LOCUS       NM_019013               1908 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens PICALM interacting mitotic regulator (PIMREG),
            transcript variant 1, mRNA.
ACCESSION   NM_019013
VERSION     NM_019013.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1908)
  AUTHORS   Zheng,H.C., Ren,D.H., Zhang,C.Y., Chen,Y. and Zhang,L.
  TITLE     A bioinformatics analysis of the clinicopathological and prognostic
            significance of FAM64A mRNA expression in gynecological cancers
  JOURNAL   J Obstet Gynaecol 43 (1), 2216280 (2023)
   PUBMED   37227120
  REMARK    GeneRIF: A bioinformatics analysis of the clinicopathological and
            prognostic significance of FAM64A mRNA expression in gynecological
            cancers.
REFERENCE   2  (bases 1 to 1908)
  AUTHORS   Fu,M., Zhang,J., Zhang,L., Feng,Y., Fang,X., Zhang,J., Wen,W.,
            Hua,W. and Mao,Y.
  TITLE     Cell Cycle-Related FAM64A Could be Activated by TGF-beta Signaling
            to Promote Glioma Progression
  JOURNAL   Cell Mol Neurobiol 43 (6), 2975-2987 (2023)
   PUBMED   37081231
  REMARK    GeneRIF: Cell Cycle-Related FAM64A Could be Activated by TGF-beta
            Signaling to Promote Glioma Progression.
REFERENCE   3  (bases 1 to 1908)
  AUTHORS   Tang,C., Qiu,S., Mou,W., Xu,J. and Wang,P.
  TITLE     Excessive activation of HOXB13/PIMREG axis promotes hepatocellular
            carcinoma progression and drug resistance
  JOURNAL   Biochem Biophys Res Commun 623, 81-88 (2022)
   PUBMED   35878427
  REMARK    GeneRIF: Excessive activation of HOXB13/PIMREG axis promotes
            hepatocellular carcinoma progression and drug resistance.
REFERENCE   4  (bases 1 to 1908)
  AUTHORS   Zhou,Y., Ou,L., Xu,J., Yuan,H., Luo,J., Shi,B., Li,X., Yang,S. and
            Wang,Y.
  TITLE     FAM64A is an androgen receptor-regulated feedback tumor promoter in
            prostate cancer
  JOURNAL   Cell Death Dis 12 (7), 668 (2021)
   PUBMED   34215720
  REMARK    GeneRIF: FAM64A is an androgen receptor-regulated feedback tumor
            promoter in prostate cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1908)
  AUTHORS   Shinden,Y., Hirashima,T., Nohata,N., Toda,H., Okada,R., Asai,S.,
            Tanaka,T., Hozaka,Y., Ohtsuka,T., Kijima,Y. and Seki,N.
  TITLE     Molecular pathogenesis of breast cancer: impact of miR-99a-5p and
            miR-99a-3p regulation on oncogenic genes
  JOURNAL   J Hum Genet 66 (5), 519-534 (2021)
   PUBMED   33177704
  REMARK    GeneRIF: Molecular pathogenesis of breast cancer: impact of
            miR-99a-5p and miR-99a-3p regulation on oncogenic genes.
REFERENCE   6  (bases 1 to 1908)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   7  (bases 1 to 1908)
  AUTHORS   Archangelo,L.F., Greif,P.A., Maucuer,A., Manceau,V., Koneru,N.,
            Bigarella,C.L., Niemann,F., dos Santos,M.T., Kobarg,J.,
            Bohlander,S.K. and Saad,S.T.
  TITLE     The CATS (FAM64A) protein is a substrate of the Kinase Interacting
            Stathmin (KIS)
  JOURNAL   Biochim Biophys Acta 1833 (5), 1269-1279 (2013)
   PUBMED   23419774
  REMARK    GeneRIF: Moreover, we showed that CATS and KIS antagonize the
            transactivation capacity of CALM/AF10.In summary, our results show
            that CATS interacts with and is a substrate for KIS, suggesting
            that KIS regulates CATS function
REFERENCE   8  (bases 1 to 1908)
  AUTHORS   Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
            Tabunoki,H.
  TITLE     Protein microarray analysis identifies human cellular prion protein
            interactors
  JOURNAL   Neuropathol Appl Neurobiol 35 (1), 16-35 (2009)
   PUBMED   18482256
REFERENCE   9  (bases 1 to 1908)
  AUTHORS   Archangelo,L.F., Greif,P.A., Holzel,M., Harasim,T., Kremmer,E.,
            Przemeck,G.K., Eick,D., Deshpande,A.J., Buske,C., de Angelis,M.H.,
            Saad,S.T. and Bohlander,S.K.
  TITLE     The CALM and CALM/AF10 interactor CATS is a marker for
            proliferation
  JOURNAL   Mol Oncol 2 (4), 356-367 (2008)
   PUBMED   19383357
REFERENCE   10 (bases 1 to 1908)
  AUTHORS   Zhao,W.M., Coppinger,J.A., Seki,A., Cheng,X.L., Yates,J.R. 3rd and
            Fang,G.
  TITLE     RCS1, a substrate of APC/C, controls the metaphase to anaphase
            transition
  JOURNAL   Proc Natl Acad Sci U S A 105 (36), 13415-13420 (2008)
   PUBMED   18757745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055872.23 and BC013966.2.
            
            On Nov 23, 2018 this sequence version replaced NM_019013.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225702.1, SRR5189661.131329.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000572447.6/ ENSP00000459235.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC055872.23        89263-89276
            15-1151             BC013966.2         1-1137
            1152-1152           AC055872.23        95521-95521
            1153-1504           BC013966.2         1139-1490
            1505-1908           AC055872.23        95874-96277
FEATURES             Location/Qualifiers
     source          1..1908
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..1908
                     /gene="PIMREG"
                     /gene_synonym="CATS; FAM64A; RCS1"
                     /note="PICALM interacting mitotic regulator"
                     /db_xref="GeneID:54478"
                     /db_xref="HGNC:HGNC:25483"
                     /db_xref="MIM:617611"
     exon            1..34
                     /gene="PIMREG"
                     /gene_synonym="CATS; FAM64A; RCS1"
                     /inference="alignment:Splign:2.1.0"
     exon            35..363
                     /gene="PIMREG"
                     /gene_synonym="CATS; FAM64A; RCS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..786
                     /gene="PIMREG"
                     /gene_synonym="CATS; FAM64A; RCS1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulator of chromosome segregation 1; protein FAM64A;
                     CALM interacting protein expressed in thymus and spleen;
                     regulator of chromosome segregation protein 1;
                     CALM-interactor expressed in thymus and spleen; family
                     with sequence similarity 64 member A; protein PIMREG"
                     /codon_start=1
                     /product="protein PIMREG isoform 1"
                     /protein_id="NP_061886.2"
                     /db_xref="CCDS:CCDS32541.1"
                     /db_xref="GeneID:54478"
                     /db_xref="HGNC:HGNC:25483"
                     /db_xref="MIM:617611"
                     /translation="MASRWQNMGTSVRRRSLQHQEQLEDSKELQPVVSHQETSVGALG
                     SLCRQFQRRLPLRAVNLNLRAGPSWKRLETPEPGQQGLQAAARSAKSALGAVSQRIQE
                     SCQSGTKWLVETQVKARRRKRGAQKGSGSPTHSLSQKSTRLSGAAPAHSAADPWEKEH
                     HRLSVRMGSHAHPLRRSRREAAFRSPYSSTEPLCSPSESDSDLEPVGAGIQHLQKLSQ
                     ELDEAIMAEESGDIVSLIHD"
     exon            364..659
                     /gene="PIMREG"
                     /gene_synonym="CATS; FAM64A; RCS1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..755
                     /gene="PIMREG"
                     /gene_synonym="CATS; FAM64A; RCS1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..800
                     /gene="PIMREG"
                     /gene_synonym="CATS; FAM64A; RCS1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1908
                     /gene="PIMREG"
                     /gene_synonym="CATS; FAM64A; RCS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1483..1488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIMREG"
                     /gene_synonym="CATS; FAM64A; RCS1"
                     /note="hexamer: AATAAA"
     polyA_site      1504
                     /gene="PIMREG"
                     /gene_synonym="CATS; FAM64A; RCS1"
                     /note="major polyA site"
     regulatory      1886..1891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIMREG"
                     /gene_synonym="CATS; FAM64A; RCS1"
                     /note="hexamer: AATAAA"
     polyA_site      1908
                     /gene="PIMREG"
                     /gene_synonym="CATS; FAM64A; RCS1"
ORIGIN      
        1 gtgctgcggc tgtgctcggc cttagtggtg tcggggtcta gtggacagag aagactcttg
       61 gccaggcaga tggcttctcg gtggcagaac atggggacct ccgtgcgccg gagatctctc
      121 cagcaccagg agcagctgga ggacagcaag gagctgcagc ctgtggtcag ccatcaggag
      181 acctctgtag gggccctggg gtccctgtgc agacagttcc aaaggaggct gcccctgaga
      241 gccgtcaacc tcaacctccg cgcagggccc tcctggaaac gcctggaaac cccagagcca
      301 ggtcagcagg gcctccaggc tgcagctcgc tcagctaaga gtgctttggg tgccgtgtcc
      361 cagagaatcc aggagtcctg ccaaagtggc accaagtggc tggtggagac ccaggtgaag
      421 gccaggaggc ggaagagagg agcacagaag ggcagtggat ccccaactca cagcctgagc
      481 cagaagagca cccggctgtc tggagccgcc cctgcccact cagccgcaga cccctgggag
      541 aaggagcatc accgcctctc tgtccggatg ggctcacatg cccacccatt acggcgatca
      601 aggcgggagg ctgccttccg gagcccctac tcctcaacag agcccctctg ctctcccagc
      661 gagtctgaca gtgacctaga gcctgtgggg gcgggaattc agcatctcca gaagctgtcc
      721 caagagctag atgaagccat tatggcggaa gagagtggtg acatcgtctc tctcattcat
      781 gactgaggaa gtgcctgcag gaaacaagcc ctgtctgacc gccaaggctt catactcaag
      841 gatgtctatg cttccccgtg agcttcctgg aaaaaacccc cgggagtcgt cagtacccct
      901 gggccactgc taacaagcac ctaacaaggg gcccagagcc ccctgctcca gccacatctg
      961 gacccatcag tgactgcctg ccatagcctg agagtgtctt ggggagacct tgcagagggg
     1021 gagaattgtt ccttctgctt tcctagggga ctcttgagct tagaaactca tcgtacactt
     1081 gaccttgagc cttctatttg cctcatctat aacatgaagt gctagcatca gatatttgag
     1141 agctcttagc tctgtacccg ggtgcctggt ttttggggag tcatccgcag agtcactcac
     1201 ccactgtgtt tctggtgcca aggctcttga gggccccact ctcatccctc ctttccctac
     1261 cagggactcg gaggaaggca taggagatat ttccaggctt acgaccctgg gctcacgggt
     1321 acctatttat atgctcagtg cagagcactg tggatgtgcc aggaggggta gccctgttca
     1381 agagcaattt ctgccctttg taaattattt aagaaacctg ctttgtcatt ttattagaaa
     1441 gaaaccagcg tgtgactttc ctagataaca ctgctttctc ataataaaga ctatttgcat
     1501 ttgacatctg ttccctttca ccggcaacct ccaacctccc ccgccctccc acaccactct
     1561 gggctataga tttgtaattt gtggtttggg gtctggccct catccacctc tgctccgagc
     1621 cagtctgccc ccaatcccac cccagggaga acatgtagaa agggaaaggt ttctcaactt
     1681 agttcagacc aaaacacatt gtaaaggcaa agaaggtttt tatttaagtg acaacatttg
     1741 agagctaaaa accagctcac atcaaaatca agacccagtt gtaaaaatct tttaactcca
     1801 taatgctgtt tttgtcttgt tagaaatctg atatcttaca ttagcgtttc taacggattt
     1861 tgtacaaggc agccataagg aatataataa acctttttca ccacagaa
//
