LOCUS       NM_031220               7149 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens PITPNM family member 3 (PITPNM3), transcript variant
            1, mRNA.
ACCESSION   NM_031220
VERSION     NM_031220.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7149)
  AUTHORS   Ding,D., Zhang,L., Liu,X., Sun,C., He,J., Li,J., Gao,X., Guan,F.
            and Zhang,L.
  TITLE     Chemokine CCL18 Promotes Phagocytosis Through Its Receptor CCR8
            Rather than PITPNM3 in Human Microglial Cells
  JOURNAL   J Interferon Cytokine Res 42 (1), 19-28 (2022)
   PUBMED   35041514
  REMARK    GeneRIF: Chemokine CCL18 Promotes Phagocytosis Through Its Receptor
            CCR8 Rather than PITPNM3 in Human Microglial Cells.
REFERENCE   2  (bases 1 to 7149)
  AUTHORS   Jiang,X., Huang,Z., Sun,X., Zheng,X., Liu,J., Shen,J., Jia,B.,
            Luo,H., Mai,Z., Chen,G. and Zhao,J.
  TITLE     CCL18-NIR1 promotes oral cancer cell growth and metastasis by
            activating the JAK2/STAT3 signaling pathway
  JOURNAL   BMC Cancer 20 (1), 632 (2020)
   PUBMED   32641093
  REMARK    GeneRIF: CCL18-NIR1 promotes oral cancer cell growth and metastasis
            by activating the JAK2/STAT3 signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7149)
  AUTHORS   Tang,T., Tao,X., Bao,X., Chen,J., Dai,J., Ye,J. and Yan,Y.
  TITLE     Mitofusin-2 (Mfn-2) Might Have Anti-Cancer Effect through
            Interaction with Transcriptional Factor SP1 and Consequent
            Regulation on Phosphatidylinositol Transfer Protein 3 (PITPNM3)
            Expression
  JOURNAL   Med Sci Monit 26, e918599 (2020)
   PUBMED   31955176
  REMARK    GeneRIF: Mitofusin-2 (Mfn-2) Might Have Anti-Cancer Effect through
            Interaction with Transcriptional Factor SP1 and Consequent
            Regulation on Phosphatidylinositol Transfer Protein 3 (PITPNM3)
            Expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7149)
  AUTHORS   Shi,L., Zhang,B., Sun,X., Zhang,X., Lv,S., Li,H., Wang,X., Zhao,C.,
            Zhang,H., Xie,X., Wang,Y. and Zhang,P.
  TITLE     CC chemokine ligand 18(CCL18) promotes migration and invasion of
            lung cancer cells by binding to Nir1 through Nir1-ELMO1/DOC180
            signaling pathway
  JOURNAL   Mol Carcinog 55 (12), 2051-2062 (2016)
   PUBMED   26756176
  REMARK    GeneRIF: CCL18 can increase the invasive ability of non-small cell
            lung cancer cells by binding to its receptor Nir1.
REFERENCE   5  (bases 1 to 7149)
  AUTHORS   Lin,Z., Li,W., Zhang,H., Wu,W., Peng,Y., Zeng,Y., Wan,Y., Wang,J.
            and Ouyang,N.
  TITLE     CCL18/PITPNM3 enhances migration, invasion, and EMT through the
            NF-kappaB signaling pathway in hepatocellular carcinoma
  JOURNAL   Tumour Biol 37 (3), 3461-3468 (2016)
   PUBMED   26449829
  REMARK    GeneRIF: CCL18 enhances hepatocellular carcinoma (HCC) cell
            migration, invasion, and epithelial-mesenchymal transition (EMT)
            through the expression of PITPNM3 and the activation of the
            NF-kappaB signaling pathway.
REFERENCE   6  (bases 1 to 7149)
  AUTHORS   Kohn,L., Kohl,S., Bowne,S.J., Sullivan,L.S., Kellner,U.,
            Daiger,S.P., Sandgren,O. and Golovleva,I.
  TITLE     PITPNM3 is an uncommon cause of cone and cone-rod dystrophies
  JOURNAL   Ophthalmic Genet 31 (3), 139-140 (2010)
   PUBMED   20590364
  REMARK    GeneRIF: Thus, mutations in PITPNM3 do not appear to be a major
            cause of cone or cone-rod dystrophy.
REFERENCE   7  (bases 1 to 7149)
  AUTHORS   Kohn,L., Kadzhaev,K., Burstedt,M.S., Haraldsson,S., Sandgren,O. and
            Golovleva,I.
  TITLE     Mutation in the PYK2-binding domain of PITPNM3 causes autosomal
            dominant cone dystrophy (CORD5) in two Swedish families
  JOURNAL   Adv Exp Med Biol 613, 229-234 (2008)
   PUBMED   18188949
  REMARK    GeneRIF: Mutation in the PYK2-binding domain of PITPNM3 causes
            autosomal dominant cone dystrophy (CORD5) in two Swedish families.
REFERENCE   8  (bases 1 to 7149)
  AUTHORS   Kohn,L., Kadzhaev,K., Burstedt,M.S., Haraldsson,S., Hallberg,B.,
            Sandgren,O. and Golovleva,I.
  TITLE     Mutation in the PYK2-binding domain of PITPNM3 causes autosomal
            dominant cone dystrophy (CORD5) in two Swedish families
  JOURNAL   Eur J Hum Genet 15 (6), 664-671 (2007)
   PUBMED   17377520
  REMARK    GeneRIF: Our finding on the first mutation in the human homologue
            of Drosophila rdgB indicates novel pathways and a potential
            important role of the PITPNM3 in mammalian phototransduction.
REFERENCE   9  (bases 1 to 7149)
  AUTHORS   Ocaka,L., Spalluto,C., Wilson,D.I., Hunt,D.M. and Halford,S.
  TITLE     Chromosomal localization, genomic organization and evolution of the
            genes encoding human phosphatidylinositol transfer protein
            membrane-associated (PITPNM) 1, 2 and 3
  JOURNAL   Cytogenet Genome Res 108 (4), 293-302 (2005)
   PUBMED   15627748
REFERENCE   10 (bases 1 to 7149)
  AUTHORS   Lev,S., Hernandez,J., Martinez,R., Chen,A., Plowman,G. and
            Schlessinger,J.
  TITLE     Identification of a novel family of targets of PYK2 related to
            Drosophila retinal degeneration B (rdgB) protein
  JOURNAL   Mol Cell Biol 19 (3), 2278-2288 (1999)
   PUBMED   10022914
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055872.23, AF334586.1,
            BC035799.1 and AI333030.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_031220.3.
            
            Summary: This gene encodes a member of a family of
            membrane-associated phosphatidylinositol transfer domain-containing
            proteins. The calcium-binding protein has phosphatidylinositol (PI)
            transfer activity and interacts with the protein tyrosine kinase
            PTK2B (also known as PYK2). The protein is homologous to a
            Drosophila protein that is implicated in the visual transduction
            pathway in flies. Mutations in this gene result in autosomal
            dominant cone dystrophy. Multiple transcript variants encoding
            different isoforms have been found for this gene.[provided by
            RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1894184.1, BC128583.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262483.13/ ENSP00000262483.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AC055872.23        201193-201363       c
            172-2578            AF334586.1         171-2577
            2579-3013           BC035799.1         2376-2810
            3014-6824           AC055872.23        96396-100206        c
            6825-7149           AI333030.1         11-335              c
FEATURES             Location/Qualifiers
     source          1..7149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2-p13.1"
     gene            1..7149
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /note="PITPNM family member 3"
                     /db_xref="GeneID:83394"
                     /db_xref="HGNC:HGNC:21043"
                     /db_xref="MIM:608921"
     exon            1..171
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..3074
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /note="isoform 1 is encoded by transcript variant 1; PYK2
                     N-terminal domain-interacting receptor 1;
                     membrane-associated phosphatidylinositol transfer protein
                     3; NIR-1; PITPnm 3; phosphatidylinositol transfer protein,
                     membrane-associated 3; retinal degeneration B alpha 3;
                     cone rod dystrophy 5; atypical chemokine receptor 6"
                     /codon_start=1
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 3 isoform 1"
                     /protein_id="NP_112497.2"
                     /db_xref="CCDS:CCDS11076.1"
                     /db_xref="GeneID:83394"
                     /db_xref="HGNC:HGNC:21043"
                     /db_xref="MIM:608921"
                     /translation="MAKAGRAGGPPPGGGAPWHLRNVLSDSVESSDDEFFDAREEMAE
                     GKNAILIGMSQWNSNDLVEQIETMGKLDEHQGEGTAPCTSSILQEKQRELYRVSLRRQ
                     RFPAQGSIEIHEDSEEGCPQRSCKTHVLLLVLHGGNILDTGAGDPSCKAADIHTFSSV
                     LEKVTRAHFPAALGHILIKFVPCPAICSEAFSLVSHLNPYSHDEGCLSSSQDHVPLAA
                     LPLLAISSPQYQDAVATVIERANQVYREFLKSSDGIGFSGQVCLIGDCVGGLLAFDAI
                     CYSAGPSGDSPASSSRKGSISSTQDTPVAVEEDCSLASSKRLSKSNIDISSGLEDEEP
                     KRPLPRKQSDSSTYDCEAITQHHAFLSSIHSSVLKDESETPAAGGPQLPEVSLGRFDF
                     DVSDFFLFGSPLGLVLAMRRTVLPGLDGFQVRPACSQVYSFFHCADPSASRLEPLLEP
                     KFHLVPPVSVPRYQRFPLGDGQSLLLADALHTHSPLFLEGSSRDSPPLLDAPASPPQA
                     SRFQRPGRRMSEGSSHSESSESSDSMAPVGASRITAKWWGSKRIDYALYCPDVLTAFP
                     TVALPHLFHASYWESTDVVAFILRQVMRYESVNIKESARLDPAALSPANPREKWLRKR
                     TQVKLRNVTANHRANDVIAAEDGPQVLVGRFMYGPLDMVALTGEKVDILVMAEPSSGR
                     WVHLDTEITNSSGRITYNVPRPRRLGVGVYPVKMVVRGDQTCAMSYLTVLPRGMECVV
                     FSIDGSFAASVSIMGSDPKVRPGAVDVVRHWQDLGYMILYITGRPDMQKQRVVSWLSQ
                     HNFPQGMIFFSDGLVHDPLRQKAIFLRNLMQECFIKISAAYGSTKDISVYSVLGLPAS
                     QIFIVGRPTKKYQTQCQFLSEGYAAHLAALEASHRSRPKKNNSRMILRKGSFGLHAQP
                     EFLRKRNHLRRTMSVQQPDPPAANPKPERAQSQPESDKDHERPLPALSWARGPPKFES
                     VP"
     exon            172..267
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            268..375
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            376..423
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            424..500
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            501..736
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            737..926
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1049
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1234
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1407
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1578
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1773
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1922
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2039
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2156
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2305
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2455
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2639
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2768
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..7149
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7127..7132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /note="hexamer: AATAAA"
     polyA_site      7149
                     /gene="PITPNM3"
                     /gene_synonym="ACKR6; CORD5; NIR1; RDGBA3"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggct gcggtggcgg cagccgaggc gagcggggcg ggggcgcggg cgcggcgctc
       61 ggagtccgtt cggggccgga ggcggtcggg gccgggcccg ggaagcgcga ggagcgcgcg
      121 tagcgccgcc ggagcccgcc gcccgggaca tggccaaggc gggccgtgca ggtggtcctc
      181 ccccgggcgg cggtgccccc tggcaccttc gaaatgtcct cagtgactct gtggagagct
      241 cagatgatga attctttgat gccagagagg agatggctga agggaagaat gccatcctca
      301 ttgggatgag ccagtggaac tccaatgacc tcgtggagca gatcgagacc atggggaaac
      361 tggacgagca tcaaggagaa gggaccgcgc cgtgcacatc cagcatcctc caggagaagc
      421 agcgagaact gtaccgggtt tccttgagaa gacagaggtt cccagcccag ggaagcatcg
      481 agatccacga agacagcgag gaaggctgcc cgcagcgctc ctgcaagaca catgtcctcc
      541 tgctggtcct gcatggggga aacatcctgg acacgggtgc cggggacccg tcctgcaagg
      601 cagccgacat ccacaccttc agctccgtgc tggagaaggt cacacgagcc catttccctg
      661 ctgccctggg ccacatcctc atcaagttcg tcccctgtcc tgccatctgc tctgaggctt
      721 tctcgcttgt ctctcacctg aacccctaca gccacgatga gggctgcctc agcagcagcc
      781 aggaccacgt ccctctggcc gcccttcccc tgttggccat ctcctccccg cagtaccagg
      841 atgctgtcgc caccgtcatc gagcgagcca accaggtcta cagagagttc ctgaagtcct
      901 ctgatgggat tggcttcagt gggcaggtgt gtctcatcgg ggactgtgtg gggggcctcc
      961 tggccttcga tgccatctgc tacagtgcgg ggccctcagg ggacagccct gccagcagca
     1021 gccggaaggg gagcatcagc agcacccagg acaccccagt cgcggtggag gaagattgca
     1081 gcctggccag cagcaagcgt ctcagcaaaa gcaacattga catctccagt gggttggagg
     1141 atgaggagcc caagaggccg ttgccgcgga aacagagcga ctcctccacc tatgactgcg
     1201 aggccatcac ccagcaccat gccttcctct caagcatcca ctccagcgtg ctaaaggatg
     1261 agtctgagac cccggcggct ggggggccgc agctccctga ggtcagcctg ggccgctttg
     1321 acttcgatgt gtccgacttc ttcctcttcg gctcgccact gggcctggtc ctggccatgc
     1381 ggaggacggt gctgcctggg ctggacggct tccaggtgcg tcctgcctgc agccaggtct
     1441 acagcttctt ccattgcgca gacccctctg cctcacggct cgagccactg ctggagccca
     1501 agttccacct ggtgccgcct gtcagcgtgc ctcgctacca gaggttccca ctgggcgatg
     1561 ggcagtccct cctcctcgct gatgccctac acacccacag ccccctcttc ctggagggca
     1621 gctcccggga cagcccgcca cttctggatg cccctgcctc gccccctcag gcctcgaggt
     1681 tccagcgccc aggacggagg atgagcgagg ggagctccca cagcgagagc tcggagtcct
     1741 cggacagcat ggcacccgtg ggtgcctccc gcatcacagc caagtggtgg ggaagcaaga
     1801 ggatcgacta tgccctgtac tgccctgatg tcctcacggc cttccccacc gtggccctgc
     1861 cccacctctt ccacgccagt tactgggagt ccacagacgt ggtggccttc atcctgagac
     1921 aggtaatgcg ctatgagagc gtgaacatca aggaaagcgc ccgcctggac cctgcagcac
     1981 tgagtcctgc caacccccgg gagaagtggc ttcgtaagcg gactcaggtc aagctgagga
     2041 atgtcacggc taatcaccgg gccaatgatg tgattgctgc tgaagatggc ccccaggtcc
     2101 tggtggggcg gttcatgtac gggcccctcg acatggtggc tctgactgga gagaaggtgg
     2161 acatcctagt aatggcagag ccatcctcag gccgctgggt acacctggac acagagatca
     2221 ccaacagcag tggtcgcatc acatacaatg tgccgcggcc ccggcgcctg ggggttggtg
     2281 tctatcctgt gaagatggtc gtcaggggcg accagacctg tgccatgagc tacctcacgg
     2341 tgttgcccag gggcatggag tgtgtagtgt tcagcattga tgggtccttc gcggccagcg
     2401 tgtctatcat gggaagcgac cccaaggtcc ggccgggtgc agtggatgtt gtccggcact
     2461 ggcaggactt gggctacatg atcctttaca tcacgggacg gccggacatg cagaagcagc
     2521 gggtggtgtc gtggctgtcc cagcacaact tcccacaggg catgatcttc ttctccgatg
     2581 ggctggtgca tgacccgctg cggcagaagg ccatcttcct gcgcaacctc atgcaggagt
     2641 gcttcatcaa aatcagtgcg gcctatggct ccacgaagga catctctgtc tacagcgtgc
     2701 tgggcctgcc tgcctcccag atcttcattg tgggccggcc caccaagaag taccaaaccc
     2761 agtgccagtt cctgagcgag ggctacgccg cacacctggc cgcgctggag gccagccacc
     2821 gctcacgccc aaagaagaac aactcgcgca tgatcctgcg caagggcagc ttcgggctgc
     2881 acgcgcagcc agagttcctg cggaagcgca accacctgcg cagaaccatg tcagtgcagc
     2941 agcccgaccc gcccgccgcc aaccccaagc ccgagcgggc ccagagccag cccgagtcgg
     3001 acaaagacca cgagcggccg ctgccggcgc tcagctgggc gcgtgggccc cccaagttcg
     3061 agtcggtgcc ctgaggggtg ggctgtgctc agagcaggga gcggggggcc caatcaggct
     3121 gcctgcgggg acgggagggg gctgccctct ccccgacaca ggcgttttcc tgctttttcc
     3181 ctcccgtgtc tgtccagcag tgtccgacca gagcggggag ggatcctgcc cgagcccggg
     3241 gggctccctg agctgcgacg gggtgaggtc cggggatctc ggtgcagcca ctgctgcctc
     3301 ccacgggcct gcgaccgcaa gcccaagtca gggttcatgt ttgtgtcatc ctgggggcag
     3361 gcttgcccgg ggctgaagcg tttgggcaaa gtcgaccacc ctcctgcgtc cccaggcttc
     3421 acagcgagct aggcaggccc tcaagggggc agccccagcc tcggcaccaa gcgccgctgg
     3481 caggcacagc ctctgggctg tcttgtggag gtgtgagtgg catttgtgcc cgcccttcct
     3541 gtggtttggg tcaccatttt ggggttggcg ctcttatggc aagatggcca ctttctggga
     3601 gtgagagcac atccccgggc tcatgttacg ccgtctctgt ccacagccct cgggggtggg
     3661 gtctggtgct gacggtctgt cctgcagctg tccattgtcc ccaacccccg ttgtcctcag
     3721 tgtcctcacc atttccctgt ggccctggag gccagggctt cctcttcccg gagccctgcc
     3781 tcatgccctc ccttgggagg ctgcagcctt gggctctggc tcagctgggc tggctgtgag
     3841 cccctgagct ggttgcttgc cctctctggg ctccgtcttc cttctgttat tggaggggtc
     3901 cccctagctg agattggtgt gagtctttga ctcccaagat gtcctgcagt ttggcccatt
     3961 gaggctcttc aggcctaagg gtccctccga gtgtcctgtg acccacacct ttcacacagc
     4021 ctgggagagg gggtctgggt gggctggaaa ggaggggctc ttaaaggagc ctctctgggt
     4081 gggctgggaa gggatcccta ctccacggag aggtgcagct ggtttgcctt gcactgcgtg
     4141 tcccagggac aacccactca aactgggtgt cctagggaca acccacctcc ctctcctgcc
     4201 aaaaggttac tgattgggct ccccataacc ccagctctgc caggaccctt ttatcctttt
     4261 tggctcccag aggcatagag ctgagattcc agggttctag gggttcctgg aagtttggct
     4321 ccaactgttg tattctcttc cctttcccct gctgctcagt ttgtgcccat aacctcctcc
     4381 tgggtagtcc cctgaggttg gcaggacttg gcccttctgg ggcccctaaa gcctgctcag
     4441 gccctcctgc tgctgaacct tggcctgggc actgctttcc tgcatcctgg aaaaccccga
     4501 ctccctggcc caggcccaca cctgctgtgt ggggctgccc acgtggccac tgagccccca
     4561 taggctgcca tcaaggccgg tcccagcaat ttcagccagg ctgccccagg gcccagacgt
     4621 ctgtatacac agcaggcacc tgtgtcagct cagtgtcgct tctgctcaat gtctacctct
     4681 cgcggctccc atgcagccag tgacgctgct ggtgggggcg gctggcaccg ccgttgtgaa
     4741 ttgcctggca aattgggtgc cctcctgggg ctggaggggt ctgggctcct aacccccatc
     4801 cctgctctcc ccactagaaa tgtgtcttca gtctgccagc tcttctgctc tacttccagt
     4861 gctgcatcct gcactcaagc ccagggctgc tggcgagtct atggggagga gtgcggatca
     4921 ggctcagcct cagcctcagc ctcagcctcc tctatggtcc tgtctcctgg cggttcacag
     4981 gtgcccatcc cccctttaac atttcacagt tcttggcttt ccaaaggcac cagctcatat
     5041 ggcatagcca ccccaaccct aatccttccc ccaaatatcc tgatttaaac ttgggcagac
     5101 ttagtctgat tcttgaaaac tctaccatct ccttcttgca gaaggcactg gttacactaa
     5161 aatgataaaa taattagtat ggggtacttt gctcccagtt acattccctc ttccctgaga
     5221 accccaggct aggcgagaga gggagaggga gagagaaaga gagagaggga gagagagaga
     5281 gagagaggga gagagaaaga gagagagaaa gaaaggaaga cagaggaaag aaaggaagac
     5341 agagagagga aggcagagag agagagggag aaagaaagac aggaaggcag agagagagag
     5401 agagagagaa aggaagacag agagagagag agaggaagag agagagagag aggaagagag
     5461 agagagagct catgagccag gatccctggg gaatttgaag tcagtgtgac cagggttctg
     5521 tggctctggg gtcagagctg ggacacagga cccagcagga gggccaccac cccttccttt
     5581 tggaaacagc tctggttcca agcagcaatc aggtaggagg atcggggctt tggctgatga
     5641 tgcacacaca agatgctgat ggtgtacggt gagatattgt gaacgcaaca actggagctg
     5701 tagttggcgt gtgtgagtgt gtacctgcgg ttctgtttag tggcgagaca aggtatgttt
     5761 cagtactgct ttcacggcaa ctgtgtaatg catatgctct ttctacacta gcggtttgct
     5821 cagttttgtc tgtccggtta agttggagaa agaaccaagt tgtgttgttc tctggagggg
     5881 gtgctgctgc ctctccttga gtagttctgt gacccccaat ccagctgttt tgtagagaat
     5941 ccttctagct tctggtatgc ctgctctcca gcagctggaa acagatcttc ctgcctgacc
     6001 aaagctcctt gtttcttgcg tggcatgttt gttcttcccg atccggtggc tgtcgtagcc
     6061 gagggcctgc ctgccacctt cctttatcat ttgccctgtt ggggttcagg gtgcatcctt
     6121 agcccaggac ctgctcttcc agcatcatgg gttttttcct aaagatctca acggctccct
     6181 tgggctccat aaaatatttc ttttttaaaa aagcagactc ctttcatgca ttgggatgaa
     6241 cggccctctt gtctgggtgc tgggctacag caaacaaatg tgtttgaatc ccagtattcc
     6301 agagattcct ggcggtgggc tgtctagaag aggcgaggct ggatctcacg gtttttaaac
     6361 tgtattttta cccctttggg acccatacct gtgccctgga gtctttcatg aggcacgtgg
     6421 gtcctctgca tcctcactct cccccctagc ccaggtgcag ccccgggagg ggtgccctga
     6481 ccccgcctta aacaaccaac tttcccaccg aatcccatcg gcgggcgggg ggggggggtt
     6541 tgggtgccaa gtgccctgga aacctattgt cttttggctc agccaaaaga aacattccct
     6601 ccttcctttc cttccgggct tgggggaaac cttcgtaaaa atcatagtta gggttaagtc
     6661 caagcagtga ggcctgacct gggctctgct ctccttgttg agacactaac aggcagttgg
     6721 gaggaaaatc tgcatttgac tccaccctct ttggggcaaa ggagaaacag gtgacccgag
     6781 ggggggcagg ccagaggagg gcgactcgtg cacagggacc cccacccttg gaccccgctg
     6841 tccttttcta gttgtttact tggtggtggc agccagtctg accttgtctg tggtctgact
     6901 gttcctaagt gtgtaacttt cagtattatc tgtgacagat ggttctgtgg tgaaaaaggt
     6961 ttattatatt ccttatggct gccttgtaca aaatccgtta gaaacgctaa tgtaagatat
     7021 cagatttcta acaagacaaa aacagcatta tggagttaaa agatttttac aactgggtct
     7081 tgattttgat gtgagctggt ttttagctct caaatgttgt cacttaaata aaaaccttct
     7141 ttgccttta
//
