LOCUS       NM_018710               2759 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
            (PIP4P2), mRNA.
ACCESSION   NM_018710
VERSION     NM_018710.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2759)
  AUTHORS   Nigorikawa,K., Fukushima,Y., Shimada,C., Matsumoto,D. and Nomura,W.
  TITLE     CRISPRa Analysis of Phosphoinositide Phosphatases Shows That
            TMEM55A Is a Positive Regulator of Autophagy
  JOURNAL   Biol Pharm Bull 47 (6), 1148-1153 (2024)
   PUBMED   38880622
  REMARK    GeneRIF: CRISPRa Analysis of Phosphoinositide Phosphatases Shows
            That TMEM55A Is a Positive Regulator of Autophagy.
REFERENCE   2  (bases 1 to 2759)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   3  (bases 1 to 2759)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2759)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2759)
  AUTHORS   Ungewickell,A., Hugge,C., Kisseleva,M., Chang,S.C., Zou,J.,
            Feng,Y., Galyov,E.E., Wilson,M. and Majerus,P.W.
  TITLE     The identification and characterization of two
            phosphatidylinositol-4,5-bisphosphate 4-phosphatases
  JOURNAL   Proc Natl Acad Sci U S A 102 (52), 18854-18859 (2005)
   PUBMED   16365287
  REMARK    GeneRIF: identification and characterization of two previously
            undescribed human enzymes, PtdIns-4,5-P(2) 4-phosphatase type I and
            type II
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK313783.1, CR749733.1 and AC087439.6.
            
            On Nov 24, 2018 this sequence version replaced NM_018710.2.
            
            Summary: TMEM55A catalyzes the degradation of phosphatidylinositol
            4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate
            (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033892.1, SRR1803617.9944.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285419.8/ ENSP00000285419.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-884               AK313783.1         30-913
            885-1390            CR749733.1         565-1070
            1391-1391           AC087439.6         114423-114423
            1392-2290           CR749733.1         1071-1969
            2291-2759           AC087439.6         115323-115791
FEATURES             Location/Qualifiers
     source          1..2759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..2759
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
                     /note="phosphatidylinositol-4,5-bisphosphate 4-phosphatase
                     2"
                     /db_xref="GeneID:55529"
                     /db_xref="HGNC:HGNC:25452"
                     /db_xref="MIM:609864"
     exon            1..216
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..884
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
                     /EC_number="3.1.3.78"
                     /note="PtdIns-4,5-P(2) 4-phosphatase type II;
                     ptdIns-4,5-P2 4-Ptase II; type II phosphatidylinositol
                     4,5-bisphosphate 4-phosphatase; type 2 PtdIns-4,5-P2
                     4-Ptase; transmembrane protein 55A; type II
                     PtdIns-4,5-P(2) 4-phosphatase"
                     /codon_start=1
                     /product="type 2 phosphatidylinositol 4,5-bisphosphate
                     4-phosphatase"
                     /protein_id="NP_061180.1"
                     /db_xref="CCDS:CCDS6252.1"
                     /db_xref="GeneID:55529"
                     /db_xref="HGNC:HGNC:25452"
                     /db_xref="MIM:609864"
                     /translation="MAADGVDERSPLLSASHSGNVTPTAPPYLQESSPRAELPPPYTA
                     IASPDASGIPVINCRVCQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCN
                     CLLICKDTSRRIGCPRPNCRRIINLGPVMLISEEQPAQPALPIQPEGTRVVCGHCGNT
                     FLWMELRFNTLAKCPHCKKISSVGSALPRRRCCAYITIGMICIFIGVGLTVGTPDFAR
                     RFRATYVSWAIAYLLGLICLIRACYWGAIRVSYPEHSFA"
     exon            217..365
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
                     /inference="alignment:Splign:2.1.0"
     exon            366..472
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
                     /inference="alignment:Splign:2.1.0"
     exon            473..596
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
                     /inference="alignment:Splign:2.1.0"
     exon            597..649
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
                     /inference="alignment:Splign:2.1.0"
     exon            650..740
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
                     /inference="alignment:Splign:2.1.0"
     exon            741..2759
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2269..2274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
                     /note="hexamer: AATAAA"
     polyA_site      2290
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
                     /note="major polyA site"
     regulatory      2729..2734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
                     /note="hexamer: AATAAA"
     regulatory      2741..2746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
                     /note="hexamer: AATGAA"
     polyA_site      2746
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
     polyA_site      2759
                     /gene="PIP4P2"
                     /gene_synonym="TMEM55A"
ORIGIN      
        1 agcagcagct gcagcggcag cagcggcagc agaggcagca gcagtagcca ccactccgcc
       61 gaggccgcaa ccccggctcg gcctccccag gccccgccgc tgccgcagtc atggctgctg
      121 atggggtgga cgaacgctcg cctctgctgt cagcatccca ctccggaaat gtcactccca
      181 ccgccccacc gtacttgcaa gaaagcagcc ccagagcgga gctcccacct ccatatacag
      241 ccattgccag tccagacgcc agtggtattc cagtaataaa ctgccgtgtg tgccaatcac
      301 taatcaattt ggatggcaag cttcaccagc atgtggttaa gtgcacagtt tgcaatgaag
      361 ctacgccaat caaaaacccc ccaacaggca agaaatatgt tagatgccct tgtaattgtc
      421 ttctcatttg taaggacaca tctcggcgaa taggatgccc aagacccaac tgtagacgga
      481 taattaacct tggcccagta atgcttattt ctgaagaaca accagctcag cctgcattgc
      541 caatccaacc agaaggtaca agggtcgtgt gtgggcactg tggaaacaca ttcctgtgga
      601 tggaactgag gttcaacact ctggcaaaat gcccacactg caaaaaaatc tcctcagtgg
      661 gtagtgcact tccacgaaga cgctgctgtg catatattac cattggaatg atatgtattt
      721 tcattggagt tgggttaact gttggcaccc cagattttgc aaggcgattt cgagcaacct
      781 atgtttcttg ggcaattgct tatctcctag gattgatctg ccttatccga gcttgttatt
      841 ggggagccat aagagtcagt tatccagaac acagttttgc ataagcttgt ttatgattca
      901 gtaatgcagg tgagagtgtc tagcagttct tggtaagcta ctctggacat ctttaaatta
      961 tttatcctaa tggattccat tctggtttat gtataatcgt ttcaagactt tgggagtctt
     1021 ttatgaacaa atgctcattg cactatatta tatgcaaatt gttttgctgc taggttttca
     1081 aaatttgaat aataaagcct tttcatgttc ttttacatct cttatagata tttttggatt
     1141 tgttaccaaa cattacattt actctcaccc ttttattatt tttaaataag ttatttcatt
     1201 acttgctgat acatgagtat tcctaagtgt ttataaatat ttctataata gtttcacatt
     1261 tatatttaca ttttaattaa acagtatcaa aattgcttgc ttaaaaccta agcaatatgc
     1321 attttgcttg aactgcttac tgtaacttta acctaagatt atagtgacct tattcaggaa
     1381 aaaaaaaaaa atttagtgta acttcaaaga cttgacattc ttgtcagagg aaaaaaaatt
     1441 tctagatact gtttgcttgt tttttgttgt ttgtagaaag ataaaatatt ttggtagtaa
     1501 tttaaaatac aagaacgaat atttatttgt ccacagttgg agatgttgga taaatgtctt
     1561 ttctcaaaga tcacaggact tttgtctttc atttttgcct ttttatttac catttataaa
     1621 agatctggtc tggattatgg aatttaatgt ttatcagctc tatgtattcc tttatagagg
     1681 cttgaggaag tatttcacat aacatgtttt ataatactta accatttatc caaagatata
     1741 tttacattgg gttgtgcccc tttcccttag atcatggtaa atttttctta ttgaggtaat
     1801 tatgtactac ttatatttga aggaagctta tgacatttta cagtagctaa aatgttgaga
     1861 ttagaggtac ttttactatt cttctcaaag gtaactgatc agataattac ccaaattatt
     1921 caagaaaata gatcagaaat aaagaacaac ataattttct aagaattcat tgaaatttat
     1981 ggaatcagct ctcgcactgc ccatctttgc agttttgaaa aagaaattgc ttaatcacaa
     2041 atgttctaca gtctttaaat gtagtagaat tagacagtga gatcatctga gtaaattgat
     2101 tggtgattcc agagataaga ctaatatttt aaattattta tgatactgat tagtataaaa
     2161 acgtactcat cacagaattt gaagcaaaat acatgtacac ttcaaagagt aaatgacaaa
     2221 tgtataaatg ctgtagctca ggattatatg tacctttaaa aatacactaa taaagattat
     2281 tgttcaaaaa ttaccttgtt ttattccatt aaaaataatg tcacttccag agttgccttg
     2341 aaatcttgct gtaaagtttt catgtttagg aatgtacctg tttctttata taatattcat
     2401 ttatgttttt tgtactattt tcaaatggtt ttatttttaa aatatagttt ttaaatccat
     2461 ttgtaataca cttgatgtta ggtataaaat aatcttactt cttttcctaa tggttaacta
     2521 gttgtaacag cattgtatac tgaataatcc attctttccc tcattgattg gaaagctcac
     2581 attaaattat atgctatgtc atattccttc tggaataata actttatgag agcaagaacc
     2641 ctggtagtct tgttcacagc tttatcccca cttagaacag ttcttagtgt acatgtgctc
     2701 aatttacgtg aatgaatatg catgaatgaa taaatggttg aatgaattgc tattttaaa
//
