LOCUS       NM_001135638            3800 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
            (PIP5K1A), transcript variant 1, mRNA.
ACCESSION   NM_001135638
VERSION     NM_001135638.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3800)
  AUTHORS   Revu,S.K., Yang,W., Rajasundaram,D., Brady,A., Majumder,S.,
            Gaffen,S.L., Hawse,W., Xia,Z. and McGeachy,M.J.
  TITLE     Human IL-17A protein production is controlled through a
            PIP5K1alpha-dependent translational checkpoint
  JOURNAL   Sci Signal 16 (808), eabo6555 (2023)
   PUBMED   37874883
  REMARK    GeneRIF: Human IL-17A protein production is controlled through a
            PIP5K1alpha-dependent translational checkpoint.
REFERENCE   2  (bases 1 to 3800)
  AUTHORS   Li,C., Yoon,B., Stefani,G. and Slack,F.J.
  TITLE     Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through
            interacting with nuclear export protein XPO5
  JOURNAL   Nucleic Acids Res 51 (18), 9849-9862 (2023)
   PUBMED   37655623
  REMARK    GeneRIF: Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis
            through interacting with nuclear export protein XPO5.
REFERENCE   3  (bases 1 to 3800)
  AUTHORS   Larsson,P.F., Karlsson,R., Sarwar,M., Miftakhova,R., Wang,T., Syed
            Khaja,A.S., Semenas,J., Chen,S., Hedblom,A., Ali,A.,
            Ekstrom-Holka,K., Simoulis,A., Kumar,A., Wingren,A.G., Robinson,B.,
            Nyunt Wai,S., Mongan,N.P., Heery,D.M., Ohlund,D., Grundstrom,T.,
            Odum,N. and Persson,J.L.
  TITLE     FcgammaRIIIa receptor interacts with androgen receptor and
            PIP5K1alpha to promote growth and metastasis of prostate cancer
  JOURNAL   Mol Oncol 16 (13), 2496-2517 (2022)
   PUBMED   34932854
  REMARK    GeneRIF: FcgammaRIIIa receptor interacts with androgen receptor and
            PIP5K1alpha to promote growth and metastasis of prostate cancer.
REFERENCE   4  (bases 1 to 3800)
  AUTHORS   Feng,N., Guo,Z., Wu,X., Tian,Y., Li,Y., Geng,Y. and Yu,Y.
  TITLE     Circ_PIP5K1A regulates cisplatin resistance and malignant
            progression in non-small cell lung cancer cells and xenograft
            murine model via depending on miR-493-5p/ROCK1 axis
  JOURNAL   Respir Res 22 (1), 248 (2021)
   PUBMED   34537072
  REMARK    GeneRIF: Circ_PIP5K1A regulates cisplatin resistance and malignant
            progression in non-small cell lung cancer cells and xenograft
            murine model via depending on miR-493-5p/ROCK1 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3800)
  AUTHORS   Parkhitko,A.A., Singh,A., Hsieh,S., Hu,Y., Binari,R., Lord,C.J.,
            Hannenhalli,S., Ryan,C.J. and Perrimon,N.
  TITLE     Cross-species identification of PIP5K1-, splicing- and
            ubiquitin-related pathways as potential targets for RB1-deficient
            cells
  JOURNAL   PLoS Genet 17 (2), e1009354 (2021)
   PUBMED   33591981
  REMARK    GeneRIF: Cross-species identification of PIP5K1-, splicing- and
            ubiquitin-related pathways as potential targets for RB1-deficient
            cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3800)
  AUTHORS   Kisseleva,M., Feng,Y., Ward,M., Song,C., Anderson,R.A. and
            Longmore,G.D.
  TITLE     The LIM protein Ajuba regulates phosphatidylinositol
            4,5-bisphosphate levels in migrating cells through an interaction
            with and activation of PIPKI alpha
  JOURNAL   Mol Cell Biol 25 (10), 3956-3966 (2005)
   PUBMED   15870270
  REMARK    GeneRIF: in addition to its effects upon Rac activity, Ajuba can
            also influence cell migration through regulation of PI(4,5)P2
            synthesis through direct activation of PIPKIalpha enzyme activity
REFERENCE   7  (bases 1 to 3800)
  AUTHORS   Luo,B., Prescott,S.M. and Topham,M.K.
  TITLE     Diacylglycerol kinase zeta regulates phosphatidylinositol
            4-phosphate 5-kinase Ialpha by a novel mechanism
  JOURNAL   Cell Signal 16 (8), 891-897 (2004)
   PUBMED   15157668
REFERENCE   8  (bases 1 to 3800)
  AUTHORS   Doughman,R.L., Firestone,A.J., Wojtasiak,M.L., Bunce,M.W. and
            Anderson,R.A.
  TITLE     Membrane ruffling requires coordination between type Ialpha
            phosphatidylinositol phosphate kinase and Rac signaling
  JOURNAL   J Biol Chem 278 (25), 23036-23045 (2003)
   PUBMED   12682053
  REMARK    GeneRIF: Membrane ruffling requires coordination between this
            enzyme and Rac signaling.
REFERENCE   9  (bases 1 to 3800)
  AUTHORS   Xie,Y., Zhu,L. and Zhao,G.
  TITLE     Assignment of type I phosphatidylinositol-4-phosphate 5-kinase
            (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 197-199 (2000)
   PUBMED   10828584
REFERENCE   10 (bases 1 to 3800)
  AUTHORS   Loijens,J.C. and Anderson,R.A.
  TITLE     Type I phosphatidylinositol-4-phosphate 5-kinases are distinct
            members of this novel lipid kinase family
  JOURNAL   J Biol Chem 271 (51), 32937-32943 (1996)
   PUBMED   8955136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592424.13.
            
            On Nov 24, 2018 this sequence version replaced NM_001135638.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.110396.1, U78576.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368888.9/ ENSP00000357883.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-530               AL592424.13        92655-93184
            531-565             AL592424.13        118348-118382
            566-601             AL592424.13        118474-118509
            602-682             AL592424.13        121423-121503
            683-813             AL592424.13        125774-125904
            814-931             AL592424.13        126351-126468
            932-1084            AL592424.13        126654-126806
            1085-1384           AL592424.13        128300-128599
            1385-1590           AL592424.13        130661-130866
            1591-1674           AL592424.13        132285-132368
            1675-1723           AL592424.13        133233-133281
            1724-1808           AL592424.13        134058-134142
            1809-1955           AL592424.13        136226-136372
            1956-2085           AL592424.13        136541-136670
            2086-2131           AL592424.13        141023-141068
            2132-3800           AL592424.13        141966-143634
FEATURES             Location/Qualifiers
     source          1..3800
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..3800
                     /gene="PIP5K1A"
                     /note="phosphatidylinositol-4-phosphate 5-kinase type 1
                     alpha"
                     /db_xref="GeneID:8394"
                     /db_xref="HGNC:HGNC:8994"
                     /db_xref="MIM:603275"
     exon            1..530
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             446..2134
                     /gene="PIP5K1A"
                     /EC_number="2.7.1.68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PIP5KIalpha; PIP5K1-alpha; ptdIns(4)P-5-kinase 1 alpha;
                     phosphatidylinositol 4-phosphate 5-kinase type I alpha; 68
                     kDa type I phosphatidylinositol 4-phosphate 5-kinase
                     alpha"
                     /codon_start=1
                     /product="phosphatidylinositol 4-phosphate 5-kinase type-1
                     alpha isoform 1"
                     /protein_id="NP_001129110.1"
                     /db_xref="CCDS:CCDS44219.1"
                     /db_xref="GeneID:8394"
                     /db_xref="HGNC:HGNC:8994"
                     /db_xref="MIM:603275"
                     /translation="MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVLEA
                     RQDSYISLVPYASGMPIKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLST
                     KPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDD
                     YLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQN
                     PRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREK
                     PLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDH
                     AQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDDHMGGIPARNSK
                     GERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVF
                     KKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVHLG
                     RPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKLEVAESEFTH"
     exon            531..565
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            566..601
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            602..682
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            683..813
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            814..931
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1084
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1384
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1590
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1674
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1723
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1808
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1955
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2085
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2131
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..3800
                     /gene="PIP5K1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3776..3781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIP5K1A"
                     /note="hexamer: AATAAA"
     polyA_site      3800
                     /gene="PIP5K1A"
                     /note="major polyA site"
ORIGIN      
        1 gattttttgc ttggctaccc ggagtgaagc ggccgggttg ggcgattaac aggccgtggt
       61 taggaaggac ggagaagggg cgttcgctcc tttgggactt ttcatgcctc gttttttttt
      121 cagatgtggc ttggtctggg cgcaaggtcc cagcagccag cttaagctta ctcttctgtg
      181 aaaggggaaa gtatcccctg tggaaagcgg ttaaacttgt ggagggggtg cgggacgtga
      241 gttcttcccc atgccaggcg aatggtgtgg ccttgagctg gtccaggagc cggctcgacg
      301 tgtctgaggg aggccccgga gggggcgggg aggtggccca cagaacgcgg gttctgtaaa
      361 gagacgttgg gaagattcga ttccgagaag aggaagaacc ggattgaaag agagccaggc
      421 cgctgagggg gagggggctg ctaagatggc gtcggcctcc tccgggccgt cgtcttcggt
      481 cggtttttca tcctttgatc ccgcggtccc ttcctgtacc ttgtcctcag cagcatctgg
      541 aatcaagaga cccatggcat ctgaggtctt ggaagctaga caggattctt acatctcatt
      601 ggtgccttat gcctctggca tgcccatcaa gaaaataggc catagaagtg ttgattcctc
      661 aggagagaca acatataaaa agacaacctc atcagccttg aaaggtgcca tccagttagg
      721 cattacccac actgtgggga gcctgagtac caaaccagag cgtgatgtcc tcatgcaaga
      781 tttctacgtg gttgagagta tcttctttcc cagtgaaggg agcaacctga cccctgctca
      841 tcactacaat gactttcgtt tcaagaccta tgcacctgtt gccttccgct acttccggga
      901 gctatttggt atccggcccg atgattactt gtattccctc tgcagtgagc cgctgattga
      961 actctgtagc tctggagcta gtggttccct attctatgtg tccagcgacg atgagttcat
     1021 tattaagaca gtccaacata aagaggcgga atttctgcag aagctgcttc caggatacta
     1081 catgaacctc aaccagaacc ctcggacttt gctgcctaaa ttctatggac tgtactgtgt
     1141 gcaggcaggt ggcaagaaca ttcggattgt ggtgatgaac aatcttttac caagatcggt
     1201 aaaaatgcat atcaaatatg acctcaaagg ctcaacctac aaacggcggg cttcccagaa
     1261 agagcgagag aagcctcttc ccacatttaa agacctagac ttcttacaag acatccctga
     1321 tggtcttttt ttggatgctg acatgtacaa cgctctctgt aagaccctgc agcgtgactg
     1381 tttggtgctg cagagcttca agataatgga ttacagcctc ttgatgtcaa tccataatat
     1441 agatcatgca caacgagagc ccttaagcag tgaaacacag tactcagttg atactcgaag
     1501 accggccccc caaaaggctc tgtattccac agccatggaa tccatccagg gagaggctcg
     1561 acggggtggt accatggaga ctgatgacca tatgggtggc atccctgccc ggaatagtaa
     1621 aggggaaagg cttctgcttt atattggcat cattgacatt ctacagtctt acaggtttgt
     1681 taagaagttg gagcactctt ggaaagccct ggtacatgac ggagacactg tctcagtgca
     1741 tcgcccaggc ttctacgctg aacggttcca gcgcttcatg tgcaacacag tatttaagaa
     1801 gattcccttg aagccttctc cttccaaaaa gtttcggtct ggctcatctt tctctcggcg
     1861 agcaggctcc agtggcaact cctgcattac ttaccagcca tcggtctctg gggaacacaa
     1921 ggcacaagtg acaacaaagg cagaagtgga gccaggcgtt caccttggtc gtcctgatgt
     1981 tttacctcag actccacctt tggaggaaat cagtgagggc tcgcctattc ctgaccccag
     2041 tttctcacct ctagttggag agactttgca aatgctaact acaagtacaa ccttggaaaa
     2101 gcttgaagtt gcagagtcag agttcaccca ttaagcgcaa agcctcagaa gacctggaac
     2161 aagattctgc catctctgtg atcccaagat gtcagccctt gccccagcaa tgctgaattt
     2221 tcttctactt ggtcatcaaa aaaggagtgt aatagaagtg aggggagctg ctcctccatc
     2281 ttcttcctga agaagaacct tctctccttc ctcttcctca tgaatgggcc ttagtgcctc
     2341 agagagttga ggaccgcagc atcccctcca ctccagagtt gggtggtatg gattttcaac
     2401 tggccaaccc tttgcctcca ctattgaatt tttttcagac ccccattctt catgctggaa
     2461 atgggattgc tggacttggc agctttcttt cccctcgtct ttgactagga accggactct
     2521 taatttcctc aggacagact agctggcaca ttatccctac cttagttctt tctctctgac
     2581 tcctggaaga atactcctgt aatctctgta aaggtttttg ggggataagg gtgtttaacc
     2641 acctcccagc tttcttcttc tttttttttt tctgaaaaaa ggaaaaagca cacagcacac
     2701 aatttcaagc cattttcaga tcagaactcc agaagtgttg acaagatgcc tattcgtaga
     2761 gttccctcag aagagccatg gtgtttatga agagaagagt agtgattgct ctgccagaag
     2821 cagctcctct ttaaactcct cctctcttga tgaatttctt aaggctgaag gaatgaagag
     2881 agtgggacat ggggtaatct ttatcccttt tgttaaaaca ggaggcagcc atgggctggg
     2941 agatcatagc ccttcctagg cagaatcctg ttcactgcca ggctatagta attattacta
     3001 ttttgcaatt tgaaatatat tctggttgtt tttctaaatg tgaagactta ccaaatgaat
     3061 tttagatcat tctccagagg agattttttt tgctcttctc atcttttcca acagtgttct
     3121 cctgtttgtg gagctaaggt aaagagggga cacttctgtc tgtttaacag acagtccata
     3181 tctgtgaggc cagcaaatat tttcttaaac tcatggggag acagcagatt cttgccttgg
     3241 tgaggtcatt gctgtgccat atgtcctacc cccctgtctt catgcaggga agttggaaat
     3301 gggggctaca tatgccctct cctccccgtc tacaagagtt gtggttttcc atctgatcct
     3361 tccactcttg tcaggggaag aagggggcct ggtatctcag gcagattgtt gaattcctgt
     3421 tctatccctt ctctatccca ccctgccttg ataatatgtt agcccatacc ccaaataact
     3481 gtctatatta gacaccccca gccagtttct ggctgcctgt ctttgctgcc atgtttttta
     3541 caagaaggaa agaattcttg ctattttttt ttcataattt actatttatg atgtatttaa
     3601 gtgttttatt aaggacagag ttctgttagg ggtgggaggg aatatttgag ggagggctgg
     3661 gtcttaggga aaggaatggg gaagcaacat ttttattaag tgttactatt tgcctctact
     3721 ttgtattgtt cagaaatggc aaatacaata taaaagtgat atatggtttt aatgtaataa
     3781 actttaatga gttatttaga
//
