LOCUS       NM_001300921            2291 bp    mRNA    linear   PRI 12-FEB-2024
DEFINITION  Homo sapiens polycystin 2 like 2, transient receptor potential
            cation channel (PKD2L2), transcript variant 4, mRNA.
ACCESSION   NM_001300921
VERSION     NM_001300921.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2291)
  AUTHORS   Li,Q., Liu,Y., Zhao,W. and Chen,X.Z.
  TITLE     The calcium-binding EF-hand in polycystin-L is not a domain for
            channel activation and ensuing inactivation
  JOURNAL   FEBS Lett 516 (1-3), 270-278 (2002)
   PUBMED   11959145
REFERENCE   2  (bases 1 to 2291)
  AUTHORS   Stayner,C. and Zhou,J.
  TITLE     Polycystin channels and kidney disease
  JOURNAL   Trends Pharmacol Sci 22 (11), 543-546 (2001)
   PUBMED   11698076
REFERENCE   3  (bases 1 to 2291)
  AUTHORS   Guo,L., Schreiber,T.H., Weremowicz,S., Morton,C.C., Lee,C. and
            Zhou,J.
  TITLE     Identification and characterization of a novel polycystin family
            member, polycystin-L2, in mouse and human: sequence, expression,
            alternative splicing, and chromosomal localization
  JOURNAL   Genomics 64 (3), 241-251 (2000)
   PUBMED   10756092
REFERENCE   4  (bases 1 to 2291)
  AUTHORS   Veldhuisen,B., Spruit,L., Dauwerse,H.G., Breuning,M.H. and
            Peters,D.J.
  TITLE     Genes homologous to the autosomal dominant polycystic kidney
            disease genes (PKD1 and PKD2)
  JOURNAL   Eur J Hum Genet 7 (8), 860-872 (1999)
   PUBMED   10602361
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG721989.1, AF182034.1 and AC106753.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001300921.1.
            
            Transcript Variant: This variant (4) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The resulting isoform (4)
            is longer and has a distinct C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF182034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000508883.6/ ENSP00000424725.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BG721989.1         27-35
            10-1554             AF182034.1         1-1545
            1555-1586           AC106753.3         10334-10365
            1587-2291           AF182034.1         1578-2282
FEATURES             Location/Qualifiers
     source          1..2291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..2291
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /note="polycystin 2 like 2, transient receptor potential
                     cation channel"
                     /db_xref="GeneID:27039"
                     /db_xref="HGNC:HGNC:9012"
                     /db_xref="MIM:604669"
     exon            1..66
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1910
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /note="isoform 4 is encoded by transcript variant 4;
                     polycystin-L2; polycystic kidney disease 2-like 2 protein;
                     polycystin-2L2; transient receptor potential cation
                     channel subfamily P member 5; polycystin-2-like protein 2"
                     /codon_start=1
                     /product="polycystin-2-like protein 2 isoform 4"
                     /protein_id="NP_001287850.1"
                     /db_xref="CCDS:CCDS78062.1"
                     /db_xref="GeneID:27039"
                     /db_xref="HGNC:HGNC:9012"
                     /db_xref="MIM:604669"
                     /translation="MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCI
                     LTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWD
                     SWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTS
                     ANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDL
                     RLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVS
                     YYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFN
                     TYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKT
                     MSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIV
                     LGDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKADYSIGRRLD
                     FELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMK
                     KWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
                     "
     exon            67..168
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            169..302
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            303..559
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            560..781
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            782..1010
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1181
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1363
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1484
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1586
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1651
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1706
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1819
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1927
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2291
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2263..2268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /note="hexamer: AATAAA"
     polyA_site      2291
                     /gene="PKD2L2"
                     /gene_synonym="TRPP5"
                     /note="major polyA site"
ORIGIN      
        1 aggcgaacga acgggcggtg tagtgcaggt ccgccatggc tgaggcgtca cggtggcacc
       61 gaggcggggc ttcgaaacat aagttgcatt acagaaagga agtagaaatt acaaccacac
      121 ttcaggaatt gttactctac tttatttttt taataaacct atgtatattg acttttggga
      181 tggtaaaccc acatatgtat tacttaaaca aggttatgtc atctctattt ttggacactt
      241 ctgtgcctgg tgaagaaaga accaacttta agtccattcg cagcataact gatttttgga
      301 agtttatgga aggacccctt ttggaaggtc tgtactggga ttcatggtac aataaccagc
      361 agctgtataa tttaaagaac agcagtcgca tctactatga aaatatactt ctaggagttc
      421 ccagagttcg tcaactaaaa gtccgcaaca acacatgcaa agtctattca tcttttcagt
      481 ctttgatgag tgaatgttat ggcaaatata cttctgcaaa tgaagacctc tctaattttg
      541 gccttcaaat taatactgaa tggagatatt ctacttctaa taccaactcc ccttggcact
      601 ggggatttct tggtgtttac cgaaatgggg gatacatttt cactttatca aaatcgaaat
      661 ctgaaaccaa aaacaagttc attgaccttc gactgaacag ctggatcaca agagggacta
      721 gagttatttt tattgatttt tccttatata atgctaatgt aaatctattt tgtattatca
      781 gattggtggc agaattccct gcaactggag gaatacttac ttcatggcag ttttactctg
      841 tgaagctcct cagatatgtt agctactatg actattttat tgcttcctgt gaaatcacat
      901 tctgtatttt tctttttgtc ttcacaacac aagaagtcaa aaaaataaaa gaatttaagt
      961 ctgcctattt caaaagtatt tggaactggc tagaattgct acttttgctg ttgtgttttg
     1021 tggctgtttc cttcaacaca tactataatg tacaaatttt tctcttactt ggacagctgt
     1081 tgaaaagtac tgaaaaatat tcagatttct attttcttgc atgctggcac atttattaca
     1141 ataatataat tgctattacc atcttttttg catggataaa gatattcaaa ttcataagct
     1201 ttaacaagac aatgtctcag ctgtcatcaa ccttgtcccg ttgtgttaaa gacatagtag
     1261 gatttgccat catgtttttt ataatattct ttgcttatgc ccagttagga tttcttgttt
     1321 ttggatcaca agttgatgac ttttccactt ttcagaattc catatttgca caatttcgaa
     1381 ttgttcttgg agattttaat tttgctggta ttcagcaagc caatcctatc ttgggaccca
     1441 tttacttcat cactttcatc ttttttgtgt tctttgtcct gctgaatatg ttcttggcaa
     1501 ttattaatga tacctattct gaagtgaaag ctgactattc aataggcaga aggctagatt
     1561 ttgaacttgg caaaatgatt aaacagagtt acaaaaatgt tctcgagaaa ttcagactga
     1621 agaaagctca aaaagatgaa gacaagaaaa ccaaaggcag cggagatttg gctgaacaag
     1681 ccagaagaga aggctttgac gaaaatgaga ttcaaaacgc agagcagatg aaaaaatgga
     1741 aagagaggct tgagaaaaag tattattcta tggaaattca agatgactac cagcctgtca
     1801 ctcaagaaga atttcgagaa ctttttttat atgctgtgga gctggagaag gaattacact
     1861 acatcaattt gaagctaaat caagtggtga gaaaggtttc agctctatag tattgagaca
     1921 agtggagaga cagagtctca ctctgtcgcc caggctggaa cagcggtgcg acagtggcct
     1981 caacatcctc caaacagaga atcaagtgat cctcttgcct cagcctccca agtatctggg
     2041 actacacgcg aacaccacca cccctggcta atttaaacaa aatttttata cagtctgggt
     2101 cccactatat tgcccaggct ggtcttgaac tcctggcctc aagggatcct cctgcctcag
     2161 cttcaaaaac tgctgggatt ataggcatga gccactgtgc ctggctagat ttttttttaa
     2221 tttttgaaat acagtaatgt tttatttaaa aatgggaatg acaataaata tttgcaaatc
     2281 acacttgaaa a
//
