LOCUS       NM_005028               3820 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
            (PIP4K2A), transcript variant 1, mRNA.
ACCESSION   NM_005028
VERSION     NM_005028.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3820)
  AUTHORS   Nie,D., Tang,X., Deng,H., Yang,X., Tao,J., Xu,F., Liu,Y., Wu,K.,
            Wang,K., Mei,Z., Huang,A. and Tang,N.
  TITLE     Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA Splicing as a
            Noncanonical Mechanism to Suppress Hepatocellular Carcinoma
            Metastasis
  JOURNAL   Adv Sci (Weinh) 11 (5), e2305374 (2024)
   PUBMED   38059827
  REMARK    GeneRIF: Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA
            Splicing as a Noncanonical Mechanism to Suppress Hepatocellular
            Carcinoma Metastasis.
REFERENCE   2  (bases 1 to 3820)
  AUTHORS   Liu,X., Xiao,M., Xing,Z., Jiang,H., Zhu,C., Zhang,X., Li,W.,
            Wang,Z., Wu,F. and Chen,Y.
  TITLE     Contributions of ARID5B, IKZF1, PIP4K2A, and GATA3 Gene
            Polymorphisms to Childhood Acute Lymphoblastic Leukemia in a
            Chinese Population
  JOURNAL   J Pediatr Hematol Oncol 45 (3), 123-129 (2023)
   PUBMED   36952466
  REMARK    GeneRIF: Contributions of ARID5B, IKZF1, PIP4K2A, and GATA3 Gene
            Polymorphisms to Childhood Acute Lymphoblastic Leukemia in a
            Chinese Population.
REFERENCE   3  (bases 1 to 3820)
  AUTHORS   Fedorenko,O.Y., Mikhalitskaya,E.V., Toshchakova,V.A.,
            Loonen,A.J.M., Bokhan,N.A. and Ivanova,S.A.
  TITLE     Association of PIP4K2A Polymorphisms with Alcohol Use Disorder
  JOURNAL   Genes (Basel) 12 (10), 1642 (2021)
   PUBMED   34681036
  REMARK    GeneRIF: Association of PIP4K2A Polymorphisms with Alcohol Use
            Disorder.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3820)
  AUTHORS   Goroshchuk,O., Kolosenko,I., Kunold,E., Vidarsdottir,L.,
            Pirmoradian,M., Azimi,A., Jafari,R. and Palm-Apergi,C.
  TITLE     Thermal proteome profiling identifies PIP4K2A and ZADH2 as
            off-targets of Polo-like kinase 1 inhibitor volasertib
  JOURNAL   FASEB J 35 (7), e21741 (2021)
   PUBMED   34143546
  REMARK    GeneRIF: Thermal proteome profiling identifies PIP4K2A and ZADH2 as
            off-targets of Polo-like kinase 1 inhibitor volasertib.
REFERENCE   5  (bases 1 to 3820)
  AUTHORS   Chen,S., Chandra Tjin,C., Gao,X., Xue,Y., Jiao,H., Zhang,R., Wu,M.,
            He,Z., Ellman,J. and Ha,Y.
  TITLE     Pharmacological inhibition of PI5P4Kalpha/beta disrupts cell energy
            metabolism and selectively kills p53-null tumor cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (21) (2021)
   PUBMED   34001596
  REMARK    GeneRIF: Pharmacological inhibition of PI5P4Kalpha/beta disrupts
            cell energy metabolism and selectively kills p53-null tumor cells.
            Erratum:[Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2118029118.
            doi: 10.1073/pnas.2118029118.. PMID: 34789578]
REFERENCE   6  (bases 1 to 3820)
  AUTHORS   Rameh,L.E., Tolias,K.F., Duckworth,B.C. and Cantley,L.C.
  TITLE     A new pathway for synthesis of
            phosphatidylinositol-4,5-bisphosphate
  JOURNAL   Nature 390 (6656), 192-196 (1997)
   PUBMED   9367159
REFERENCE   7  (bases 1 to 3820)
  AUTHORS   Loijens,J.C., Boronenkov,I.V., Parker,G.J. and Anderson,R.A.
  TITLE     The phosphatidylinositol 4-phosphate 5-kinase family
  JOURNAL   Adv Enzyme Regul 36, 115-140 (1996)
   PUBMED   8869744
  REMARK    Review article
REFERENCE   8  (bases 1 to 3820)
  AUTHORS   Divecha,N., Truong,O., Hsuan,J.J., Hinchliffe,K.A. and Irvine,R.F.
  TITLE     The cloning and sequence of the C isoform of PtdIns4P 5-kinase
  JOURNAL   Biochem J 309 (Pt 3) (Pt 3), 715-719 (1995)
   PUBMED   7639683
REFERENCE   9  (bases 1 to 3820)
  AUTHORS   Tolias,K.F., Cantley,L.C. and Carpenter,C.L.
  TITLE     Rho family GTPases bind to phosphoinositide kinases
  JOURNAL   J Biol Chem 270 (30), 17656-17659 (1995)
   PUBMED   7629060
REFERENCE   10 (bases 1 to 3820)
  AUTHORS   Boronenkov,I.V. and Anderson,R.A.
  TITLE     The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a
            novel family of lipid kinases
  JOURNAL   J Biol Chem 270 (7), 2881-2884 (1995)
   PUBMED   7852364
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390318.20, DB504104.1,
            BC018034.1 and AL513128.11.
            
            On Nov 23, 2018 this sequence version replaced NM_005028.4.
            
            Summary: Phosphatidylinositol-5,4-bisphosphate, the precursor to
            second messengers of the phosphoinositide signal transduction
            pathways, is thought to be involved in the regulation of secretion,
            cell proliferation, differentiation, and motility. The protein
            encoded by this gene is one of a family of enzymes capable of
            catalyzing the phosphorylation of phosphatidylinositol-5-phosphate
            on the fourth hydroxyl of the myo-inositol ring to form
            phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of
            this enzyme does not show homology to other kinases, but the
            recombinant protein does exhibit kinase activity. This gene is a
            member of the phosphatidylinositol-5-phosphate 4-kinase family.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018034.1, U14957.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376573.9/ ENSP00000365757.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL390318.20        103368-103371       c
            5-194               DB504104.1         2-191
            195-1509            BC018034.1         172-1486
            1510-3820           AL513128.11        153767-156077       c
FEATURES             Location/Qualifiers
     source          1..3820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.2"
     gene            1..3820
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /note="phosphatidylinositol-5-phosphate 4-kinase type 2
                     alpha"
                     /db_xref="GeneID:5305"
                     /db_xref="HGNC:HGNC:8997"
                     /db_xref="MIM:603140"
     exon            1..396
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1473
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /EC_number="2.7.1.149"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol-4-phosphate 5-kinase, type II, alpha;
                     PIP5KIIalpha; 1-phosphatidylinositol-4-phosphate kinase;
                     1-phosphatidylinositol-4-phosphate-5-kinase; PIP5KIII;
                     PIP4KII-alpha; PI(5)P 4-kinase type II alpha;
                     diphosphoinositide kinase 2-alpha; 1-phosphatidylinositol
                     5-phosphate 4-kinase 2-alpha; phosphatidylinositol
                     5-phosphate 4-kinase type II alpha; PI5P4Kalpha"
                     /codon_start=1
                     /product="phosphatidylinositol 5-phosphate 4-kinase type-2
                     alpha isoform 1"
                     /protein_id="NP_005019.2"
                     /db_xref="CCDS:CCDS7141.1"
                     /db_xref="GeneID:5305"
                     /db_xref="HGNC:HGNC:8997"
                     /db_xref="MIM:603140"
                     /translation="MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWG
                     VNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLR
                     ERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILK
                     KYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVA
                     REASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSL
                     LVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDP
                     NIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQ
                     YSKRFLDFIGHILT"
     exon            397..494
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            495..591
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            592..744
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            745..891
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            892..930
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1044
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1288
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1392
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..3820
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3680..3685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /note="hexamer: AATAAA"
     polyA_site      3705
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /note="major polyA site"
     regulatory      3803..3808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
                     /note="hexamer: AATGAA"
     polyA_site      3805
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
     polyA_site      3820
                     /gene="PIP4K2A"
                     /gene_synonym="PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA;
                     PIPK"
ORIGIN      
        1 agccgcgggc tgagcgcgga tccgcggcgg gcgcaggata cgggccgggg cgcgagccga
       61 gcgcagtctg ccgggccgag cgggcggagc gagccgagtg gggctgagcg cgccggcggc
      121 ggcgggcgga gcggagcgcg gcgcgccggg gccgccgccg gggggatgcg gctgcctccc
      181 cgggccgggg tgtagagagg gcgggtcccc ggcctcggga gcacggcggt ggaggggaca
      241 taggaggcgg ccatggcgac ccccggcaac ctagggtcct ctgtcctggc gagcaagacc
      301 aagaccaaga agaagcactt cgtagcgcag aaagtgaagc tgtttcgggc cagcgacccg
      361 ctgctcagcg tcctcatgtg gggggtaaac cactcgatca atgaactgag ccatgttcaa
      421 atccctgtta tgttgatgcc agatgacttc aaagcctatt caaaaataaa ggtggacaat
      481 caccttttta acaaagaaaa catgccgagc catttcaagt ttaaggaata ctgcccgatg
      541 gtcttccgta acctgcggga gaggtttgga attgatgatc aagatttcca gaattccctg
      601 accaggagcg cacccctccc caacgactcc caggcccgca gtggagctcg ttttcacact
      661 tcctacgaca aaagatacat catcaagact attaccagtg aagacgtggc cgaaatgcac
      721 aacatcctga agaaatacca ccagtacata gtggaatgtc atgggatcac ccttcttccc
      781 cagttcttgg gcatgtaccg gcttaatgtt gatggagttg aaatatatgt gatagttaca
      841 agaaatgtat tcagccaccg tttgtctgtg tataggaaat acgacttaaa gggctctaca
      901 gtggctagag aagctagtga caaagaaaag gccaaagaac tgccaactct gaaagataat
      961 gatttcatta atgagggcca aaagatttat attgatgaca acaacaagaa ggtcttcctg
     1021 gaaaaactaa aaaaggatgt tgagtttctg gcccagctga agctcatgga ctacagtctg
     1081 ctggtgggaa ttcatgatgt ggagagagcc gaacaggagg aagtggagtg tgaggagaac
     1141 gatggggagg aggagggcga gagcgatggc acccacccgg tgggaacccc cccagatagc
     1201 cccgggaata cactgaacag ctcaccaccc ctggctcccg gggagttcga tccgaacatc
     1261 gacgtctatg gaattaagtg ccatgaaaac tcgcctagga aggaggtgta cttcatggca
     1321 attattgaca tccttactca ttatgatgca aaaaagaaag ctgcccatgc tgcaaaaact
     1381 gttaaacatg gcgctggcgc ggagatctcc accgtgaacc cagaacagta ttcaaagcgc
     1441 tttttggact ttattggcca catcttgacg taacctcctg cgcagcctcg gacagacatg
     1501 aacattggat ggacagaggt ggcttcggtg taggaaaaat gaaaaccaaa ctcagtgaag
     1561 tactcatctt gcaggaagca aacctccttg tttacatctt caggccaaga tgactgattt
     1621 gggggctact cgctttacag ctacctgatt ttcccagcat cgttctagct atttctgact
     1681 ttgtgtatat gtgtgtgtgt gtgtgttggg ggggggtgag tgtgtgcgcg cgtgtgcatt
     1741 ttaaaagtca taaattaatt aaaacagatc cacttcggtc agtatgtgtc ccaacaaaga
     1801 ccctttgatt ccagctatgg ccgaatgaat gagtgagtga gtgagtgagt gaatgaacac
     1861 acgtgtgggg gaggggagaa ggaagtgcat gatgtcaggc accgtgttgg catcacacaa
     1921 caaactgtgg atcagttttt tttttttttt tttttttttg gagttgaaag atgtgagaca
     1981 gtattcagaa taatgaagat aataatgatg attattataa taatgatgat gattccaagg
     2041 aaaaaaccta cagcgaatgt tccatttcta ccccgcacgc agacactctc cctaacactg
     2101 ataacctgag cccccagcac tggacggaag aatgctggcg tctccgtgtg tactggttca
     2161 gggttctggc cccagccttg tcaggacccc ctggtgtcca gagcccccac ccctcccgca
     2221 acaagcagct gatgccccag tgattctcta tacatttttc acctcggcca atatgtccag
     2281 gaaaactgct tacttctctt ttcttgcctg gagccttcat tgttcaccct tacgttgcaa
     2341 tataggaatt aatgctacaa aataaaagta aagcttacct gaaaagtgca tagtttgggg
     2401 caatggtatc tacatctccc actgtgggaa aaccagcaaa gcatcaaaac tctcaattct
     2461 cctgttacca aatgcagatc tgaattataa gatgtttatg tttgaccatt gtttcaacaa
     2521 tgggattttg ttacgaatta tccctttaac tgaaaccctc agttttactg tttacattat
     2581 taggaaaaca gggatatctt ttgaatctaa aaatttgatg tacagcatgt gatttttgaa
     2641 gtttacatgt aaagtcacag tataggtgaa ataacgtttg tcatattttg agacgtatcc
     2701 tgcagccatg tttttacgtg agtgttttag tcaaagtaca tggtagacag tctttcacaa
     2761 taaaaggaaa aggatttttt tttcctccaa atgtacattt atcaacctaa tgattgattt
     2821 ttttaaaaag agatttcgcc ccagtctggt ttatgaaagt tcattgccct aaactgtgct
     2881 gattgttttt aatcaagtta taaatttcca acctagatca tgtatctacc aactctcctg
     2941 cattttccaa aaggcattga gcttaaatat tagtcttgct tagagtaggt tatccactta
     3001 catgctgcgc taaagccatg cctttgaaac tccttgttta aaacatgata tgatttttgt
     3061 gggcagtttc agaaaagaaa acaaacaaac aaaaatcgac cctttaatta ttacttgcaa
     3121 ctcaacagat ctccctgccg tactgccttt tccaggaact ttacttcagg gctgtccaga
     3181 ttgcagctgt gccccgtgta tgtggatcta gttcacagag tctttggaag ccagcagtcg
     3241 tgccctccgt atactgtcca ctcattttat gtagatttgg tatcctcagc agccagtgtt
     3301 aacaccactg tcacgtagtg tacagattca tcttttatgt atttaaagta atccatacta
     3361 tgatttggtt tttccctgca ccattaattc tggcatcaga tcagtttttg tgttgtgaag
     3421 ttctactgtg gtttgaccca agaccacaac catgagaccc tgaagtaaag ataaggtaca
     3481 catacattat ttgagtaact gtttccttgg gggccaatct gtgtatgctt ttagaagttt
     3541 acagaatgct tttatttttg tctataacaa acagtctgtc atttatttct gttgataaac
     3601 catttggaca gagtgaggac gtttgccctg ttatctccta gtgctaacaa tacactccag
     3661 tcatgagccg ggctttacaa ataaagcact tttgatgact cacaagatga atcctttttt
     3721 cctctgtccc aattgtgtgt ctctgttcca aacacatttt aaatactcgg tcctgacagt
     3781 gtctttagct aatccttgaa gaaatgaaag tggaattgaa
//
