LOCUS       NM_002652                578 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens prolactin induced protein (PIP), mRNA.
ACCESSION   NM_002652
VERSION     NM_002652.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 578)
  AUTHORS   Urbaniak,A., Jablonska,K., Suchanski,J., Partynska,A.,
            Szymczak-Kulus,K., Matkowski,R., Maciejczyk,A., Ugorski,M. and
            Dziegiel,P.
  TITLE     Prolactin-induced protein (PIP) increases the sensitivity of breast
            cancer cells to drug-induced apoptosis
  JOURNAL   Sci Rep 13 (1), 6574 (2023)
   PUBMED   37085653
  REMARK    GeneRIF: Prolactin-induced protein (PIP) increases the sensitivity
            of breast cancer cells to drug-induced apoptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 578)
  AUTHORS   Lee,H.W., Shin,J., Wilson,B.S. and Oh,J.W.
  TITLE     Peripheral immune tolerance by prolactin-induced protein originated
            from human invariant natural killer T cells
  JOURNAL   Bioengineered 12 (1), 461-475 (2021)
   PUBMED   33509033
  REMARK    GeneRIF: Peripheral immune tolerance by prolactin-induced protein
            originated from human invariant natural killer T cells.
REFERENCE   3  (bases 1 to 578)
  AUTHORS   Chivasso,C., Nesverova,V., Jarva,M., Blanchard,A., Rose,K.L.,
            Oberg,F.K., Wang,Z., Martin,M., Lhotellerie,F., Zindy,E.,
            Junqueira,B., Leroy,K., Vanhollebeke,B., Delforge,V., Bolaky,N.,
            Perret,J., Soyfoo,M.S., Moscato,S., Baldini,C., Chaumont,F.,
            Mattii,L., Schey,K.L., Myal,Y., Tornroth-Horsefield,S. and
            Delporte,C.
  TITLE     Unraveling Human AQP5-PIP Molecular Interaction and Effect on AQP5
            Salivary Glands Localization in SS Patients
  JOURNAL   Cells 10 (8), 2108 (2021)
   PUBMED   34440877
  REMARK    GeneRIF: Unraveling Human AQP5-PIP Molecular Interaction and Effect
            on AQP5 Salivary Glands Localization in SS Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 578)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 578)
  AUTHORS   Ruffenach,G., Umar,S., Vaillancourt,M., Hong,J., Cao,N., Sarji,S.,
            Moazeni,S., Cunningham,C.M., Ardehali,A., Reddy,S.T., Saggar,R.,
            Fishbein,G. and Eghbali,M.
  TITLE     Histological hallmarks and role of Slug/PIP axis in pulmonary
            hypertension secondary to pulmonary fibrosis
  JOURNAL   EMBO Mol Med 11 (9), e10061 (2019)
   PUBMED   31468711
  REMARK    GeneRIF: The increased vascular wall thickness in pulmonary
            hypertension secondary to pulmonary fibrosis patients is
            concomitant with a significantly increased expression of the
            transcription factor Slug within the macrophages and its target
            prolactin-induced protein.
REFERENCE   6  (bases 1 to 578)
  AUTHORS   Autiero,M., Bouchier,C., Basmaciogullari,S., Zaborski,P., el
            Marhomy,S., Martin,M., Guardiola,J. and Piatier-Tonneau,D.
  TITLE     Isolation from a human seminal vesicle library of the cDNA for
            gp17, a CD4 binding factor
  JOURNAL   Immunogenetics 46 (4), 345-348 (1997)
   PUBMED   9218538
REFERENCE   7  (bases 1 to 578)
  AUTHORS   Myal,Y., Robinson,D.B., Iwasiow,B., Tsuyuki,D., Wong,P. and
            Shiu,R.P.
  TITLE     The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning,
            structure and regulation
  JOURNAL   Mol Cell Endocrinol 80 (1-3), 165-175 (1991)
   PUBMED   1955075
REFERENCE   8  (bases 1 to 578)
  AUTHORS   Schaller,J., Akiyama,K., Kimura,H., Hess,D., Affolter,M. and
            Rickli,E.E.
  TITLE     Primary structure of a new actin-binding protein from human seminal
            plasma
  JOURNAL   Eur J Biochem 196 (3), 743-750 (1991)
   PUBMED   2013294
REFERENCE   9  (bases 1 to 578)
  AUTHORS   Myal,Y., Gregory,C., Wang,H., Hamerton,J.L. and Shiu,R.P.
  TITLE     The gene for prolactin-inducible protein (PIP), uniquely expressed
            in exocrine organs, maps to chromosome 7
  JOURNAL   Somat Cell Mol Genet 15 (3), 265-270 (1989)
   PUBMED   2727805
REFERENCE   10 (bases 1 to 578)
  AUTHORS   Murphy,L.C., Tsuyuki,D., Myal,Y. and Shiu,R.P.
  TITLE     Isolation and sequencing of a cDNA clone for a prolactin-inducible
            protein (PIP). Regulation of PIP gene expression in the human
            breast cancer cell line, T-47D
  JOURNAL   J Biol Chem 262 (31), 15236-15241 (1987)
   PUBMED   3667631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093659.4 and Y10179.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002652.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP334025.1, BP334523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291009.4/ ENSP00000291009.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC093659.4         50546-50549
            5-578               Y10179.1           1-574
FEATURES             Location/Qualifiers
     source          1..578
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..578
                     /gene="PIP"
                     /gene_synonym="BRST-2; GCDFP-15; GCDFP15; GPIP4"
                     /note="prolactin induced protein"
                     /db_xref="GeneID:5304"
                     /db_xref="HGNC:HGNC:8993"
                     /db_xref="MIM:176720"
     exon            1..135
                     /gene="PIP"
                     /gene_synonym="BRST-2; GCDFP-15; GCDFP15; GPIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..481
                     /gene="PIP"
                     /gene_synonym="BRST-2; GCDFP-15; GCDFP15; GPIP4"
                     /note="prolactin-inducible protein; SABP; secretory
                     actin-binding protein; gross cystic disease fluid protein
                     15; apocrine"
                     /codon_start=1
                     /product="prolactin-inducible protein precursor"
                     /protein_id="NP_002643.1"
                     /db_xref="CCDS:CCDS34768.1"
                     /db_xref="GeneID:5304"
                     /db_xref="HGNC:HGNC:8993"
                     /db_xref="MIM:176720"
                     /translation="MRLLQLLFRASPATLLLVLCLQLGANKAQDNTRKIIIKNFDIPK
                     SVRPNDEVTAVLAVQTELKECMVVKTYLISSIPLQGAFNYKYTACLCDDNPKTFYWDF
                     YTNRTVQIAAVVDVIRELGICPDDAAVIPIKNNRFYTIEILKVE"
     exon            136..241
                     /gene="PIP"
                     /gene_synonym="BRST-2; GCDFP-15; GCDFP15; GPIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            242..356
                     /gene="PIP"
                     /gene_synonym="BRST-2; GCDFP-15; GCDFP15; GPIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            357..578
                     /gene="PIP"
                     /gene_synonym="BRST-2; GCDFP-15; GCDFP15; GPIP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      560..565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIP"
                     /gene_synonym="BRST-2; GCDFP-15; GCDFP15; GPIP4"
                     /note="hexamer: AATAAA"
     polyA_site      578
                     /gene="PIP"
                     /gene_synonym="BRST-2; GCDFP-15; GCDFP15; GPIP4"
                     /note="major polyA site"
ORIGIN      
        1 accacttctc tgggacacat tgccttctgt tttctccagc atgcgcttgc tccagctcct
       61 gttcagggcc agccctgcca ccctgctcct ggttctctgc ctgcagttgg gggccaacaa
      121 agctcaggac aacactcgga agatcataat aaagaatttt gacattccca agtcagtacg
      181 tccaaatgac gaagtcactg cagtgcttgc agttcaaaca gaattgaaag aatgcatggt
      241 ggttaaaact tacctcatta gcagcatccc tctacaaggt gcatttaact ataagtatac
      301 tgcctgccta tgtgacgaca atccaaaaac cttctactgg gacttttaca ccaacagaac
      361 tgtgcaaatt gcagccgtcg ttgatgttat tcgggaatta ggcatctgcc ctgatgatgc
      421 tgctgtaatc cccatcaaaa acaaccggtt ttatactatt gaaatcctaa aggtagaata
      481 atggaagccc tgtctgtttg ccacacccag gtgatttcct ctaaagaaac ttggctggaa
      541 tttctgctgt ggtctataaa ataaacttct taacatgc
//
