFTQNI
                     AHSCTRYGLFVYPKFQPPWDNVTGTTLFQSFTVWESAGGAQIFRSSNLRLKNFKVYSC
                     RDFGIDVLESDANTSVTDSLLLGHFAHKGSLCMSSGIKTPKRWELMVSNTTFVNFDLI
                     NCVAIRTCSDCSQGQGGFTVKTSQLKFTNSSNLVAFPFPHAAILEDLDGSLSGKNRSH
                     ILASMETLSASCLVNSSFGRVVHGSACGGGVLFHRMSIGLANTPEVSYDLTMTDSRNK
                     TTTVNYVRDTLSNPRGWMALLLDQETYSLQSENLWINRSLQYSATFDNFAPGNYLLLV
                     HTDLPPYPDILLRCGSRVGLSFPFLPSPGQNQGCDWFFNSQLRQLTYLVSGEGQVQVI
                     LRVKEGMPPTISASTSAPESALKWSLPETWQGVEEGWGGYNNTIPGPGDDVLILPNRT
                     VLVDTDLPFFKGLYVMGTLDFPVDRSNVLSVACMVIAGGELKVGTLENPLEKEQKLLI
                     LLRASEGVFCDRMNGIHIDPGTIGVYGKVHLYSAYPKNSWTHLGADIASGNERIIVED
                     AVDWRPHDKIVLSSSSYEPHEAEVLTVKEVKGHHVRIYERLKHRHIGSVHVTEDGRHI
                     RLAAEVGLLTRNIQIQPDVSCRGRLFVGSFRKSSREEFSGVLQLLNVEIQNFGSPLYS
                     SVEFSNVSAGSWIISSTLHQSCGGGIHAAASHGVLLNDNIVFGTAGHGIDLEGQAYTV
                     TNNLVVLMTQPAWSTIWVAGIKVNQVKDINLHGNVVAGSERLGFHIRGHKCSSCELLW
                     SDNVAHSSLHGLHLYKESGLDNCTRISGFLAFKNFDYGAMLHVENSVEIENITLVDNT
                     IGLLAVVYVFSAPQNSVKKVQIVLRNSVIVATSSSFDCIQDKVKPHSANLTSTDRAPS
                     NPRGGRIGILWPVFTSEPNQWPQEPWHKVRNDHSISGIMKLQDVTFSSFVKSCYSDDL
                     DVCILPNAENSGIMHPITAERTRMLKIKDKNKFYFPSLQPRKDLGKVVCPELDCASPR
                     KYLFKDLDGRALGLPPPVSVFPKTEAEWTASFFNAGTFREEQKCTYQFLMQGFICKQT
                     DQVVLILDSADAIWAIQKLYPVVSVTSGFVDVFSSVNANIPCSTSGSVSTFYSILPIR
                     QITKVCFMDQTPQVLRFFLLGNKSTSKLLLAVFYHELQSPHVFLGESFIPPTLVQSAS
                     LLLNESIGANYFNIMDNLLYVVLQGEEPIEIRSGVSIHLALTVMVSVLEKGWEIVILE
                     RLTNFLQIGQNQIRFIHEMPGHEETLKAIADSRAKRKRNCPTVTCTSHYRRVGQRRPL
                     MMEMNSHRASPPMTVETISKVIVIEIGDSPTVRSTGMISSLSSNKLQNLAHRVITAQQ
                     TGVLENVLNMTIGALLVTQSKGVIGYGNTSSFKTGNLIYIRPYALSILVQPSDGEVGN
                     ELPVQPQLVFLDEQNRRVESLGPPSEPWTISASLEGASDSVLKGCTQAETQDGYVSFY
                     NLAVLISGSNWHFIFTVTSPPGVNFTARSKPFAVLPVTRKEKSTIILAASLSSVASWL
                     ALSCLVCCWLKRSKSRKTKPEEIPESQTNNQNIHIHISSKRRESQGPKKEDTVVGEDM
                     RMKVMLGKVNQCPHQLMNGVSRRKVSRHIVREEEAAVPAPGTTGITSHGHICAPGAPA
                     QQVYLQETGNWKEGQEQLLRYQLAGQNQLLLLCPDFRQERQQLPGQSRLSKQSGSLGL
                     SQEKKASCGATEAFCLHSVHPETIQEQL"
ORIGIN      
        1 gggacacaaa cgagttagca caaaagctat gctgctccaa tcaaaactga aaatgctttt
       61 aatgtctgag caatcttaag agtattgatt taagtggaca gaatgactgc ctggctgatc
      121 tctctgatga gtattgaagt actacttttg gcagtacgtc acctgagttt acatattgaa
      181 cctgaagaag gtagccttgc agggggaacg tggatcacag tcatttttga tggtttggag
      241 ttgggtgttc tttaccccaa caatggctct caattggaga tacacctggt gaacgtgaac
      301 atggtggtgc ccgcactgcg gagtgttccc tgtgacgtct ttcctgtttt cttggatttg
      361 cctgtggtga catgccggac cagatctgtg ctgtctgaag cacatgaggg tctgtacttc
      421 ctggaagcat acttcggggg acagctggta agcagtccaa atccaggacc acgagatagc
      481 tgtactttca agttttccaa ggcgcagaca cccatcgttc accaagttta tccaccaagt
      541 ggtgttccag gaaaactaat acatgtatat ggctggatta tcactggaag attggaaact
      601 tttgattttg atgctgagta cattgatagc ccagtgatct tggaagctca aggagacaaa
      661 tgggttactc cttgctctct tataaatagg cagatgggaa gctgttatcc tattcaggag
      721 gaccatggtc ttgggactct gcagtgccat gtggaaggcg actacatcgg ctcccagaat
      781 gttagcttct cagtatttaa caaaggaaag tcaatggtcc acaagaaggc atggctgatc
      841 agtgctaaac aggatctttt cctataccag acacactcag aaatattatc tgtgtttcca
      901 gaaactggga gccttggggg aagaacaaac atcacaatta caggagactt ttttgacaat
      961 tctgcccagg ttaccattgc aggcattcca tgtgatatta gacacgtgtc tcccaggaag
     1021 attgagtgca ccactcgggc tccaggaaaa gatgtgaggc tcaccacccc tcagccaggc
     1081 aatcgagggc ttctttttga agttggagat gctgttgagg gactggaact gactgaagcc
     1141 accccagggt acaggtggca gattgtccct aatgccagtt ctccatttgg gttttggtca
     1201 caggaaggac aacctttcag agcacggctc agtgggttct ttgtggctcc agagacaaat
     1261 aattacactt tctggattca ggcagatagc caagcttcct tgcatttcag ttggtcagag
     1321 gaaccaagga ctaaggtgaa agtggcctcc atcagcgtcg gcactgctga ctggtttgac
     1381 tcctgggagc agaataggga tgaagggacc tggcagcaga agactcccaa gttggagctg
     1441 ttgggtggag ccatgtacta cctggaagca gagcatcatg ggatagcccc aagcaggggg
     1501 atgaggattg gtgtccagat tcacaacacc tggctgaatc ctgatgtggt caccacttac
     1561 ctacgggaga agcaccagat ccgagtccga gcccagaggc ttccagaagt acaggtgctg
     1621 aatgtatcag gcagaggaaa cttcttcctt acttgggaca atgtctctag tcagccaatc
     1681 cctgcaaatg ccacagccca tctgattcaa acaaccattg aggagttact tgcagtaaaa
     1741 tgcaaactgg aacccctttg gtctaacatc cttctccggc ttggatttga acgaggccca
     1801 gaagtttcca actctgatgg ggacctcacc agtgggacgg agcccttctg tggcaggttc
     1861 agcctccgtc agcctcgaca ccttgtcctt actcccccgg ctgcccagaa gggctatcgg
     1921 ctagatcagt atacacacct gtgtcttgca tacaaaggcc acatgaacaa gatcctgaag
     1981 atgattgtgt ccttcacaat cggctttcaa aacatggtaa agaataccac ctgtgactgg
     2041 agtctcacga ggaccagccc cgagagctgg cagttcgatt gcactgacct ctgggagact
     2101 tgtgtgcgtt gcttcgggga tctccagccc cctccggcaa actccccagt gctggttcat
     2161 cagatcaacc ttctccctct ggcccaggag acgggcctgt tctatgtgga tgaaattatt
     2221 attgcagaca caaacgtaac agtttctcaa gctgattctg gaacggctcg cccagggggc
     2281 aatctggtgg aatcagtctc tgtggtggga tcccctccgg tctacagtgt cacctcctgg
     2341 ctggcggggt gtggcacgga gctcccgctc atcactgcac gctctgtgcc cactgaagga
     2401 acagaagagg gatctggact ggtcctggtg acgacacaga gacgacagcg gacaagtcca
     2461 cctctaggag gacactttcg catccagctt cctaatacag tgatttctga tgtccctgta
     2521 caaatttctg ctcatcacct tcaccagctc ttacagaata atgccgatga cttcacatcc
     2581 aggtacctca atgccagtga cttcactgtg aaggaggatc tatacacttg ctacgaacac
     2641 gtgtggacct tgtcctggtc cactcagatt ggggatttgc ccaattttat cagggtctct
     2701 gatgaaaacc ttactggagt gaatcctgct gcagccacgc gtgtggtata tgatggtgga
     2761 gtttttcttg gacccatatt tggagacatg ttggctactg ccaaccagca tactcaggtg
     2821 gttgtgcgag tgaatgatgt accagctcat tgcccaggtt cctgctcttt ccagtacctc
     2881 caagggtcaa ctccctgtgt ccattctgtg tggtactcca ttgatggtga catcaaccta
     2941 atgatttaca ttaccggaac tggtttctct ggtgactccc agttcttgca ggttacagtg
     3001 aacaaaacga gttgcaaagt tattttctca aaccagacca atgtagtctg tcagacagat
     3061 ttgctacctg ttggaatgca tcggatcttg atgttggtga gaccctctgg tcttgccatc
     3121 agtgccactg gagaagacct cttcctaaat gtgaaaccta gactggatat ggtggagcct
     3181 tccagagctg cggatattgg agggctctgg gccaccatcc gaggctctag tttggaaggt
     3241 gttagcctga tattatttgg atcttactcg tgtgccatca atgtcgctac aagcaattca
     3301 agcagaattc agtgcaaagt tccacccagg gggaaagatg gacgcattgt gaatgtgact
     3361 gtgatcagag gggactattc tgcagttctt cccagagcat ttacatatgt ctcttcctta
     3421 aatccagtta ttgtgactct gagcagaaac ataagcaata tagcaggcgg tgagaccctg
     3481 gtcattggag tggcgaggct gatgaactat acggatttgg atgtggaagt ccacgtccag
     3541 gatgccttgg ctccggttca cacacagtcg gcttggggcc tggaggtggc actgccccca
     3601 ctgccagctg gtctccacag aatttccgtc tctatcaatg gggtcagcat tcactcacaa
     3661 ggggttgatc tccacatcca gtacctcaca gaagttttca gcatcgagcc ttgctgtggg
     3721 tccctgctgg gagggaccat cctcagcatc tcaggaatag gcttcagcag ggacccagct
     3781 ttggtttggg tacttgtggg caatcggtcc tgtgacattg tgaacttaac ggaggcgagc
     3841 atctggtgtg aaaccctgcc agccccccag atacccgatg cgggcgctcc cactgttcca
     3901 gctgccgtgg aggtctgggc tggcaacagg ttcttcgccc gtggtccttc accaagcttg
     3961 gtggggaaag gcttcacctt catgtatgaa gcggcagcaa caccagtagt cactgccatg
     4021 caaggagaaa tcacaaatag cagcctgagc ctgcatgtgg gaggaagtaa cctctccaac
     4081 tcagtcatcc ttctggggaa cctgaactgt gatgttgaga cacagtcctt ccagggcaac
     4141 gtgagcctgt ctggatgctc catccctctt cacagtctgg aggctggcat ctatcctctc
     4201 caagtacgtc agaagcagat gggatttgct aatatgtctg tggtgctcca gcaatttgca
     4261 gtgatgcctc ggataatggc catcttccca tcgcagggtt cggcatgtgg tgggaccata
     4321 cttactgtga gggggttgct tcttaactct agaaggaggt cagttcgggt tgacctctcg
     4381 ggtcctttta cttgtgtgat tttgagtttg ggagaccaca ccattctctg ccaggttagc
     4441 ctggagggtg accccttgcc tggagcttcc ttctccctga acgtcacagt cctggtcaat
     4501 gggctaacca gcgagtgtca ggggaattgc actcttttca taagggaaga ggcaagtcct
     4561 gtcatggatg ccttgtccac aaacaccagt gggtctctga ccactgtgct gattaggggt
     4621 cagaggttag ccaccacagc tgatgagccg atggtatttg tggatgatca acttccttgc
     4681 aatgtaactt tttttaatgc aagccacgtt gtgtgccaga caagagactt ggccccagga
     4741 ccccactacc tgtcagtttt ttatacaaga aatgggtatg cttgttctgg taatgtttcc
     4801 agacacttct acattatgcc ccaagtgttt cattattttc ctaagaattt cagcttacat
     4861 ggtggaagcc tcttgaccat agagggcaca ggcctgagag gacagaacac cacgtcagtc
     4921 tatattgacc agcagacctg cctgacggtg aacatcggtg ctgagctcat ccggtgcatt
     4981 gttcccacag ggaatggctc tgttgccctg gaaatagagg tagatggact ttggtatcac
     5041 ataggagtca ttggttataa caaggccttt accccagaat tgatctctat ttctcagagc
     5101 gatgacatct taacctttgc agtggcccag atctcaggag ctgcaaacat tgacattttt
     5161 ataggaatgt caccctgtgt gggtgtctct ggtaaccaca ccgttcttca gtgcgtggtc
     5221 ccttcccttc cggccgggga gtaccacgtc agaggctatg actgcatcag agggtgggcc
     5281 tcatctgccc tggtgttcac ctcaagagtt attattacag cagtgacgga gaacttcggc
     5341 tgcctgggtg gaaggctggt gcatgtgttt ggagcgggat tttctccagg gaatgtctca
     5401 gctgctgtgt gtggtgctcc ctgccgagtc ctggctaatg ctacagtgtc tgccttcagc
     5461 tgcttggttc tgcccctgga tgtgtccttg gccttcctgt gtggcctgaa gcgtgaggag
     5521 gacagctgtg aggctgccag acacacctat gtgcagtgtg atttgacagt tgccatggcg
     5581 acagagcaac tgcttgaatc gtggccttac ctctacattt gcgaggaaag ttcccaatgc
     5641 ctctttgtgc cagatcattg ggcagagtca atgtttccat cattctcggg cctctttatc
     5701 agccctaaat tggaaagaga tgaagttctc atctataata gctcctgtaa cattaccatg
     5761 gaaactgagg cagagatgga gtgtgagacg cccaatcagc caattaccgt caagattact
     5821 gagatacgga aacgctgggg ccagaacact cagggcaact tttctttaca gttctgccgg
     5881 agatggtcca ggactcacag ctggtttcct gaaaggctgc cacaagatgg cgacaacgtc
     5941 acagtggaga atggccaatt gcttctgctg gacactaaca caagcatcct caacttactg
     6001 cacattaaag ggggcaagct gattttcatg gccccaggac ccatcgagct cagggcacac
     6061 gccatccttg tttctgatgg tggagagctc cggattggat ccgaagacaa gcccttccaa
     6121 ggcagagctc agatcacact ctacgggagt tcctactcaa ctcccttctt tccctatgga
     6181 gtcaagttcc tggctgtgag gaatggaact ctttctctgc acggttcact accagaagta
     6241 attgtcacct gtcttagagc aactgcccat gccctagaca cagtgctggc tttagaagat
     6301 gctgtggact ggaaccctgg ggatgaagtt gtcatcatca gtggaacagg tgttaaaggt
     6361 gccaaaccga tggaagagat tgtcactgtg gaaactgtgc aggatacaga cctctatctt
     6421 aagtcacctt tgagatattc tcacaacttt acagagaatt gggtggctgg agagcaccat
     6481 attttaaagg ccactgtggc tctgctcagc aggagtatta ccatacaagg aaatctcact
     6541 aatgagaggg agaagctgct tgtttcatgc caggaggcca atgctccaga aggtaatctg
     6601 cagcactgtt tgtattccat gagtgagaag atgctaggat ccagggatat gggagccaga
     6661 gtgatcgttc agtccttccc agaagagccc agccaggtcc agttgaaggg agtgcagttt
     6721 caagtcttgg ggcaagcctt ccataagcat ctgagctcac tcactctggt gggagctatg
     6781 agagagtctt tcatacaggg ctgcacagtg aggaactcct tcagtagagg cctcagcatg
     6841 tgcgggacct tgggcctgaa ggtggacagt aatgtattct acaatatttt aggtcatgcg
     6901 ctgctagttg ggacatgcac ggagatgaga tatatctcct gggaggcaat tcatggaagg
     6961 aaagatgact ggtcaggaca tggaaatata ataagaaaca acgtgatcat ccaggtttct
     7021 ggtgccgagg gactctccaa tcctgaaatg ttgacaccat ctggcatcta tatctgcagt
     7081 cccaccaatg ttatagaggg gaacagagtg tgtggtgctg gctatggcta ctttttccat
     7141 ctcatgacca accaaacatc acaagctccg cttctttcct tcactcagaa cattgcacat
     7201 tcttgtacca ggtatggtct ctttgtatac cctaaatttc agccaccttg ggataatgtc
     7261 actggcacca ctctgttcca gagcttcaca gtttgggaaa gtgcaggtgg tgcccagatt
     7321 tttagaagta gcaatcttcg cctgaaaaac ttcaaagttt attcatgcag agattttgga
     7381 attgacgtct tggaaagtga tgcaaatact tcagttactg acagcttatt acttggtcat
     7441 tttgcccaca agggaagtct gtgtatgtca tctgggatta aaactcctaa aagatgggaa
     7501 ctgatggtgt ctaacacaac ctttgttaat tttgatctca tcaactgtgt ggccattaga
     7561 acctgttcag actgttccca aggacaaggt ggatttactg tgaagaccag ccagttgaag
     7621 tttacaaact cttcaaactt agtggcattt ccatttcctc atgcagcaat tttggaagac
     7681 ttggatgggt ctctgtctgg gaaaaacaga agtcacattc ttgcttctat ggaaaccctt
     7741 tcagcttctt gtttggtcaa ttcaagcttt ggtcgggttg tccatggcag tgcctgtgga
     7801 ggaggtgttc tttttcatcg tatgtctatt ggtttagcga atactcctga agtttcttat
     7861 gatttaacca tgactgacag cagaaataaa acaaccactg tcaattatgt acgtgataca
     7921 ttgtctaacc ctcgtggctg gatggctctg ctcttggacc aagagaccta ctcattgcaa
     7981 tctgagaacc tttggatcaa cagatctctg cagtactcag caacctttga caactttgct
     8041 cctggtaatt acctactgct ggtgcacaca gatttgccgc cttaccctga catcctccta
     8101 agatgtggga gtcgagtggg tctgtctttt ccatttcttc catcaccagg tcagaaccaa
     8161 ggctgtgact ggttcttcaa tagccagctg aggcaactca cctatctggt ttcaggtgaa
     8221 ggccaagttc aagtcattct ccgggtgaag gaaggtatgc ccccaactat ttcagcttct
     8281 acctctgccc ctgaatcagc tttaaaatgg tccctccctg aaacatggca aggtgttgaa
     8341 gaaggctggg gaggatacaa caataccatt ccaggccctg gggatgacgt tctcatttta
     8401 cccaacagaa ctgtccttgt ggatacagat cttccattct tcaaagggct gtatgtgatg
     8461 gggaccttag acttccctgt ggacagaagc aatgttctga gtgtggcatg catggtcatt
     8521 gcaggcgggg agctgaaagt tggtacttta gaaaatccct tagaaaagga acaaaagctt
     8581 ctgattctcc ttagagcctc agagggagtc ttttgtgacc gtatgaatgg aattcatatt
     8641 gacccaggaa caattggggt ttatgggaaa gttcatcttt acagtgctta tcctaagaac
     8701 tcctggacac atcttggagc tgatattgcc tcaggaaatg agagaattat agtagaagat
     8761 gcagtggatt ggcgccccca tgacaaaata gtccttagct cctcttctta tgagcctcat
     8821 gaagcagagg tcctcactgt gaaagaagtc aagggccacc atgtgaggat ctatgaacgg
     8881 ctcaaacacc ggcatattgg aagtgtacat gtcacggagg atggccgaca cattcgtttg
     8941 gctgctgagg ttggactgtt gacccgaaat atacaaattc agcctgacgt atcatgtagg
     9001 gggagactgt ttgtggggtc cttcaggaag tccagccgag aagaattttc aggtgtcctt
     9061 caacttctta atgtggaaat tcagaacttc gggtcaccat tgtactcatc tgttgaattc
     9121 agtaatgtgt cagcaggatc ctggatcata tcatctactc tgcaccagag ctgtggcggg
     9181 ggcattcatg cagctgccag tcatggagta cttttaaatg acaatattgt gtttggcaca
     9241 gctggccatg gcatagattt agagggtcag gcctatactg tcactaataa ccttgtggtt
     9301 ctgatgacac agccagcgtg gtccaccatt tgggtggcgg gaatcaaagt gaaccaggta
     9361 aaggacatca acctccatgg caacgttgtg gcaggatcag agagacttgg ctttcacatc
     9421 cgaggccaca agtgctcctc ttgtgaactg ctttggtctg acaatgtggc gcattcaagt
     9481 cttcatggcc ttcatctcta taaggaaagt ggacttgaca actgtaccag aatctctggc
     9541 ttcttggctt tcaagaactt tgactatggt gccatgttac atgtagagaa cagcgtggag
     9601 atagagaaca ttactctggt agacaatact attggtcttt tggcagtagt gtatgtattt
     9661 tctgctccac aaaattccgt caaaaaagtg cagattgtgc ttaggaattc agtcattgtg
     9721 gccaccagct cttcttttga ctgcattcag gacaaagtga agccgcactc agccaacttg
     9781 acatcaacag atagagctcc ctccaatcca agaggaggtc gaattggtat tctgtggcct
     9841 gtattcacct cagaaccaaa tcagtggcct caggagccat ggcacaaagt gaggaatgat
     9901 cattcaattt caggaatcat gaaacttcaa gatgttacct tttctagttt tgtgaagagt
     9961 tgctatagcg atgacctgga tgtctgcatt ctaccaaatg cagagaacag tggaattatg
    10021 cacccaataa cagcagagag gaccaggatg ctaaagataa aagataaaaa caagttctac
    10081 tttccttcat tacaacccag gaaagattta ggaaaagtag tctgtcctga attagactgt
    10141 gcaagtccaa gaaaatatct cttcaaggat ctggatggga gagccctggg tctgcctcca
    10201 ccagtttctg tatttcctaa aacagaggca gaatggactg catccttctt caacgcaggt
    10261 acatttagag aagaacagaa atgtacatac caatttctga tgcaaggatt catctgcaaa
    10321 cagactgacc aagtggtcct aattcttgat agcgctgatg ccatttgggc aattcagaag
    10381 ttatatccag ttgtatctgt gactagtggt tttgttgatg tctttagcag tgtaaatgcc
    10441 aatattccct gctctacttc tgggtcagtg tctactttct attctatctt acccatcagg
    10501 caaatcacca aagtctgctt catggatcaa actcctcaag ttttgcgctt ttttctattg
    10561 gggaacaaaa gtacctccaa gcttctcttg gctgtattct accatgagct ccagagcccc
    10621 cacgtcttct taggggaaag ttttattcca cccactctgg ttcagtcagc ttccttattg
    10681 ctgaatgaat ctattggtgc caactatttc aacatcatgg ataacctctt gtatgttgtc
    10741 ctacaaggag aggagcccat tgaaatacgc tcaggtgttt ccattcactt ggccctcact
    10801 gtgatggttt cagtcttaga aaaaggctgg gaaatagtaa tactcgaaag actaactaac
    10861 ttcttacaga ttggccaaaa ccaaatcagg tttattcacg agatgcctgg ccatgaagag
    10921 accttaaagg ccattgctga cagtagagca aaaagaaagc gcaattgccc tactgtgact
    10981 tgcactagtc attatagaag agttggtcaa cgtaggcctc tcatgatgga aatgaactca
    11041 catagggctt cacccccaat gactgtggaa actatctcaa aagtgattgt cattgaaatt
    11101 ggtgattcgc caacagtaag gagcactgga atgatttcat ccttatcaag taacaaatta
    11161 cagaatttgg ctcatcgagt catcactgct caacagactg gggtactaga gaatgttctg
    11221 aatatgacta tcggggcctt actagttact cagtcaaagg gagtcattgg ctatggaaat
    11281 acaagcagtt ttaaaactgg gaacttgata tatattcggc cctatgcact ttccatccta
    11341 gtccagcctt cagatggaga agtgggaaat gagcttccag tgcagccaca attggtattt
    11401 ttggatgagc agaatcgaag agtagagtcc ctgggacctc cttcagagcc atggacaatt
    11461 tcagcttccc tggaaggagc atcagactca gtgctaaaag ggtgcaccca ggcagaaact
    11521 caagatggtt atgttagctt ctacaacttg gcagtcttga tctctgggtc aaactggcac
    11581 tttattttta ctgtcacttc tcctccagga gtcaatttta cagctcgatc caagccattt
    11641 gctgtcttgc ctgtgactag gaaggagaag tcgaccatca tcctggctgc ttccctgtcc
    11701 tctgtggcct catggctggc tctgagctgt ctggtgtgct gttggcttaa aagaagcaaa
    11761 agcagaaaaa caaaacctga agagattcct gaatcccaga ctaataatca aaatattcat
    11821 atccacatct catccaaacg ccgagaatca caagggccca aaaaagaaga cactgtggtg
    11881 ggagaagata tgagaatgaa ggtcatgctg ggcaaggtga accagtgccc ccaccagttg
    11941 atgaatggag tgtccagaag gaaagttagc cgccacattg tccgagagga agaggctgct
    12001 gtgcctgctc ctggtactac tggcatcaca tcccatgggc acatctgtgc tccaggtgct
    12061 cctgctcagc aggtgtacct gcaagagact gggaactgga aggagggcca agagcagttg
    12121 ctcagatacc agctggcagg ccaaaatcag ctgctgctgc tatgcccaga cttcagacaa
    12181 gagaggcagc agttgccagg gcaaagtcgg ctgagtaagc aaagtggcag cttggggctt
    12241 tcccaagaga agaaagcctc ctgcggggcc actgaggcat tctgccttca ttcagtacac
    12301 ccggaaacta ttcaggagca actgtgatca gggaagttgg gggcatttgg cctgaaaggc
    12361 agaatgttcc cagtatttct ggataataag ctggggaagt gaggactgtc ctgctgggac
    12421 aactaagaag agagaatgtg gactctgaat ccctttttca actttaaaat ggaaaacagt
    12481 catataaatg cttacagact gaaaaatgtc tcatacatat tttgcagcta tcatgatcct
    12541 agttcaatgc taggcaaata atggcacttg ttaattattt accagttttt aacttaagcc
    12601 tgattttaac aacttgataa tggtgtaata ctgacttata ccagcagggg ttattattaa
    12661 gcattctctg gattgaccac ccacaatgct ttgagcttct tttatagaag ggatcatgaa
    12721 aaggtctggt cagctacagt ttaattccac actgttacag aaaagcattt ctttatcctg
    12781 tagtagcatt tgaagggaca gttcaacacc ctgctccctg atctgtcaga gcttaccttc
    12841 caaccacaag gcaacttcct ggctttttac aagtggattt tatttcatgg tttaaattca
    12901 atcattattg agaacctaca gtagtgtgag cgtatcaaat ttgcacttca tgaggattta
    12961 cacatgaaaa ttgatattct catgggcttt gctgagagtt tagttaagga caaagatgta
    13021 aaaatgccaa atttgggaaa ggaaattttg tatgaccact gttctatttt tcagtgattc
    13081 tctctgttag tagctgggtc acatttacaa ctggaaaaga actacattgg gagatcagag
    13141 aaagccaagt ggccaagtcc tttatcaaaa agctgctttt tggagaagat gatgcataaa
    13201 gctgtgatac taaggagagg agagattatg tcatatgcaa ctgctctagg ctgtgcaggg
    13261 ggtttaaatg gagatcagaa caaaggctca cctggtattg atacatttgg taaggttgtt
    13321 aaaggcaatt tcaccaaatt cacacatttg tacggggccc atttcttttc aaactgaaga
    13381 atactttaaa cagcctgact gtgtccttgg ctctggatcc agaaggcctt atgctccaag
    13441 catgtaaaga aaagatcgca ggaatgtgga gagcttccaa aaagagattg ctctcagatt
    13501 ttcctgaaaa tcctgaaaac caggattttc caatctctac aatgttaagg ggttgttgtg
    13561 tagttgcatt ggaagagaga aaggaaacac actctttcat tgctgaattc taaataatga
    13621 tgccctgaat tagttctatg agaagtactg gcagacagct gttatgtctg cagggcatca
    13681 aggggcaggt gtgtctcacc ctactaagaa ttggcagaaa tgttttaacc tcttctttag
    13741 gcatctggtg agtattgcag atcttcaggc tgtccctaaa aggaggtagg tagccttctc
    13801 tgtggtcact gtgttggatt tggaagaaaa tataagtaga tgttaaggtc agtgctctcc
    13861 aggagatttc aatccaggct atctgtgttc agggaatgat ttgcaagaag ttggtttata
    13921 gacgtttact ctggaggcac aagctggctg ccatgctgag taagtcctct ttgtagatga
    13981 tgtattttgc ttgggcacca acagaattaa aaacgaaaaa caaaaaaaaa ctcgaatgac
    14041 ttaggcagaa catgccttcc ctagtttaat tagtccctgt tataaccagt tatttatctt
    14101 tttttgtaga ttctcggtct tgaagtcatt tgcctttgca atctctactt tagtatactc
    14161 attggatcct caaagagccg taagcttttt ggaaaaaaac atttcagaag tgaaggcttt
    14221 tgaggtttat aaaatggtag cagtcttagt ccttgccctg cctcagttta cctgcacatg
    14281 ctttctttca tttcctcgga ttctttcacc actttttaag ttttttttcc acaggtattt
    14341 ttcctgagct ctataccatg catttagctg cctagtgaga atatccagta ggttatccta
    14401 tagttactat gaagttaaca cagcccaaaa acctacttct ccttgtgttt ttttccaact
    14461 caatgaatga catcactgca ctcagaccag aaatctagaa gtcagtcatg actcttcatt
    14521 ctatttcgcc cttcacaaag agttagctgc cagctctgtt atttctgccc cttctttacc
    14581 cttcttccaa tttttattat cttcttattt atcctctatg tgtcacaaga ccagtctttc
    14641 tgggaggcat gttttatcct atccctctgc gtaggaataa ccataattat cttactaatt
    14701 ccatcccaga aaagcctgtg atccctgagg ccagaattga ctctttgggc ctaaatagca
    14761 gctataaaca tcttcagtaa cttgccaggc tctagcatgt ggcatggaat tttggcatct
    14821 agctaaaatt cctcaaccca tagttaagct actcctcttt ctcctaaaaa aaaaaaaaaa
    14881 tgagagaatt agggaaacac caaaagcaaa gagagcagct ctatgttcat tcatgtctgg
    14941 agatgagcca atttgagcac cactgtaggc caactctaaa tttattcaga tcgttaacat
    15001 gggtaaccca gcaaatattt cccagcagtg acaatctaca ccctttatct aaataaatat
    15061 tgagatgtgc ttttttcctg tgttagttca aagaatctct tcttgcctcc cattgctgat
    15121 tttctgtatt gatggactca tttctctcaa gagattggac aagctaaaat tctagagagt
    15181 tcaaaagtgt ttgaaagtac attttaagtg ttctcaccac aaaaaatgct agtgtgtgag
    15241 gtgatacata tgttaattag ttcaactgat ccattccaca atgtatacat atttcaaact
    15301 atcgagttgt acatgataaa tatatacaat ttttatttgt caaataaaga acatctataa
    15361 atatttatag atttcaaaat tgagaaagaa gtatatatgg agccacggtt gttttgacca
    15421 tttctccatg ctttttgttt ggggaggggg acattttttg gggggcaggg actgtgttca
    15481 gggaaagtac ctgaccaaca gaacttcaag tctcttccag agtgcgagac tcagcttatc
    15541 tgatcaaggt gaacttgccc ttcaatagac ttgcccttgt tactgcccag tgaggccacc
    15601 aaggaccaag aacagttgag ctctctcagg gccttcccct ttcaacaatt tagttgaatg
    15661 actcccttcc atctatcagt cttactccaa atatatgaaa ttactataca ttgaaatgcc
    15721 tgcaaactat atgcaaaaat gagtatgagg aaatcaaatg taaatcatat gcaaatatta
    15781 ttcaaccaag cttctataaa attgtacgtg tcaataacag taaagaattt taattaattc
    15841 tgtcatttaa aattcatgca ttccatattt tgctttcaga acttatagtc tatgccaatt
    15901 ttgaaaaaac tataagcaca aggaattaaa tactattgag tatagaactg ttgatttcaa
    15961 catacactat agcactttga ctaattacag atatatttga tagaaaagtc acatttctac
    16021 aaggtaattt tcaaaaagaa ataaaacatt tctgtaaact taaatgtgga ttaagtggca
    16081 gaatacagag atttgaatgt ttacaaata
//
