LOCUS       NM_004764               3897 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens piwi like RNA-mediated gene silencing 1 (PIWIL1),
            transcript variant 1, mRNA.
ACCESSION   NM_004764
VERSION     NM_004764.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3897)
  AUTHORS   Li,J., Hong,X., Jiang,M., Kho,A.T., Tiwari,A., Wang,A.L.,
            Chase,R.P., Celedon,J.C., Weiss,S.T., McGeachie,M.J. and
            Tantisira,K.G.
  TITLE     A novel piwi-interacting RNA associates with type 2-high asthma
            phenotypes
  JOURNAL   J Allergy Clin Immunol 153 (3), 695-704 (2024)
   PUBMED   38056635
  REMARK    GeneRIF: A novel piwi-interacting RNA associates with type 2-high
            asthma phenotypes.
REFERENCE   2  (bases 1 to 3897)
  AUTHORS   Liu,S., Yan,Y., Cui,Z., Feng,H., Zhong,F., Liu,Z., Li,Y., Ou,X. and
            Li,W.
  TITLE     Relationship between PIWIL1 gene polymorphisms and epithelial
            ovarian cancer susceptibility among southern Chinese woman: a
            three-center case-control study
  JOURNAL   BMC Cancer 23 (1), 1149 (2023)
   PUBMED   38012622
  REMARK    GeneRIF: Relationship between PIWIL1 gene polymorphisms and
            epithelial ovarian cancer susceptibility among southern Chinese
            woman: a three-center case-control study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3897)
  AUTHORS   Hu,D., Wang,L., Chen,X., Lin,Y., Zhang,S., Fan,Z. and Peng,F.
  TITLE     Impact of PIWIL1 Single Nucleotide Polymorphisms on Gastric Cancer
            Risk in a Chinese Population
  JOURNAL   Genet Test Mol Biomarkers 27 (6), 185-192 (2023)
   PUBMED   37382906
  REMARK    GeneRIF: Impact of PIWIL1 Single Nucleotide Polymorphisms on
            Gastric Cancer Risk in a Chinese Population.
REFERENCE   4  (bases 1 to 3897)
  AUTHORS   Wang,X., Gou,L.T. and Liu,M.F.
  TITLE     Noncanonical functions of PIWIL1/piRNAs in animal male germ cells
            and human diseasesdagger
  JOURNAL   Biol Reprod 107 (1), 101-108 (2022)
   PUBMED   35403682
  REMARK    GeneRIF: Noncanonical functions of PIWIL1/piRNAs in animal male
            germ cells and human diseasesdagger.
            Review article
REFERENCE   5  (bases 1 to 3897)
  AUTHORS   Heng,B., Xie,X., Zeng,W., Li,H., Shi,L., Ye,W. and Wu,F.
  TITLE     PIWI-Interacting RNA Pathway Genes: Potential Biomarkers for Clear
            Cell Renal Cell Carcinoma
  JOURNAL   Dis Markers 2022, 3480377 (2022)
   PUBMED   35273654
  REMARK    GeneRIF: PIWI-Interacting RNA Pathway Genes: Potential Biomarkers
            for Clear Cell Renal Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3897)
  AUTHORS   Tahbaz,N., Kolb,F.A., Zhang,H., Jaronczyk,K., Filipowicz,W. and
            Hobman,T.C.
  TITLE     Characterization of the interactions between mammalian PAZ PIWI
            domain proteins and Dicer
  JOURNAL   EMBO Rep 5 (2), 189-194 (2004)
   PUBMED   14749716
REFERENCE   7  (bases 1 to 3897)
  AUTHORS   Sasaki,T., Shiohama,A., Minoshima,S. and Shimizu,N.
  TITLE     Identification of eight members of the Argonaute family in the
            human genome
  JOURNAL   Genomics 82 (3), 323-330 (2003)
   PUBMED   12906857
REFERENCE   8  (bases 1 to 3897)
  AUTHORS   Qiao,D., Zeeman,A.M., Deng,W., Looijenga,L.H. and Lin,H.
  TITLE     Molecular characterization of hiwi, a human member of the piwi gene
            family whose overexpression is correlated to seminomas
  JOURNAL   Oncogene 21 (25), 3988-3999 (2002)
   PUBMED   12037681
  REMARK    GeneRIF: specifically expressed in both normal and malignant
            spermatogenic cells in a maturation stage-dependent pattern, in
            which it might function in germ cell proliferation
REFERENCE   9  (bases 1 to 3897)
  AUTHORS   Sharma,A.K., Nelson,M.C., Brandt,J.E., Wessman,M., Mahmud,N.,
            Weller,K.P. and Hoffman,R.
  TITLE     Human CD34(+) stem cells express the hiwi gene, a human homologue
            of the Drosophila gene piwi
  JOURNAL   Blood 97 (2), 426-434 (2001)
   PUBMED   11154219
REFERENCE   10 (bases 1 to 3897)
  AUTHORS   Cox,D.N., Chao,A., Baker,J., Chang,L., Qiao,D. and Lin,H.
  TITLE     A novel class of evolutionarily conserved genes defined by piwi are
            essential for stem cell self-renewal
  JOURNAL   Genes Dev 12 (23), 3715-3727 (1998)
   PUBMED   9851978
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127071.3, DB072454.1,
            BC028581.2, AF104260.2 and DB527532.1.
            
            On May 17, 2019 this sequence version replaced NM_004764.4.
            
            Summary: This gene encodes a member of the PIWI subfamily of
            Argonaute proteins, evolutionarily conserved proteins containing
            both PAZ and Piwi motifs that play important roles in stem cell
            self-renewal, RNA silencing, and translational regulation in
            diverse organisms. The encoded protein may play a role as an
            intrinsic regulator of the self-renewal capacity of germline and
            hematopoietic stem cells. Alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028581.2, AF104260.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000245255.7/ ENSP00000245255.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC127071.3         16825-16825
            2-141               DB072454.1         1-140
            142-204             DB072454.1         142-204
            205-1744            BC028581.2         1-1540
            1745-3030           AF104260.2         1529-2814
            3031-3583           BC028581.2         2827-3379
            3584-3592           DB527532.1         441-449
            3593-3897           AC127071.3         51271-51575
FEATURES             Location/Qualifiers
     source          1..3897
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..3897
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /note="piwi like RNA-mediated gene silencing 1"
                     /db_xref="GeneID:9271"
                     /db_xref="HGNC:HGNC:9007"
                     /db_xref="MIM:605571"
     exon            1..260
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            261..350
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..2858
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /note="isoform 1 is encoded by transcript variant 1; piwi
                     homolog; piwi-like protein 1"
                     /codon_start=1
                     /product="piwi-like protein 1 isoform 1"
                     /protein_id="NP_004755.2"
                     /db_xref="CCDS:CCDS9268.1"
                     /db_xref="GeneID:9271"
                     /db_xref="HGNC:HGNC:9007"
                     /db_xref="MIM:605571"
                     /translation="MTGRARARARGRARGQETAQLVGSTASQQPGYIQPRPQPPPAEG
                     ELFGRGRQRGTAGGTAKSQGLQISAGFQELSLAERGGRRRDFHDLGVNTRQNLDHVKE
                     SKTGSSGIIVRLSTNHFRLTSRPQWALYQYHIDYNPLMEARRLRSALLFQHEDLIGKC
                     HAFDGTILFLPKRLQQKVTEVFSKTRNGEDVRITITLTNELPPTSPTCLQFYNIIFRR
                     LLKIMNLQQIGRNYYNPNDPIDIPSHRLVIWPGFTTSILQYENSIMLCTDVSHKVLRS
                     ETVLDFMFNFYHQTEEHKFQEQVSKELIGLVVLTKYNNKTYRVDDIDWDQNPKSTFKK
                     ADGSEVSFLEYYRKQYNQEITDLKQPVLVSQPKRRRGPGGTLPGPAMLIPELCYLTGL
                     TDKMRNDFNVMKDLAVHTRLTPEQRQREVGRLIDYIHKNDNVQRELRDWGLSFDSNLL
                     SFSGRILQTEKIHQGGKTFDYNPQFADWSKETRGAPLISVKPLDNWLLIYTRRNYEAA
                     NSLIQNLFKVTPAMGMQMRKAIMIEVDDRTEAYLRVLQQKVTADTQIVVCLLSSNRKD
                     KYDAIKKYLCTDCPTPSQCVVARTLGKQQTVMAIATKIALQMNCKMGGELWRVDIPLK
                     LVMIVGIDCYHDMTAGRRSIAGFVASINEGMTRWFSRCIFQDRGQELVDGLKVCLQAA
                     LRAWNSCNEYMPSRIIVYRDGVGDGQLKTLVNYEVPQFLDCLKSIGRGYNPRLTVIVV
                     KKRVNTRFFAQSGGRLQNPLPGTVIDVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVIY
                     DNSGLKPDHIQRLTYKLCHIYYNWPGVIRVPAPCQYAHKLAFLVGQSIHREPNLSLSN
                     RLYYL"
     exon            351..462
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            463..588
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            589..803
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            804..925
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1006
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1204
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1316
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1443
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1561
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1676
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1864
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1937
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2138
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2242
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2313
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2467
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2593
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2741
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..3897
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3562..3567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /note="hexamer: AATAAA"
     polyA_site      3588
                     /gene="PIWIL1"
                     /gene_synonym="CT80.1; HIWI; MIWI; PIWI"
                     /note="major polyA site"
ORIGIN      
        1 gttactgggc gtatggcgta cagacacgag gccggcgccc gggaggcggt gttcatccgc
       61 ccgggaaaag agcgcctgtt gctcgctgcc cgcgtgtccc tggctctctc gggaacccag
      121 cgccgaaggc gaggtgggcg cgggccgaag gaggtcctgg gaggtcggcg gcgcggaggg
      181 atctccgcgg gagccgttgg ggctgttggc ctcgggctga ggtgcaagga ccaggactag
      241 ggcgagggca gcggtccaag aaatagaaaa caatgactgg gagagcccga gccagagcca
      301 gaggaagggc ccgcggtcag gagacagcgc agctggtggg ctccactgcc agtcagcaac
      361 ctggttatat tcagcctagg cctcagccgc caccagcaga gggggaatta tttggccgtg
      421 gacggcagag aggaacagca ggaggaacag ccaagtcaca aggactccag atatctgctg
      481 gatttcagga gttatcgtta gcagagagag gaggtcgtcg tagagatttt catgatcttg
      541 gtgtgaatac aaggcagaac ctagaccatg ttaaagaatc aaaaacaggt tcttcaggca
      601 ttatagtaag gttaagcact aaccatttcc ggctgacatc ccgtccccag tgggccttat
      661 atcagtatca cattgactat aacccactga tggaagccag aagactccgt tcagctcttc
      721 tttttcaaca cgaagatcta attggaaagt gtcatgcttt tgatggaacg atattatttt
      781 tacctaaaag actacagcaa aaggttactg aagtttttag taagacccgg aatggagagg
      841 atgtgaggat aacgatcact ttaacaaatg aacttccacc tacatcacca acttgtttgc
      901 agttctataa tattattttc aggaggcttt tgaaaatcat gaatttgcaa caaattggac
      961 gaaattatta taacccaaat gacccaattg atattccaag tcacaggttg gtgatttggc
     1021 ctggcttcac tacttccatc cttcagtatg aaaacagcat catgctctgc actgacgtta
     1081 gccataaagt ccttcgaagt gagactgttt tggatttcat gttcaacttt tatcatcaga
     1141 cagaagaaca taaatttcaa gaacaagttt ccaaagaact aataggttta gttgttctta
     1201 ccaagtataa caataagaca tacagagtgg atgatattga ctgggaccag aatcccaaga
     1261 gcacctttaa gaaagccgac ggctctgaag tcagcttctt agaatactac aggaagcaat
     1321 acaaccaaga gatcaccgac ttgaagcagc ctgtcttggt cagccagccc aagagaaggc
     1381 ggggccctgg ggggacactg ccagggcctg ccatgctcat tcctgagctc tgctatctta
     1441 caggtctaac tgataaaatg cgtaatgatt ttaacgtgat gaaagactta gccgttcata
     1501 caagactaac tccagagcaa aggcagcgtg aagtgggacg actcattgat tacattcata
     1561 aaaacgataa tgttcaaagg gagcttcgag actggggttt gagctttgat tccaacttac
     1621 tgtccttctc aggaagaatt ttgcaaacag aaaagattca ccaaggtgga aaaacatttg
     1681 attacaatcc acaatttgca gattggtcca aagaaacaag aggtgcacca ttaattagtg
     1741 ttaagccact agataactgg ctgttgatct atacgcgaag aaattatgaa gcagccaatt
     1801 cattgataca aaatctattt aaagttacac cagccatggg catgcaaatg agaaaagcaa
     1861 taatgattga agtggatgac agaactgaag cctacttaag agtcttacag caaaaggtca
     1921 cagcagacac ccagatagtt gtctgtctgt tgtcaagtaa tcggaaggac aaatacgatg
     1981 ctattaaaaa atacctgtgt acagattgcc ctaccccaag tcagtgtgtg gtggcccgaa
     2041 ccttaggcaa acagcaaact gtcatggcca ttgctacaaa gattgcccta cagatgaact
     2101 gcaagatggg aggagagctc tggagggtgg acatccccct gaagctcgtg atgatcgttg
     2161 gcatcgattg ttaccatgac atgacagctg ggcggaggtc aatcgcagga tttgttgcca
     2221 gcatcaatga agggatgacc cgctggttct cacgctgcat atttcaggat agaggacagg
     2281 agctggtaga tgggctcaaa gtctgcctgc aagcggctct gagggcttgg aatagctgca
     2341 atgagtacat gcccagccgg atcatcgtgt accgcgatgg cgtaggagac ggccagctga
     2401 aaacactggt gaactacgaa gtgccacagt ttttggattg tctaaaatcc attggtagag
     2461 gttacaaccc tagactaacg gtaattgtgg tgaagaaaag agtgaacacc agattttttg
     2521 ctcagtctgg aggaagactt cagaatccac ttcctggaac agttattgat gtagaggtta
     2581 ccagaccaga atggtatgac ttttttatcg tgagccaggc tgtgagaagt ggtagtgttt
     2641 ctcccacaca ttacaatgtc atctatgaca acagcggcct gaagccagac cacatacagc
     2701 gcttgaccta caagctgtgc cacatctatt acaactggcc aggtgtcatt cgtgttcctg
     2761 ctccttgcca gtacgcccac aagctggctt ttcttgttgg ccagagtatt cacagagagc
     2821 caaatctgtc actgtcaaac cgcctttact acctctaacc tgcagaagac gatgcagccg
     2881 cttttctttt tgaaatgact ttgggatttt tttaagcttt tatttacttt ttttttaact
     2941 gttatctttc tggatgaaac ttgggaaggg gattaggaga tctagcattt tatttctagc
     3001 attgctattc accggcttcc ttattttata cgtaaaaatt aagattttat attttatctt
     3061 cttgtttctc atagatattt tgtgagcatt tttttgttta ttttgaagaa atgtggataa
     3121 gatacttggt agtataaaac agactctctg agagtatttg aaatgtgttt ggagatttac
     3181 ttaaacgtac tttcaggagt gagcaagtcc tacttataaa cctatattaa ctttattttt
     3241 gagatacctg ttttgaattt aaaggagata agaggcgtaa agtaggatgc tcactacaac
     3301 cataggtggg gtttcagctc atatcttaaa gataaaaggt actattatat aacctataca
     3361 caagatacag gagaaaatat gcttgatttt tatttggcag gggggctagg ttgtatggga
     3421 gtaaaaaaaa cattgaaaat ttttaaattg tccaaagaaa cattttaaga ctctttaaca
     3481 aaaaaggcca tgagtaaatc tctatattaa cattactatt tattttgttt tggaactggg
     3541 acatgattct atttgttata aaataaaatt gatgtgattg tcaccttatt tgaataactg
     3601 taattcttgt tttactgaaa gtatgtgcgt tttcttttca tttaattttt aaaagtgcat
     3661 acaattccat tcataaaagc taaattagcc tgaccaacat ggtgaaaccc catctctact
     3721 aaaaatacaa aattagccag atgtggtgcc aggaggctga ggcaggagaa tcacttgaac
     3781 ctgagaggcg gaggttgcag tgagcagaga tcacgccact gcactccagc ctgggcaaca
     3841 gagtgagact ccgtctcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
