LOCUS       NM_004910               4217 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens phosphatidylinositol transfer protein membrane
            associated 1 (PITPNM1), transcript variant 1, mRNA.
ACCESSION   NM_004910
VERSION     NM_004910.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4217)
  AUTHORS   Liu,Z., Shi,Y., Lin,Q., Yang,W., Luo,Q., Cen,Y., Li,J., Fang,X.,
            Jiang,W.G. and Gong,C.
  TITLE     Attenuation of PITPNM1 Signaling Cascade Can Inhibit Breast Cancer
            Progression
  JOURNAL   Biomolecules 11 (9), 1265 (2021)
   PUBMED   34572478
  REMARK    GeneRIF: Attenuation of PITPNM1 Signaling Cascade Can Inhibit
            Breast Cancer Progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4217)
  AUTHORS   Wang,H. and Tai,A.W.
  TITLE     Nir2 Is an Effector of VAPs Necessary for Efficient Hepatitis C
            Virus Replication and Phosphatidylinositol 4-Phosphate Enrichment
            at the Viral Replication Organelle
  JOURNAL   J Virol 93 (22), e00742-19 (2019)
   PUBMED   31484747
  REMARK    GeneRIF: Authors found that the phosphatidylinositol transfer
            protein Nir2 acts as an LTP and may replenish PI at the HCV RO by
            interacting with VAMP-associated proteins (VAPs), enabling
            continuous viral replication during chronic infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4217)
  AUTHORS   Chang,C.L. and Liou,J.
  TITLE     Phosphatidylinositol 4,5-Bisphosphate Homeostasis Regulated by Nir2
            and Nir3 Proteins at Endoplasmic Reticulum-Plasma Membrane
            Junctions
  JOURNAL   J Biol Chem 290 (23), 14289-14301 (2015)
   PUBMED   25887399
  REMARK    GeneRIF: Phosphatidic acid production triggers Phosphatidylinositol
            4,5-Bisphosphate replenishment mediated by Nir2 and Nir3 at
            endoplasmic reticulum-plasma membrane junctions.
REFERENCE   4  (bases 1 to 4217)
  AUTHORS   Keinan,O., Kedan,A., Gavert,N., Selitrennik,M., Kim,S., Karn,T.,
            Becker,S. and Lev,S.
  TITLE     The lipid-transfer protein Nir2 enhances epithelial-mesenchymal
            transition and facilitates breast cancer metastasis
  JOURNAL   J Cell Sci 127 (Pt 21), 4740-4749 (2014)
   PUBMED   25179602
  REMARK    GeneRIF: results suggest that Nir2 not only enhances EMT in vitro
            and breast cancer metastasis in animal models, but also contributes
            to breast cancer progression in human patients.
            Erratum:[J Cell Sci. 2019 Mar 7;132(5):jcs227868. doi:
            10.1242/jcs.227868.. PMID: 30846603]
REFERENCE   5  (bases 1 to 4217)
  AUTHORS   Chang,C.L., Hsieh,T.S., Yang,T.T., Rothberg,K.G., Azizoglu,D.B.,
            Volk,E., Liao,J.C. and Liou,J.
  TITLE     Feedback regulation of receptor-induced Ca2+ signaling mediated by
            E-Syt1 and Nir2 at endoplasmic reticulum-plasma membrane junctions
  JOURNAL   Cell Rep 5 (3), 813-825 (2013)
   PUBMED   24183667
  REMARK    GeneRIF: Results suggest a feedback mechanism that replenishes PM
            PIP2 during receptor-induced Ca(2+) signaling via the Ca(2+)
            effector E-Syt1 and the PITP Nir2 at ER-PM junctions.
REFERENCE   6  (bases 1 to 4217)
  AUTHORS   Fullwood,Y., dos Santos,M. and Hsuan,J.J.
  TITLE     Cloning and characterization of a novel human phosphatidylinositol
            transfer protein, rdgBbeta
  JOURNAL   J Biol Chem 274 (44), 31553-31558 (1999)
   PUBMED   10531358
REFERENCE   7  (bases 1 to 4217)
  AUTHORS   Lev,S., Hernandez,J., Martinez,R., Chen,A., Plowman,G. and
            Schlessinger,J.
  TITLE     Identification of a novel family of targets of PYK2 related to
            Drosophila retinal degeneration B (rdgB) protein
  JOURNAL   Mol Cell Biol 19 (3), 2278-2288 (1999)
   PUBMED   10022914
REFERENCE   8  (bases 1 to 4217)
  AUTHORS   Aikawa,Y., Hara,H. and Watanabe,T.
  TITLE     Molecular cloning and characterization of mammalian homologues of
            the Drosophila retinal degeneration B gene
  JOURNAL   Biochem Biophys Res Commun 236 (3), 559-564 (1997)
   PUBMED   9245688
REFERENCE   9  (bases 1 to 4217)
  AUTHORS   Rubboli,F., Bulfone,A., Bogni,S., Marchitiello,A., Zollo,M.,
            Borsani,G., Ballabio,A. and Banfi,S.
  TITLE     A mammalian homologue of the Drosophila retinal degeneration B
            gene: implications for the evolution of phototransduction
            mechanisms
  JOURNAL   Genes Funct 1 (3), 205-213 (1997)
   PUBMED   9680295
REFERENCE   10 (bases 1 to 4217)
  AUTHORS   Vihtelic,T.S., Hyde,D.R. and O'Tousa,J.E.
  TITLE     Isolation and characterization of the Drosophila retinal
            degeneration B (rdgB) gene
  JOURNAL   Genetics 127 (4), 761-768 (1991)
   PUBMED   1903119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA318858.1, AF334584.1, AA465501.1, AK312886.1 and X98654.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004910.2.
            
            Summary: PITPNM1 belongs to a family of membrane-associated
            phosphatidylinositol transfer domain-containing proteins that share
            homology with the Drosophila retinal degeneration B (rdgB) protein
            (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF334584.1, SRR1660805.203889.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356404.8/ ENSP00000348772.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                DA318858.1         10-53
            45-2415             AF334584.1         1-2371
            2416-2454           AA465501.1         33-71
            2455-3952           AK312886.1         2242-3739
            3953-4217           X98654.1           3925-4189
FEATURES             Location/Qualifiers
     source          1..4217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..4217
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /note="phosphatidylinositol transfer protein membrane
                     associated 1"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
     exon            1..176
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            177..295
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..3952
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /note="isoform a is encoded by transcript variant 1; PYK2
                     N-terminal domain-interacting receptor 2;
                     membrane-associated phosphatidylinositol transfer protein
                     1; NIR-2; PITPnm 1; drosophila retinal degeneration B
                     homolog; retinal degeneration B alpha 1"
                     /codon_start=1
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform a"
                     /protein_id="NP_004901.2"
                     /db_xref="CCDS:CCDS31620.1"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
                     /translation="MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILA
                     NRPYTDGPGGSGQYTHKVYHVGSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCP
                     FVEKFSIEIETYYLPDGGQQPNVFNLSGAERRQRILDTIDIVRDAVAPGEYKAEEDPR
                     LYHSVKTGRGPLSDDWARTAAQTGPLMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRV
                     MLRAHRQAWCWQDEWTELSMADIRALEEETARMLAQRMAKCNTGSEGSEAQPPGKPST
                     EARSAASNTGTPDGPEAPPGPDASPDASFGKQWSSSSRSSYSSQHGGAVSPQSLSEWR
                     MQNIARDSENSSEEEFFDAHEGFSDSEEVFPKEMTKWNSNDFIDAFASPVEAEGTPEP
                     GAEAAKGIEDGAQAPRDSEGLDGAGELGAEACAVHALFLILHSGNILDSGPGDANSKQ
                     ADVQTLSSAFEAVTRIHFPEALGHVALRLVPCPPICAAAYALVSNLSPYSHDGDSLSR
                     SQDHIPLAALPLLATSSSRYQGAVATVIARTNQAYSAFLRSPEGAGFCGQVALIGDGV
                     GGILGFDALCHSANAGTGSRGSSRRGSMNNELLSPEFGPVRDPLADGVEGLGRGSPEP
                     SALPPQRIPSDMASPEPEGSQNSLQAAPATTSSWEPRRASTAFCPPAASSEAPDGPSS
                     TARLDFKVSGFFLFGSPLGLVLALRKTVMPALEAAQMRPACEQIYNLFHAADPCASRL
                     EPLLAPKFQAIAPLTVPRYQKFPLGDGSSLLLADTLQTHSSLFLEELEMLVPSTPTST
                     SGAFWKGSELATDPPAQPAAPSTTSEVVKILERWWGTKRIDYSLYCPEALTAFPTVTL
                     PHLFHASYWESADVVAFILRQVIEKERPQLAECEEPSIYSPAFPREKWQRKRTQVKIR
                     NVTSNHRASDTVVCEGRPQVLSGRFMYGPLDVVTLTGEKVDVYIMTQPLSGKWIHFGT
                     EVTNSSGRLTFPVPPERALGIGVYPVRMVVRGDHTYAECCLTVVARGTEAVVFSIDGS
                     FTASVSIMGSDPKVRAGAVDVVRHWQDSGYLIVYVTGRPDMQKHRVVAWLSQHNFPHG
                     VVSFCDGLTHDPLRQKAMFLQSLVQEVELNIVAGYGSPKDVAVYAALGLSPSQTYIVG
                     RAVRKLQAQCQFLSDGYVAHLGQLEAGSHSHASSGPPRAALGKSSYGVAAPVDFLRKQ
                     SQLLRSRGPSQAEREGPGTPPTTLARGKARSISLKLDSEE"
     exon            296..510
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..632
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..857
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1184
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1280
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1388
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1450
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1701
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1891
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1999
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2157
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2363
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2534
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2699
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2848
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2959
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3076
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3225
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3375
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3559
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3688
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3689..4217
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4196..4201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /note="hexamer: AATAAA"
     polyA_site      4217
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /note="major polyA site"
ORIGIN      
        1 aggggcgccg gcgggcggat cgagaggaag gtcggggcca tgggccggca ctgcgcctcg
       61 ggagggtccg gccaccgctg gaacccgagg ccggggctgg gggcgctccg ggctccgacc
      121 cacgggccgg ccggccctgc ccgggctggg tgaggggcgc ccgcctcaag ctagaggagg
      181 agcggaggcc gcgcgcggcc cgccgagcgc cttcaggatg ctcatcaagg aataccacat
      241 tctgctgccc atgagcctgg acgagtacca ggtggcccag ctctacatga tccagaaaaa
      301 gagccgggag gagtctagtg gtgagggcag cggcgtggag atcctggcca accggcccta
      361 cacggatggg cccgggggca gcgggcaata cacacacaag gtgtaccacg tgggctccca
      421 catcccaggc tggttccggg cactgctgcc caaggctgcc ctgcaggtag aagaggaatc
      481 ctggaatgcc tacccctaca cccgaacccg gtacacctgc cctttcgtgg agaaattctc
      541 cattgaaatt gagacctatt acctgcctga tggggggcag cagccaaacg tcttcaacct
      601 gagcggggcc gagaggagac agcgcatcct ggacaccatc gacatcgtgc gggatgcagt
      661 ggccccaggc gagtacaaag cagaagagga cccccggctt tatcactcgg tcaagacggg
      721 ccgagggcca ctgtctgatg actgggcacg gacggcggca cagacggggc cccttatgtg
      781 tgcctataag ctgtgcaagg ttgagttccg ctactggggc atgcaagcca agatcgagca
      841 gttcatccat gatgtaggtc tgcgtcgggt gatgctgcgg gcccaccgcc aggcctggtg
      901 ctggcaggat gagtggacag agctgagcat ggctgacatc cgggcactgg aagaggagac
      961 tgctcgcatg ctggcccagc gcatggccaa gtgcaacaca ggcagtgagg ggtccgaggc
     1021 ccagcccccc gggaaaccga gcaccgaggc ccggtctgcg gccagcaaca ctggcacccc
     1081 cgatgggcct gaggcccccc caggcccaga tgcctccccc gatgccagct ttgggaagca
     1141 gtggtcctca tcctcccgtt cctcctactc atcccaacat ggaggggctg tgtctcccca
     1201 gagcttgtct gagtggcgca tgcagaacat tgcccgagac tctgagaaca gctccgagga
     1261 agagttcttt gatgcccacg aaggcttctc ggacagtgag gaggtcttcc ccaaggagat
     1321 gaccaagtgg aactccaatg acttcattga tgcctttgcc tccccagtgg aggcagaggg
     1381 aacgccagag cctggagccg aggcagctaa aggcattgag gatggggccc aagcacccag
     1441 ggactcagag ggcctggatg gagccgggga gctgggggct gaggcatgcg cagtccacgc
     1501 cctcttcctt atcctgcaca gcggcaacat cctggactca ggccctggag acgccaactc
     1561 caagcaggcg gatgtgcaga cgctgagctc cgccttcgag gccgtcaccc gcatccactt
     1621 ccctgaggcc ttgggccacg tggcgctgcg actggtgccc tgtccaccca tctgcgccgc
     1681 cgcctatgcc cttgtctcca acctgagccc ttacagccac gatggggaca gcctgtctcg
     1741 ctcccaagac cacattccac tggctgccct gccactgctg gccacctcat cctcccgcta
     1801 ccagggcgcc gtggccaccg tcattgcccg caccaaccag gcctactcag ccttcctgcg
     1861 ctcacctgag ggtgccggct tctgtgggca ggtcgcactg attggagatg gtgttggtgg
     1921 catcctgggc tttgatgcac tctgccacag tgctaacgcg ggcaccggga gtcggggcag
     1981 cagccgccgt gggagcatga acaatgagct gctctctccg gagtttggcc cagtgcggga
     2041 ccccctggca gatggtgtgg aaggcctggg tcggggcagc ccagaaccct cggccttgcc
     2101 tccccagcgc atccccagcg acatggccag tcctgagccc gagggctctc agaacagcct
     2161 tcaggcagcc cccgcaacca cctcctcctg ggagccccgg cgggcaagca cggccttctg
     2221 cccacccgct gccagttccg aggcacctga cggccccagc agcactgccc gccttgactt
     2281 caaggtctct ggcttcttcc tcttcggctc cccactgggc ctggtgctgg ctctgcgcaa
     2341 aactgtgatg cccgccctgg aggcagccca gatgcgccca gcctgtgaac agatctacaa
     2401 cctcttccac gcggctgacc cctgcgcctc acgcctcgag cccctgctgg ccccgaagtt
     2461 ccaggccatc gccccactga ccgtgccccg ctaccagaag ttccccctgg gagatggctc
     2521 atccctgctg ctggccgaca ctctgcagac gcactccagc ctctttctgg aggagctgga
     2581 gatgctggtg ccctcaacac ccacctctac tagcggtgcc ttctggaagg gcagtgagtt
     2641 ggccactgac cccccggccc agccagccgc ccccagcacc accagtgagg tggttaagat
     2701 cctggagcgc tggtggggga ccaagcggat cgactactcg ctgtactgcc ccgaggcgct
     2761 caccgccttt cccaccgtca cgctgcccca cctcttccac gccagctact gggagtccgc
     2821 cgacgtggtg gcgttcatcc tgcgccaggt gatcgagaag gagcggccac agctggcgga
     2881 atgcgaggag ccgtccatct acagcccggc cttccccagg gagaagtggc agcgaaaacg
     2941 cacgcaggtc aagatccgga acgtcacttc caaccaccgg gcgagcgaca cggtggtgtg
     3001 cgagggccgc ccccaggtgc taagcgggcg cttcatgtac gggcccctgg acgtcgtcac
     3061 gctcactgga gagaaggtgg atgtctacat catgacgcag ccgctgtcgg gcaagtggat
     3121 ccactttggc accgaagtca ccaatagctc gggccgcctc accttcccag ttcccccaga
     3181 acgcgcgctg ggcattggtg tctaccccgt gcgcatggtg gtcaggggcg accacaccta
     3241 tgccgaatgc tgcctgactg tggtggcccg cggcacggag gctgtggtct tcagcatcga
     3301 cggctccttc accgccagcg tctccatcat gggcagcgac cccaaggtgc gagctggcgc
     3361 cgtggacgtg gtcaggcact ggcaggactc cggctacctg atcgtgtatg tcacaggccg
     3421 gccggatatg cagaagcacc gcgtggtggc atggctgtcg cagcacaact tcccccacgg
     3481 cgtcgtctcc ttctgcgacg gcctcaccca cgacccacta cgccagaagg caatgtttct
     3541 gcagagcctg gtgcaggagg tagaactgaa catcgtggcc ggttatgggt ctcccaaaga
     3601 tgtggctgta tacgcggcgc tggggctgtc cccgagccag acctacatcg tgggccgtgc
     3661 cgtgcggaag ctacaggcgc agtgccagtt cctgtcagac ggctatgtgg cccacctggg
     3721 ccagctggaa gcgggctcgc actcgcatgc ctcctcggga cccccgagag ctgccttggg
     3781 caagagcagc tatggtgtgg ctgcccccgt ggacttcctg cgcaaacaga gccagctgct
     3841 tcgctcgagg ggccccagcc aggcggagcg tgagggcccg ggaacaccac ccaccaccct
     3901 ggcacggggc aaagcacgga gcatcagcct gaagctggac agcgaggagt gaggcccaca
     3961 ccagcctgga cctgggttat ttattgacac acccaagggg cccgaggggc tgcgtgtggg
     4021 aggctgggga cccagacttt tggccccagc gctggccccc ccagccccac accctatatc
     4081 tccgtgtgct cctcggtgtt acttcccttt catatgaggg gacccagcgc cggggggagg
     4141 gaggagggcg tgggcatggg cgcagaggct tttccagtgt gtataaatcc atgaaaataa
     4201 acgccacctg cacccca
//
