LOCUS       NM_181536               5623 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens polycystin 1 like 3, transient receptor potential
            channel interacting (PKD1L3), mRNA.
ACCESSION   NM_181536 XM_001133467 XM_001134223 XM_001724502
VERSION     NM_181536.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5623)
  AUTHORS   Zheng,W., Hussein,S., Yang,J., Huang,J., Zhang,F.,
            Hernandez-Anzaldo,S., Fernandez-Patron,C., Cao,Y., Zeng,H., Tang,J.
            and Chen,X.Z.
  TITLE     A novel PKD2L1 C-terminal domain critical for trimerization and
            channel function
  JOURNAL   Sci Rep 5, 9460 (2015)
   PUBMED   25820328
  REMARK    GeneRIF: our study identified C1 as the first PKD2L1 domain
            essential for both PKD2L1 trimerization and channel function, and
            suggest that PKD2L1 and PKD2L1/PKD1L3 channels share the PKD2L1
            trimerization process.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5623)
  AUTHORS   Ishii,S., Kurokawa,A., Kishi,M., Yamagami,K., Okada,S., Ishimaru,Y.
            and Misaka,T.
  TITLE     The response of PKD1L3/PKD2L1 to acid stimuli is inhibited by
            capsaicin and its pungent analogs
  JOURNAL   FEBS J 279 (10), 1857-1870 (2012)
   PUBMED   22420714
REFERENCE   3  (bases 1 to 5623)
  AUTHORS   Yu,Y., Ulbrich,M.H., Li,M.H., Dobbins,S., Zhang,W.K., Tong,L.,
            Isacoff,E.Y. and Yang,J.
  TITLE     Molecular mechanism of the assembly of an acid-sensing receptor ion
            channel complex
  JOURNAL   Nat Commun 3, 1252 (2012)
   PUBMED   23212381
  REMARK    GeneRIF: functions as a channel-forming subunit in an acid-sensing
            heteromeric complex formed by PKD1L3 and TRPP3
REFERENCE   4  (bases 1 to 5623)
  AUTHORS   Yamamoto,K., Ishimaru,Y., Ohmoto,M., Matsumoto,I., Asakura,T. and
            Abe,K.
  TITLE     Genetic tracing of the gustatory neural pathway originating from
            Pkd1l3-expressing type III taste cells in circumvallate and foliate
            papillae
  JOURNAL   J Neurochem 119 (3), 497-506 (2011)
   PUBMED   21883212
  REMARK    GeneRIF: Among the three gustatory regions innervated by peripheral
            gustatory neurons in the geniculate ganglion, transgenic Pkd1l3 is
            expressed in the foliate papillae, not in the fungiform papillae or
            palate.
REFERENCE   5  (bases 1 to 5623)
  AUTHORS   Ishimaru,Y., Katano,Y., Yamamoto,K., Akiba,M., Misaka,T.,
            Roberts,R.W., Asakura,T., Matsunami,H. and Abe,K.
  TITLE     Interaction between PKD1L3 and PKD2L1 through their transmembrane
            domains is required for localization of PKD2L1 at taste pores in
            taste cells of circumvallate and foliate papillae
  JOURNAL   FASEB J 24 (10), 4058-4067 (2010)
   PUBMED   20538909
REFERENCE   6  (bases 1 to 5623)
  AUTHORS   Huque,T., Cowart,B.J., Dankulich-Nagrudny,L., Pribitkin,E.A.,
            Bayley,D.L., Spielman,A.I., Feldman,R.S., Mackler,S.A. and
            Brand,J.G.
  TITLE     Sour ageusia in two individuals implicates ion channels of the ASIC
            and PKD families in human sour taste perception at the anterior
            tongue
  JOURNAL   PLoS One 4 (10), e7347 (2009)
   PUBMED   19812697
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5623)
  AUTHORS   Ishii,S., Misaka,T., Kishi,M., Kaga,T., Ishimaru,Y. and Abe,K.
  TITLE     Acetic acid activates PKD1L3-PKD2L1 channel--a candidate sour taste
            receptor
  JOURNAL   Biochem Biophys Res Commun 385 (3), 346-350 (2009)
   PUBMED   19464260
REFERENCE   8  (bases 1 to 5623)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 5623)
  AUTHORS   Anney,R.J., Lasky-Su,J., O'Dushlaine,C., Kenny,E., Neale,B.M.,
            Mulligan,A., Franke,B., Zhou,K., Chen,W., Christiansen,H.,
            Arias-Vasquez,A., Banaschewski,T., Buitelaar,J., Ebstein,R.,
            Miranda,A., Mulas,F., Oades,R.D., Roeyers,H., Rothenberger,A.,
            Sergeant,J., Sonuga-Barke,E., Steinhausen,H., Asherson,P.,
            Faraone,S.V. and Gill,M.
  TITLE     Conduct disorder and ADHD: evaluation of conduct problems as a
            categorical and quantitative trait in the international multicentre
            ADHD genetics study
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1369-1378 (2008)
   PUBMED   18951430
REFERENCE   10 (bases 1 to 5623)
  AUTHORS   Li,A., Tian,X., Sung,S.W. and Somlo,S.
  TITLE     Identification of two novel polycystic kidney disease-1-like genes
            in human and mouse genomes
  JOURNAL   Genomics 81 (6), 596-608 (2003)
   PUBMED   12782129
  REMARK    GeneRIF: genes are mapped to chromosomes and gene structures are
            characterized; protein structure is predicted and contains strong
            ion channel signature motifs that suggest their possible function
            as components of cation channel pores
            Erratum:[Genomics. 2003 Oct;82(4):498-500]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009127.10 and KF459693.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 11, 2020 this sequence version replaced NM_181536.1.
            
            Summary: This gene encodes a member of the polycystin protein
            family. The encoded protein contains 11 transmembrane domains, a
            latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a
            polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein
            may function as a component of cation channel pores.[provided by
            RefSeq, Apr 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY164485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620267.2/ ENSP00000480090.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-719               AC009127.10        11986-12704
            720-842             AC009127.10        13994-14116
            843-959             AC009127.10        19056-19172
            960-1009            AC009127.10        22059-22108
            1010-1258           AC009127.10        25919-26167
            1259-1390           AC009127.10        28221-28352
            1391-1567           AC009127.10        30153-30329
            1568-1695           AC009127.10        32254-32381
            1696-1822           AC009127.10        32476-32602
            1823-1951           AC009127.10        34005-34133
            1952-2183           AC009127.10        34921-35152
            2184-2377           AC009127.10        38871-39064
            2378-2608           AC009127.10        42283-42513
            2609-2710           AC009127.10        44381-44482
            2711-2889           AC009127.10        45073-45251
            2890-3036           AC009127.10        49037-49183
            3037-3233           AC009127.10        58087-58283
            3234-3433           AC009127.10        59295-59494
            3434-3614           AC009127.10        60644-60824
            3615-3807           AC009127.10        62078-62270
            3808-4042           AC009127.10        62371-62605
            4043-4142           KF459693.1         94-193
            4143-4283           AC009127.10        68214-68354
            4284-4748           AC009127.10        69360-69824
            4749-4876           AC009127.10        74965-75092
            4877-5037           AC009127.10        76866-77026
            5038-5248           AC009127.10        78259-78469
            5249-5350           AC009127.10        78863-78964
            5351-5482           AC009127.10        82201-82332
            5483-5623           AC009127.10        82706-82846
FEATURES             Location/Qualifiers
     source          1..5623
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.2"
     gene            1..5623
                     /gene="PKD1L3"
                     /note="polycystin 1 like 3, transient receptor potential
                     channel interacting"
                     /db_xref="GeneID:342372"
                     /db_xref="HGNC:HGNC:21716"
                     /db_xref="MIM:607895"
     exon            1..719
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..5623
                     /gene="PKD1L3"
                     /note="polycystic kidney disease protein 1-like 3;
                     polycystin-1L3; PC1-like 3 protein; polycystic kidney
                     disease 1-like 3; polycystin-1-like protein 3"
                     /codon_start=1
                     /product="polycystin-1-like protein 3 precursor"
                     /protein_id="NP_853514.1"
                     /db_xref="CCDS:CCDS73912.1"
                     /db_xref="GeneID:342372"
                     /db_xref="HGNC:HGNC:21716"
                     /db_xref="MIM:607895"
                     /translation="MFFKGGSWLWLYIRTSIILGSELNSPAPHGQNNCYQLNRFQCSF
                     EEAQHYCHVQRGFLAHIWNKEVQDLIRDYLEEGKKWWIGQNVMPLKKHQDNKYPADVA
                     ANGPPKPLSCTYLSRNFIRISSKGDKCLLKYYFICQTGDFLDGDAHYERNGNNSHLYQ
                     RHKKTKRGVAIARDKMPPGPGHLPTTCHYPLPAHLSKTLCHPISQFPSVLSSITSQVT
                     SAASEPSSQPLPVITQLTMPVSVTHAGQSLAETTSSPKEEGHPNTFTSYLQVSLQKAS
                     GQVIDEIAGNFSRAVHGLQALNKLQEACEFLQKLTALTPRFSKPAQVNLINSLIYLSE
                     ELLRIPFQNNNSLGFKVPPTVCPFHSLNNVTKAGEGSWLESKRHTEPVEDILEMSLVE
                     FGNIGEAFLEQNQSPESSVTLTSANATLLLSRQNISTLPLSSYTLGHPAPVRLGFPSA
                     LALKELLNKHPGVNVQITGLAFNPFKDLDNRNIVGSIGSVLLSANRKLLQVHDLMEDI
                     EIMLWRNVSLETHPTSLNMSTHQLTITVNVTSLEKSLIVSIDPDSPLLMTLYLGFQYQ
                     PNCTHFHLNITLPKDKVWQKDEEYTWVLNPEHLQHGIGTYYITAVLSERQEGAQQTPS
                     LVSVITAVTQCYYWEIHNQTWSSAGCQVGPQSTILRTQCLCNHLTFFASDFFVVPRTV
                     NVEDTIKLFLRVTNNPVGVSLLASLLGFYVITVVWARKKDQADMQKVKVTVLADNDPS
                     AQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLT
                     TWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELD
                     RVFIPVSKRELFSFRHLFSSMIVEKFTQDYLWLSIATRHPWNQFTRVQRLSCCMTLLL
                     CNMVINVMFWKINSTTAKRDEQMRPFAVAWSELLVSIHTAVILFPINLVIGRLFPLIE
                     PQETLPLFPPIQASCLSDASVEPLSATMVVEELKETVRFLLRRNTYLLSKCEQPPWSS
                     WDITKLVKLLSSLVSSHLEGQGCHQQGERHWARVVPENHHHFCCYLHRVLQRLKSHLG
                     TLGLTQGHQSCDFLDAASQLQKLQELLETHILPTEQEPSREVTSFAILSSEEGKKPIS
                     NGLSKWLTSVCWLLLGFTSLASAFFTALYSLELSKDQATSWMISIILSVLQNIFISQP
                     VKVVFFTFLYSLMMSRMPRLNKENEQQTKRILALLAKCSSSVPGSRDKNNPVYVAPAI
                     NSPTKHPERTLKKKKLFKLTGDILVQILFLTLLMTAIYSAKNSNRFYLHQAIWKTFSH
                     QFSEIKLLQDFYPWANHILLPSLYGDYRGKNAVLEPSHCKCGVQLIFQIPRTKTYEKV
                     DEGQLAFCDNGHTCGRPKSLFPGLHLRRFSYICSPRPMVLIPTDELHERLTSKNENGF
                     SYIMRGAFFTSLRLESFTSLQMSKKGCVWSIISQVIYYLLVCYYAFIQGCQLKQQKWR
                     FFTGKRNILDTSIILISFILLGLDMKSISLHKKNMARYRDDQDRFISFYEAVKVNSAA
                     THLVGFPVLLATVQLWNLLRHSPRLRVISRTLSRAWDEVVGFLLIILILLTGYAIAFN
                     LLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVFALDPVLGTFLILTSVILMVLVVIN
                     LFVSAILMAFGKERKSLKKEAALIDTLLQKLSNLLGISWPQKTSSEQAATTAVGSDTE
                     VLDELP"
     exon            720..842
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            843..959
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1009
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1258
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1390
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1567
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1695
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1822
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1951
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2183
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2377
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2608
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2710
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2889
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3036
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3233
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3433
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3614
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3807
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            3808..4042
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            4043..4142
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            4143..4283
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            4284..4748
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            4749..4876
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            4877..5037
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            5038..5248
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            5249..5350
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            5351..5482
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            5483..5623
                     /gene="PKD1L3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagatcatgc cactgcactc cagcctgacc aacagaatga gaccctgcct cagaaaagaa
       61 aaagctacac ttattaattt ttagcagcac taacttagat gttagatatt catcatcctc
      121 tacccagtgc agcttagact cagctttata atcgatctct atttgctaaa ggcatattcg
      181 gtaggtagac acagatggtg gggccccaga taaaaagggc cattgtttta ttgatctctg
      241 ctatttgttt tcagcttgta ggacctgcac ctgggtcctc aaaacaaaac cttttgtatc
      301 cttggtaaat tgttcccaat tcataaaaga ataatactaa taagacaagc ccgccaatat
      361 atatatttaa aggaccaggc agctgctaaa cccccacact ttttcttgct acaattcaga
      421 gaaaatgttc ttcaaaggag gaagctggct ttggttatac atcagaacaa gtattattct
      481 aggaagtgag ctaaacagcc cagcaccaca tgggcaaaat aattgttacc agcttaacag
      541 atttcaatgc agctttgagg aagcacagca ttactgtcat gtgcagagag gattcctagc
      601 tcatatttgg aacaaggaag ttcaagatct catccgggac tatctggaag aaggaaagaa
      661 gtggtggatt gggcaaaatg taatgccatt gaaaaagcat caagacaaca aatacccagc
      721 agacgttgca gccaacgggc ccccaaagcc cctcagctgc acctacctgt ccagaaactt
      781 cattcggatc tcatccaaag gggacaagtg cttactgaaa tactatttca tttgccagac
      841 tggtgacttt ttggacggag atgcccatta tgaaagaaat ggaaataatt cccatttgta
      901 ccagagacac aagaagacaa aaagaggagt tgcaatagca agagacaaaa tgcccccagg
      961 acctggtcat cttccaacca catgtcacta tcctcttcct gctcatcttt ccaagaccct
     1021 gtgtcatccc atcagccagt ttccttcagt actatcaagt atcacatcac aggtaacatc
     1081 agccgcatct gaacccagca gccagcctct ccctgtgata acacagctca ccatgcccgt
     1141 gtctgtcacg catgctgggc aatctctggc agaaacaact tcaagcccaa aggaagaagg
     1201 tcatccgaat accttcacct cttatctaca agtgtcattg cagaaggcat ctggtcaggt
     1261 catagatgag atagcaggga acttcagcag agcagttcat ggtttgcaag ctcttaacaa
     1321 actacaggaa gcttgtgagt tcctccagaa actaacagcc ttaaccccaa gattttctaa
     1381 gccagctcag gttaatctca tcaattccct tatttacctg agtgaggagt tactcaggat
     1441 cccatttcag aacaacaaca gtctgggctt caaagttcct ccaactgtct gcccctttca
     1501 ttccctcaac aatgtcacca aagctggaga aggaagttgg ctggaatcca agcgtcatac
     1561 tgagccggta gaagacatcc tggaaatgtc cttggtggag tttgggaata tcggggaagc
     1621 atttctagag cagaaccagt ctcccgagtc ttcagtgact ttgacctctg ccaatgctac
     1681 tctgctgctg agcagacaaa acatatcaac tttaccgctg agctcttaca ctctgggtca
     1741 cccagcccct gtgaggctag gctttccgtc ggctttagct ttgaaggagc tcttgaataa
     1801 acatccagga gttaatgtcc aaataacagg actagctttc aatcccttca aggatttgga
     1861 caacagaaac attgttggaa gcattggaag tgtgttacta agcgctaatc gtaaattgct
     1921 ccaagtccat gatttaatgg aggacattga gatcatgctc tggagaaatg ttagcttgga
     1981 aacccatccc accagcctca acatgagcac acatcagctt acaatcacag tgaacgtcac
     2041 ttccttggag aaatccttga tagtgagcat agatcctgac agtccccttt taatgacact
     2101 ctacctgggg ttccagtatc agcctaactg cactcacttc cacctgaaca tcacccttcc
     2161 aaaggataag gtgtggcaaa aagatgagga gtacacgtgg gtgctgaatc cagagcatct
     2221 gcagcacggg attggcacct actatataac agctgtgctg agtgagaggc aggagggtgc
     2281 tcagcagaca cccagcttgg tctcggtcat caccgccgtc actcagtgtt actactggga
     2341 gatccacaac cagacatgga gcagcgccgg atgccaagtt gggccacaga gcacaattct
     2401 gaggacacag tgtctctgta accacctgac cttctttgcc agcgacttct ttgtcgtgcc
     2461 caggaccgtg aatgttgaag acacgatcaa actgttcctt cgcgtgacca acaatcctgt
     2521 tggggtgtca ctgctggcca gccttttagg attttatgtg atcacagttg tgtgggctcg
     2581 gaaaaaggat caagcagata tgcagaaggt gaaggtcact gtcctggctg ataatgaccc
     2641 cagcgctcaa tttcactacc ttattcaggt ctacaccgga tatcgaagaa gcgctgctac
     2701 aacagctaag gttgtcatca ccctctatgg atcagaggga cggagtgagc cccatcacct
     2761 ctgtgacccc cagaagacag tctttgaacg agggggcctg gatgtcttcc ttctcaccac
     2821 ttggacctct ctagggaacc tgcacagcct tcggctctgg catgacaatt ctggcgtcag
     2881 tccctcctgg tatgtcagcc aggtaattgt ctgtgacatg gcagttaaga ggaagtggca
     2941 tttcctgtgc aattgctggc tggctgtgga cctcggagac tgtgagcttg accgggtctt
     3001 catcccagtt tcaaagagag agctcttttc ctttagacat ctgttttcct ccatgattgt
     3061 ggaaaagttc acccaggatt atctgtggct ttcaattgca actcggcatc cctggaacca
     3121 gtttacaagg gtccaacggc tgtcttgctg catgacactg ctactctgca acatggtcat
     3181 caatgttatg ttctggaaga taaacagcac cactgccaag agagatgagc aaatgcgtcc
     3241 atttgctgtg gcctggtctg aactgctggt cagcatccat actgctgtca tcctcttccc
     3301 aatcaatctt gtcatagggc ggctcttccc gttgattgag ccacaggaga ctctgcccct
     3361 ctttcctccc atccaggcct cctgcctctc agatgcttct gttgagcctc tctctgccac
     3421 aatggtagtt gaggaattaa aggaaactgt gagattcctg ctcaggagaa atacatacct
     3481 actctccaag tgtgagcagc cgccatggag ttcttgggac attactaagc tggtgaaact
     3541 tttatccagc ctcgtatcat ctcacttgga gggtcaaggc tgtcatcagc agggagagcg
     3601 ccactgggca cgtgttgttc ctgaaaacca ccatcatttc tgctgttacc tgcatagagt
     3661 tctgcagagg ctgaaatctc acttaggcac gctgggtctc acccagggtc accagtcctg
     3721 tgacttccta gatgcagcca gccaacttca aaaactccag gaactcttgg aaacacatat
     3781 tcttcccacg gagcaagagc catccaggga agtcaccagt tttgccatcc tgagctcaga
     3841 agaaggaaaa aagcccatct caaatggcct gtccaaatgg ttgacttcag tctgctggct
     3901 cctcttaggt ttcactagcc tggcttcagc cttttttaca gcactttata gcttggaatt
     3961 gagcaaagac caagccacca gctggatgat ttcaattatt ttatcagtgc ttcagaacat
     4021 cttcatcagc cagccagtaa aggtggtctt cttcacattc ttatactcac tgatgatgag
     4081 caggatgcca cggcttaaca aagagaatga acaacaaaca aagaggatct tggcactctt
     4141 ggcaaaatgt tcttcgtcag taccaggttc aagagataag aacaaccccg tctatgtagc
     4201 cccagctata aatagtccaa ctaagcaccc agaaagaacc ttgaaaaaga agaaactctt
     4261 caagctgact ggagatattt tggtacaaat cctcttcctt accctgttga tgactgcaat
     4321 ctactctgca aagaactcca atagatttta cctccaccaa gctatctgga agacattttc
     4381 gcaccagttc tcggaaatca aacttcttca ggatttctac ccctgggcca atcatatcct
     4441 tcttcctagc ctgtatgggg attacagagg taagaatgca gtcctggagc ccagtcattg
     4501 caaatgtggg gtacaattaa ttttccaaat accccgtacc aagacctatg agaaagtgga
     4561 cgaaggtcag ctggcgtttt gtgataacgg ccatacctgt gggcgtccca agagcctatt
     4621 ccctggactt catctaagga ggttcagtta catctgttca cccaggccca tggtgctgat
     4681 tcccactgat gagcttcacg aaaggctgac aagcaagaat gagaatggat tcagttacat
     4741 catgagaggt gctttcttca cctctttgag actggaaagc ttcacttccc ttcagatgtc
     4801 aaagaagggc tgtgtctggt ctatcatctc acaagtcatc tattatctac tggtctgtta
     4861 ctatgccttc atacagggtt gtcagctgaa acagcagaag tggaggttct tcactgggaa
     4921 aagaaacatt ctggacacaa gtataatcct cattagcttc atcctcctgg ggcttgacat
     4981 gaagagtatt tctctacata agaaaaacat ggcacgatac cgcgatgacc aggacagatt
     5041 catcagcttc tatgaggcag taaaagtgaa ctctgctgcg actcaccttg tgggcttccc
     5101 ggttctcctg gcaactgttc agttatggaa cctgctgcgt catagcccca ggctgcgggt
     5161 catcagcagg acactgagcc gagcctggga cgaggtggtg ggctttctgc tgatcatcct
     5221 aatcctgctg acaggctatg ccattgcctt taacctgctg tttggatgca gcatctctga
     5281 ctaccggaca tttttcagct cagcagtgac tgttgttggt ctcctgatgg gaatttctca
     5341 ccaagaggag gttttcgctt tagacccagt cctgggcacc tttctgatcc tcaccagtgt
     5401 catcttgatg gtacttgtgg taattaatct tttcgtttcg gccattctca tggcctttgg
     5461 aaaagaaaga aagtcgctta agaaagaagc tgcactaata gatacactgc tacagaagct
     5521 ctcaaatttg ttaggaatca gttggcccca aaaaacctca tctgagcaag cagccacgac
     5581 agcagtgggc agtgacactg aagttttaga tgaactacct taa
//
