LOCUS       NM_003559               5383 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens phosphatidylinositol-5-phosphate 4-kinase type 2 beta
            (PIP4K2B), mRNA.
ACCESSION   NM_003559
VERSION     NM_003559.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5383)
  AUTHORS   Takeuchi,K., Senda,M., Ikeda,Y., Okuwaki,K., Fukuzawa,K.,
            Nakagawa,S., Sasaki,M., Sasaki,A.T. and Senda,T.
  TITLE     Functional molecular evolution of a GTP sensing kinase: PI5P4Kbeta
  JOURNAL   FEBS J 290 (18), 4419-4428 (2023)
   PUBMED   36856076
  REMARK    GeneRIF: Functional molecular evolution of a GTP sensing kinase:
            PI5P4Kbeta.
REFERENCE   2  (bases 1 to 5383)
  AUTHORS   Geroldinger-Simic,M., Bayati,S., Pohjanen,E., Sepp,N., Nilsson,P.
            and Pin,E.
  TITLE     Autoantibodies against PIP4K2B and AKT3 Are Associated with Skin
            and Lung Fibrosis in Patients with Systemic Sclerosis
  JOURNAL   Int J Mol Sci 24 (6), 5629 (2023)
   PUBMED   36982700
  REMARK    GeneRIF: Autoantibodies against PIP4K2B and AKT3 Are Associated
            with Skin and Lung Fibrosis in Patients with Systemic Sclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5383)
  AUTHORS   Poli,A., Pennacchio,F.A., Ghisleni,A., di Gennaro,M., Lecacheur,M.,
            Nastaly,P., Crestani,M., Pramotton,F.M., Iannelli,F.,
            Beznusenko,G., Mironov,A.A., Panzetta,V., Fusco,S., Sheth,B.,
            Poulikakos,D., Ferrari,A., Gauthier,N., Netti,P.A., Divecha,N. and
            Maiuri,P.
  TITLE     PIP4K2B is mechanoresponsive and controls heterochromatin-driven
            nuclear softening through UHRF1
  JOURNAL   Nat Commun 14 (1), 1432 (2023)
   PUBMED   36918565
  REMARK    GeneRIF: PIP4K2B is mechanoresponsive and controls
            heterochromatin-driven nuclear softening through UHRF1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5383)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5383)
  AUTHORS   Chen,S., Chandra Tjin,C., Gao,X., Xue,Y., Jiao,H., Zhang,R., Wu,M.,
            He,Z., Ellman,J. and Ha,Y.
  TITLE     Pharmacological inhibition of PI5P4Kalpha/beta disrupts cell energy
            metabolism and selectively kills p53-null tumor cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (21) (2021)
   PUBMED   34001596
  REMARK    GeneRIF: Pharmacological inhibition of PI5P4Kalpha/beta disrupts
            cell energy metabolism and selectively kills p53-null tumor cells.
            Erratum:[Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2118029118.
            doi: 10.1073/pnas.2118029118.. PMID: 34789578]
REFERENCE   6  (bases 1 to 5383)
  AUTHORS   Kutsenko,A.S., Gizatullin,R.Z., Al-Amin,A.N., Wang,F., Kvasha,S.M.,
            Podowski,R.M., Matushkin,Y.G., Gyanchandani,A., Muravenko,O.V.,
            Levitsky,V.G., Kolchanov,N.A., Protopopov,A.I., Kashuba,V.I.,
            Kisselev,L.L., Wasserman,W., Wahlestedt,C. and Zabarovsky,E.R.
  TITLE     NotI flanking sequences: a tool for gene discovery and verification
            of the human genome
  JOURNAL   Nucleic Acids Res 30 (14), 3163-3170 (2002)
   PUBMED   12136098
REFERENCE   7  (bases 1 to 5383)
  AUTHORS   Boronenkov,I.V., Loijens,J.C., Umeda,M. and Anderson,R.A.
  TITLE     Phosphoinositide signaling pathways in nuclei are associated with
            nuclear speckles containing pre-mRNA processing factors
  JOURNAL   Mol Biol Cell 9 (12), 3547-3560 (1998)
   PUBMED   9843587
REFERENCE   8  (bases 1 to 5383)
  AUTHORS   Rao,V.D., Misra,S., Boronenkov,I.V., Anderson,R.A. and Hurley,J.H.
  TITLE     Structure of type IIbeta phosphatidylinositol phosphate kinase: a
            protein kinase fold flattened for interfacial phosphorylation
  JOURNAL   Cell 94 (6), 829-839 (1998)
   PUBMED   9753329
REFERENCE   9  (bases 1 to 5383)
  AUTHORS   Rameh,L.E., Tolias,K.F., Duckworth,B.C. and Cantley,L.C.
  TITLE     A new pathway for synthesis of
            phosphatidylinositol-4,5-bisphosphate
  JOURNAL   Nature 390 (6656), 192-196 (1997)
   PUBMED   9367159
REFERENCE   10 (bases 1 to 5383)
  AUTHORS   Castellino,A.M., Parker,G.J., Boronenkov,I.V., Anderson,R.A. and
            Chao,M.V.
  TITLE     A novel interaction between the juxtamembrane region of the p55
            tumor necrosis factor receptor and phosphatidylinositol-4-phosphate
            5-kinase
  JOURNAL   J Biol Chem 272 (9), 5861-5870 (1997)
   PUBMED   9038203
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI333549.1, U85245.1 and
            AC006449.19.
            
            On Aug 11, 2020 this sequence version replaced NM_003559.4.
            
            Summary: The protein encoded by this gene catalyzes the
            phosphorylation of phosphatidylinositol-5-phosphate on the fourth
            hydroxyl of the myo-inositol ring to form
            phosphatidylinositol-5,4-bisphosphate. This gene is a member of the
            phosphatidylinositol-5-phosphate 4-kinase family. The encoded
            protein sequence does not show similarity to other kinases, but the
            protein does exhibit kinase activity. Additionally, the encoded
            protein interacts with p55 TNF receptor. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853558.10347.1,
                                           SRR11853563.13998.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619039.5/ ENSP00000482548.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               AI333549.1         155-430
            277-1402            U85245.1           625-1750
            1403-5383           AC006449.19        210694-214674       c
FEATURES             Location/Qualifiers
     source          1..5383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..5383
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /note="phosphatidylinositol-5-phosphate 4-kinase type 2
                     beta"
                     /db_xref="GeneID:8396"
                     /db_xref="HGNC:HGNC:8998"
                     /db_xref="MIM:603261"
     exon            1..291
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1383
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /EC_number="2.7.1.149"
                     /note="phosphatidylinositol-4-phosphate 5-kinase, type II,
                     beta; 1-phosphatidylinositol-4-phosphate kinase;
                     PTDINS(4)P-5-kinase; PIP4KII-beta; PI(5)P 4-kinase type II
                     beta; diphosphoinositide kinase 2-beta;
                     1-phosphatidylinositol 5-phosphate 4-kinase 2-beta;
                     phosphatidylinositol 5-phosphate 4-kinase type II beta"
                     /codon_start=1
                     /product="phosphatidylinositol 5-phosphate 4-kinase type-2
                     beta"
                     /protein_id="NP_003550.1"
                     /db_xref="CCDS:CCDS11329.1"
                     /db_xref="GeneID:8396"
                     /db_xref="HGNC:HGNC:8998"
                     /db_xref="MIM:603261"
                     /translation="MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILS
                     VLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMV
                     FRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEM
                     HNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLK
                     GSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKI
                     MDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFP
                     RFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAG
                     AEISTVNPEQYSKRFNEFMSNILT"
     exon            292..389
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /inference="alignment:Splign:2.1.0"
     exon            390..486
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /inference="alignment:Splign:2.1.0"
     exon            487..639
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /inference="alignment:Splign:2.1.0"
     exon            640..786
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /inference="alignment:Splign:2.1.0"
     exon            787..825
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /inference="alignment:Splign:2.1.0"
     exon            826..939
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1198
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1302
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..5383
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5359..5364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /note="hexamer: AATAAA"
     polyA_site      5383
                     /gene="PIP4K2B"
                     /gene_synonym="PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta;
                     PIP5P4KB"
                     /note="major polyA site"
ORIGIN      
        1 aacgggacgg gcgcgaccat ggcgcggtga gggagcgggg gtggggatcg gtccggggga
       61 ggcctgaggc cgctggcttg tgcgctgtct ccgccgcccc cctctttcgc cgccgccgcc
      121 gccgccccgg gcatgtcgtc caactgcacc agcaccacgg cggtggcggt ggcgccgctc
      181 agcgccagca agaccaagac caagaagaag catttcgtgt gccagaaagt gaagctattc
      241 cgggccagcg agccgatcct cagcgtcctg atgtgggggg tgaaccacac gatcaatgag
      301 ctgagcaatg ttcctgttcc tgtcatgcta atgccagatg acttcaaagc ctacagcaag
      361 atcaaggtgg acaatcatct cttcaataag gagaacctgc ccagccgctt taagtttaag
      421 gagtattgcc ccatggtgtt ccgaaacctt cgggagaggt ttggaattga tgatcaggat
      481 taccagaatt cagtgacgcg cagcgccccc atcaacagtg acagccaggg tcggtgtggc
      541 acgcgtttcc tcaccaccta cgaccggcgc tttgtcatca agactgtgtc cagcgaggac
      601 gtggcggaga tgcacaacat cttaaagaaa taccaccagt ttatagtgga gtgtcatggc
      661 aacacgcttt tgccacagtt cctgggcatg taccgcctga ccgtggatgg tgtggaaacc
      721 tacatggtgg ttaccaggaa cgtgttcagc catcggctca ctgtgcatcg caagtatgac
      781 ctcaagggtt ctacggttgc cagagaagcg agcgacaagg agaaggccaa ggacttgcca
      841 acattcaaag acaatgactt cctcaatgaa gggcagaagc tgcatgtggg agaggagagt
      901 aaaaagaact tcctggagaa actgaagcgg gacgttgagt tcttggcaca gctgaagatc
      961 atggactaca gcctgctggt gggcatccac gacgtggacc gggcagagca ggaggagatg
     1021 gaggtggagg agcgggcaga ggacgaggag tgtgagaatg atggggtggg tggcaaccta
     1081 ctctgctcct atggcacacc tccggacagc cctggcaacc tcctcagctt tcctcggttc
     1141 tttggtcctg gggaattcga cccctctgtt gacgtctatg ccatgaaaag ccatgaaagt
     1201 tcccccaaga aggaggtgta tttcatggcc atcattgata tcctcacgcc atacgataca
     1261 aagaagaaag ctgcacatgc tgccaaaacg gtgaaacacg gggcaggggc cgagatctcg
     1321 actgtgaacc ctgagcagta ctccaaacgc ttcaacgagt ttatgtccaa catcctgacg
     1381 tagttctctt ctaccttcag ccagagccag agagctggat atggggtcgg ggatcgggag
     1441 ttagggagaa gggtgtattt gggctagatg ggagggtggg agcagagtcg ggtttgggag
     1501 ggctttagca atgagactgc agcctgtgac accgaaagag actttagctg aagaggaggg
     1561 ggatgtgctg tgtgtgcacc tgctcacagg atgtaacccc accttctgct tacccttgat
     1621 tttttctccc catttgacac ccaggttaaa aaggggttcc ctttttggta ccttgtaacc
     1681 ttttaagata ccttggggct agagatgact tcgtgggttt atttgggttt tgtttctgaa
     1741 atttcattgc tccaggtttg ctatttataa tcatatttca tcagcctacc caccctcccc
     1801 atctttgctg agctctcagt tcccttcaat taaagagata cccggtagac ccagcacaag
     1861 ggtccttcca gaaccaagtg ctatggatgc cagattggag aggtcagaca cctcgccctg
     1921 ctgcatttgc tcttgtctgg attaactttg taatttatgg agtattgtgc acaacttcct
     1981 ccacctttcc cttggattca agtgaaaact gttgcattat tcctccatcc tgtctggaat
     2041 acaccaggtc aacaccagag atctcagatc agaatcagag atctcagagg ggaataagtt
     2101 catcctcatg ggatggtgag gggcaggaaa gcggctgggc tcttggacac ctggttctca
     2161 gagaaccctg tgatgatcac ccaagcccca ggctgtctta gcccctggag ttcagaagtc
     2221 ctctctgtaa agcctgcctc ccactaggtc aagaggaact agagtacctt tggatttatc
     2281 aggaccctca tgtttaaatg gttatttccc tttgggaaaa cttcagaaac tgatgtatca
     2341 aatgaggccc tgtgccctcg atctatttcc ttcttccttc tgacctcctc ccaggcactc
     2401 ttacttctag ccgaactctt agctctgggc agatctccaa gcgcctggag tgctttttag
     2461 cagagacacc tcgttaagct ccgggatgac cttgtaggag atctgtctcc ctgtgcctgg
     2521 agagttacag ccagcaaggt gcccccatct tagagtgtgg tgtccaaacg tgaggtggct
     2581 tcctagttac atgaggatgt gatccaggaa atccagtttg gaggcttgat gtgggttttg
     2641 acctggcctc agccttgggg ctgtttttcc ttgttgcccc gctctagact tttagcagat
     2701 ctgcagccca caggcttttt tggaaggagt ggcttcctgc aggtgttcca cctgccttcg
     2761 gagcctgcca cccaggccct cagaactgag ccacaggctg ctctggccag gagagaaaca
     2821 gctctgttgt tctgcattgg gggaggtaca ttcctgcatc ttctcacccc ctcaaccagg
     2881 aactggggat ttgggatgag atatggtcag acttgtagat aaccccaaag atgtgaagat
     2941 cgcttgtgaa accattttga atgaatagat tggtttcctg tggctccctc caaacctggc
     3001 caagcccagc ttccgaagca ggaaccagca ctgtctctgt gcctgactca cagcatatag
     3061 gtcaggaaag aatggagacg gcattcttgg acttcactgg ggctgctgga ttggatggga
     3121 aaccttctgg aagaggcaga tgggggtcaa accactgcct tggccccagg aaggggccat
     3181 aggtaggtct gaacaactgc cgcaagacca ctacatgact tagggaactt gaaaccaact
     3241 ggctcatgga gaaaacaaat ttgacttggg aaagggatta tgtaggaata atgtttggac
     3301 ttgatttccc cacgtcataa tgaagaatgg aagtttggat ctgctcctcg tcaggcgcag
     3361 catctctgaa gcttggaaag ctgtcttcca gcagcctccg tggcctcggg ttcctaccgg
     3421 cttctctgca tttggtctgc tgatcatgtt gccataatgt gtatggaaag tgtaacacat
     3481 tcttactggt taaagacgac taccaggtat ctaacttgtt taacattgag tttgtgtgtg
     3541 tgtgtgtatg tttgtgtgtt ttgtatattg tttacatttt gagaggtagc attctgtttc
     3601 aaatgctttt tgtttttctg acagtattgt tgactgggtc ataacatttt gagctgtggt
     3661 ttggtggatt ttcaattttt ttttttaaag gtcattcgct gtgctatctt caaaaccttg
     3721 agtttggccc ccaatttttg gcattcaaat gtttaaaagc tatttatctt ggtttataca
     3781 agtttccttt ctcttctttt tgtcatggta ttctatttgg tctgcagttt gaatgtagag
     3841 aaagtggact gatcccccaa gcgttgtctg cccccactct ttcctccttg ggtcccgcca
     3901 ttcttttact gggcagtcga gggcattgga ggggaagtga ctgccctcag cctcactccc
     3961 tggggccatg aagaaaagct aaacagtctc atggcatctc agaataatgt tgggtctccc
     4021 aagaagaaag gtgtaagaat aacgacatgg ctgattaggc gaggccagga tagggctaag
     4081 gccaggattc ctggctggca tccagtcacc ccttctccca tccttccccc tcttcttcca
     4141 caagtccgca gccgagacac tgtagtctcc cagccacagt gatgagtgcc ctggagactc
     4201 cactgacctc tagatgaagg cccctggccc tggttcctgt taattaacct ctgggtcttt
     4261 gagtccccca gcacaaactt ctttcctgta ccctgcggct tggggtcaca gggcatgccg
     4321 ggaagccaca gctgaggggc gcagactgaa gcagtgctcc acctctcctt ctttagctca
     4381 ggggttgctg gtctgtggca ggcgccacga gtggcccctg tggctgttct cagtggcagt
     4441 ctcttaagtt cccaccacag gcagctcttt atcccctctc cctacttgac tctttctctt
     4501 gcctgtgctt ttggcctcaa acaggcctgc tggtagcgct cagggcgtga ggctacactc
     4561 ctgccctgcc tttcctgtct tcatggtctg ccagggcata ccttggggag gtggaccaaa
     4621 gacccaggac tttttgcagt agccagtcct accccccagt tgtcttttta ccaattcagg
     4681 gtgggagaga aaactgcagc accccagcat gtgagttact caggtgttgg gggctagaag
     4741 ggacagtgcg tttaaacaac actcagagct ctggccttaa acctgtggcc ccccaagtct
     4801 aggagcctca tctcttcctg gcagtcatgc gggcaggagg tcctgaaagg gaaaacccat
     4861 tcagacaact gttccccaat ctaccagcca tctgcagggg tcagtgaccg tggccctctc
     4921 cctcctctag aatgtgccac ttatgaagag tgccccatgg ggaaaaggag actcagctgt
     4981 cccttggcag cttgtgccag tatcccaggg cagaagtttc cacaggagcc tcttgccctt
     5041 gcgcagagcc actgtgagag gcggtgggag ccaacaccct tgggggaggg ggcagtactg
     5101 ctcggcacat cccagcatca ggtcagatca ttgaaattaa aaaatgtgaa ttaagttcat
     5161 atccaccttt tggggaagca ggacaaacca ccaccccacc aagtgtgtga cttctccata
     5221 tcccactgca gtttccattt tttaaatggg aattttcaat cccctgtgct tgtctaacgt
     5281 ctgctttaaa aagtttgaga ccctgttact gtttgaaaat gcatgcatgt tacgatgaat
     5341 ctccaacctg aggaaaaaaa taaaactcaa aaagctttgt gta
//
