LOCUS       NM_024779               3176 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
            (PIP4K2C), transcript variant 1, mRNA.
ACCESSION   NM_024779
VERSION     NM_024779.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3176)
  AUTHORS   Rogava,M., Aprati,T.J., Chi,W.Y., Melms,J.C., Hug,C., Davis,S.H.,
            Earlie,E.M., Chung,C., Deshmukh,S.K., Wu,S., Sledge,G., Tang,S.,
            Ho,P., Amin,A.D., Caprio,L., Gurjao,C., Tagore,S., Ngo,B.,
            Lee,M.J., Zanetti,G., Wang,Y., Chen,S., Ge,W., Melo,L.M.N.,
            Allies,G., Rosler,J., Gibney,G.T., Schmitz,O.J., Sykes,M.,
            Creusot,R.J., Tuting,T., Schadendorf,D., Rocken,M., Eigentler,T.K.,
            Molotkov,A., Mintz,A., Bakhoum,S.F., Beyaz,S., Cantley,L.C.,
            Sorger,P.K., Meckelmann,S.W., Tasdogan,A., Liu,D., Laughney,A.M.
            and Izar,B.
  TITLE     Loss of Pip4k2c confers liver-metastatic organotropism through
            insulin-dependent PI3K-AKT pathway activation
  JOURNAL   Nat Cancer 5 (3), 433-447 (2024)
   PUBMED   38286827
  REMARK    GeneRIF: Loss of Pip4k2c confers liver-metastatic organotropism
            through insulin-dependent PI3K-AKT pathway activation.
REFERENCE   2  (bases 1 to 3176)
  AUTHORS   Zhang,Y., Wang,H., Chen,T., Wang,H., Liang,X., Zhang,Y., Duan,J.,
            Qian,S., Qiao,K., Zhang,L., Liu,Y. and Wang,J.
  TITLE     C24-Ceramide Drives Gallbladder Cancer Progression Through Directly
            Targeting Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Gamma to
            Facilitate Mammalian Target of Rapamycin Signaling Activation
  JOURNAL   Hepatology 73 (2), 692-712 (2021)
   PUBMED   32374916
  REMARK    GeneRIF: C24-Ceramide Drives Gallbladder Cancer Progression Through
            Directly Targeting Phosphatidylinositol 5-Phosphate 4-Kinase Type-2
            Gamma to Facilitate Mammalian Target of Rapamycin Signaling
            Activation.
REFERENCE   3  (bases 1 to 3176)
  AUTHORS   Wang,D.G., Paddock,M.N., Lundquist,M.R., Sun,J.Y., Mashadova,O.,
            Amadiume,S., Bumpus,T.W., Hodakoski,C., Hopkins,B.D., Fine,M.,
            Hill,A., Yang,T.J., Baskin,J.M., Dow,L.E. and Cantley,L.C.
  TITLE     PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent
            Mechanism
  JOURNAL   Cell Rep 27 (7), 1991-2001 (2019)
   PUBMED   31091439
  REMARK    GeneRIF: the loss of PIP4Ks (PIP4K2A, PIP4K2B, and PIP4K2C) in
            vitro results in a paradoxical increase in PI(4,5)P2 and a
            concomitant increase in insulin-stimulated production of
            PI(3,4,5)P3.
REFERENCE   4  (bases 1 to 3176)
  AUTHORS   Lima,K., Coelho-Silva,J.L., Kinker,G.S., Pereira-Martins,D.A.,
            Traina,F., Fernandes,P.A.C.M., Markus,R.P., Lucena-Araujo,A.R. and
            Machado-Neto,J.A.
  TITLE     PIP4K2A and PIP4K2C transcript levels are associated with
            cytogenetic risk and survival outcomes in acute myeloid leukemia
  JOURNAL   Cancer Genet 233-234, 56-66 (2019)
   PUBMED   31109595
  REMARK    GeneRIF: study provides additional evidence of the involvement of
            members of the PIP4K2 family, in particular PIP4K2A and PIP4K2C, in
            AML
REFERENCE   5  (bases 1 to 3176)
  AUTHORS   Mathre,S., Reddy,K.B., Ramya,V., Krishnan,H., Ghosh,A. and Raghu,P.
  TITLE     Functional analysis of the biochemical activity of mammalian
            phosphatidylinositol 5 phosphate 4-kinase enzymes
  JOURNAL   Biosci Rep 39 (2) (2019)
   PUBMED   30718367
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3176)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 3176)
  AUTHORS   Raychaudhuri,S., Remmers,E.F., Lee,A.T., Hackett,R., Guiducci,C.,
            Burtt,N.P., Gianniny,L., Korman,B.D., Padyukov,L., Kurreeman,F.A.,
            Chang,M., Catanese,J.J., Ding,B., Wong,S., van der Helm-van
            Mil,A.H., Neale,B.M., Coblyn,J., Cui,J., Tak,P.P., Wolbink,G.J.,
            Crusius,J.B., van der Horst-Bruinsma,I.E., Criswell,L.A.,
            Amos,C.I., Seldin,M.F., Kastner,D.L., Ardlie,K.G., Alfredsson,L.,
            Costenbader,K.H., Altshuler,D., Huizinga,T.W., Shadick,N.A.,
            Weinblatt,M.E., de Vries,N., Worthington,J., Seielstad,M.,
            Toes,R.E., Karlson,E.W., Begovich,A.B., Klareskog,L.,
            Gregersen,P.K., Daly,M.J. and Plenge,R.M.
  TITLE     Common variants at CD40 and other loci confer risk of rheumatoid
            arthritis
  JOURNAL   Nat Genet 40 (10), 1216-1223 (2008)
   PUBMED   18794853
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 3176)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   9  (bases 1 to 3176)
  AUTHORS   Carpenter,C.L.
  TITLE     Btk-dependent regulation of phosphoinositide synthesis
  JOURNAL   Biochem Soc Trans 32 (Pt 2), 326-329 (2004)
   PUBMED   15046600
  REMARK    Review article
REFERENCE   10 (bases 1 to 3176)
  AUTHORS   Rameh,L.E., Tolias,K.F., Duckworth,B.C. and Cantley,L.C.
  TITLE     A new pathway for synthesis of
            phosphatidylinositol-4,5-bisphosphate
  JOURNAL   Nature 390 (6656), 192-196 (1997)
   PUBMED   9367159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022506.38 and KF459552.2.
            
            On Nov 23, 2018 this sequence version replaced NM_024779.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.29977.1,
                                           SRR1803611.219239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354947.10/ ENSP00000347032.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               AC022506.38        16623-16894         c
            273-370             AC022506.38        13964-14061         c
            371-467             AC022506.38        12864-12960         c
            468-611             AC022506.38        12055-12198         c
            612-758             AC022506.38        8875-9021           c
            759-797             AC022506.38        8648-8686           c
            798-911             AC022506.38        7649-7762           c
            912-1179            KF459552.2         76-343              c
            1180-1283           AC022506.38        6738-6841           c
            1284-3176           AC022506.38        4668-6560           c
FEATURES             Location/Qualifiers
     source          1..3176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..3176
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /note="phosphatidylinositol-5-phosphate 4-kinase type 2
                     gamma"
                     /db_xref="GeneID:79837"
                     /db_xref="HGNC:HGNC:23786"
                     /db_xref="MIM:617104"
     exon            1..272
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1364
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /EC_number="2.7.1.149"
                     /note="isoform a is encoded by transcript variant 1;
                     phosphatidylinositol-4-phosphate 5-kinase, type II, gamma;
                     phosphatidylinositol 4-phosphate 5-kinase; PIP4KII-gamma;
                     PI(5)P 4-kinase type II gamma; phosphatidylinositol
                     5-phosphate 4-kinase type II gamma"
                     /codon_start=1
                     /product="phosphatidylinositol 5-phosphate 4-kinase type-2
                     gamma isoform a"
                     /protein_id="NP_079055.3"
                     /db_xref="CCDS:CCDS8946.1"
                     /db_xref="GeneID:79837"
                     /db_xref="HGNC:HGNC:23786"
                     /db_xref="MIM:617104"
                     /translation="MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAA
                     DPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKE
                     YCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIA
                     DMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYD
                     LKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQL
                     KIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGG
                     YIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTV
                     KHGAGAEISTVHPEQYAKRFLDFITNIFA"
     exon            273..370
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /inference="alignment:Splign:2.1.0"
     exon            371..467
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /inference="alignment:Splign:2.1.0"
     exon            468..611
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /inference="alignment:Splign:2.1.0"
     exon            612..758
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /inference="alignment:Splign:2.1.0"
     exon            759..797
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /inference="alignment:Splign:2.1.0"
     exon            798..911
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1179
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1283
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..3176
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3157..3162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /note="hexamer: AATAAA"
     polyA_site      3176
                     /gene="PIP4K2C"
                     /gene_synonym="PIP5K2C"
                     /note="major polyA site"
ORIGIN      
        1 ggtcacgtga cagcagcgca ggtgagcgcc gcttccgggg tcgggcgcct ggatagctgc
       61 cggctccggc ttccacttgg tcggttgcgc gggagactat ggcgtcctcc tcggtcccac
      121 cagccacggt atcggcggcg acagcaggcc ccggcccagg tttcggcttc gcctccaaga
      181 ccaagaagaa gcatttcgtg cagcagaagg tgaaggtgtt ccgggcggcc gacccgctgg
      241 tgggtgtgtt cctgtggggc gtagcccact cgatcaatga gctcagccag gtgcctcccc
      301 cggtgatgct gctgccagat gactttaagg ccagctccaa gatcaaggtc aacaatcacc
      361 ttttccacag ggaaaatctg cccagtcatt tcaagttcaa ggagtattgt ccccaggtct
      421 tcaggaacct ccgtgatcga tttggcattg atgaccaaga ttacttggtg tcccttaccc
      481 gaaacccccc cagcgaaagt gaaggcagtg atggtcgctt ccttatctcc tacgatcgga
      541 ctctggtcat caaagaagta tccagtgagg acattgctga catgcatagc aacctctcca
      601 actatcacca gtacattgtg aagtgccatg gcaacacgct tctgccccag ttcctgggga
      661 tgtaccgagt cagtgtggac aacgaagaca gctacatgct tgtgatgcgc aatatgttta
      721 gccaccgtct tcctgtgcac aggaagtatg acctcaaggg ttccctagtg tcccgggaag
      781 ccagcgataa ggaaaaggtt aaagaattgc ccacccttaa ggatatggac tttctcaaca
      841 agaaccagaa agtatatatt ggtgaagagg agaagaaaat atttctggag aagctgaaga
      901 gagatgtgga gtttctagtg cagctgaaga tcatggacta cagccttctg ctaggcatcc
      961 acgacatcat tcggggctct gaaccagagg aggaagcgcc cgtgcgggag gatgagtcag
     1021 aggtggatgg ggactgcagc ctgactggac ctcctgctct ggtgggctcc tatggcacct
     1081 ccccagaggg tatcggaggc tacatccatt cccatcggcc cctgggccca ggagagtttg
     1141 agtccttcat tgatgtctat gccatccgga gtgctgaagg agccccccag aaggaggtct
     1201 acttcatggg cctcattgat atccttacac agtatgatgc taagaagaaa gcagctcatg
     1261 cagccaaaac tgtcaagcat ggggctgggg cagagatctc tactgtccat ccggagcagt
     1321 atgctaagcg attcctggat tttattacca acatctttgc ctaagagact gcctggttct
     1381 ctctgatgtt caaggtggtg gggttctgag acacttgggg gaattgtggg gatattctag
     1441 ccaccagttc tcttcttcct ttgctaaatt caggctgcag gctccttcca tccagataac
     1501 tccatcctgt cgagtaggct ctttctgacc ctcagaaata cattgtcctt tttcctcttt
     1561 gcccattttt cttccctctc ttcctcccca tgagaagtct gcttgtagta ttagaatgtt
     1621 attgttgact ctctcccaag tgccttgatc tttgtaatat ctcctgttgt ttctatgata
     1681 taggagctag gggaaggggg ttgtttgcct tcttcaggac ctgactggac agatggacct
     1741 ggctcaagca actactctgg atgcactttg ctgtgtggga tgaactaaaa gtgtctgaat
     1801 tttgctgata actttataaa actcactatg gcatgcttcc ctcctggtgg gccctaggat
     1861 ggatgacact caagatacta cagatgtggg tgcaggcatg cacacacacg atggaatatg
     1921 gccattccta cacaggtggg gtagagagtg ggtcagcagc ctggcacctc acagaggtgg
     1981 gacctaagag gactcatgat tatgcagaga attggattgg gtctctgtca tagattgagt
     2041 aatctcttcc cttacctcaa ttccatctcc acccatctct acatctgggc acagcaaccc
     2101 agagatggcc aaaagcattc aagcctgggg gaagatgttt gactattgct gctcttcacc
     2161 agaacctcac acctctcctg ggactggaac ccttcagtgg gtgtgtggcc agttttggag
     2221 gctggaatga tgggccaggg tgtaggattc attctccatg taaagtttcc tttcatcctg
     2281 cctagccatc cccaaggttt atttccagaa gaaaggaata tctctacttg gatcaattct
     2341 ggtcatttca agaggatgga ggcctcaagt gtgggaactt cccctactcc ctggatgtgt
     2401 gtacctagca cacttccttc tcccacccct ttttccagtt ggatttgttt ttctgttctc
     2461 ttctgtcctg tcttatactg caactgtgtc tcctagggga cagatggcct tctttgtcat
     2521 cttcactctc cacccccaga gaggagtcag agccataact caatcactca gcccctccaa
     2581 agatagttga tgtgtgataa tctcataatg ttgagaaccc tgatgagata cattgtcttc
     2641 ctctccctac aatgcctctg gggccaaggc acccattctt cttgctatcc tccatccccc
     2701 ttgaggcttc cacttttttt ttttttagac ataaagctgg gcatcagcaa ctggcctgtg
     2761 gtgatgcaaa gctgctttgc tctgtatctg gctggactga tctgtctcac aagaagccat
     2821 gaggccatag ggagaagctc cctctcccct tcatcttctg ctccaaaggt ggtagcaaga
     2881 ggagtaccca gttaggggtt ggagccccca tataacatct tcctgtcaga agactgatgg
     2941 atctttttca ttccaaccat ctccctttcc cccgatgaat gcaataaaac tctgtgacac
     3001 cagcaaccat tgctctttag aaatgggttt tctgatcata tggctgatgt gttatgggca
     3061 gtatggatgt cttcatttgt tgcttctgtt tttcatcttt tttgttttat taataaaaat
     3121 ttatgtattt gctcctgtta ctataataat acagggaata aattattcaa tccaaa
//
