LOCUS       NM_006221               1009 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1
            (PIN1), transcript variant 1, mRNA.
ACCESSION   NM_006221
VERSION     NM_006221.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1009)
  AUTHORS   Boussetta,T., Raad,H., Bedouhene,S., Arabi Derkawi,R.,
            Gougerot-Pocidalo,M.A., Hayem,G., Dang,P.M. and El-Benna,J.
  TITLE     The peptidyl-prolyl isomerase Pin1 controls GM-CSF-induced priming
            of NADPH oxidase in human neutrophils and priming at inflammatory
            sites
  JOURNAL   Int Immunopharmacol 137, 112425 (2024)
   PUBMED   38851160
  REMARK    GeneRIF: The peptidyl-prolyl isomerase Pin1 controls GM-CSF-induced
            priming of NADPH oxidase in human neutrophils and priming at
            inflammatory sites.
REFERENCE   2  (bases 1 to 1009)
  AUTHORS   Wang,Y., Liu,Y., Chen,H., Xu,Z., Jiang,W., Xu,X., Shan,J.,
            Chang,J., Zhou,T., Wang,J., Chenyan,A., Fan,S., Tao,Z., Shao,K.,
            Li,X., Chen,X., Ji,G. and Wu,X.
  TITLE     PIN1 promotes the metastasis of cholangiocarcinoma cells by
            RACK1-mediated phosphorylation of ANXA2
  JOURNAL   Cell Oncol (Dordr) 47 (4), 1233-1252 (2024)
   PUBMED   38386231
  REMARK    GeneRIF: PIN1 promotes the metastasis of cholangiocarcinoma cells
            by RACK1-mediated phosphorylation of ANXA2.
REFERENCE   3  (bases 1 to 1009)
  AUTHORS   Jin,Y., Shangguan,Z., Pang,J., Chen,Y., Lin,S. and Liu,H.
  TITLE     Pin1 Exacerbates Non-Alcoholic Fatty Liver Disease by Enhancing Its
            Activity through Binding to ACC1
  JOURNAL   Int J Mol Sci 25 (11), 5822 (2024)
   PUBMED   38892011
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1009)
  AUTHORS   Chen,Y., Pang,J., Ye,L., Zhang,Z., Kang,J., Qiu,Z., Lin,N. and
            Liu,H.
  TITLE     Pin1 Downregulation Is Involved in Excess Retinoic Acid-Induced
            Failure of Neural Tube Closure
  JOURNAL   Int J Mol Sci 25 (11), 5588 (2024)
   PUBMED   38891776
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1009)
  AUTHORS   Ferreon,J.C., Ta,H.M., Yun,H., Choi,K.J., Quan,M.D., Tsoi,P.S.,
            Kim,C., Lee,C.W. and Ferreon,A.C.M.
  TITLE     Stereospecific NANOG PEST Stabilization by Pin1
  JOURNAL   Biochemistry 63 (9), 1067-1074 (2024)
   PUBMED   38619104
  REMARK    GeneRIF: Stereospecific NANOG PEST Stabilization by Pin1.
REFERENCE   6  (bases 1 to 1009)
  AUTHORS   Crenshaw,D.G., Yang,J., Means,A.R. and Kornbluth,S.
  TITLE     The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25
            and Plx1
  JOURNAL   EMBO J 17 (5), 1315-1327 (1998)
   PUBMED   9482729
REFERENCE   7  (bases 1 to 1009)
  AUTHORS   Campbell,H.D., Webb,G.C., Fountain,S. and Young,I.G.
  TITLE     The human PIN1 peptidyl-prolyl cis/trans isomerase gene maps to
            human chromosome 19p13 and the closely related PIN1L gene to 1p31
  JOURNAL   Genomics 44 (2), 157-162 (1997)
   PUBMED   9299231
REFERENCE   8  (bases 1 to 1009)
  AUTHORS   Ranganathan,R., Lu,K.P., Hunter,T. and Noel,J.P.
  TITLE     Structural and functional analysis of the mitotic rotamase Pin1
            suggests substrate recognition is phosphorylation dependent
  JOURNAL   Cell 89 (6), 875-886 (1997)
   PUBMED   9200606
REFERENCE   9  (bases 1 to 1009)
  AUTHORS   Lu,K.P., Hanes,S.D. and Hunter,T.
  TITLE     A human peptidyl-prolyl isomerase essential for regulation of
            mitosis
  JOURNAL   Nature 380 (6574), 544-547 (1996)
   PUBMED   8606777
REFERENCE   10 (bases 1 to 1009)
  AUTHORS   Maleszka,R., Hanes,S.D., Hackett,R.L., de Couet,H.G. and
            Miklos,G.L.
  TITLE     The Drosophila melanogaster dodo (dod) gene, conserved in humans,
            is functionally interchangeable with the ESS1 cell division gene of
            Saccharomyces cerevisiae
  JOURNAL   Proc Natl Acad Sci U S A 93 (1), 447-451 (1996)
   PUBMED   8552658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI827672.1, AK291074.1 and
            CA439440.1.
            
            On Dec 4, 2019 this sequence version replaced NM_006221.3.
            
            Summary: Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze
            the cis/trans isomerization of peptidyl-prolyl peptide bonds. This
            gene encodes one of the PPIases, which specifically binds to
            phosphorylated ser/thr-pro motifs to catalytically regulate the
            post-phosphorylation conformation of its substrates. The
            conformational regulation catalyzed by this PPIase has a profound
            impact on key proteins involved in the regulation of cell growth,
            genotoxic and other stress responses, the immune response,
            induction and maintenance of pluripotency, germ cell development,
            neuronal differentiation, and survival. This enzyme also plays a
            key role in the pathogenesis of Alzheimer's disease and many
            cancers. Multiple alternatively spliced transcript variants have
            been found for this gene.[provided by RefSeq, Jun 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.13343.1,
                                           SRR11853561.14349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247970.9/ ENSP00000247970.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BI827672.1         115-119
            6-1002              AK291074.1         1-997
            1003-1009           CA439440.1         19-25               c
FEATURES             Location/Qualifiers
     source          1..1009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1009
                     /gene="PIN1"
                     /gene_synonym="DOD; UBL5"
                     /note="peptidylprolyl cis/trans isomerase,
                     NIMA-interacting 1"
                     /db_xref="GeneID:5300"
                     /db_xref="HGNC:HGNC:8988"
                     /db_xref="MIM:601052"
     exon            1..85
                     /gene="PIN1"
                     /gene_synonym="DOD; UBL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..519
                     /gene="PIN1"
                     /gene_synonym="DOD; UBL5"
                     /EC_number="5.2.1.8"
                     /note="protein (peptidyl-prolyl cis/trans isomerase)
                     NIMA-interacting 1; PPIase Pin1; rotamase Pin1; protein
                     interacting with never in mitosis A1; parvulin PIN1"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase
                     NIMA-interacting 1"
                     /protein_id="NP_006212.1"
                     /db_xref="CCDS:CCDS12220.1"
                     /db_xref="GeneID:5300"
                     /db_xref="HGNC:HGNC:8988"
                     /db_xref="MIM:601052"
                     /translation="MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSG
                     GKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEED
                     FESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIIL
                     RTE"
     exon            86..298
                     /gene="PIN1"
                     /gene_synonym="DOD; UBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            299..409
                     /gene="PIN1"
                     /gene_synonym="DOD; UBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            410..1009
                     /gene="PIN1"
                     /gene_synonym="DOD; UBL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      985..990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIN1"
                     /gene_synonym="DOD; UBL5"
                     /note="hexamer: ATTAAA"
     polyA_site      1009
                     /gene="PIN1"
                     /gene_synonym="DOD; UBL5"
                     /note="major polyA site"
ORIGIN      
        1 ggagcaggcg ctgcggcagg agggaagatg gcggacgagg agaagctgcc gcccggctgg
       61 gagaagcgca tgagccgcag ctcaggccga gtgtactact tcaaccacat cactaacgcc
      121 agccagtggg agcggcccag cggcaacagc agcagtggtg gcaaaaacgg gcagggggag
      181 cctgccaggg tccgctgctc gcacctgctg gtgaagcaca gccagtcacg gcggccctcg
      241 tcctggcggc aggagaagat cacccggacc aaggaggagg ccctggagct gatcaacggc
      301 tacatccaga agatcaagtc gggagaggag gactttgagt ctctggcctc acagttcagc
      361 gactgcagct cagccaaggc caggggagac ctgggtgcct tcagcagagg tcagatgcag
      421 aagccatttg aagacgcctc gtttgcgctg cggacggggg agatgagcgg gcccgtgttc
      481 acggattccg gcatccacat catcctccgc actgagtgag ggtggggagc ccaggcctgg
      541 cctcggggca gggcagggcg gctaggccgg ccagctcccc cttgcccgcc agccagtggc
      601 cgaacccccc actccctgcc accgtcacac agtatttatt gttcccacaa tggctgggag
      661 ggggcccttc cagattgggg gccctggggt ccccactccc tgtccatccc cagttggggc
      721 tgcgaccgcc agattctccc ttaaggaatt gacttcagca ggggtgggag gctcccagac
      781 ccagggcagt gtggtgggag gggtgttcca aagagaaggc ctggtcagca gagccgcccc
      841 gtgtcccccc aggtgctgga ggcagactcg agggccgaat tgtttctagt taggccacgc
      901 tcctctgttc agtcgcaaag gtgaacactc atgcggccca gccatgggcc ctctgagcaa
      961 ctgtgcagca ccctttcacc cccaattaaa cccagaacca ctgctctgc
//
