LOCUS       NM_138295               9105 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens polycystin 1 like 1, transient receptor potential
            channel interacting (PKD1L1), mRNA.
ACCESSION   NM_138295
VERSION     NM_138295.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9105)
  AUTHORS   Whitchurch,J.B., Schneider,S., Hilger,A.C., Kollges,R.,
            Stegmann,J.D., Waffenschmidt,L., Dyer,L., Thiele,H., Dhabhai,B.,
            Dakal,T.C., Muller,A., Norris,D.P. and Reutter,H.M.
  TITLE     PKD1L1 Is Involved in Congenital Chylothorax
  JOURNAL   Cells 13 (2), 149 (2024)
   PUBMED   38247840
  REMARK    GeneRIF: PKD1L1 Is Involved in Congenital Chylothorax.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9105)
  AUTHORS   Vetrini,F., D'Alessandro,L.C., Akdemir,Z.C., Braxton,A.,
            Azamian,M.S., Eldomery,M.K., Miller,K., Kois,C., Sack,V., Shur,N.,
            Rijhsinghani,A., Chandarana,J., Ding,Y., Holtzman,J.,
            Jhangiani,S.N., Muzny,D.M., Gibbs,R.A., Eng,C.M., Hanchard,N.A.,
            Harel,T., Rosenfeld,J.A., Belmont,J.W., Lupski,J.R. and Yang,Y.
  TITLE     Bi-allelic Mutations in PKD1L1 Are Associated with Laterality
            Defects in Humans
  JOURNAL   Am J Hum Genet 99 (4), 886-893 (2016)
   PUBMED   27616478
  REMARK    GeneRIF: identification of bi-allelic PKD1L1 mutations
            recapitulates previous findings regarding phenotypic consequences
            of loss of function of the orthologous genes in mice and medaka
            fish and further expands our understanding of genetic contributions
            to laterality defects in humans
REFERENCE   3  (bases 1 to 9105)
  AUTHORS   DeCaen,P.G., Liu,X., Abiria,S. and Clapham,D.E.
  TITLE     Atypical calcium regulation of the PKD2-L1 polycystin ion channel
  JOURNAL   Elife 5, e13413 (2016)
   PUBMED   27348301
  REMARK    GeneRIF: The authors report that the human PKD2-L1 selectivity
            filter is partially selective to calcium ions (Ca(2+)) moving into
            the cell, but blocked by high internal Ca(2+)concentrations, a
            unique feature of this transient receptor potential (TRP) channel
            family member.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9105)
  AUTHORS   Otowa,T., Maher,B.S., Aggen,S.H., McClay,J.L., van den Oord,E.J.
            and Hettema,J.M.
  TITLE     Genome-wide and gene-based association studies of anxiety disorders
            in European and African American samples
  JOURNAL   PLoS One 9 (11), e112559 (2014)
   PUBMED   25390645
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9105)
  AUTHORS   DeCaen,P.G., Delling,M., Vien,T.N. and Clapham,D.E.
  TITLE     Direct recording and molecular identification of the calcium
            channel of primary cilia
  JOURNAL   Nature 504 (7479), 315-318 (2013)
   PUBMED   24336289
  REMARK    Erratum:[Nature. 2014 Sep 11;513(7517):266]
REFERENCE   6  (bases 1 to 9105)
  AUTHORS   Patin,E., Kutalik,Z., Guergnon,J., Bibert,S., Nalpas,B.,
            Jouanguy,E., Munteanu,M., Bousquet,L., Argiro,L., Halfon,P.,
            Boland,A., Mullhaupt,B., Semela,D., Dufour,J.F., Heim,M.H.,
            Moradpour,D., Cerny,A., Malinverni,R., Hirsch,H., Martinetti,G.,
            Suppiah,V., Stewart,G., Booth,D.R., George,J., Casanova,J.L.,
            Brechot,C., Rice,C.M., Talal,A.H., Jacobson,I.M., Bourliere,M.,
            Theodorou,I., Poynard,T., Negro,F., Pol,S., Bochud,P.Y. and Abel,L.
  CONSRTM   Swiss Hepatitis C Cohort Study Group, International Hepatitis C
            Genetics Consortium; French ANRS HC EP 26 Genoscan Study Group
  TITLE     Genome-wide association study identifies variants associated with
            progression of liver fibrosis from HCV infection
  JOURNAL   Gastroenterology 143 (5), 1244-1252 (2012)
   PUBMED   22841784
REFERENCE   7  (bases 1 to 9105)
  AUTHORS   Yuasa,T., Takakura,A., Denker,B.M., Venugopal,B. and Zhou,J.
  TITLE     Polycystin-1L2 is a novel G-protein-binding protein
  JOURNAL   Genomics 84 (1), 126-138 (2004)
   PUBMED   15203210
REFERENCE   8  (bases 1 to 9105)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 9105)
  AUTHORS   Lakkis,M. and Zhou,J.
  TITLE     Molecular complexes formed with polycystins
  JOURNAL   Nephron Exp Nephrol 93 (1), e3-e8 (2003)
   PUBMED   12411743
  REMARK    Review article
REFERENCE   10 (bases 1 to 9105)
  AUTHORS   Yuasa,T., Venugopal,B., Weremowicz,S., Morton,C.C., Guo,L. and
            Zhou,J.
  TITLE     The sequence, expression, and chromosomal localization of a novel
            polycystic kidney disease 1-like gene, PKD1L1, in human
  JOURNAL   Genomics 79 (3), 376-386 (2002)
   PUBMED   11863367
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT004668.1, AB061683.1,
            AI860869.1 and AC019066.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 20, 2019 this sequence version replaced NM_138295.4.
            
            Summary: This gene encodes a member of the polycystin protein
            family containing 11 transmembrane domains, a receptor for egg
            jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin
            (PLAT) domain. The encoded protein may play a role in the male
            reproductive system. Alternative splice variants have been
            described but their biological nature has not been determined.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB061683.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289672.7/ ENSP00000289672.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CT004668.1         26-51
            27-8644             AB061683.1         1-8618
            8645-9067           AI860869.1         1-423               c
            9068-9105           AC019066.6         58520-58557         c
FEATURES             Location/Qualifiers
     source          1..9105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p12.3"
     gene            1..9105
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /note="polycystin 1 like 1, transient receptor potential
                     channel interacting"
                     /db_xref="GeneID:168507"
                     /db_xref="HGNC:HGNC:18053"
                     /db_xref="MIM:609721"
     exon            1..70
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..8576
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /note="polycystin-1L1; polycystic kidney disease protein
                     1-like 1; PC1-like 1 protein; polycystic kidney disease 1
                     like 1"
                     /codon_start=1
                     /product="polycystin-1-like protein 1"
                     /protein_id="NP_612152.1"
                     /db_xref="CCDS:CCDS34633.1"
                     /db_xref="GeneID:168507"
                     /db_xref="HGNC:HGNC:18053"
                     /db_xref="MIM:609721"
                     /translation="MAEEAAQNISDDQERCLQAACCLSFGGELSVSTDKSWGLHLCSC
                     SPPGGGLWVEVYANHVLLMSDGKCGCPWCALNGKAEDRESQSPSSSASRQKNIWKTTS
                     EAALSVVNEKTQAVVNEKTQAPLDCDNSADRIPHKPFIIIARAWSSGGPRFHHRRLCA
                     TGTADSTFSALLQLQGTTSAAAPCSLKMEASCCVLRLLCCAEDVATGLLPGTVTMETP
                     TKVARPTQTSSQRVPLWPISHFPTSPRSSHGLPPGIPRTPSFTASQSGSEILYPPTQH
                     PPVAILARNSDNFMNPVLNCSLEVEARAPPNLGFRVHMASGEALCLMMDFGDSSGVEM
                     RLHNMSEAMAVTAYHQYSKGIFFHLLHFQLDMSTYKEAETQNTTLNVYLCQSENSCLE
                     DSDPSNLGYELISAFVTKGVYMLKAVIYNEFHGTEVELGPYYVEIGHEAVSAFMNSSS
                     VHEDEVLVFADSQVNQKSTVVIHHFPSIPSYNVSFISQTQVGDSQAWHSMTVWYKMQS
                     VSVYTNGTVFATDTDITFTAVTKETIPLEFEWYFGEDPPVRTTSRSIKKRLSIPQWYR
                     VMVKASNRMSSVVSEPHVIRVQKKIVANRLTSPSSALVNASVAFECWINFGTDVAYLW
                     DFGDGTVSLGSSSSSHVYSREGEFTVEVLAFNNVSASTLRQQLFIVCEPCQPPLVKNM
                     GPGKVQIWRSQPVRLGVTFEAAVFCDISQGLSYTWNLMDSEGLPVSLPAAVDTHRQTL
                     ILPSHTLEYGNYTALAKVQIEGSVVYSNYCVGLEVRAQAPVSVISEGTHLFFSRTTSS
                     PIVLRGTQSFDPDDPGATLRYHWECATAGSPAHPCFDSSTAHQLDAAAPTVSFEAQWL
                     SDSYDQFLVMLRVSSGGRNSSETRVFLSPYPDSAFRFVHISWVSFKDTFVNWNDELSL
                     QAMCEDCSEIPNLSYSWDLFLVNATEKNRIEVPFCRVVGLLGSLGLGAISESSQLNLL
                     PTEPGTADPDATTTPFSREPSPVTLGQPATSAPRGTPTEPMTGVYWIPPAGDSAVLGE
                     APEEGSLDLEPGPQSKGSLMTGRSERSQPTHSPDPHLSDFEAYYSDIQEAIPSGGRQP
                     AKDTSFPGSGPSLSAEESPGDGDNLVDPSLSAGRAEPVLMIDWPKALLGRAVFQGYSS
                     SGITEQTVTIKPYSLSSGETYVLQVSVASKHGLLGKAQLYLTVNPAPRDMACQVQPHH
                     GLEAHTVFSVFCMSGKPDFHYEFSYQIGNTSKHTLYHGRDTQYYFVLPAGEHLDNYKV
                     MVSTEITDGKGSKVQPCTVVVTVLPRYHGNDCLGEDLYNSSLKNLSTLQLMGSYTEIR
                     NYITVITRILSRLSKEDKTASCNQWSRIQDALISSVCRLAFVDQEEMIGSVLMLRDLV
                     SFSNKLGFMSAVLILKYTRALLAQGQFSGPFVIDKGVRLELIGLISRVWEVSEQENSK
                     EEVYRHEEGITVISDLLLGCLSLNHVSTGQMEFRTLLHYNLQSSVQSLGSVQVHLPGD
                     LAGHSPAGAETQSPCYISQLILFKKNPYPGSQAPGQIGGVVGLNLYTCSSRRPINRQW
                     LRKPVMVEFGEEDGLDNRRNKTTFVLLRDKVNLHQFTELSENPQESLQIEIEFSKPVT
                     RAFPVMLLVRFSEKPTPSDFLVKQIYFWDESIVQIYIPAASQKDASVGYLSLLDADYD
                     RKPPNRYLAKAVNYTVHFQWIRCLFWDKREWKSERFSPQPGTSPEKVNCSYHRLAAFA
                     LLRRKLKASFEVSDISKLQSHPENLLPSIFIMGSVILYGFLVAKSRQVDHHEKKKAGY
                     IFLQEASLPGHQLYAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFER
                     NSRHTFILSAPAQLGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLS
                     AGRHDGRVERELTCLQGGLGFRKLFYCKFTEYLEDFHVWLSVYSRPSSSRYLHTPRLT
                     VSFSLLCVYACLTALVAAGGQEQPHLDVSPTLGSFRVGLLCTLLASPGAQLLSLLFRL
                     SKEAPGSARVEPHSPLRGGAQTEAPHGPNSWGRIPDAQEPRKQPASAILSGSGRAQRK
                     AASDNGTACPAPKLQVHGADHSRTSLMGKSHCCPPHTQAPSSGLEGLMPQWSRALQPW
                     WSSAVWAICGTASLACSLGTGFLAYRFGQEQCVQWLHLLSLSVVCCIFITQPLMVCLM
                     ALGFAWKRRADNHFFTESLCEATRDLDSELAERSWTRLPFSSSCSIPDCAGEVEKVLA
                     ARQQARHLRWAHPPSKAQLRGTRQRMRRESRTRAALRDISMDILMLLLLLCVIYGRFS
                     QDEYSLNQAIRKEFTRNARNCLGGLRNIADWWDWSLTTLLDGLYPGGTPSARVPGAQP
                     GALGGKCYLIGSSVIRQLKVFPRHLCKPPRPFSALIEDSIPTCSPEVGGPENPYLIDP
                     ENQNVTLNGPGGCGTREDCVLSLGRTRTEAHTALSRLRASMWIDRSTRAVSVHFTLYN
                     PPTQLFTSVSLRVEILPTGSLVPSSLVESFSIFRSDSALQYHLMLPQLVFLALSLIHL
                     CVQLYRMMDKGVLSYWRKPRNWLELSVVGVSLTYYAVSGHLVTLAGDVTNQFHRGLCR
                     AFMDLTLMASWNQRARWLRGILLFLFTLKCVYLPGIQNTMASCSSMMRHSLPSIFVAG
                     LVGALMLAALSHLHRFLLSMWVLPPGTFTDAFPGLLFHFPRRSQKDCLLGLSKSDQRA
                     MACYFGILLIVSATLCFGMLRGFLMTLPQKRKSFQSKSFVRLKDVTAYMWEKVLTFLR
                     LETPKLEEAEMVENHNYYLDEFANLLDELLMKINGLSDSLQLPLLEKTSNNTGEARTE
                     ESPLVDISSYQAAEPADIKDF"
     exon            71..186
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            187..311
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            312..424
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            425..545
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            546..763
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1086
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1254
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1428
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1548
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1717
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1957
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2090
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2297
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2479
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2701
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2862
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..3231
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3291
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3468
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..3546
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3689
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            3690..3810
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            3811..3922
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            3923..4118
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            4119..4175
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            4176..4388
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            4389..4616
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            4617..4727
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            4728..4885
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            4886..4986
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            4987..5179
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            5180..5263
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            5264..5471
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            5472..5578
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            5579..5795
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            5796..5969
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            5970..6080
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            6081..6153
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            6154..6200
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            6201..6363
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            6364..6499
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            6500..6584
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            6585..6761
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            6762..6880
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            6881..6991
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            6992..7115
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            7116..7199
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            7200..7372
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            7373..7607
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            7608..7712
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            7713..7853
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            7854..7988
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            7989..8219
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            8220..8381
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            8382..8552
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     exon            8553..9105
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8907..8912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /note="hexamer: ATTAAA"
     polyA_site      8931
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /note="major polyA site"
     regulatory      9003..9008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /note="hexamer: AGTAAA"
     polyA_site      9029
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
     regulatory      9082..9087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /note="hexamer: TATAAA"
     polyA_site      9105
                     /gene="PKD1L1"
                     /gene_synonym="HTX8; PRO19563"
                     /note="major polyA site"
ORIGIN      
        1 atacttgtga ccagcttgca caggacatgg ccgaggaggc agcccagaac atttctgatg
       61 accaggaaag gtgtctccag gctgcctgct gcctttcctt tggtggtgag ctgtctgtga
      121 gcactgacaa gagctggggt cttcatctgt gcagctgtag ccctcctgga ggtggattgt
      181 gggtcgaggt ctatgctaat catgtgcttc ttatgagtga tgggaagtgt ggctgtcctt
      241 ggtgtgctct gaatggaaag gcagaagacc gggaatcaca gagcccatcc tcatcagctt
      301 ccaggcagaa gaacatttgg aaaacaacta gtgaagcagc gttaagtgtt gttaatgaaa
      361 aaacacaggc tgttgttaat gaaaaaacac aggcgcctct ggattgtgat aacagtgctg
      421 atagaattcc ccacaaacct ttcattataa tcgcaagggc ctggagcagt ggtggcccca
      481 ggttccatca caggcggctg tgtgctactg ggaccgcaga cagcacattc tctgctcttc
      541 tccagctcca gggcaccact tctgcagcag ctccctgcag cctgaagatg gaggcttcct
      601 gctgtgtcct gagactgctg tgctgtgcgg aggatgtggc cacggggctg cttcctggga
      661 ctgtcacgat ggagaccccc accaaggtgg ccagacccac tcagaccagc tcccagcgag
      721 tgcccctgtg gccgatttca cattttccca cttctcccag aagctcccac ggccttccgc
      781 ctggcattcc tcgcaccccc agcttcacgg catcgcagtc tggttctgag atcctctatc
      841 cccctactca gcatcctcct gtggccatcc tagctcgaaa ttctgataac ttcatgaacc
      901 ctgttcttaa ttgctccctg gaagtggaag ctcgggcacc tccaaatctg ggattccgtg
      961 ttcatatggc ttctggagag gctctctgtc tgatgatgga tttcggggac agttctgggg
     1021 ttgaaatgag gctacacaac atgtctgagg caatggcggt gactgcctac caccagtact
     1081 caaaaggtat tttttttcat cttttacatt ttcagttgga tatgtccacc tacaaagaag
     1141 cagagacaca aaatacaact ttaaatgttt acttgtgcca aagtgaaaac agctgcctgg
     1201 aagactcaga ccccagtaac cttggatatg agcttatttc tgcctttgtc accaaaggag
     1261 tctatatgct caaggctgtt atttataacg agtttcatgg aaccgaagtg gagcttgggc
     1321 cttattatgt ggagattggc catgaggccg tgtctgcgtt catgaactcc agcagtgtcc
     1381 atgaagatga agtgcttgtc tttgctgact cccaagtgaa tcagaaaagc actgtggtta
     1441 tacatcactt tccatctatt ccttcatata acgtgtcctt tatttctcag actcaagtgg
     1501 gtgacagcca ggcttggcac agcatgactg tctggtataa gatgcaatcc gtctctgtct
     1561 acacaaatgg aactgtgttt gccacagaca cagacattac atttacagct gttaccaagg
     1621 aaacaatacc cctggaattt gagtggtatt ttggagagga tccaccagtg aggacaactt
     1681 caagaagcat taaaaaaaga ctcagcatcc cccaatggta tcgtgtgatg gttaaggctt
     1741 ccaacaggat gagcagtgtg gtctctgagc cccatgtcat cagggtgcag aagaaaattg
     1801 tggccaatcg gctcacgtcc ccctcctcag ctctggtaaa tgccagtgtg gcctttgagt
     1861 gctggatcaa cttcggcaca gatgttgcct acctgtggga ctttggggat ggcaccgtca
     1921 gcctggggag cagctccagc agccatgtct acagtaggga aggagaattt acagtggagg
     1981 tccttgcctt caataatgtc agtgcctcca ctctaagaca gcaacttttc atcgtgtgcg
     2041 agccctgcca gccacccctg gtgaagaaca tggggcctgg gaaagtccag atatggaggt
     2101 ctcagcctgt gaggctggga gtgacgtttg aagctgcagt cttctgtgat atttcccaag
     2161 gtctttctta cacctggaac ttgatggact ctgaagggct ccctgtctcc ctccctgctg
     2221 ctgtggacac tcacagacag accctcatcc tcccgagcca caccttggag tatgggaact
     2281 acactgccct tgccaaggtt cagattgaag gcagtgtggt gtacagcaac tactgtgtgg
     2341 gcctggaggt gcgagcccag gcccctgtca gtgtgatctc cgagggcaca cacctattct
     2401 tctccaggac cacctcatcc cccattgtcc tcagagggac ccagtccttc gaccctgacg
     2461 accctggggc gactctcagg tatcactggg aatgcgccac cgctggctcc ccagcacatc
     2521 cctgcttcga ctcctccact gcacaccaac tggatgccgc ggctcccact gtttcctttg
     2581 aggcacaatg gctcagtgac agctatgatc agttccttgt gatgctgagg gtctccagtg
     2641 gtggccggaa ctcttctgag acccgggtgt tcctgtcccc ctaccctgac tcggcgttca
     2701 gattcgtcca catctcctgg gtcagcttta aagacacctt cgtcaactgg aatgacgaac
     2761 tctctcttca agctatgtgt gaggactgca gtgaaatacc gaatctgtct tattcctggg
     2821 atctcttttt agtcaatgca acagaaaaga ataggataga agttcccttc tgcagagtag
     2881 tggggctgct tggctcgctg ggactcggtg ccatttcaga gtcatcacag ttaaacctgc
     2941 tgcccactga gcctggcact gcagatcctg atgcaacgac cacaccattc tcacgggaac
     3001 cttcacccgt gacccttggc caacctgcca cttcagctcc aaggggaacc cccacagagc
     3061 ccatgactgg agtctactgg attcctcctg cgggggactc tgcagtcctg ggggaggctc
     3121 cagaggaagg ttcactagac ctagagccag ggccacagag caagggatcc ctgatgactg
     3181 gccgctctga gagaagtcag cccacccaca gccctgaccc tcacctctct gattttgaag
     3241 cctattacag tgacattcaa gaagcaatac catcgggagg aagacagcca gctaaggaca
     3301 ccagctttcc aggatcagga cctagcttga gtgccgagga gagccctgga gatggggata
     3361 acctggtgga cccctccctg tctgcaggca gagccgagcc tgtcctcatg attgactggc
     3421 ccaaggccct gctgggtcga gcagttttcc aaggctattc atcctcaggt attacagaac
     3481 agacagtgac aatcaagcca tactctctga gcagtggaga gacgtacgtc ctgcaagtgt
     3541 ctgtggcttc gaagcatggc ttactgggta aagctcagct gtacttgaca gtcaacccgg
     3601 ctcctcggga catggcctgt caggtgcagc cccaccatgg tctggaagca cacaccgtct
     3661 tcagtgtctt ctgcatgtct ggaaaaccgg acttccatta tgaatttagt taccagatag
     3721 gaaacacctc caaacacact ttgtaccatg ggagagacac ccagtattat tttgtgttgc
     3781 cagctggtga gcacttggac aattacaaag tcatggtttc cactgaaatc acagatggca
     3841 aaggctccaa ggtccagccg tgcactgtgg tggtgactgt gctgccccgc taccatggaa
     3901 atgactgtct gggcgaggac ctgtataatt ccagcctgaa aaacctttct accctccagc
     3961 tgatggggag ttacacagaa atcaggaact acatcactgt gatcaccaga atcctgagtc
     4021 gtttgtctaa ggaggacaaa actgcctcct gcaaccaatg gtcacgaata caggatgcat
     4081 taatttcttc agtatgcaga ttggcttttg tagatcagga agaaatgatt ggttctgttc
     4141 ttatgttgag ggacctcgtg agcttctcta ataagctagg ctttatgagt gcggttctca
     4201 tcctcaagta cacccgggca ctccttgctc aaggccagtt ctcggggcca tttgtgattg
     4261 acaaaggagt gaggcttgag ctcatcggtc tcatatccag agtctgggaa gtctctgagc
     4321 aagaaaactc gaaggaggaa gtctatcgac atgaagaagg aattacagtc atctcagatt
     4381 tattgttggg ttgtctctct ttgaaccatg ttagcactgg gcagatggag ttccggaccc
     4441 ttcttcatta caaccttcag agctctgtcc agagcctggg atctgtccag gtgcatttac
     4501 ctggtgacct tgctgggcac agtcctgctg gggcggagac acagagccca tgctacatta
     4561 gccagctcat actcttcaag aagaacccat atccagggag ccaagctcct gggcagattg
     4621 gtggagttgt gggcctcaac ctctatacct gctccagcag aagacccatc aacaggcaat
     4681 ggctaaggaa acccgtgatg gtcgagtttg gggaggagga tggcctggat aataggagaa
     4741 ataaaacgac atttgtatta cttcgggata aagtgaatct ccatcagttc actgagcttt
     4801 ccgaaaaccc ccaggaatct ctacagatag aaattgaatt ttccaaacct gttacaaggg
     4861 catttcccgt catgttgcta gtaagattct ctgagaaacc tactccctct gattttcttg
     4921 tgaagcagat ctacttctgg gatgagtcaa ttgtgcagat ttatatacct gctgcttctc
     4981 agaaagatgc cagtgtaggc tatttatcct tattggatgc tgactatgac agaaaacctc
     5041 caaacagata tttagctaag gcagtgaact atacagtaca tttccagtgg atccgatgcc
     5101 tgttttggga caagagagag tggaaatctg aacgtttctc tccacaacca gggacttctc
     5161 ctgaaaaagt gaactgcagc taccatcgcc tcgcggcatt cgctctccta aggagaaagc
     5221 tgaaggccag ttttgaagtg agtgacattt ccaagctaca gagccaccca gaaaacttgc
     5281 ttcccagtat ttttattatg ggttctgtga ttctttatgg atttttggtc gctaaaagta
     5341 gacaagtaga tcatcatgaa aaaaagaaag ctggttacat ctttctgcaa gaagcttccc
     5401 tgccgggcca tcagctatat gcggtcgtca ttgacactgg cttccgagct ccggccaggt
     5461 tgacctcaaa ggtgtacatt gttttatgtg gcgacaatgg actgtcagaa accaaggagc
     5521 tctcctgtcc agagaagccc ctgtttgaaa ggaattccag acacaccttt atcctgagcg
     5581 ctcctgccca actgggcctg ctgaggaaga tccgcctctg gcacgacagc cgtgggcctt
     5641 ccccaggctg gttcatcagc cacgtgatgg tgaaggagct gcacacggga cagggctggt
     5701 tcttccctgc ccagtgctgg ctgtctgccg gcaggcatga tggtcgcgtg gagcgggagc
     5761 tcacctgtct gcaaggggga ctcggcttcc ggaagctttt ctattgcaag ttcacagagt
     5821 acctggagga tttccatgtc tggctgtcgg tgtacagcag gccctcctcc agccgctacc
     5881 tgcacacgcc gcgcctcacc gtgtccttct ccctgctgtg cgtctacgcg tgtctcactg
     5941 ccctggttgc tgctggaggg caagagcagc cccacttgga cgtcagcccc acccttggat
     6001 ccttcagggt gggtctcctg tgtaccctcc tggcttctcc aggggcccag ctcttgtccc
     6061 tgctcttcag gctcagcaag gaagccccgg ggtctgcccg agtggagcca cacagcccac
     6121 ttagaggagg agcacagacc gaggcacccc atggtcctaa ttcctgggga aggataccag
     6181 acgcacagga gccacgcaag caacctgcat cagccattct ctctgggagt ggcagggccc
     6241 aaaggaaggc ggcaagtgac aatggcacag cttgtccagc ccctaagctg caggttcatg
     6301 gggctgacca cagcaggact tctctgatgg ggaaaagcca ctgctgccct ccccacactc
     6361 aagcacccag cagtggtttg gagggactaa tgccccagtg gtcaagggcc cttcagcctt
     6421 ggtggagctc tgcagtgtgg gccatttgtg ggaccgcttc tttggcctgc agtttgggga
     6481 caggatttct agcctacagg tttggccagg agcaatgtgt gcagtggctg cacctgctgt
     6541 ccctctccgt ggtctgctgt attttcatca cccagccact tatggtatgc ctcatggcct
     6601 tgggttttgc ttggaaaaga agagctgaca accacttttt tactgagtct ttatgtgagg
     6661 ctaccaggga tctggactct gaattggcag aacgttcctg gactcgcctc cccttctctt
     6721 caagctgcag tattcctgac tgtgcaggcg aggttgaaaa agtcttggct gcccgacaac
     6781 aagctcgcca cctgcgctgg gcgcatccac catccaaggc ccagctgagg ggcaccagac
     6841 agaggatgag gagagagagt cgcacacggg ctgccctgag agacatttcc atggacatcc
     6901 tcatgctgct tctgcttttg tgtgtaatat atgggagatt ttcccaagat gaatactccc
     6961 tcaatcaagc tatccggaaa gaatttacaa gaaatgccag aaactgcttg ggtggcctga
     7021 gaaacatcgc tgactggtgg gactggagtc tgaccacact tctggatggc ctgtacccgg
     7081 gaggcacccc gtcagcccgt gtgccggggg ctcagcctgg agctcttgga ggaaaatgct
     7141 acctaatagg cagttccgta attaggcagc taaaagtttt tcctaggcat ttatgcaagc
     7201 ctcccaggcc attttcagca ctcatcgaag actctattcc tacatgtagt cccgaagttg
     7261 gaggccctga gaacccctac ctgatagacc cagagaacca aaacgtgacc ctgaatggtc
     7321 ctgggggctg tgggacaagg gaggactgtg tgctcagcct gggcagaaca aggactgaag
     7381 cccacacagc cctgtcccga ctcagggcca gcatgtggat tgaccgcagc accagggctg
     7441 tgtctgtgca cttcactctc tataaccctc caacccaact cttcaccagc gtgtccctga
     7501 gagtggagat cctccctacg gggagtctcg tcccctcatc cctggtggag tcattcagca
     7561 tcttccgcag cgactcagcc ctgcagtacc acctcatgct tccccagctg gtcttcctgg
     7621 cactcagcct gatccacctc tgtgttcaac tctaccgtat gatggacaag ggcgtcctca
     7681 gctactggcg aaagccaagg aactggctgg agctctccgt ggttggagtg agcctcacct
     7741 actatgcagt ttccggccac cttgttactc ttgctggaga tgtcactaac cagtttcaca
     7801 gaggactttg ccgagcattt atggacctca cccttatggc atcatggaat cagagggctc
     7861 gatggctccg gggaatcctc ttattcctct tcacattaaa atgcgtctat cttcctggca
     7921 ttcaaaacac aatggcatcc tgctcctcca tgatgcgcca ctcactcccc agcatctttg
     7981 tagcagggct ggtgggggca ctgatgctgg ccgccctctc ccacctgcac cgatttctgc
     8041 tctctatgtg ggttctacca cctggcacct tcacagacgc cttccccggg ctgctgtttc
     8101 attttcccag aagaagccaa aaagactgcc tccttggcct ttccaagtct gaccagcggg
     8161 ccatggcttg ttactttggg atccttttaa tagtctctgc cacactgtgt tttggaatgc
     8221 tgagaggttt tctcatgact ttaccccaaa aaagaaaatc ttttcaaagt aaatcttttg
     8281 tgagacttaa agatgtcact gcttatatgt gggaaaaggt cctcaccttt ctgagactgg
     8341 aaacaccaaa gttggaagag gctgagatgg ttgagaatca caattactac ttggatgaat
     8401 ttgcaaatct gttagacgaa cttctgatga agattaatgg tttgtccgac agcctacaac
     8461 tcccccttct ggaaaaaaca tccaacaaca caggggaggc aaggacagaa gagagtccct
     8521 tagtggacat ttctagttac caagctgctg agccagcaga catcaaggac ttctgaggag
     8581 cctggtacct tgcataggca ctatggaccc tgttttgctt aacccaccca acagccaatt
     8641 ttagcagaca tcctagtttt gcaggtgaga agagctgagg tacgaagaag ttttgttaat
     8701 ttttccagtt cacgtaacaa gtaaatggga aaccaggatg aaaatcaagg tttatctgtc
     8761 atcagactgt tactcataat caccattcgg agagttcaga tgtgggacaa gattctaact
     8821 ccagccttct cccaaatggt taatttgcca gttgccctag agttacatat tgtcttattt
     8881 gtttgtttta ctgaatctgt ctgagtatta aaagccttgt atcttgtgaa atttctttca
     8941 ggtctcataa aagcgatgaa agagaccagg ataacattct aatatttaaa taagattttt
     9001 gaagtaaaat ccttattttg taaatttaac aattgaatct tgctagatta ataacgcatc
     9061 tttcctgatt tactaattca atataaaatg gttattcaaa ctgaa
//
