LOCUS       NM_020845               7134 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens phosphatidylinositol transfer protein membrane
            associated 2 (PITPNM2), transcript variant 1, mRNA.
ACCESSION   NM_020845
VERSION     NM_020845.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7134)
  AUTHORS   Lescai,F., Als,T.D., Li,Q., Nyegaard,M., Andorsdottir,G.,
            Biskopsto,M., Hedemand,A., Fiorentino,A., O'Brien,N., Jarram,A.,
            Liang,J., Grove,J., Pallesen,J., Eickhardt,E., Mattheisen,M.,
            Bolund,L., Demontis,D., Wang,A.G., McQuillin,A., Mors,O., Wang,J.
            and Borglum,A.D.
  TITLE     Whole-exome sequencing of individuals from an isolated population
            implicates rare risk variants in bipolar disorder
  JOURNAL   Transl Psychiatry 7 (2), e1034 (2017)
   PUBMED   28195573
  REMARK    GeneRIF: PITPNM2 was associated with bipolar disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7134)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   3  (bases 1 to 7134)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (bases 1 to 7134)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   5  (bases 1 to 7134)
  AUTHORS   Ramsuran,V., Kulkarni,H., He,W., Mlisana,K., Wright,E.J.,
            Werner,L., Castiblanco,J., Dhanda,R., Le,T., Dolan,M.J., Guan,W.,
            Weiss,R.A., Clark,R.A., Karim,S.S., Ahuja,S.K. and Ndung'u,T.
  TITLE     Duffy-null-associated low neutrophil counts influence HIV-1
            susceptibility in high-risk South African black women
  JOURNAL   Clin Infect Dis 52 (10), 1248-1256 (2011)
   PUBMED   21507922
REFERENCE   6  (bases 1 to 7134)
  AUTHORS   Ocaka,L., Spalluto,C., Wilson,D.I., Hunt,D.M. and Halford,S.
  TITLE     Chromosomal localization, genomic organization and evolution of the
            genes encoding human phosphatidylinositol transfer protein
            membrane-associated (PITPNM) 1, 2 and 3
  JOURNAL   Cytogenet Genome Res 108 (4), 293-302 (2005)
   PUBMED   15627748
REFERENCE   7  (bases 1 to 7134)
  AUTHORS   Tomsig,J.L., Snyder,S.L. and Creutz,C.E.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
REFERENCE   8  (bases 1 to 7134)
  AUTHORS   Lev,S., Hernandez,J., Martinez,R., Chen,A., Plowman,G. and
            Schlessinger,J.
  TITLE     Identification of a novel family of targets of PYK2 related to
            Drosophila retinal degeneration B (rdgB) protein
  JOURNAL   Mol Cell Biol 19 (3), 2278-2288 (1999)
   PUBMED   10022914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073857.30 and AC026362.38.
            
            On Jun 23, 2020 this sequence version replaced NM_020845.2.
            
            Summary: PITPNM2 belongs to a family of membrane-associated
            phosphatidylinositol transfer domain-containing proteins that share
            homology with the Drosophila retinal degeneration B (rdgB) protein
            (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar
            2008].
            
            ##Evidence-Data-START##
            CDS exon combination :: AF334585.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320201.10/ ENSP00000322218.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AC073857.30        86423-86760
            339-442             AC073857.30        127025-127128
            443-615             AC026362.38        106889-107061       c
            616-830             AC026362.38        86204-86418         c
            831-952             AC026362.38        84989-85110         c
            953-1180            AC026362.38        82226-82453         c
            1181-1489           AC026362.38        77616-77924         c
            1490-1585           AC026362.38        76770-76865         c
            1586-1690           AC026362.38        73430-73534         c
            1691-1761           AC026362.38        73154-73224         c
            1762-2009           AC026362.38        69701-69948         c
            2010-2199           AC026362.38        69097-69286         c
            2200-2319           AC026362.38        68834-68953         c
            2320-2591           AC026362.38        67765-68036         c
            2592-2770           AC026362.38        67177-67355         c
            2771-2941           AC026362.38        64875-65045         c
            2942-3106           AC026362.38        62921-63085         c
            3107-3268           AC026362.38        62163-62324         c
            3269-3417           AC026362.38        61100-61248         c
            3418-3534           AC026362.38        60610-60726         c
            3535-3651           AC026362.38        60161-60277         c
            3652-3800           AC026362.38        59887-60035         c
            3801-3950           AC026362.38        59657-59806         c
            3951-4134           AC026362.38        59022-59205         c
            4135-4263           AC026362.38        58812-58940         c
            4264-7134           AC026362.38        55856-58726         c
FEATURES             Location/Qualifiers
     source          1..7134
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..7134
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /note="phosphatidylinositol transfer protein membrane
                     associated 2"
                     /db_xref="GeneID:57605"
                     /db_xref="HGNC:HGNC:21044"
                     /db_xref="MIM:608920"
     exon            1..338
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            339..442
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            443..615
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             538..4587
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /note="isoform 1 is encoded by transcript variant 1; PYK2
                     N-terminal domain-interacting receptor 3;
                     membrane-associated phosphatidylinositol transfer protein
                     2; retinal degeneration B alpha 2"
                     /codon_start=1
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 2 isoform 1"
                     /protein_id="NP_065896.1"
                     /db_xref="CCDS:CCDS9242.1"
                     /db_xref="GeneID:57605"
                     /db_xref="HGNC:HGNC:21044"
                     /db_xref="MIM:608920"
                     /translation="MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGEGSGVEILE
                     NRPYTDGPGGSGQYTHKVYHVGMHIPSWFRSILPKAALRVVEESWNAYPYTRTRFTCP
                     FVEKFSIDIETFYKTDAGENPDVFNLSPVEKNQLTIDFIDIVKDPVPHNEYKTEEDPK
                     LFQSTKTQRGPLSENWIEEYKKQVFPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRR
                     VMVRAHRQAWCWQDEWYGLSMENIRELEKEAQLMLSRKMAQFNEDGEEATELVKHEAV
                     SDQTSGEPPEPSSSNGEPLVGRGLKKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIA
                     RDSDESSDDEFFDAHEDLSDTEEMFPKDITKWSSNDLMDKIESPEPEDTQDGLYRQGA
                     PEFRVASSVEQLNIIEDEVSQPLAAPPSKIHVLLLVLHGGTILDTGAGDPSSKKGDAN
                     TIANVFDTVMRVHYPSALGRLAIRLVPCPPVCSDAFALVSNLSPYSHDEGCLSSSQDH
                     IPLAALPLLATSSPQYQEAVATVIQRANLAYGDFIKSQEGMTFNGQVCLIGDCVGGIL
                     AFDALCYSNQPVSESQSSSRRGSVVSMQDNDLLSPGILMNAAHCCGGGGGGGGGGGSS
                     GGGGSSGGSSLESSRHLSRSNVDIPRSNGTEDPKRQLPRKRSDSSTYELDTIQQHQAF
                     LSSLHASVLRTEPCSRHSSSSTMLDGTGALGRFDFEITDLFLFGCPLGLVLALRKTVI
                     PALDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCS
                     TLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQ
                     KAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAK
                     WWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILEL
                     DGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLD
                     MVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVR
                     GDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYL
                     IIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRV
                     HAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRAR
                     PARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQR
                     GQRSMSVAAGCWGRAMTGRLEPGAAAGPK"
     exon            616..830
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..952
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1180
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1489
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1585
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1690
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1761
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..2009
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2199
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2319
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2591
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2770
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2941
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3106
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3268
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3417
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..3534
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3651
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3652..3800
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3801..3950
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4134
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4135..4263
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4264..7134
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6157..6162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /note="hexamer: TATAAA"
     polyA_site      6181
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
     regulatory      7113..7118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /note="hexamer: ATTAAA"
     polyA_site      7134
                     /gene="PITPNM2"
                     /gene_synonym="NIR-3; NIR3; RDGB2; RDGBA2"
                     /note="major polyA site"
ORIGIN      
        1 agcagcggcc gctggggtgc gcggggcacc gcggcgccgc ggcgtagagc tgtccagccg
       61 gccccggccg cccgcccggc gcttccttct cagctcgcgg ccgcctcagc gagagccgcc
      121 cgccagcacg tgcgccgccg ccgcccgcct gcgacgctcg ggagcaatgc ccgccggggc
      181 tctgccgctc gcccggggcc agcaggcggc gggggcgcgc ggggcgcagc cggccgggcc
      241 ggggccgcgg ggcgggcgct ccccgtgagg cggcgtgagg tggcggcggc ccagccgggg
      301 ccccgaagag gacagagccc gcggccgcgc cgagcgggga tgctggcacg tgtgtcctgg
      361 tcctcaacaa ccttctgtga gcctagggac ccatttctcc tcctttgaca gggacatcag
      421 tggagccttc tcagacccac aggggtcctt ggtgaatttt gtcatggtta tttaaggaac
      481 cttgcctaga agtcccaact tgcagttccc catcgacggg aaggcttgga ctccaagatg
      541 attataaagg aatatcggat tcctctgcca atgaccgtgg aggagtaccg catcgcccag
      601 ctgtacatga tacagaagaa gagccgtaac gagacatatg gcgaaggcag cggcgtggag
      661 atcctggaga accggccgta cacagatggc ccaggcggct ctgggcagta cacacacaag
      721 gtgtatcatg tgggcatgca cattcccagc tggttccgct ccatcctgcc caaggcagcc
      781 ctgcgggtgg tggaggagtc ttggaatgcc tacccctaca cccgaaccag gttcacctgt
      841 cctttcgtgg agaaattctc catcgacatt gaaacctttt ataaaactga tgctggagaa
      901 aaccccgacg tgttcaacct ctctcctgtg gaaaagaacc agctgacaat cgacttcatc
      961 gacattgtca aagaccctgt gccccacaac gagtataaga cagaagagga ccccaagctg
     1021 ttccagtcaa ccaagaccca gcgggggccc ctgtccgaga actggatcga ggagtacaag
     1081 aagcaggtct tccccatcat gtgcgcatac aagctctgca aggtggagtt ccgctactgg
     1141 ggcatgcagt ccaagatcga gaggttcatc cacgacaccg gactacggag ggtgatggtg
     1201 cgggctcacc ggcaggcctg gtgctggcag gacgagtggt atgggctgag catggagaac
     1261 atccgggagc tggagaagga ggcacagctc atgctttccc gtaagatggc ccagttcaat
     1321 gaggatggtg aggaggccac tgagctcgtc aagcacgaag ccgtctcgga ccagacctct
     1381 ggggagcccc cggagcccag cagcagcaat ggggagcccc tagtggggcg cggcctcaag
     1441 aaacagtggt ccacatcctc caagtcgtct cggtcgtcca agcggggagc gagtccttcc
     1501 cgccacagca tctcagagtg gaggatgcag agtattgcca gggactcgga tgagagctca
     1561 gatgatgagt tcttcgatgc gcacgaggac ctgtccgaca cagaggaaat gttccccaag
     1621 gacatcacca agtggagctc caatgacctc atggacaaga tcgagagccc agagccggaa
     1681 gacacacaag atggtctgta ccgccagggt gcccctgagt tcagggtggc ctccagtgtg
     1741 gagcagctga acatcataga ggacgaggtt agccagccgc tggctgcacc gccctccaag
     1801 atccacgtgc tgctactggt gctgcacgga ggcaccatcc tggacacagg cgccggggac
     1861 cccagctcca agaagggcga tgctaacacc atcgccaacg tgttcgacac cgtcatgcgc
     1921 gtgcactacc ccagcgccct gggccgcctt gccatccgcc tggtgccctg cccgcccgtc
     1981 tgctctgacg cctttgccct ggtctccaac ctcagcccct acagccatga cgaaggctgt
     2041 ctgtccagca gtcaggacca cattcccctg gctgccctcc ccctgctggc cacctcctcc
     2101 ccccagtacc aggaggcagt tgccacagtg attcagcgag ccaaccttgc ctatggggac
     2161 ttcatcaagt cccaggaggg catgaccttc aatgggcagg tctgcctgat tggggactgc
     2221 gtcgggggca tcctggcatt tgatgccctg tgctacagta accagccggt gtctgagagt
     2281 cagagcagca gccgccgggg cagcgtggtc agcatgcagg acaatgacct gctgtccccg
     2341 ggcatcctga tgaatgcagc acactgctgc ggtggtggcg gtggcggcgg tggcggtggt
     2401 ggcagcagtg gtggtggtgg cagtagtggt ggctccagcc tggagagcag tcggcacctg
     2461 agccgaagca acgtcgacat cccccgcagc aacggcactg aggaccccaa aaggcaactg
     2521 ccccgcaaga ggagcgactc atccacctac gagctggata ccatccagca gcaccaggcc
     2581 ttcctgtcca gcctccatgc cagcgtgctg aggactgagc cctgctcacg ccattccagc
     2641 agctccacca tgctggatgg cacaggtgcc ctgggcaggt ttgactttga gatcaccgac
     2701 ctcttcctct tcgggtgccc gctggggctg gtcctggcct tgaggaagac tgtcatccca
     2761 gccctggatg ttttccagct gcggccggcc tgccagcaag tctacaacct cttccacccc
     2821 gcggacccgt cagcttcacg cctggagccg ctgctggaac ggcgctttca cgccctgccg
     2881 cctttcagcg tcccccgcta ccaacgctac ccgctggggg atggctgctc cacgctgctg
     2941 gcggatgtgc tccagaccca caatgcagcc ttccaagagc atggcgcccc ctcctcgccg
     3001 ggcactgccc ctgccagtcg tggcttccgc cgagccagtg agatcagcat cgccagccag
     3061 gtgtcaggca tggctgagag ctacacggca tccagcatcg cccagaaggc ccccgatgcg
     3121 ctcagccata cccccagcgt caggcgtctg tccctgctcg ccctgcccgc ccccagcccc
     3181 accacccctg gcccccaccc tccagccagg aaggcaagcc ctggcctgga gagggcccct
     3241 ggcctccctg agctggacat tggagaagtc gctgcaaagt ggtggggcca gaagcggatc
     3301 gactacgccc tgtactgccc tgacgccctc acggccttcc ccacggtggc tctgcctcac
     3361 ctcttccacg ccagctactg ggagtcaaca gacgtggtct cctttctgct gagacaggtc
     3421 atgaggcatg acaactccag catcttggag ctggatggca aggaagtgtc ggtgttcacc
     3481 ccctcaaagc caagggagaa gtggcagcgc aagcggaccc acgtgaagct gcggaacgtg
     3541 acggccaacc accggatcaa tgatgccctt gccaatgagg acggccccca ggttctgacg
     3601 ggcaggttca tgtatgggcc cctggacatg gtcaccctga ctggggagaa ggtggatgtg
     3661 cacatcatga cccagccgcc ctcaggcgag tggctctacc tggatacgct ggtgaccaac
     3721 aacagtgggc gtgtctccta caccatccct gagtcgcacc gcctgggcgt gggtgtctac
     3781 cctatcaaga tggtggtcag gggagaccac acgtttgccg acagctacat caccgtgctg
     3841 cccaagggca cagagttcgt ggtcttcagc atcgacggtt cctttgccgc tagcgtgtcc
     3901 atcatgggca gcgaccccaa ggtgcgggcc ggggccgtgg acgtggtgcg gcactggcag
     3961 gacctgggct acctcatcat ctacgtgacg ggccggcccg acatgcagaa gcagcgggtg
     4021 gtggcgtggc tggcccagca caacttcccc catggcgtgg tgtccttctg tgacggcctg
     4081 gtgcatgacc cgctgcggca caaggccaac ttcctgaagc tgctcatctc cgagctgcac
     4141 ctgcgcgtgc acgcggccta tggctccacc aaggacgtgg cggtgtacag cgccattagc
     4201 ctgtccccca tgcagatcta catcgtgggc cggcccacca agaagctgca gcagcagtgc
     4261 cagttcatca cggatggcta cgcggcccac ctggcgcagc tgaagtacag ccaccgggcg
     4321 cggcccgctc gcaacacggc cacccgcatg gcgctgcgca agggcagctt cggcctgccc
     4381 ggccagggcg actttctgcg ctcccggaac cacctgcttc gcaccatctc ggcccagccc
     4441 agcgggccca gccaccggca cgagcggaca cagagccagg cggatggcga gcagcggggc
     4501 cagcgcagca tgagtgtggc ggccggctgc tggggccgcg ccatgactgg ccgcctggag
     4561 ccgggggcag ccgcgggccc caagtagggc accgtgagtg cagcgcgggg tctccatggt
     4621 gctaggccag ggtggccagc cccgccagga ggcctggcct gggcacacgc actgacgtgg
     4681 gcctgggaga ttgtcccagg gccttgtgga ggacacgggc cgcaccacac agtgctccct
     4741 gccctgcctc acgtcctcgg gcctgacggg tccggcttgt catggaagct ggcagggacc
     4801 accagcccca ggatggcaga gggaccagaa cctcccactc agactggccc gggaggttct
     4861 cccagacatt ttgccctgtg tggatctcca agtgtcctgg tgccaggtgt gggcccaggc
     4921 gcagcctgcc acctccccat ccactggcca ccctcactcc caggtcccct cccatttggt
     4981 agcagctcca acaggggtcc agcctgcatc ttgttaactc gagtttctca actgttcaac
     5041 ctcactggtt ttgcactgat ttttgagagc ggagacccat taccacctcc tatggctaca
     5101 gccccgttga catgcatgaa actcagtacc tgctgaccca ggacctacaa ccacactgaa
     5161 ggctccagtg cggcagagcc tcgtgcaagc aggagagaaa ggctgtatct taatttctgc
     5221 accccggacc ctgcccacct gtctgcctgc cccgcctgga gcccaggcca gtgttgtttc
     5281 cagcctcagg ccacgggctg gacgggcctg gccgcctctt ccgctccctg ccatcagtca
     5341 aggccgcccg cccacgtttc tacgcctttc tacttctcaa tctgatttct atgaggtttt
     5401 tttaaacgag caatccttgg ctgcttcctt ttcttaactc tttcagtact gagagcagcc
     5461 cctccacact gaaaacaccc agcactgtga cggagtccag cctggttctg ggtcccgtgg
     5521 gccctgctcc tgcccactta gcgaggcatg ggctccttgc ctcacctggc cccggcaatc
     5581 ccactgaatt tctactctgg ggtgggtggg gcacacactt cggttttttt aatgccaatt
     5641 ccgttttcat gccgaatcta agaagccaca acttgctttg tcagcttcag ggcaggcagc
     5701 catgacttca tttctcgcct gaacaaggac catgctgtcc tgcacgctgg gtctgaccgt
     5761 ctgccctctc tccccagcac caagcgtgac cttggctgtg gcgctcaacg gccagctccg
     5821 gcggcccctc tgctgctcct cggctttccc ggaagtggga gagcctgcct ggcctcggcc
     5881 tttgtccagc gaccaggctc tgtccccgag aagctacggc cgacctgggt ctggtgttgg
     5941 gacgcatgga ccgggctggg gaggtgcaca gagtgatgtt aactttttcc cgtgtgtaga
     6001 tatgtacagc caaagggtcg tgtaaatgtt ctgcaaaagt gggtctatac agagtgaaag
     6061 ctatttattt tgtgcagaga aaaaagtctg gagggatgga accttcaggg tttattcata
     6121 tttaagatgt agctttttgt tgtttcaggc attatgtata aagcaacgat tattttatgg
     6181 accaagtttt catgtaactg ttgcagtgaa agtgcaatat ctgacccccc tgctcccagc
     6241 aggaagttgc ttggcccgac aatcacagcc cctgtcaggg gccctgtggc cagtgcctcc
     6301 tcctctcttg gccccacctt atcctgtctt gcctgctgcc tgggagacca gccatccaga
     6361 gaagcacctg gaagagtctc gggccctcct gcaataaagg ccgggaggcc ctgtgggcag
     6421 tgggctcagc ctctccccag gggggcagct cccccacggc tcctcactcc ccgcctgcct
     6481 gcccagccgc cagccatgcc aaggacaaca gcaatagtcc cctggggctc tcccagcggc
     6541 cctcagccat agatggcaag gtgggcagcc tgccccccca tgggaagtct cttctgtatc
     6601 caggtctgct ttccacctcc cttcagattc cttttggcac attctcctct tgaggaagta
     6661 ccagtctttc tgaaactaag agagggaggg cagcgtcctt taaaaatacc aaaaatgttt
     6721 acagagttgg gtgctgagct gcagggctca ggcctgacca gtcataacca aagggtgagg
     6781 caggccttgc tgactgccac cccccaggcc tgttagaata gaagccttag tcccactccc
     6841 accacacccc cacgccccac cacctgcctt ctctttgatt tctaaagagg gattcagcag
     6901 agacccccca cccctccctg gctcggtctg agtcccactg cccaccccat cacagccttc
     6961 acgtctcagc ccctcccgtc tggtctgtcc gtgtgccgtc tgtttctctg ggccatgtgt
     7021 gagcagtgtc cccatctccc catccgtccc tgctgtcccc gcatcattgg gcctgagtgt
     7081 gctctgtata caacgtcatg tctgttacac caattaaaga agcgggaagg cttc
//
