LOCUS       NM_006223               1239 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 4
            (PIN4), transcript variant 1, mRNA.
ACCESSION   NM_006223 XM_001126085
VERSION     NM_006223.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Naito,M., Ikeda,K., Aoyama,S., Kanamoto,M., Akasaka,Y., Kido,Y.,
            Nakanishi,M., Kanna,M., Yamamotoya,T., Matsubara,A., Hinata,N.,
            Asano,T. and Nakatsu,Y.
  TITLE     Par14 interacts with the androgen receptor, augmenting both its
            transcriptional activity and prostate cancer proliferation
  JOURNAL   Cancer Med 12 (7), 8464-8475 (2023)
   PUBMED   36583514
  REMARK    GeneRIF: Par14 interacts with the androgen receptor, augmenting
            both its transcriptional activity and prostate cancer
            proliferation.
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1239)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1239)
  AUTHORS   Kessler,D., Papatheodorou,P., Stratmann,T., Dian,E.A.,
            Hartmann-Fatu,C., Rassow,J., Bayer,P. and Mueller,J.W.
  TITLE     The DNA binding parvulin Par17 is targeted to the mitochondrial
            matrix by a recently evolved prepeptide uniquely present in
            Hominidae
  JOURNAL   BMC Biol 5, 37 (2007)
   PUBMED   17875217
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1239)
  AUTHORS   Mueller,J.W., Kessler,D., Neumann,D., Stratmann,T.,
            Papatheodorou,P., Hartmann-Fatu,C. and Bayer,P.
  TITLE     Characterization of novel elongated Parvulin isoforms that are
            ubiquitously expressed in human tissues and originate from
            alternative transcription initiation
  JOURNAL   BMC Mol Biol 7, 9 (2006)
   PUBMED   16522211
  REMARK    GeneRIF: Identification of a longer Parvulin isoform (Par17) that
            has an extension at the 5' end including a 75 bp extended open
            reading frame.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1239)
  AUTHORS   Surmacz,T.A., Bayer,E., Rahfeld,J.U., Fischer,G. and Bayer,P.
  TITLE     The N-terminal basic domain of human parvulin hPar14 is responsible
            for the entry to the nucleus and high-affinity DNA-binding
  JOURNAL   J Mol Biol 321 (2), 235-247 (2002)
   PUBMED   12144781
  REMARK    GeneRIF: The N-terminal basic domain of human parvulin hPar14 is
            responsible for the entry to the nucleus and high-affinity
            DNA-binding.
REFERENCE   7  (bases 1 to 1239)
  AUTHORS   Fujiyama,S., Yanagida,M., Hayano,T., Miura,Y., Isobe,T.,
            Fujimori,F., Uchida,T. and Takahashi,N.
  TITLE     Isolation and proteomic characterization of human
            Parvulin-associating preribosomal ribonucleoprotein complexes
  JOURNAL   J Biol Chem 277 (26), 23773-23780 (2002)
   PUBMED   11960984
  REMARK    Erratum:[J Biol Chem. 2002 Nov 1;277(44):42418.]
REFERENCE   8  (bases 1 to 1239)
  AUTHORS   Terada,T., Shirouzu,M., Fukumori,Y., Fujimori,F., Ito,Y.,
            Kigawa,T., Yokoyama,S. and Uchida,T.
  TITLE     Solution structure of the human parvulin-like peptidyl prolyl
            cis/trans isomerase, hPar14
  JOURNAL   J Mol Biol 305 (4), 917-926 (2001)
   PUBMED   11162102
REFERENCE   9  (bases 1 to 1239)
  AUTHORS   Rulten,S., Thorpe,J. and Kay,J.
  TITLE     Identification of eukaryotic parvulin homologues: a new subfamily
            of peptidylprolyl cis-trans isomerases
  JOURNAL   Biochem Biophys Res Commun 259 (3), 557-562 (1999)
   PUBMED   10364457
REFERENCE   10 (bases 1 to 1239)
  AUTHORS   Uchida,T., Fujimori,F., Tradler,T., Fischer,G. and Rahfeld,J.U.
  TITLE     Identification and characterization of a 14 kDa human protein as a
            novel parvulin-like peptidyl prolyl cis/trans isomerase
  JOURNAL   FEBS Lett 446 (2-3), 278-282 (1999)
   PUBMED   10100858
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AV709926.2, BC112281.1,
            BE504461.1 and AL135749.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 15, 2018 this sequence version replaced NM_006223.3.
            
            Summary: This gene encodes a member of the parvulin subfamily of
            the peptidyl-prolyl cis/trans isomerase protein family. The encoded
            protein catalyzes the isomerization of peptidylprolyl bonds, and
            may play a role in the cell cycle, chromatin remodeling, and/or
            ribosome biogenesis. The encoded protein may play an additional
            role in the mitochondria. [provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111394.1, BC070288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 10364457, 17875217
            MANE Ensembl match                 :: ENST00000373669.8/
                                                  ENSP00000362773.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AV709926.2         31-38
            9-507               BC112281.1         87-585
            508-554             BE504461.1         437-483             c
            555-1239            AL135749.3         11545-12229
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..1239
                     /gene="PIN4"
                     /gene_synonym="EPVH; hEPVH; hPar14; hPar17; PAR14; PAR17"
                     /note="peptidylprolyl cis/trans isomerase,
                     NIMA-interacting 4"
                     /db_xref="GeneID:5303"
                     /db_xref="HGNC:HGNC:8992"
                     /db_xref="MIM:300252"
     exon            1..72
                     /gene="PIN4"
                     /gene_synonym="EPVH; hEPVH; hPar14; hPar17; PAR14; PAR17"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..425
                     /gene="PIN4"
                     /gene_synonym="EPVH; hEPVH; hPar14; hPar17; PAR14; PAR17"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peptidyl-prolyl cis-trans isomerase NIMA-interacting 4;
                     rotamase PIN4; PPIase PIN4; parvulin-14; parvulin-17;
                     eukaryotic parvulin homolog; protein (peptidylprolyl
                     cis/trans isomerase) NIMA-interacting, 4 (parvulin);
                     peptidyl-prolyl cis-trans isomerase Pin4; peptidyl-prolyl
                     cis/trans isomerase EPVH"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase
                     NIMA-interacting 4 isoform 1"
                     /protein_id="NP_006214.3"
                     /db_xref="CCDS:CCDS14417.2"
                     /db_xref="GeneID:5303"
                     /db_xref="HGNC:HGNC:8992"
                     /db_xref="MIM:300252"
                     /translation="MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHIL
                     CEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALP
                     VSGMDKPVFTDPPVKTKFGYHIIMVEGRK"
     exon            73..146
                     /gene="PIN4"
                     /gene_synonym="EPVH; hEPVH; hPar14; hPar17; PAR14; PAR17"
                     /inference="alignment:Splign:2.1.0"
     exon            147..266
                     /gene="PIN4"
                     /gene_synonym="EPVH; hEPVH; hPar14; hPar17; PAR14; PAR17"
                     /inference="alignment:Splign:2.1.0"
     exon            267..1239
                     /gene="PIN4"
                     /gene_synonym="EPVH; hEPVH; hPar14; hPar17; PAR14; PAR17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      421..426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIN4"
                     /gene_synonym="EPVH; hEPVH; hPar14; hPar17; PAR14; PAR17"
                     /note="hexamer: AATAAA"
     polyA_site      444
                     /gene="PIN4"
                     /gene_synonym="EPVH; hEPVH; hPar14; hPar17; PAR14; PAR17"
                     /note="major polyA site"
     regulatory      963..968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIN4"
                     /gene_synonym="EPVH; hEPVH; hPar14; hPar17; PAR14; PAR17"
                     /note="hexamer: AATAAA"
     polyA_site      990
                     /gene="PIN4"
                     /gene_synonym="EPVH; hEPVH; hPar14; hPar17; PAR14; PAR17"
     regulatory      1220..1225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIN4"
                     /gene_synonym="EPVH; hEPVH; hPar14; hPar17; PAR14; PAR17"
                     /note="hexamer: AATAAA"
     polyA_site      1239
                     /gene="PIN4"
                     /gene_synonym="EPVH; hEPVH; hPar14; hPar17; PAR14; PAR17"
ORIGIN      
        1 ggttcagcgt tcaacaacaa gcttccaaga tgccgcccaa aggaaaaagt ggttctggaa
       61 aagcggggaa agggggagca gcctctggga gtgacagtgc tgacaagaag gctcaaggtc
      121 ccaaaggtgg tggcaatgca gtaaaggtca gacacattct atgtgaaaaa catggcaaaa
      181 tcatggaagc catggaaaag ttaaagtctg ggatgagatt caatgaagtg gccgcacagt
      241 atagtgaaga taaagccagg caagggggtg acttgggttg gatgaccaga gggtccatgg
      301 tgggaccatt tcaagaagca gcatttgcct tgcctgtaag tgggatggat aagcctgtgt
      361 ttacagaccc accggttaag acaaaatttg gatatcatat tattatggtc gaaggaagaa
      421 aataaaatca tatgaaagac tgaataagtt ttatacattt tgtttcttta aaaggtatta
      481 catattcttt tgagctggag ctgcaaggaa atacaaaaat ttttaaaaag aaaagatatt
      541 ggatgctcct tgtattctgt gaaagctcta agtatgggtt tgtaggtgta agagagggtg
      601 gggctaagtg aatgtcaact gtagtaggta ttcagtcagt ctttctcaaa gagaagtcaa
      661 gcagactccc tttaacctgt attctctttc ctcccagaac tatatctgac tctcagtctg
      721 tcccataaat taattcagaa accatcttca ggggaagcag atatcaactc acactattca
      781 cacaactgaa aatattgggc atcaaataga ttagtgtgtg agaatcataa aataagttcc
      841 tagacaacat ttgttttaca tgttagtcaa ctctgatctt ccaggacagg tggtattagc
      901 tccactgtct taacatagta cgtggcacgt tatgcctttc agtgttaact cctttctttt
      961 taaataaatg tttattggag gaaaaaagca ctcagttgtt ccatgagttg ttttgtacta
     1021 gactaaccga gtgctggtta aagggaggga tgtcagcata aaaatgtcat tccctcatct
     1081 tcagtgtatg ggttacatta agactgtcct ttccagggcc aatgttctgt gcatctaaat
     1141 ttttaaaatt taaaatgcca tatttatgac atataaaaaa gtataaagat tactaatata
     1201 aatactatac tgcttcaaaa ataaaacttt gccaacaca
//
