LOCUS       NM_017884               1546 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens PIN2 (TERF1) interacting telomerase inhibitor 1
            (PINX1), transcript variant 1, mRNA.
ACCESSION   NM_017884
VERSION     NM_017884.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1546)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1546)
  AUTHORS   Yang,M., Chen,F., Yu,C., Cai,Z., Zhong,Q., Feng,J., Li,G., Shen,C.
            and Wen,Z.
  TITLE     PinX1-Promoted Autophagy Inhibits Cell Proliferation and Induces
            Cell Apoptosis by Inhibiting the NF-kappaB/p65 Signaling Pathway in
            Nasopharyngeal Carcinoma
  JOURNAL   Front Biosci (Landmark Ed) 28 (8), 170 (2023)
   PUBMED   37664923
  REMARK    GeneRIF: PinX1-Promoted Autophagy Inhibits Cell Proliferation and
            Induces Cell Apoptosis by Inhibiting the NF-kappaB/p65 Signaling
            Pathway in Nasopharyngeal Carcinoma.
REFERENCE   3  (bases 1 to 1546)
  AUTHORS   Qi,Y.Y., Liu,X.R., He,Y.X., Zhou,M., Ning,X.H., Zhai,Y.L.,
            Zhang,X.X., Wang,X.Y., Zhao,Y.F., Cui,Y. and Zhao,Z.Z.
  TITLE     Association of the PINX1 Variant rs6984094, Which Lengthens
            Telomeres, with Systemic Lupus Erythematosus Susceptibility in
            Chinese Populations
  JOURNAL   J Immunol Res 2021, 7079359 (2021)
   PUBMED   34337078
  REMARK    GeneRIF: Association of the PINX1 Variant rs6984094, Which
            Lengthens Telomeres, with Systemic Lupus Erythematosus
            Susceptibility in Chinese Populations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1546)
  AUTHORS   Flores-Ramirez,I., Rivas-Torres,M.A., Rodriguez-Dorantes,M.,
            Gutierrez-Sagal,R., Baranda-Avila,N. and Langley,E.
  TITLE     Oncogenic role of PinX1 in prostate cancer cells through androgen
            receptor dependent and independent mechanisms
  JOURNAL   J Steroid Biochem Mol Biol 210, 105858 (2021)
   PUBMED   33647521
  REMARK    GeneRIF: Oncogenic role of PinX1 in prostate cancer cells through
            androgen receptor dependent and independent mechanisms.
REFERENCE   5  (bases 1 to 1546)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1546)
  AUTHORS   Liao,C., Zhao,M.J., Zhao,J., Song,H., Pineau,P., Marchio,A.,
            Dejean,A., Tiollais,P., Wang,H.Y. and Li,T.P.
  TITLE     Mutation analysis of novel human liver-related putative tumor
            suppressor gene in hepatocellular carcinoma
  JOURNAL   World J Gastroenterol 9 (1), 89-93 (2003)
   PUBMED   12508358
  REMARK    GeneRIF: Data show that liver-related putative tumor suppressor
            gene (LPTS) mutations occur in hepatocellular carcinoma but are
            infrequent and of little effect on the telomerase inhibitory
            function of the protein.
REFERENCE   7  (bases 1 to 1546)
  AUTHORS   Liao,C., Zhao,M.J., Zhao,J., Jia,D., Song,H. and Li,Z.P.
  TITLE     Over-expression of LPTS-L in hepatocellular carcinoma cell line
            SMMC-7721 induces crisis
  JOURNAL   World J Gastroenterol 8 (6), 1050-1052 (2002)
   PUBMED   12439923
  REMARK    GeneRIF: Over-expression of LPTS-L can induce hepatoma cells into
            crisis due to the reduction of telomerase activity.
REFERENCE   8  (bases 1 to 1546)
  AUTHORS   Guglielmi,B. and Werner,M.
  TITLE     The yeast homolog of human PinX1 is involved in rRNA and small
            nucleolar RNA maturation, not in telomere elongation inhibition
  JOURNAL   J Biol Chem 277 (38), 35712-35719 (2002)
   PUBMED   12107183
  REMARK    GeneRIF: role in rRNA and small nucleolar RNA maturation, not in
            telomere elongation inhibition
REFERENCE   9  (bases 1 to 1546)
  AUTHORS   Zhou,X.Z. and Lu,K.P.
  TITLE     The Pin2/TRF1-interacting protein PinX1 is a potent telomerase
            inhibitor
  JOURNAL   Cell 107 (3), 347-359 (2001)
   PUBMED   11701125
REFERENCE   10 (bases 1 to 1546)
  AUTHORS   Liao,C., Zhao,M., Song,H., Uchida,K., Yokoyama,K.K. and Li,T.
  TITLE     Identification of the gene for a novel liver-related putative tumor
            suppressor at a high-frequency loss of heterozygosity region of
            chromosome 8p23 in human hepatocellular carcinoma
  JOURNAL   Hepatology 32 (4 Pt 1), 721-727 (2000)
   PUBMED   11003615
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF418553.1 and AC105001.3.
            
            On Nov 22, 2018 this sequence version replaced NM_017884.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.524727.1, AJ344104.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158188, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314787.8/ ENSP00000318966.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-682               AF418553.1         14-695
            683-1546            AC105001.3         120854-121717       c
FEATURES             Location/Qualifiers
     source          1..1546
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..1546
                     /gene="PINX1"
                     /gene_synonym="Gno1; LPTL; LPTS; Pxr1"
                     /note="PIN2 (TERF1) interacting telomerase inhibitor 1"
                     /db_xref="GeneID:54984"
                     /db_xref="HGNC:HGNC:30046"
                     /db_xref="MIM:606505"
     exon            1..138
                     /gene="PINX1"
                     /gene_synonym="Gno1; LPTL; LPTS; Pxr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1106
                     /gene="PINX1"
                     /gene_synonym="Gno1; LPTL; LPTS; Pxr1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hepatocellular carcinoma-related putative tumor
                     suppressor; PIN2-interacting protein 1; pin2-interacting
                     protein X1; 67-11-3 protein; protein 67-11-3;
                     TRF1-interacting protein 1; liver-related putative tumor
                     suppressor"
                     /codon_start=1
                     /product="PIN2/TERF1-interacting telomerase inhibitor 1
                     isoform 1"
                     /protein_id="NP_060354.4"
                     /db_xref="CCDS:CCDS47801.1"
                     /db_xref="GeneID:54984"
                     /db_xref="HGNC:HGNC:30046"
                     /db_xref="MIM:606505"
                     /translation="MSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKG
                     LGAQEQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDS
                     SDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDLDCIFGKRQSKKTPEGDA
                     SPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKE
                     ATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQD
                     AGDHVQPPEGRDFTLKPKKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK"
     exon            139..248
                     /gene="PINX1"
                     /gene_synonym="Gno1; LPTL; LPTS; Pxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            249..341
                     /gene="PINX1"
                     /gene_synonym="Gno1; LPTL; LPTS; Pxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..420
                     /gene="PINX1"
                     /gene_synonym="Gno1; LPTL; LPTS; Pxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..513
                     /gene="PINX1"
                     /gene_synonym="Gno1; LPTL; LPTS; Pxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..590
                     /gene="PINX1"
                     /gene_synonym="Gno1; LPTL; LPTS; Pxr1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..1546
                     /gene="PINX1"
                     /gene_synonym="Gno1; LPTL; LPTS; Pxr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1325..1330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PINX1"
                     /gene_synonym="Gno1; LPTL; LPTS; Pxr1"
                     /note="hexamer: AATAAA"
     polyA_site      1348
                     /gene="PINX1"
                     /gene_synonym="Gno1; LPTL; LPTS; Pxr1"
                     /note="major polyA site"
     regulatory      1525..1530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PINX1"
                     /gene_synonym="Gno1; LPTL; LPTS; Pxr1"
                     /note="hexamer: ATTAAA"
     polyA_site      1546
                     /gene="PINX1"
                     /gene_synonym="Gno1; LPTL; LPTS; Pxr1"
ORIGIN      
        1 gtccgctgca gtccgccggc gagggagtta cgcacgtcct gattctcctg gagtctccag
       61 cccgcccagt ggccgcagtc acccaggtcc agaggcggcg gtatcacagg ctctccgaca
      121 tgtctatgct ggctgaacgt cggcggaagc agaagtgggc tgtggatcct cagaacactg
      181 cctggagtaa tgacgattcc aagtttggcc agcggatgct agagaagatg gggtggtcta
      241 aaggaaaggg tttaggggct caggagcaag gagccacaga tcatattaaa gttcaagtga
      301 aaaataacca cctgggactc ggagctacca tcaataatga agacaactgg attgcccatc
      361 aggatgattt taaccagctt ctggccgaac tgaacacttg ccatgggcag gaaaccacag
      421 attcctcgga caagaaggaa aagaaatctt ttagccttga ggaaaagtcc aaaatctcca
      481 aaaaccgtgt tcactatatg aaattcacaa aagggaagga tctgtcatct cggagcaaaa
      541 cagatcttga ctgcattttt gggaaaagac agagtaagaa gactcccgag ggcgatgcca
      601 gtccctccac tccagaggag aacgaaacca cgacaaccag cgccttcacc atccaggagt
      661 actttgccaa gcggatggca gcactgaaga acaagcccca ggttccagtt ccagggtctg
      721 acatttctga gacgcaggtg gaacgtaaaa gggggaagaa aagaaataaa gaggccacag
      781 gtaaagatgt ggaaagttac ctccagccta aggccaagag gcacacggag ggaaagcccg
      841 agagggccga ggcccaggag cgagtggcca agaagaagag cgcgccagca gaagagcagc
      901 tcagaggccc ctgctgggac cagagttcca aggcctctgc tcaggatgca ggggaccatg
      961 tgcagccgcc tgagggccgg gacttcaccc tgaagcccaa aaagaggaga gggaagaaaa
     1021 agctgcaaaa accagtagag atagcagagg acgctacact agaagaaacg ctagtgaaaa
     1081 agaagaagaa gaaagattcc aaatgaatcc ttcccagccg gggccttccg accactcagc
     1141 tgtcagggca ctgcgggggc agacacctct ggcctgaagt cacagcagag ttcaccccag
     1201 agcgcctggg cgcatcttgt ggcatgccca tgggctgccg agtcctgccc tctcgccaca
     1261 tttcccccaa gttacattcc caggaggacc tttttaatgt tctcaatcgt ggctctcaga
     1321 cacaaataaa tttttttgta aactctgagc ccttcagcaa gagagtttaa ttataatcat
     1381 tacaaataca tgcattcatg taagtgtgca cacgtgtgtg tgcatgtgcg catctgtgtg
     1441 tgtgtgtgtg tgtcactatc tccgtttgct ctcggttccc ttcaataaca atgaatggtg
     1501 ctttcttctg aaagactcag cctaattaaa ggattaagag gcaata
//
