LOCUS       NM_138694              16271 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens PKHD1 ciliary IPT domain containing
            fibrocystin/polyductin (PKHD1), transcript variant 1, mRNA.
ACCESSION   NM_138694
VERSION     NM_138694.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16271)
  AUTHORS   Abdelwahed,M., Benoit,V., Maalej,B., Hilbert,P., Calemard,L.M.,
            Kamoun,H., Ammar-Keskes,L. and Belguith,N.
  TITLE     Genetic insights into fetal kidney development: Variants in HNF1A
            and PKHD1 genes
  JOURNAL   Gene 927, 148625 (2024)
   PUBMED   38830515
  REMARK    GeneRIF: Genetic insights into fetal kidney development: Variants
            in HNF1A and PKHD1 genes.
REFERENCE   2  (bases 1 to 16271)
  AUTHORS   Han,L., Gong,F., Wu,X., Tang,W., Bao,H., Wang,Y., Wang,D., Sun,Y.
            and Li,P.
  TITLE     Comprehensive characterization of PKHD1 mutation in human colon
            cancer
  JOURNAL   Cancer Med 13 (1), e6796 (2024)
   PUBMED   38178618
  REMARK    GeneRIF: Comprehensive characterization of PKHD1 mutation in human
            colon cancer.
REFERENCE   3  (bases 1 to 16271)
  AUTHORS   Giacobbe,C., Di Dato,F., Palma,D., Amitrano,M., Iorio,R. and
            Fortunato,G.
  TITLE     Rare variants in PKHD1 associated with Caroli syndrome: Two case
            reports
  JOURNAL   Mol Genet Genomic Med 10 (8), e1998 (2022)
   PUBMED   35715958
  REMARK    GeneRIF: Rare variants in PKHD1 associated with Caroli syndrome:
            Two case reports.
REFERENCE   4  (bases 1 to 16271)
  AUTHORS   Ishiko,S., Morisada,N., Kondo,A., Nagai,S., Aoto,Y., Okada,E.,
            Rossanti,R., Sakakibara,N., Nagano,C., Horinouchi,T., Yamamura,T.,
            Ninchoji,T., Kaito,H., Hamada,R., Shima,Y., Nakanishi,K.,
            Matsuo,M., Iijima,K. and Nozu,K.
  TITLE     Clinical features of autosomal recessive polycystic kidney disease
            in the Japanese population and analysis of splicing in PKHD1 gene
            for determination of phenotypes
  JOURNAL   Clin Exp Nephrol 26 (2), 140-153 (2022)
   PUBMED   34536170
  REMARK    GeneRIF: Clinical features of autosomal recessive polycystic kidney
            disease in the Japanese population and analysis of splicing in
            PKHD1 gene for determination of phenotypes.
REFERENCE   5  (bases 1 to 16271)
  AUTHORS   Onuchic,L.F., Furu,L., Nagasawa,Y., Hou,X., Eggermann,T., Ren,Z.,
            Bergmann,C., Senderek,J., Esquivel,E., Zeltner,R.,
            Rudnik-Schoneborn,S., Mrug,M., Sweeney,W., Avner,E.D., Zerres,K.,
            Guay-Woodford,L.M., Somlo,S. and Germino,G.G.
  TITLE     PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a
            novel large protein containing multiple immunoglobulin-like
            plexin-transcription-factor domains and parallel beta-helix 1
            repeats
  JOURNAL   Am J Hum Genet 70 (5), 1305-1317 (2002)
   PUBMED   11898128
  REMARK    GeneRIF: PKHD1, the polycystic kidney and hepatic disease 1 gene,
            encodes a novel large protein containing multiple
            immunoglobulin-like plexin-transcription-factor domains and
            parallel beta-helix 1 repeats.
REFERENCE   6  (bases 1 to 16271)
  AUTHORS   Ward,C.J., Hogan,M.C., Rossetti,S., Walker,D., Sneddon,T., Wang,X.,
            Kubly,V., Cunningham,J.M., Bacallao,R., Ishibashi,M.,
            Milliner,D.S., Torres,V.E. and Harris,P.C.
  TITLE     The gene mutated in autosomal recessive polycystic kidney disease
            encodes a large, receptor-like protein
  JOURNAL   Nat Genet 30 (3), 259-269 (2002)
   PUBMED   11919560
  REMARK    GeneRIF: characterization of mutation in autosomal recessive
            polycystic kidney disease
REFERENCE   7  (bases 1 to 16271)
  AUTHORS   Mucher,G., Becker,J., Knapp,M., Buttner,R., Moser,M.,
            Rudnik-Schoneborn,S., Somlo,S., Germino,G., Onuchic,L., Avner,E.,
            Guay-Woodford,L. and Zerres,K.
  TITLE     Fine mapping of the autosomal recessive polycystic kidney disease
            locus (PKHD1) and the genes MUT, RDS, CSNK2 beta, and GSTA1 at
            6p21.1-p12
  JOURNAL   Genomics 48 (1), 40-45 (1998)
   PUBMED   9503014
REFERENCE   8  (bases 1 to 16271)
  AUTHORS   Zerres,K., Mucher,G., Bachner,L., Deschennes,G., Eggermann,T.,
            Kaariainen,H., Knapp,M., Lennert,T., Misselwitz,J., von
            Muhlendahl,K.E. et al.
  TITLE     Mapping of the gene for autosomal recessive polycystic kidney
            disease (ARPKD) to chromosome 6p21-cen
  JOURNAL   Nat Genet 7 (3), 429-432 (1994)
   PUBMED   7920664
REFERENCE   9  (bases 1 to 16271)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
REFERENCE   10 (bases 1 to 16271)
  AUTHORS   Burgmaier,K., Gimpel,C., Schaefer,F. and Liebau,M.
  TITLE     Autosomal Recessive Polycystic Kidney Disease - PKHD1
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301501
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY074797.1 and AL355997.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_138694.3.
            
            Summary: The protein encoded by this gene is predicted to have a
            single transmembrane (TM)-spanning domain and multiple copies of an
            immunoglobulin-like plexin-transcription-factor domain. Alternative
            splicing results in two transcript variants encoding different
            isoforms. Other alternatively spliced transcripts have been
            described, but the full length sequences have not been determined.
            Several of these transcripts are predicted to encode truncated
            products which lack the TM and may be secreted. Mutations in this
            gene cause autosomal recessive polycystic kidney disease, also
            known as polycystic kidney and hepatic disease-1. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform of
            this protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY074797.1, AF480064.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371117.8/ ENSP00000360158.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16223             AY074797.1         13-16235
            16224-16271         AL355997.10        26310-26357         c
FEATURES             Location/Qualifiers
     source          1..16271
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3-p12.2"
     gene            1..16271
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /note="PKHD1 ciliary IPT domain containing
                     fibrocystin/polyductin"
                     /db_xref="GeneID:5314"
                     /db_xref="HGNC:HGNC:9016"
                     /db_xref="MIM:606702"
     exon            1..180
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..316
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..12489
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /note="isoform 1 is encoded by transcript variant 1; TIG
                     multiple domains 1; polyductin; tigmin; fibrocystin;
                     polycystic kidney and hepatic disease 1 protein;
                     polycystic kidney and hepatic disease 1 (autosomal
                     recessive); fibrocystin/polyductin complex; PKHD1,
                     fibrocystin/polyductin"
                     /codon_start=1
                     /product="fibrocystin isoform 1"
                     /protein_id="NP_619639.3"
                     /db_xref="CCDS:CCDS4935.1"
                     /db_xref="GeneID:5314"
                     /db_xref="HGNC:HGNC:9016"
                     /db_xref="MIM:606702"
                     /translation="MTAWLISLMSIEVLLLAVRHLSLHIEPEEGSLAGGTWITVIFDG
                     LELGVLYPNNGSQLEIHLVNVNMVVPALRSVPCDVFPVFLDLPVVTCRTRSVLSEAHE
                     GLYFLEAYFGGQLVSSPNPGPRDSCTFKFSKAQTPIVHQVYPPSGVPGKLIHVYGWII
                     TGRLETFDFDAEYIDSPVILEAQGDKWVTPCSLINRQMGSCYPIQEDHGLGTLQCHVE
                     GDYIGSQNVSFSVFNKGKSMVHKKAWLISAKQDLFLYQTHSEILSVFPETGSLGGRTN
                     ITITGDFFDNSAQVTIAGIPCDIRHVSPRKIECTTRAPGKDVRLTTPQPGNRGLLFEV
                     GDAVEGLELTEATPGYRWQIVPNASSPFGFWSQEGQPFRARLSGFFVAPETNNYTFWI
                     QADSQASLHFSWSEEPRTKVKVASISVGTADWFDSWEQNRDEGTWQQKTPKLELLGGA
                     MYYLEAEHHGIAPSRGMRIGVQIHNTWLNPDVVTTYLREKHQIRVRAQRLPEVQVLNV
                     SGRGNFFLTWDNVSSQPIPANATAHLIQTTIEELLAVKCKLEPLWSNILLRLGFERGP
                     EVSNSDGDLTSGTEPFCGRFSLRQPRHLVLTPPAAQKGYRLDQYTHLCLAYKGHMNKI
                     LKMIVSFTIGFQNMVKNTTCDWSLTRTSPESWQFDCTDLWETCVRCFGDLQPPPANSP
                     VLVHQINLLPLAQETGLFYVDEIIIADTNVTVSQADSGTARPGGNLVESVSVVGSPPV
                     YSVTSWLAGCGTELPLITARSVPTEGTEEGSGLVLVTTQRRQRTSPPLGGHFRIQLPN
                     TVISDVPVQISAHHLHQLLQNNADDFTSRYLNASDFTVKEDLYTCYEHVWTLSWSTQI
                     GDLPNFIRVSDENLTGVNPAAATRVVYDGGVFLGPIFGDMLATANQHTQVVVRVNDVP
                     AHCPGSCSFQYLQGSTPCVHSVWYSIDGDINLMIYITGTGFSGDSQFLQVTVNKTSCK
                     VIFSNQTNVVCQTDLLPVGMHRILMLVRPSGLAISATGEDLFLNVKPRLDMVEPSRAA
                     DIGGLWATIRGSSLEGVSLILFGSYSCAINVATSNSSRIQCKVPPRGKDGRIVNVTVI
                     RGDYSAVLPRAFTYVSSLNPVIVTLSRNISNIAGGETLVIGVARLMNYTDLDVEVHVQ
                     DALAPVHTQSAWGLEVALPPLPAGLHRISVSINGVSIHSQGVDLHIQYLTEVFSIEPC
                     CGSLLGGTILSISGIGFSRDPALVWVLVGNRSCDIVNLTEASIWCETLPAPQIPDAGA
                     PTVPAAVEVWAGNRFFARGPSPSLVGKGFTFMYEAAATPVVTAMQGEITNSSLSLHVG
                     GSNLSNSVILLGNLNCDVETQSFQGNVSLSGCSIPLHSLEAGIYPLQVRQKQMGFANM
                     SVVLQQFAVMPRIMAIFPSQGSACGGTILTVRGLLLNSRRRSVRVDLSGPFTCVILSL
                     GDHTILCQVSLEGDPLPGASFSLNVTVLVNGLTSECQGNCTLFIREEASPVMDALSTN
                     TSGSLTTVLIRGQRLATTADEPMVFVDDQLPCNVTFFNASHVVCQTRDLAPGPHYLSV
                     FYTRNGYACSGNVSRHFYIMPQVFHYFPKNFSLHGGSLLTIEGTGLRGQNTTSVYIDQ
                     QTCLTVNIGAELIRCIVPTGNGSVALEIEVDGLWYHIGVIGYNKAFTPELISISQSDD
                     ILTFAVAQISGAANIDIFIGMSPCVGVSGNHTVLQCVVPSLPAGEYHVRGYDCIRGWA
                     SSALVFTSRVIITAVTENFGCLGGRLVHVFGAGFSPGNVSAAVCGAPCRVLANATVSA
                     FSCLVLPLDVSLAFLCGLKREEDSCEAARHTYVQCDLTVAMATEQLLESWPYLYICEE
                     SSQCLFVPDHWAESMFPSFSGLFISPKLERDEVLIYNSSCNITMETEAEMECETPNQP
                     ITVKITEIRKRWGQNTQGNFSLQFCRRWSRTHSWFPERLPQDGDNVTVENGQLLLLDT
                     NTSILNLLHIKGGKLIFMAPGPIELRAHAILVSDGGELRIGSEDKPFQGRAQITLYGS
                     SYSTPFFPYGVKFLAVRNGTLSLHGSLPEVIVTCLRATAHALDTVLALEDAVDWNPGD
                     EVVIISGTGVKGAKPMEEIVTVETVQDTDLYLKSPLRYSHNFTENWVAGEHHILKATV
                     ALLSRSITIQGNLTNEREKLLVSCQEANAPEGNLQHCLYSMSEKMLGSRDMGARVIVQ
                     SFPEEPSQVQLKGVQFQVLGQAFHKHLSSLTLVGAMRESFIQGCTVRNSFSRGLSMCG
                     TLGLKVDSNVFYNILGHALLVGTCTEMRYISWEAIHGRKDDWSGHGNIIRNNVIIQVS
                     GAEGLSNPEMLTPSGIYICSPTNVIEGNRVCGAGYGYFFHLMTNQTSQAPLLSFTQNI
                     AHSCTRYGLFVYPKFQPPWDNVTGTTLFQSFTVWESAGGAQIFRSSNLRLKNFKVYSC
                     RDFGIDVLESDANTSVTDSLLLGHFAHKGSLCMSSGIKTPKRWELMVSNTTFVNFDLI
                     NCVAIRTCSDCSQGQGGFTVKTSQLKFTNSSNLVAFPFPHAAILEDLDGSLSGKNRSH
                     ILASMETLSASCLVNSSFGRVVHGSACGGGVLFHRMSIGLANTPEVSYDLTMTDSRNK
                     TTTVNYVRDTLSNPRGWMALLLDQETYSLQSENLWINRSLQYSATFDNFAPGNYLLLV
                     HTDLPPYPDILLRCGSRVGLSFPFLPSPGQNQGCDWFFNSQLRQLTYLVSGEGQVQVI
                     LRVKEGMPPTISASTSAPESALKWSLPETWQGVEEGWGGYNNTIPGPGDDVLILPNRT
                     VLVDTDLPFFKGLYVMGTLDFPVDRSNVLSVACMVIAGGELKVGTLENPLEKEQKLLI
                     LLRASEGVFCDRMNGIHIDPGTIGVYGKVHLYSAYPKNSWTHLGADIASGNERIIVED
                     AVDWRPHDKIVLSSSSYEPHEAEVLTVKEVKGHHVRIYERLKHRHIGSVHVTEDGRHI
                     RLAAEVGLLTRNIQIQPDVSCRGRLFVGSFRKSSREEFSGVLQLLNVEIQNFGSPLYS
                     SVEFSNVSAGSWIISSTLHQSCGGGIHAAASHGVLLNDNIVFGTAGHGIDLEGQAYTV
                     TNNLVVLMTQPAWSTIWVAGIKVNQVKDINLHGNVVAGSERLGFHIRGHKCSSCELLW
                     SDNVAHSSLHGLHLYKESGLDNCTRISGFLAFKNFDYGAMLHVENSVEIENITLVDNT
                     IGLLAVVYVFSAPQNSVKKVQIVLRNSVIVATSSSFDCIQDKVKPHSANLTSTDRAPS
                     NPRGGRIGILWPVFTSEPNQWPQEPWHKVRNDHSISGIMKLQDVTFSSFVKSCYSDDL
                     DVCILPNAENSGIMHPITAERTRMLKIKDKNKFYFPSLQPRKDLGKVVCPELDCASPR
                     KYLFKDLDGRALGLPPPVSVFPKTEAEWTASFFNAGTFREEQKCTYQFLMQGFICKQT
                     DQVVLILDSADAIWAIQKLYPVVSVTSGFVDVFSSVNANIPCSTSGSVSTFYSILPIR
                     QITKVCFMDQTPQVLRFFLLGNKSTSKLLLAVFYHELQSPHVFLGESFIPPTLVQSAS
                     LLLNESIGANYFNIMDNLLYVVLQGEEPIEIRSGVSIHLALTVMVSVLEKGWEIVILE
                     RLTNFLQIGQNQIRFIHEMPGHEETLKAIADSRAKRKRNCPTVTCTSHYRRVGQRRPL
                     MMEMNSHRASPPMTVETISKVIVIEIGDSPTVRSTGMISSLSSNKLQNLAHRVITAQQ
                     TGVLENVLNMTIGALLVTQSKGVIGYGNTSSFKTGNLIYIRPYALSILVQPSDGEVGN
                     ELPVQPQLVFLDEQNRRVESLGPPSEPWTISASLEGASDSVLKGCTQAETQDGYVSFY
                     NLAVLISGSNWHFIFTVTSPPGVNFTARSKPFAVLPVTRKEKSTIILAASLSSVASWL
                     ALSCLVCCWLKRSKSRKTKPEEIPESQTNNQNIHIHISSKRRESQGPKKEDTVVGEDM
                     RMKVMLGKVNQCPHQLMNGVSRRKVSRHIVREEEAAVPAPGTTGITSHGHICAPGAPA
                     QQVYLQETGNWKEGQEQLLRYQLAGQNQLLLLCPDFRQERQQLPGQSRLSKQSGSLGL
                     SQEKKASCGATEAFCLHSVHPETIQEQL"
     exon            317..394
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..545
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..654
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..712
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..791
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..866
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..931
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..971
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1042
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1144
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1240
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1382
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1497
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1776
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1866
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1957
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2100
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2228
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2404
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2543
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2671
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2856
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2979
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3085
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3361
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3492
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3628
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3824
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..3892
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..5500
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            5501..5644
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            5645..5864
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            5865..6015
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            6016..6172
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            6173..6385
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            6386..6596
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            6597..6754
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            6755..6946
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            6947..7072
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            7073..7129
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            7130..7260
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            7261..7373
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            7374..7479
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            7480..7614
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            7615..7750
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            7751..7997
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            7998..8175
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            8176..8371
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            8372..8437
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            8438..8566
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            8567..8704
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            8705..8818
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            8819..8906
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            8907..9061
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            9062..9214
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            9215..10093
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            10094..10262
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            10263..10420
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            10421..11438
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            11439..11574
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            11575..11662
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            11663..11770
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            11771..11929
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            11930..12049
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            12050..16271
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12645..12650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /note="hexamer: TATAAA"
     polyA_site      12668
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /note="major polyA site"
     regulatory      15505..15510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /note="hexamer: AATAAA"
     polyA_site      15525
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
     regulatory      16244..16249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
                     /note="hexamer: AATACA"
     polyA_site      16271
                     /gene="PKHD1"
                     /gene_synonym="ARPKD; FCYT; FPC; PCYT; PKD4; TIGM1"
ORIGIN      
        1 gacacaaacg agttaggtga gttatagtct aacgtgagtg agttacctgc gtggtggctg
       61 caggctgagc tctaaccaga taacatgtcc acggattctt gacagagaga aataagatca
      121 cttagaaaga aaggatcatt tctcccttga gtcacaagga gacagaaaca gaaaaaaaag
      181 cacaaaagct atgctgctcc aatcaaaact gaaaatgctt ttaatgtctg agcaatctta
      241 agagtattga tttaagtgga cagaatgact gcctggctga tctctctgat gagtattgaa
      301 gtactacttt tggcagtacg tcacctgagt ttacatattg aacctgaaga aggtagcctt
      361 gcagggggaa cgtggatcac agtcattttt gatggtttgg agttgggtgt tctttacccc
      421 aacaatggct ctcaattgga gatacacctg gtgaacgtga acatggtggt gcccgcactg
      481 cggagtgttc cctgtgacgt ctttcctgtt ttcttggatt tgcctgtggt gacatgccgg
      541 accagatctg tgctgtctga agcacatgag ggtctgtact tcctggaagc atacttcggg
      601 ggacagctgg taagcagtcc aaatccagga ccacgagata gctgtacttt caagttttcc
      661 aaggcgcaga cacccatcgt tcaccaagtt tatccaccaa gtggtgttcc aggaaaacta
      721 atacatgtat atggctggat tatcactgga agattggaaa cttttgattt tgatgctgag
      781 tacattgata gcccagtgat cttggaagct caaggagaca aatgggttac tccttgctct
      841 cttataaata ggcagatggg aagctgttat cctattcagg aggaccatgg tcttgggact
      901 ctgcagtgcc atgtggaagg cgactacatc ggctcccaga atgttagctt ctcagtattt
      961 aacaaaggaa agtcaatggt ccacaagaag gcatggctga tcagtgctaa acaggatctt
     1021 ttcctatacc agacacactc agaaatatta tctgtgtttc cagaaactgg gagccttggg
     1081 ggaagaacaa acatcacaat tacaggagac ttttttgaca attctgccca ggttaccatt
     1141 gcaggcattc catgtgatat tagacacgtg tctcccagga agattgagtg caccactcgg
     1201 gctccaggaa aagatgtgag gctcaccacc cctcagccag gcaatcgagg gcttcttttt
     1261 gaagttggag atgctgttga gggactggaa ctgactgaag ccaccccagg gtacaggtgg
     1321 cagattgtcc ctaatgccag ttctccattt gggttttggt cacaggaagg acaacctttc
     1381 agagcacggc tcagtgggtt ctttgtggct ccagagacaa ataattacac tttctggatt
     1441 caggcagata gccaagcttc cttgcatttc agttggtcag aggaaccaag gactaaggtg
     1501 aaagtggcct ccatcagcgt cggcactgct gactggtttg actcctggga gcagaatagg
     1561 gatgaaggga cctggcagca gaagactccc aagttggagc tgttgggtgg agccatgtac
     1621 tacctggaag cagagcatca tgggatagcc ccaagcaggg ggatgaggat tggtgtccag
     1681 attcacaaca cctggctgaa tcctgatgtg gtcaccactt acctacggga gaagcaccag
     1741 atccgagtcc gagcccagag gcttccagaa gtacaggtgc tgaatgtatc aggcagagga
     1801 aacttcttcc ttacttggga caatgtctct agtcagccaa tccctgcaaa tgccacagcc
     1861 catctgattc aaacaaccat tgaggagtta cttgcagtaa aatgcaaact ggaacccctt
     1921 tggtctaaca tccttctccg gcttggattt gaacgaggcc cagaagtttc caactctgat
     1981 ggggacctca ccagtgggac ggagcccttc tgtggcaggt tcagcctccg tcagcctcga
     2041 caccttgtcc ttactccccc ggctgcccag aagggctatc ggctagatca gtatacacac
     2101 ctgtgtcttg catacaaagg ccacatgaac aagatcctga agatgattgt gtccttcaca
     2161 atcggctttc aaaacatggt aaagaatacc acctgtgact ggagtctcac gaggaccagc
     2221 cccgagagct ggcagttcga ttgcactgac ctctgggaga cttgtgtgcg ttgcttcggg
     2281 gatctccagc cccctccggc aaactcccca gtgctggttc atcagatcaa ccttctccct
     2341 ctggcccagg agacgggcct gttctatgtg gatgaaatta ttattgcaga cacaaacgta
     2401 acagtttctc aagctgattc tggaacggct cgcccagggg gcaatctggt ggaatcagtc
     2461 tctgtggtgg gatcccctcc ggtctacagt gtcacctcct ggctggcggg gtgtggcacg
     2521 gagctcccgc tcatcactgc acgctctgtg cccactgaag gaacagaaga gggatctgga
     2581 ctggtcctgg tgacgacaca gagacgacag cggacaagtc cacctctagg aggacacttt
     2641 cgcatccagc ttcctaatac agtgatttct gatgtccctg tacaaatttc tgctcatcac
     2701 cttcaccagc tcttacagaa taatgccgat gacttcacat ccaggtacct caatgccagt
     2761 gacttcactg tgaaggagga tctatacact tgctacgaac acgtgtggac cttgtcctgg
     2821 tccactcaga ttggggattt gcccaatttt atcagggtct ctgatgaaaa ccttactgga
     2881 gtgaatcctg ctgcagccac gcgtgtggta tatgatggtg gagtttttct tggacccata
     2941 tttggagaca tgttggctac tgccaaccag catactcagg tggttgtgcg agtgaatgat
     3001 gtaccagctc attgcccagg ttcctgctct ttccagtacc tccaagggtc aactccctgt
     3061 gtccattctg tgtggtactc cattgatggt gacatcaacc taatgattta cattaccgga
     3121 actggtttct ctggtgactc ccagttcttg caggttacag tgaacaaaac gagttgcaaa
     3181 gttattttct caaaccagac caatgtagtc tgtcagacag atttgctacc tgttggaatg
     3241 catcggatct tgatgttggt gagaccctct ggtcttgcca tcagtgccac tggagaagac
     3301 ctcttcctaa atgtgaaacc tagactggat atggtggagc cttccagagc tgcggatatt
     3361 ggagggctct gggccaccat ccgaggctct agtttggaag gtgttagcct gatattattt
     3421 ggatcttact cgtgtgccat caatgtcgct acaagcaatt caagcagaat tcagtgcaaa
     3481 gttccaccca gggggaaaga tggacgcatt gtgaatgtga ctgtgatcag aggggactat
     3541 tctgcagttc ttcccagagc atttacatat gtctcttcct taaatccagt tattgtgact
     3601 ctgagcagaa acataagcaa tatagcaggc ggtgagaccc tggtcattgg agtggcgagg
     3661 ctgatgaact atacggattt ggatgtggaa gtccacgtcc aggatgcctt ggctccggtt
     3721 cacacacagt cggcttgggg cctggaggtg gcactgcccc cactgccagc tggtctccac
     3781 agaatttccg tctctatcaa tggggtcagc attcactcac aaggggttga tctccacatc
     3841 cagtacctca cagaagtttt cagcatcgag ccttgctgtg ggtccctgct gggagggacc
     3901 atcctcagca tctcaggaat aggcttcagc agggacccag ctttggtttg ggtacttgtg
     3961 ggcaatcggt cctgtgacat tgtgaactta acggaggcga gcatctggtg tgaaaccctg
     4021 ccagcccccc agatacccga tgcgggcgct cccactgttc cagctgccgt ggaggtctgg
     4081 gctggcaaca ggttcttcgc ccgtggtcct tcaccaagct tggtggggaa aggcttcacc
     4141 ttcatgtatg aagcggcagc aacaccagta gtcactgcca tgcaaggaga aatcacaaat
     4201 agcagcctga gcctgcatgt gggaggaagt aacctctcca actcagtcat ccttctgggg
     4261 aacctgaact gtgatgttga gacacagtcc ttccagggca acgtgagcct gtctggatgc
     4321 tccatccctc ttcacagtct ggaggctggc atctatcctc tccaagtacg tcagaagcag
     4381 atgggatttg ctaatatgtc tgtggtgctc cagcaatttg cagtgatgcc tcggataatg
     4441 gccatcttcc catcgcaggg ttcggcatgt ggtgggacca tacttactgt gagggggttg
     4501 cttcttaact ctagaaggag gtcagttcgg gttgacctct cgggtccttt tacttgtgtg
     4561 attttgagtt tgggagacca caccattctc tgccaggtta gcctggaggg tgaccccttg
     4621 cctggagctt ccttctccct gaacgtcaca gtcctggtca atgggctaac cagcgagtgt
     4681 caggggaatt gcactctttt cataagggaa gaggcaagtc ctgtcatgga tgccttgtcc
     4741 acaaacacca gtgggtctct gaccactgtg ctgattaggg gtcagaggtt agccaccaca
     4801 gctgatgagc cgatggtatt tgtggatgat caacttcctt gcaatgtaac tttttttaat
     4861 gcaagccacg ttgtgtgcca gacaagagac ttggccccag gaccccacta cctgtcagtt
     4921 ttttatacaa gaaatgggta tgcttgttct ggtaatgttt ccagacactt ctacattatg
     4981 ccccaagtgt ttcattattt tcctaagaat ttcagcttac atggtggaag cctcttgacc
     5041 atagagggca caggcctgag aggacagaac accacgtcag tctatattga ccagcagacc
     5101 tgcctgacgg tgaacatcgg tgctgagctc atccggtgca ttgttcccac agggaatggc
     5161 tctgttgccc tggaaataga ggtagatgga ctttggtatc acataggagt cattggttat
     5221 aacaaggcct ttaccccaga attgatctct atttctcaga gcgatgacat cttaaccttt
     5281 gcagtggccc agatctcagg agctgcaaac attgacattt ttataggaat gtcaccctgt
     5341 gtgggtgtct ctggtaacca caccgttctt cagtgcgtgg tcccttccct tccggccggg
     5401 gagtaccacg tcagaggcta tgactgcatc agagggtggg cctcatctgc cctggtgttc
     5461 acctcaagag ttattattac agcagtgacg gagaacttcg gctgcctggg tggaaggctg
     5521 gtgcatgtgt ttggagcggg attttctcca gggaatgtct cagctgctgt gtgtggtgct
     5581 ccctgccgag tcctggctaa tgctacagtg tctgccttca gctgcttggt tctgcccctg
     5641 gatgtgtcct tggccttcct gtgtggcctg aagcgtgagg aggacagctg tgaggctgcc
     5701 agacacacct atgtgcagtg tgatttgaca gttgccatgg cgacagagca actgcttgaa
     5761 tcgtggcctt acctctacat ttgcgaggaa agttcccaat gcctctttgt gccagatcat
     5821 tgggcagagt caatgtttcc atcattctcg ggcctcttta tcagccctaa attggaaaga
     5881 gatgaagttc tcatctataa tagctcctgt aacattacca tggaaactga ggcagagatg
     5941 gagtgtgaga cgcccaatca gccaattacc gtcaagatta ctgagatacg gaaacgctgg
     6001 ggccagaaca ctcagggcaa cttttcttta cagttctgcc ggagatggtc caggactcac
     6061 agctggtttc ctgaaaggct gccacaagat ggcgacaacg tcacagtgga gaatggccaa
     6121 ttgcttctgc tggacactaa cacaagcatc ctcaacttac tgcacattaa agggggcaag
     6181 ctgattttca tggccccagg acccatcgag ctcagggcac acgccatcct tgtttctgat
     6241 ggtggagagc tccggattgg atccgaagac aagcccttcc aaggcagagc tcagatcaca
     6301 ctctacggga gttcctactc aactcccttc tttccctatg gagtcaagtt cctggctgtg
     6361 aggaatggaa ctctttctct gcacggttca ctaccagaag taattgtcac ctgtcttaga
     6421 gcaactgccc atgccctaga cacagtgctg gctttagaag atgctgtgga ctggaaccct
     6481 ggggatgaag ttgtcatcat cagtggaaca ggtgttaaag gtgccaaacc gatggaagag
     6541 attgtcactg tggaaactgt gcaggataca gacctctatc ttaagtcacc tttgagatat
     6601 tctcacaact ttacagagaa ttgggtggct ggagagcacc atattttaaa ggccactgtg
     6661 gctctgctca gcaggagtat taccatacaa ggaaatctca ctaatgagag ggagaagctg
     6721 cttgtttcat gccaggaggc caatgctcca gaaggtaatc tgcagcactg tttgtattcc
     6781 atgagtgaga agatgctagg atccagggat atgggagcca gagtgatcgt tcagtccttc
     6841 ccagaagagc ccagccaggt ccagttgaag ggagtgcagt ttcaagtctt ggggcaagcc
     6901 ttccataagc atctgagctc actcactctg gtgggagcta tgagagagtc tttcatacag
     6961 ggctgcacag tgaggaactc cttcagtaga ggcctcagca tgtgcgggac cttgggcctg
     7021 aaggtggaca gtaatgtatt ctacaatatt ttaggtcatg cgctgctagt tgggacatgc
     7081 acggagatga gatatatctc ctgggaggca attcatggaa ggaaagatga ctggtcagga
     7141 catggaaata taataagaaa caacgtgatc atccaggttt ctggtgccga gggactctcc
     7201 aatcctgaaa tgttgacacc atctggcatc tatatctgca gtcccaccaa tgttatagag
     7261 gggaacagag tgtgtggtgc tggctatggc tactttttcc atctcatgac caaccaaaca
     7321 tcacaagctc cgcttctttc cttcactcag aacattgcac attcttgtac caggtatggt
     7381 ctctttgtat accctaaatt tcagccacct tgggataatg tcactggcac cactctgttc
     7441 cagagcttca cagtttggga aagtgcaggt ggtgcccaga tttttagaag tagcaatctt
     7501 cgcctgaaaa acttcaaagt ttattcatgc agagattttg gaattgacgt cttggaaagt
     7561 gatgcaaata cttcagttac tgacagctta ttacttggtc attttgccca caagggaagt
     7621 ctgtgtatgt catctgggat taaaactcct aaaagatggg aactgatggt gtctaacaca
     7681 acctttgtta attttgatct catcaactgt gtggccatta gaacctgttc agactgttcc
     7741 caaggacaag gtggatttac tgtgaagacc agccagttga agtttacaaa ctcttcaaac
     7801 ttagtggcat ttccatttcc tcatgcagca attttggaag acttggatgg gtctctgtct
     7861 gggaaaaaca gaagtcacat tcttgcttct atggaaaccc tttcagcttc ttgtttggtc
     7921 aattcaagct ttggtcgggt tgtccatggc agtgcctgtg gaggaggtgt tctttttcat
     7981 cgtatgtcta ttggtttagc gaatactcct gaagtttctt atgatttaac catgactgac
     8041 agcagaaata aaacaaccac tgtcaattat gtacgtgata cattgtctaa ccctcgtggc
     8101 tggatggctc tgctcttgga ccaagagacc tactcattgc aatctgagaa cctttggatc
     8161 aacagatctc tgcagtactc agcaaccttt gacaactttg ctcctggtaa ttacctactg
     8221 ctggtgcaca cagatttgcc gccttaccct gacatcctcc taagatgtgg gagtcgagtg
     8281 ggtctgtctt ttccatttct tccatcacca ggtcagaacc aaggctgtga ctggttcttc
     8341 aatagccagc tgaggcaact cacctatctg gtttcaggtg aaggccaagt tcaagtcatt
     8401 ctccgggtga aggaaggtat gcccccaact atttcagctt ctacctctgc ccctgaatca
     8461 gctttaaaat ggtccctccc tgaaacatgg caaggtgttg aagaaggctg gggaggatac
     8521 aacaatacca ttccaggccc tggggatgac gttctcattt tacccaacag aactgtcctt
     8581 gtggatacag atcttccatt cttcaaaggg ctgtatgtga tggggacctt agacttccct
     8641 gtggacagaa gcaatgttct gagtgtggca tgcatggtca ttgcaggcgg ggagctgaaa
     8701 gttggtactt tagaaaatcc cttagaaaag gaacaaaagc ttctgattct ccttagagcc
     8761 tcagagggag tcttttgtga ccgtatgaat ggaattcata ttgacccagg aacaattggg
     8821 gtttatggga aagttcatct ttacagtgct tatcctaaga actcctggac acatcttgga
     8881 gctgatattg cctcaggaaa tgagagaatt atagtagaag atgcagtgga ttggcgcccc
     8941 catgacaaaa tagtccttag ctcctcttct tatgagcctc atgaagcaga ggtcctcact
     9001 gtgaaagaag tcaagggcca ccatgtgagg atctatgaac ggctcaaaca ccggcatatt
     9061 ggaagtgtac atgtcacgga ggatggccga cacattcgtt tggctgctga ggttggactg
     9121 ttgacccgaa atatacaaat tcagcctgac gtatcatgta gggggagact gtttgtgggg
     9181 tccttcagga agtccagccg agaagaattt tcaggtgtcc ttcaacttct taatgtggaa
     9241 attcagaact tcgggtcacc attgtactca tctgttgaat tcagtaatgt gtcagcagga
     9301 tcctggatca tatcatctac tctgcaccag agctgtggcg ggggcattca tgcagctgcc
     9361 agtcatggag tacttttaaa tgacaatatt gtgtttggca cagctggcca tggcatagat
     9421 ttagagggtc aggcctatac tgtcactaat aaccttgtgg ttctgatgac acagccagcg
     9481 tggtccacca tttgggtggc gggaatcaaa gtgaaccagg taaaggacat caacctccat
     9541 ggcaacgttg tggcaggatc agagagactt ggctttcaca tccgaggcca caagtgctcc
     9601 tcttgtgaac tgctttggtc tgacaatgtg gcgcattcaa gtcttcatgg ccttcatctc
     9661 tataaggaaa gtggacttga caactgtacc agaatctctg gcttcttggc tttcaagaac
     9721 tttgactatg gtgccatgtt acatgtagag aacagcgtgg agatagagaa cattactctg
     9781 gtagacaata ctattggtct tttggcagta gtgtatgtat tttctgctcc acaaaattcc
     9841 gtcaaaaaag tgcagattgt gcttaggaat tcagtcattg tggccaccag ctcttctttt
     9901 gactgcattc aggacaaagt gaagccgcac tcagccaact tgacatcaac agatagagct
     9961 ccctccaatc caagaggagg tcgaattggt attctgtggc ctgtattcac ctcagaacca
    10021 aatcagtggc ctcaggagcc atggcacaaa gtgaggaatg atcattcaat ttcaggaatc
    10081 atgaaacttc aagatgttac cttttctagt tttgtgaaga gttgctatag cgatgacctg
    10141 gatgtctgca ttctaccaaa tgcagagaac agtggaatta tgcacccaat aacagcagag
    10201 aggaccagga tgctaaagat aaaagataaa aacaagttct actttccttc attacaaccc
    10261 aggaaagatt taggaaaagt agtctgtcct gaattagact gtgcaagtcc aagaaaatat
    10321 ctcttcaagg atctggatgg gagagccctg ggtctgcctc caccagtttc tgtatttcct
    10381 aaaacagagg cagaatggac tgcatccttc ttcaacgcag gtacatttag agaagaacag
    10441 aaatgtacat accaatttct gatgcaagga ttcatctgca aacagactga ccaagtggtc
    10501 ctaattcttg atagcgctga tgccatttgg gcaattcaga agttatatcc agttgtatct
    10561 gtgactagtg gttttgttga tgtctttagc agtgtaaatg ccaatattcc ctgctctact
    10621 tctgggtcag tgtctacttt ctattctatc ttacccatca ggcaaatcac caaagtctgc
    10681 ttcatggatc aaactcctca agttttgcgc ttttttctat tggggaacaa aagtacctcc
    10741 aagcttctct tggctgtatt ctaccatgag ctccagagcc cccacgtctt cttaggggaa
    10801 agttttattc cacccactct ggttcagtca gcttccttat tgctgaatga atctattggt
    10861 gccaactatt tcaacatcat ggataacctc ttgtatgttg tcctacaagg agaggagccc
    10921 attgaaatac gctcaggtgt ttccattcac ttggccctca ctgtgatggt ttcagtctta
    10981 gaaaaaggct gggaaatagt aatactcgaa agactaacta acttcttaca gattggccaa
    11041 aaccaaatca ggtttattca cgagatgcct ggccatgaag agaccttaaa ggccattgct
    11101 gacagtagag caaaaagaaa gcgcaattgc cctactgtga cttgcactag tcattataga
    11161 agagttggtc aacgtaggcc tctcatgatg gaaatgaact cacatagggc ttcaccccca
    11221 atgactgtgg aaactatctc aaaagtgatt gtcattgaaa ttggtgattc gccaacagta
    11281 aggagcactg gaatgatttc atccttatca agtaacaaat tacagaattt ggctcatcga
    11341 gtcatcactg ctcaacagac tggggtacta gagaatgttc tgaatatgac tatcggggcc
    11401 ttactagtta ctcagtcaaa gggagtcatt ggctatggaa atacaagcag ttttaaaact
    11461 gggaacttga tatatattcg gccctatgca ctttccatcc tagtccagcc ttcagatgga
    11521 gaagtgggaa atgagcttcc agtgcagcca caattggtat ttttggatga gcagaatcga
    11581 agagtagagt ccctgggacc tccttcagag ccatggacaa tttcagcttc cctggaagga
    11641 gcatcagact cagtgctaaa agggtgcacc caggcagaaa ctcaagatgg ttatgttagc
    11701 ttctacaact tggcagtctt gatctctggg tcaaactggc actttatttt tactgtcact
    11761 tctcctccag gagtcaattt tacagctcga tccaagccat ttgctgtctt gcctgtgact
    11821 aggaaggaga agtcgaccat catcctggct gcttccctgt cctctgtggc ctcatggctg
    11881 gctctgagct gtctggtgtg ctgttggctt aaaagaagca aaagcagaaa aacaaaacct
    11941 gaagagattc ctgaatccca gactaataat caaaatattc atatccacat ctcatccaaa
    12001 cgccgagaat cacaagggcc caaaaaagaa gacactgtgg tgggagaaga tatgagaatg
    12061 aaggtcatgc tgggcaaggt gaaccagtgc ccccaccagt tgatgaatgg agtgtccaga
    12121 aggaaagtta gccgccacat tgtccgagag gaagaggctg ctgtgcctgc tcctggtact
    12181 actggcatca catcccatgg gcacatctgt gctccaggtg ctcctgctca gcaggtgtac
    12241 ctgcaagaga ctgggaactg gaaggagggc caagagcagt tgctcagata ccagctggca
    12301 ggccaaaatc agctgctgct gctatgccca gacttcagac aagagaggca gcagttgcca
    12361 gggcaaagtc ggctgagtaa gcaaagtggc agcttggggc tttcccaaga gaagaaagcc
    12421 tcctgcgggg ccactgaggc attctgcctt cattcagtac acccggaaac tattcaggag
    12481 caactgtgat cagggaagtt gggggcattt ggcctgaaag gcagaatgtt cccagtattt
    12541 ctggataata agctggggaa gtgaggactg tcctgctggg acaactaaga agagagaatg
    12601 tggactctga atcccttttt caactttaaa atggaaaaca gtcatataaa tgcttacaga
    12661 ctgaaaaatg tctcatacat attttgcagc tatcatgatc ctagttcaat gctaggcaaa
    12721 taatggcact tgttaattat ttaccagttt ttaacttaag cctgatttta acaacttgat
    12781 aatggtgtaa tactgactta taccagcagg ggttattatt aagcattctc tggattgacc
    12841 acccacaatg ctttgagctt cttttataga agggatcatg aaaaggtctg gtcagctaca
    12901 gtttaattcc acactgttac agaaaagcat ttctttatcc tgtagtagca tttgaaggga
    12961 cagttcaaca ccctgctccc tgatctgtca gagcttacct tccaaccaca aggcaacttc
    13021 ctggcttttt acaagtggat tttatttcat ggtttaaatt caatcattat tgagaaccta
    13081 cagtagtgtg agcgtatcaa atttgcactt catgaggatt tacacatgaa aattgatatt
    13141 ctcatgggct ttgctgagag tttagttaag gacaaagatg taaaaatgcc aaatttggga
    13201 aaggaaattt tgtatgacca ctgttctatt tttcagtgat tctctctgtt agtagctggg
    13261 tcacatttac aactggaaaa gaactacatt gggagatcag agaaagccaa gtggccaagt
    13321 cctttatcaa aaagctgctt tttggagaag atgatgcata aagctgtgat actaaggaga
    13381 ggagagatta tgtcatatgc aactgctcta ggctgtgcag ggggtttaaa tggagatcag
    13441 aacaaaggct cacctggtat tgatacattt ggtaaggttg ttaaaggcaa tttcaccaaa
    13501 ttcacacatt tgtacggggc ccatttcttt tcaaactgaa gaatacttta aacagcctga
    13561 ctgtgtcctt ggctctggat ccagaaggcc ttatgctcca agcatgtaaa gaaaagatcg
    13621 caggaatgtg gagagcttcc aaaaagagat tgctctcaga ttttcctgaa aatcctgaaa
    13681 accaggattt tccaatctct acaatgttaa ggggttgttg tgtagttgca ttggaagaga
    13741 gaaaggaaac acactctttc attgctgaat tctaaataat gatgccctga attagttcta
    13801 tgagaagtac tggcagacag ctgttatgtc tgcagggcat caaggggcag gtgtgtctca
    13861 ccctactaag aattggcaga aatgttttaa cctcttcttt aggcatctgg tgagtattgc
    13921 agatcttcag gctgtcccta aaaggaggta ggtagccttc tctgtggtca ctgtgttgga
    13981 tttggaagaa aatataagta gatgttaagg tcagtgctct ccaggagatt tcaatccagg
    14041 ctatctgtgt tcagggaatg atttgcaaga agttggttta tagacgttta ctctggaggc
    14101 acaagctggc tgccatgctg agtaagtcct ctttgtagat gatgtatttt gcttgggcac
    14161 caacagaatt aaaaacgaaa aacaaaaaaa aactcgaatg acttaggcag aacatgcctt
    14221 ccctagttta attagtccct gttataacca gttatttatc tttttttgta gattctcggt
    14281 cttgaagtca tttgcctttg caatctctac tttagtatac tcattggatc ctcaaagagc
    14341 cgtaagcttt ttggaaaaaa acatttcaga agtgaaggct tttgaggttt ataaaatggt
    14401 agcagtctta gtccttgccc tgcctcagtt tacctgcaca tgctttcttt catttcctcg
    14461 gattctttca ccacttttta agtttttttt ccacaggtat ttttcctgag ctctatacca
    14521 tgcatttagc tgcctagtga gaatatccag taggttatcc tatagttact atgaagttaa
    14581 cacagcccaa aaacctactt ctccttgtgt ttttttccaa ctcaatgaat gacatcactg
    14641 cactcagacc agaaatctag aagtcagtca tgactcttca ttctatttcg cccttcacaa
    14701 agagttagct gccagctctg ttatttctgc cccttcttta cccttcttcc aatttttatt
    14761 atcttcttat ttatcctcta tgtgtcacaa gaccagtctt tctgggaggc atgttttatc
    14821 ctatccctct gcgtaggaat aaccataatt atcttactaa ttccatccca gaaaagcctg
    14881 tgatccctga ggccagaatt gactctttgg gcctaaatag cagctataaa catcttcagt
    14941 aacttgccag gctctagcat gtggcatgga attttggcat ctagctaaaa ttcctcaacc
    15001 catagttaag ctactcctct ttctcctaaa aaaaaaaaaa aatgagagaa ttagggaaac
    15061 accaaaagca aagagagcag ctctatgttc attcatgtct ggagatgagc caatttgagc
    15121 accactgtag gccaactcta aatttattca gatcgttaac atgggtaacc cagcaaatat
    15181 ttcccagcag tgacaatcta caccctttat ctaaataaat attgagatgt gcttttttcc
    15241 tgtgttagtt caaagaatct cttcttgcct cccattgctg attttctgta ttgatggact
    15301 catttctctc aagagattgg acaagctaaa attctagaga gttcaaaagt gtttgaaagt
    15361 acattttaag tgttctcacc acaaaaaatg ctagtgtgtg aggtgataca tatgttaatt
    15421 agttcaactg atccattcca caatgtatac atatttcaaa ctatcgagtt gtacatgata
    15481 aatatataca atttttattt gtcaaataaa gaacatctat aaatatttat agatttcaaa
    15541 attgagaaag aagtatatat ggagccacgg ttgttttgac catttctcca tgctttttgt
    15601 ttggggaggg ggacattttt tggggggcag ggactgtgtt cagggaaagt acctgaccaa
    15661 cagaacttca agtctcttcc agagtgcgag actcagctta tctgatcaag gtgaacttgc
    15721 ccttcaatag acttgccctt gttactgccc agtgaggcca ccaaggacca agaacagttg
    15781 agctctctca gggccttccc ctttcaacaa tttagttgaa tgactccctt ccatctatca
    15841 gtcttactcc aaatatatga aattactata cattgaaatg cctgcaaact atatgcaaaa
    15901 atgagtatga ggaaatcaaa tgtaaatcat atgcaaatat tattcaacca agcttctata
    15961 aaattgtacg tgtcaataac agtaaagaat tttaattaat tctgtcattt aaaattcatg
    16021 cattccatat tttgctttca gaacttatag tctatgccaa ttttgaaaaa actataagca
    16081 caaggaatta aatactattg agtatagaac tgttgatttc aacatacact atagcacttt
    16141 gactaattac agatatattt gatagaaaag tcacatttct acaaggtaat tttcaaaaag
    16201 aaataaaaca tttctgtaaa cttaaatgtg gattaagtgg cagaatacag agatttgaat
    16261 gtttacaaat a
//
