LOCUS       NM_012417               6241 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens phosphatidylinositol transfer protein cytoplasmic 1
            (PITPNC1), transcript variant 1, mRNA.
ACCESSION   NM_012417
VERSION     NM_012417.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6241)
  AUTHORS   Liang,J., Liao,L., Xie,L., Tang,W., Yu,X., Lu,Y., Chen,H., Xu,J.,
            Sun,L., Wu,H., Cui,C. and Tan,Y.
  TITLE     PITPNC1 Suppress CD8+ T cell immune function and promote
            radioresistance in rectal cancer by modulating FASN/CD155
  JOURNAL   J Transl Med 22 (1), 117 (2024)
   PUBMED   38291470
  REMARK    GeneRIF: PITPNC1 Suppress CD8[+] T cell immune function and promote
            radioresistance in rectal cancer by modulating FASN/CD155.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6241)
  AUTHORS   Entrialgo-Cadierno,R., Cueto-Urena,C., Welch,C., Feliu,I.,
            Macaya,I., Vera,L., Morales,X., Michelina,S.V., Scaparone,P.,
            Lopez,I., Darbo,E., Erice,O., Vallejo,A., Moreno,H.,
            Goni-Salaverri,A., Lara-Astiaso,D., Halberg,N.,
            Cortes-Dominguez,I., Guruceaga,E., Ambrogio,C., Lecanda,F. and
            Vicent,S.
  TITLE     The phospholipid transporter PITPNC1 links KRAS to MYC to prevent
            autophagy in lung and pancreatic cancer
  JOURNAL   Mol Cancer 22 (1), 86 (2023)
   PUBMED   37210549
  REMARK    GeneRIF: The phospholipid transporter PITPNC1 links KRAS to MYC to
            prevent autophagy in lung and pancreatic cancer.
            Erratum:[Mol Cancer. 2023 Jun 16;22(1):97. doi:
            10.1186/s12943-023-01795-x.. PMID: 37328838]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6241)
  AUTHORS   Kuo,F.C., Huang,Y.C., Yen,M.R., Lee,C.H., Hsu,K.F., Yang,H.Y.,
            Wu,L.W., Lu,C.H., Hsu,Y.J. and Chen,P.Y.
  TITLE     Aberrant overexpression of HOTAIR inhibits abdominal adipogenesis
            through remodelling of genome-wide DNA methylation and
            transcription
  JOURNAL   Mol Metab 60, 101473 (2022)
   PUBMED   35292404
  REMARK    GeneRIF: Aberrant overexpression of HOTAIR inhibits abdominal
            adipogenesis through remodelling of genome-wide DNA methylation and
            transcription.
REFERENCE   4  (bases 1 to 6241)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6241)
  AUTHORS   Tan,Y., Lin,K., Zhao,Y., Wu,Q., Chen,D., Wang,J., Liang,Y., Li,J.,
            Hu,J., Wang,H., Liu,Y., Zhang,S., He,W., Huang,Q., Hu,X., Yao,Z.,
            Liang,B., Liao,W. and Shi,M.
  TITLE     Adipocytes fuel gastric cancer omental metastasis via
            PITPNC1-mediated fatty acid metabolic reprogramming
  JOURNAL   Theranostics 8 (19), 5452-5468 (2018)
   PUBMED   30555557
  REMARK    GeneRIF: Elevated expression of PITPNC1 in gastric cancer is
            correlated with an advanced clinical stage and a poor prognosis.
            PITPNC1 promotes anoikis resistance through enhanced fatty acid
            oxidation, which is regulated by omental adipocytes and
            consequently facilitates gastric cancer omental metastasis.
            Erratum:[Theranostics. 2024 Sep 5;14(14):5743-5744. doi:
            10.7150/thno.101689.. PMID: 39310096]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6241)
  AUTHORS   Garner,K., Li,M., Ugwuanya,N. and Cockcroft,S.
  TITLE     The phosphatidylinositol transfer protein RdgBbeta binds 14-3-3 via
            its unstructured C-terminus, whereas its lipid-binding domain
            interacts with the integral membrane protein ATRAP (angiotensin II
            type I receptor-associated protein)
  JOURNAL   Biochem J 439 (1), 97-111 (2011)
   PUBMED   21728994
  REMARK    GeneRIF: The phosphatidylinositol transfer protein RdgBbeta binds
            14-3-3 via its unstructured C-terminus, whereas its lipid-binding
            domain interacts with the integral membrane protein ATRAP
            (angiotensin II type I receptor-associated protein).
REFERENCE   7  (bases 1 to 6241)
  AUTHORS   Trivedi,D. and Padinjat,R.
  TITLE     RdgB proteins: functions in lipid homeostasis and signal
            transduction
  JOURNAL   Biochim Biophys Acta 1771 (6), 692-699 (2007)
   PUBMED   17543578
  REMARK    Review article
REFERENCE   8  (bases 1 to 6241)
  AUTHORS   Burgis,N.E. and Cunningham,R.P.
  TITLE     Substrate specificity of RdgB protein, a deoxyribonucleoside
            triphosphate pyrophosphohydrolase
  JOURNAL   J Biol Chem 282 (6), 3531-3538 (2007)
   PUBMED   17090528
REFERENCE   9  (bases 1 to 6241)
  AUTHORS   Allen-Baume,V., Segui,B. and Cockcroft,S.
  TITLE     Current thoughts on the phosphatidylinositol transfer protein
            family
  JOURNAL   FEBS Lett 531 (1), 74-80 (2002)
   PUBMED   12401207
  REMARK    Review article
REFERENCE   10 (bases 1 to 6241)
  AUTHORS   Fullwood,Y., dos Santos,M. and Hsuan,J.J.
  TITLE     Cloning and characterization of a novel human phosphatidylinositol
            transfer protein, rdgBbeta
  JOURNAL   J Biol Chem 274 (44), 31553-31558 (1999)
   PUBMED   10531358
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG504645.1, BC037261.1,
            BU160959.1, AF171102.1, BE906407.1, AC079331.11 and AI126821.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012417.3.
            
            Summary: This gene encodes a member of the phosphatidylinositol
            transfer protein family. The encoded cytoplasmic protein plays a
            role in multiple processes including cell signaling and lipid
            metabolism by facilitating the transfer of phosphatidylinositol
            between membrane compartments. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene, and a pseudogene of this gene is located on the long arm of
            chromosome 1. [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.42990.1,
                                           SRR1803614.41325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000581322.6/ ENSP00000464006.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BG504645.1         2-39
            39-323              BC037261.1         1-285
            324-874             BU160959.1         44-594
            875-1250            AF171102.1         1-376
            1251-1709           BE906407.1         157-615
            1710-5784           AC079331.11        20750-24824         c
            5785-6241           AI126821.1         24-480              c
FEATURES             Location/Qualifiers
     source          1..6241
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.2"
     gene            1..6241
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /note="phosphatidylinositol transfer protein cytoplasmic
                     1"
                     /db_xref="GeneID:26207"
                     /db_xref="HGNC:HGNC:21045"
                     /db_xref="MIM:605134"
     exon            1..922
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             875..1873
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /note="isoform a is encoded by transcript variant 1;
                     mammalian rdgB homolog beta; retinal degeneration B
                     homolog beta; retinal degeneration B beta 1; M-rdgB beta"
                     /codon_start=1
                     /product="cytoplasmic phosphatidylinositol transfer
                     protein 1 isoform a"
                     /protein_id="NP_036549.2"
                     /db_xref="CCDS:CCDS58588.1"
                     /db_xref="GeneID:26207"
                     /db_xref="HGNC:HGNC:21045"
                     /db_xref="MIM:605134"
                     /translation="MLLKEYRICMPLTVDEYKIGQLYMISKHSHEQSDRGEGVEVVQN
                     EPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFL
                     PKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFK
                     SEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQ
                     AFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAP
                     STPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNLPGMHSSDKPCRPKSE"
     exon            923..1071
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1160
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1168
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1240
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1336
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1492
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1556
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..6241
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1879..1884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /note="hexamer: TATAAA"
     polyA_site      1909
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /note="major polyA site"
     regulatory      4680..4685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /note="hexamer: AATAAA"
     polyA_site      4702
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
     regulatory      6220..6225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
                     /note="hexamer: AATAAA"
     polyA_site      6241
                     /gene="PITPNC1"
                     /gene_synonym="M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB;
                     RDGBB1"
ORIGIN      
        1 cccgcaccca cctcccggcc ccaggcacac tgcatcggcg cggacgctcc ggccccggcg
       61 aggtggctgc aaactcgcgg gcacgcacgg cgcccgggga gccgagggac tcgggggagg
      121 ggacgcgcgc ggaaggcgcc agcttcctcc cgcccgcccc tggcagccgc gagccgaggt
      181 tggaggcgcc cggggcccca gccgggcaga gccgagcggc ggcggcggcg gcggcttccc
      241 ttttctcccc gagccgagcc ccggagcggc gcggggaccg gccctaaaaa gagcaggaaa
      301 tcttgtttac cgcccgcgga gagaagccga tcgagccttt gtctggaaag tcagcatctc
      361 cggctccggc tgcaatgtgt tcctggtgac attagcatcg ggcagacccg ccggaggagg
      421 ggggtcgcca ggttcccgtc tgctttcgga ggcggatcga gcgggtgact tttgtgcatt
      481 cgttttaatt tttggaaatc tctctttttt cctccctcgc tcgctgccgg gcatgtcctg
      541 atctggcggc cgctcctacc accctgggca gccgagcaga gtcgtcccca gcgggtctcc
      601 ctccctgcct ccctgacttt gcaacaccgc gttccgggag gaccggcctc ggcgagggag
      661 gaggcggggg agctgcgaac acccagaccc aaaccctgac atgctctggg gcggagagga
      721 ggaagccagg agctgagcgc gccgcggggg ctgcttcgcc ctccggctcc gagcgccggg
      781 ctccgggcgc cctgccctgc gcctgggcag cagccttgct ggtcttgggg gcgccccccg
      841 cttcccgccc cgggggtccg cggccggcag gaccatgctg ctgaaagagt accggatctg
      901 catgccgctc accgtagacg agtacaaaat tggacagctg tacatgatca gcaaacacag
      961 ccatgaacag agtgaccggg gagaaggggt ggaggtcgtc cagaatgagc cctttgagga
     1021 ccctcaccat ggcaatgggc agttcaccga gaagcgggtg tatctcaaca gcaaactgcc
     1081 tagttgggct agagctgttg tccccaaaat attttatgtg acagagaagg cttggaacta
     1141 ttatccctac acaattacag aatacacatg ttcctttctg ccgaaattct ccattcatat
     1201 agaaaccaag tatgaggaca acaaaggaag caatgacacc attttcgaca atgaagccaa
     1261 agacgtggag agagaagttt gctttattga tattgcctgc gatgaaattc cagagcgcta
     1321 ctacaaagaa tctgaggatc ctaagcactt caagtcagag aagacaggac ggggacagtt
     1381 gagggaaggc tggagagata gtcatcagcc tatcatgtgc tcctacaagc tggtgactgt
     1441 gaagtttgag gtctgggggc ttcagaccag agtggaacaa tttgtacaca aggtggtccg
     1501 agacattctg ctgattggac atagacaggc ttttgcatgg gttgatgagt ggtatgacat
     1561 gacaatggat gaagtccgag aatttgaacg agccactcag gaagccacca acaagaaaat
     1621 cggcattttc ccacctgcaa tttctatctc cagcatcccc ctgctgcctt cttccgtccg
     1681 cagtgcgcct tctagtgctc catccacccc tctctccaca gacgcacccg aatttctgtc
     1741 cgttcccaaa gatcggcccc ggaaaaagtc tgccccagaa actctcacac ttccagaccc
     1801 tgagaaaaaa gccaccctga atttacccgg catgcactct tcagataagc catgtcggcc
     1861 caaatctgag taactttata taaatatctc atggggtttt atattttcat ttgttgttgt
     1921 tgtttttttt taagaatctt ctgatagaga aaaagactgc tttgtcactc aaacatgttc
     1981 cttcgacctt tcagtgtgca tgtgactcag taacttcaca tagaatatga ttccctaagt
     2041 atgctacaca gcatcatatt agatgtaaga tgtaagactt gcaaaggaca gaaggaatct
     2101 tctgtaacca catagctgta tgccagagag gaagccttgt tattgggcat ttgatgaggt
     2161 ttggcatgga cttcaaggat aaatgaatga aaactttgca ccacttttgt tacaaggtac
     2221 ggtagaaaat agtgaagtca gtttcctctc atcaaatcta aaattctcca aaatactctc
     2281 aggcataaca tacttagctg ttaaattttg aactgctaat tactaatact tgaataccaa
     2341 tagttactga gattcctatt ttgtggttag tctgactcag gatttggagc ctaattaact
     2401 ctaaactttt gaaaatttta atcatcaagc tatagaggct ccaagtgcaa ttaataataa
     2461 ctcatttata ccttccacag aatttaataa agattctact tgtttctgtc ttttaataac
     2521 tttccccttt tgtgcccttg tggcctcaga aatccttaag aattgcatgg atgaatgtga
     2581 ccataactga ttttggaatg gttcagttta ggaaccaaga ggcccaggtg aggcaacatc
     2641 ttttttctct acaggtacca acaaaccttg acttgtcagc ttccatcatc aattaagatt
     2701 ctcagaattt gcaattaatt gaatagaatt catttactat ctgcccactc aaagaagtac
     2761 aagggtagag taagctaact gggctttaac atggtcagaa tgtctggtgc atgaactata
     2821 aaaaagagaa ctgtctccca tccccttcct tgttttactc ttagtaacat ccagaattcc
     2881 ctggaacaga ttgcctacca ccagacctta gaaaagactg tcattctctt gctccttact
     2941 tgaaatacaa atattgggaa tgtcacagac atcaagcaac tactgtcaag tgggaggaga
     3001 gaatgagcag aattgctgac tcctatttgt agagtgaaaa ggaggagtga taatagatgc
     3061 ccttctgtct agctttcctt tcttcaacta gtggtaatgc aagattagaa tcaaggttga
     3121 caggaggcaa ggtcactcac tgaagtgaca gaaagacaat tctcctttgc tccaaagaga
     3181 gaaatctgtc acctttgcac ctcactgcct ttaaacacag acgggagggc aggccaaatc
     3241 tcagcattga cttttgtcct ccaagagagg aagagaagaa gtaattgggc aacttggagg
     3301 cccacgcccc agctagcctt cctgatcgta acctccaacc tcaggaaagg gaccttccca
     3361 aaacacagat cccaaaggaa acaaaataga ccaaggagca taatctgctt ctctcacaca
     3421 gcctctctgc cagtggaccc tgcctgcttc cctctcagtg ctcagcactc tgtgtagtgt
     3481 ctttcaggtt gatacactct cccaaggtgc aggcgctggc cccatgagcc cagcaccaaa
     3541 gttttctaag tcataggtca gactgtcaag atcatttctt tatctatagg ttgatattta
     3601 gcttaaaaaa aaagaataaa cctagaactc aaaggaaacc tgttgcaaat agcttagatc
     3661 aacagtgtat ctcttcccta agaatgatag tatcttagta agacaccttc tatgcatggt
     3721 atggaagcat gatttttgct tgtgggaaaa cctaatattt tatcagaccc ctcggacttc
     3781 tcaatccctc cctctccaca cagtagtact taatgaaaat gttttgcttt agagagcaaa
     3841 atgctacttt cagaagacac tgaaatagta tatgtatttg cttaccattt gcaagctaaa
     3901 atcaaggtgg gatggggtca ttattttcac atagaatgta tttattttgt gcaggctgtt
     3961 aaacacatct ggcacctagt ttttccatta agagcattgc tattttccct ttttataaag
     4021 tagcttctgc tgtcaaggtt aacaattcta tatgctttag gaagctaagt tctaatttcc
     4081 ttttgtgagt ttcatttctt ttataaccag tatgttacca cagacatcag ttgcaaagct
     4141 acgatgatag tgtgattctt agccgaaaaa aaagcgtgtg ctcttaaagt atgttcagtt
     4201 tttctgtcta catatgcttt gtgtgagtta aaaagggggt gggtggtgta aatattcctt
     4261 tagctgcttt gcatatttaa cccagtcatc aaaaggcata aatgacttca atattttata
     4321 tatcttggtt ttcaagtatc atttcacatt ctctatacat gactttgtta ttgtggaata
     4381 caagcctgca atggatgtat atatacagaa cattaataat tcttagaagg atggaagcca
     4441 aatggctgca tgatggaaat tagaagaaaa aaaaagcaga aacttgaatt tgctaagcat
     4501 gtttgggggg aaatagaatc cttaactcag tgcctctgtc tgcgatatgg aaaccttcaa
     4561 ctttgttcac caaaattgta ttatacctgt gtatatatat atatatatat atatataaat
     4621 ataaatatag tatagtgaat cagacaccat cagttttaag tctctggtag ccaaacttaa
     4681 ataaataatc catagaatat cacatacgtt cactccatct tcatctctga agttagtgga
     4741 gaccatcaaa atgactgtac atttcataac tctgggaaga tttcaaatgt gaagtgcccc
     4801 tgtgcatttt cttggccata gcacggcatt cttgctttag ctgtgctttc ctgggatgag
     4861 aagatcttgg tgtatttaac acataagctt tgttagaaat cacctctgaa gatcatttca
     4921 ttttctcact ttgggttgtt gcaagacaaa gcaaaggaaa aggaacacaa tgaaggaggc
     4981 cgtgacattt ttagttgcca ccgttgtaac tcaaacaata tgggtttgtt ggtgaactga
     5041 tttatcaagg cttctgttac ggttttgcat ctgtgtgtga ggaaaatttt aatttatttg
     5101 gaagtattta ttagccatgt tgttggtcct gaaaataaat ctctaagtag cacagttgtg
     5161 ggtatattat gcagacactt accacaatac ctgcaaaagt aactgtggtt ttctttcaag
     5221 acactgtaat aaacagtgaa ctaagagaat agattctgat acatctcgat aaatcattct
     5281 ctgcaaaagt ttcagggcta atgtatttat gtgtattttt aaattctact ttctttggca
     5341 tctcttcatg gctcagcgac aacaaagtaa taggtcattg gctggcttac gtcgatagga
     5401 attttactct taagaagggc cagtgtatag ctgactctac atataatgtg taatcagata
     5461 atccaataga gaggaattgt ccaaatagtt ttagtacctt tctgatcatc tgactcagta
     5521 ggctaggaga caatctgtca tctgagccat agttcttgag atttaaaaag tctgtccagt
     5581 gactgcaatc tgattatgaa taaactattt taactattca ttcttgctga aactgaagtg
     5641 tacacaatag cacactgttg gcatgctgag gcaaaacatt gggttctttt gtgttctacc
     5701 ttcaaaacaa tctgtttgca tttgaaatat aagtgtttaa gctttttagg agttagtgta
     5761 ataagagaat gtgaatatgt tgggaaattt tcagatgcca ttaataattg taattttgtt
     5821 gttaaattaa caaggacttt aggataagcc tcttgatgtt ttttgcttta aattgaaagc
     5881 atgtctgtca aattgcaagt ctcccttcag tttctatata tcacccagga gagggtctct
     5941 gagttggtgt tgtacctgta ccactcacat gtagctcaag tgtaatttgt agtgtttaca
     6001 ttcaagctgg gatcttgatt ggttaaatta atccacatac cactgccact gctgaaggac
     6061 caggtgttgg aatacacagc attacagact ataagcaaag caaacaaaag ttgatcctta
     6121 catatgccat ccttctgtgt cattttgtgg ctgttctgtg tttttcttcc tagttattta
     6181 ttattgttaa taacttactt tttcttacat tctgttgtaa ataaaataca aagcaatctt
     6241 c
//
