LOCUS       NM_006875               2075 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens Pim-2 proto-oncogene, serine/threonine kinase (PIM2),
            mRNA.
ACCESSION   NM_006875
VERSION     NM_006875.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2075)
  AUTHORS   Wang,M., Fan,R., Jiang,J., Sun,F., Sun,Y., Wang,Q., Jiang,A., Yu,Z.
            and Yang,T.
  TITLE     PIM2 Promotes the Development of Ovarian Endometriosis by Enhancing
            Glycolysis and Fibrosis
  JOURNAL   Reprod Sci 30 (9), 2692-2702 (2023)
   PUBMED   37059967
  REMARK    GeneRIF: PIM2 Promotes the Development of Ovarian Endometriosis by
            Enhancing Glycolysis and Fibrosis.
REFERENCE   2  (bases 1 to 2075)
  AUTHORS   Lu,C., Qiao,P., Fu,R., Wang,Y., Lu,J., Ling,X., Liu,L., Sun,Y.,
            Ren,C. and Yu,Z.
  TITLE     Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and
            cell proliferation in endometriosis
  JOURNAL   Cell Death Dis 13 (9), 790 (2022)
   PUBMED   36109523
  REMARK    GeneRIF: Phosphorylation of PFKFB4 by PIM2 promotes anaerobic
            glycolysis and cell proliferation in endometriosis.
            Erratum:[Cell Death Dis. 2024 Jul 2;15(7):469. doi:
            10.1038/s41419-024-06613-w.. PMID: 38956061]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2075)
  AUTHORS   Haas,M., Caron,G., Chatonnet,F., Manenti,S., Alaterre,E., Devin,J.,
            Delaloy,C., Bertolin,G., Viel,R., Pignarre,A., Llamas-Gutierrez,F.,
            Marchalot,A., Decaux,O., Tarte,K., Delpy,L., Moreaux,J. and Fest,T.
  TITLE     PIM2 kinase has a pivotal role in plasmablast generation and plasma
            cell survival, opening up novel treatment options in myeloma
  JOURNAL   Blood 139 (15), 2316-2337 (2022)
   PUBMED   35108359
  REMARK    GeneRIF: PIM2 kinase has a pivotal role in plasmablast generation
            and plasma cell survival, opening up novel treatment options in
            myeloma.
REFERENCE   4  (bases 1 to 2075)
  AUTHORS   Wang,F., Gu,T., Chen,Y., Chen,Y., Xiong,D. and Zhu,Y.
  TITLE     Long non-coding RNA SOX21-AS1 modulates lung cancer progress upon
            microRNA miR-24-3p/PIM2 axis
  JOURNAL   Bioengineered 12 (1), 6724-6737 (2021)
   PUBMED   34511042
  REMARK    GeneRIF: Long non-coding RNA SOX21-AS1 modulates lung cancer
            progress upon microRNA miR-24-3p/PIM2 axis.
REFERENCE   5  (bases 1 to 2075)
  AUTHORS   Lu,C., Qiao,P., Sun,Y., Ren,C. and Yu,Z.
  TITLE     Positive regulation of PFKFB3 by PIM2 promotes glycolysis and
            paclitaxel resistance in breast cancer
  JOURNAL   Clin Transl Med 11 (4), e400 (2021)
   PUBMED   33931981
  REMARK    GeneRIF: Positive regulation of PFKFB3 by PIM2 promotes glycolysis
            and paclitaxel resistance in breast cancer.
REFERENCE   6  (bases 1 to 2075)
  AUTHORS   Hammerman,P.S., Fox,C.J., Cinalli,R.M., Xu,A., Wagner,J.D.,
            Lindsten,T. and Thompson,C.B.
  TITLE     Lymphocyte transformation by Pim-2 is dependent on nuclear
            factor-kappaB activation
  JOURNAL   Cancer Res 64 (22), 8341-8348 (2004)
   PUBMED   15548703
  REMARK    GeneRIF: transcriptional induction of Pim-2 initiates a novel
            NF-kappaB activation pathway that regulates cell survival
REFERENCE   7  (bases 1 to 2075)
  AUTHORS   Mikkers,H., Nawijn,M., Allen,J., Brouwers,C., Verhoeven,E.,
            Jonkers,J. and Berns,A.
  TITLE     Mice deficient for all PIM kinases display reduced body size and
            impaired responses to hematopoietic growth factors
  JOURNAL   Mol Cell Biol 24 (13), 6104-6115 (2004)
   PUBMED   15199164
REFERENCE   8  (bases 1 to 2075)
  AUTHORS   Cohen,A.M., Grinblat,B., Bessler,H., Kristt,D., Kremer,A.,
            Schwartz,A., Halperin,M., Shalom,S., Merkel,D. and Don,J.
  TITLE     Increased expression of the hPim-2 gene in human chronic
            lymphocytic leukemia and non-Hodgkin lymphoma
  JOURNAL   Leuk Lymphoma 45 (5), 951-955 (2004)
   PUBMED   15291354
  REMARK    GeneRIF: hPim-2 mRNA expression in NHL was 1.5 to 2.6 times higher
            in involved splenic foci compared to nearby uninvolved regions.
            hPim-2 mRNA was increased 3-folds in B-CLL over normal B-cells
REFERENCE   9  (bases 1 to 2075)
  AUTHORS   Yan,B., Zemskova,M., Holder,S., Chin,V., Kraft,A., Koskinen,P.J.
            and Lilly,M.
  TITLE     The PIM-2 kinase phosphorylates BAD on serine 112 and reverses
            BAD-induced cell death
  JOURNAL   J Biol Chem 278 (46), 45358-45367 (2003)
   PUBMED   12954615
  REMARK    GeneRIF: pim-2 functions similarly to pim-1 as a pro-survival
            kinase; BAD is a legitimate PIM-2 substrate
REFERENCE   10 (bases 1 to 2075)
  AUTHORS   Baytel,D., Shalom,S., Madgar,I., Weissenberg,R. and Don,J.
  TITLE     The human Pim-2 proto-oncogene and its testicular expression
  JOURNAL   Biochim Biophys Acta 1442 (2-3), 274-285 (1998)
   PUBMED   9804974
  REMARK    Erratum:[Biochim Biophys Acta 1999 Feb 16;1444(2):312-3]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290931.1, BC018111.1 and
            AC233300.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006875.3.
            
            Summary: This gene encodes a protooncogene that acts as a
            serine/threonine protein kinase. Studies determined the encoded
            protein functions to prevent apoptosis and to promote cell
            survival.[provided by RefSeq, Nov 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.498291.1,
                                           SRR3476690.126295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376509.4/ ENSP00000365692.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AK290931.1         1-17
            18-1669             BC018111.1         1-1652
            1670-1728           AC233300.2         151316-151374       c
            1729-2075           BC018111.1         1708-2054
FEATURES             Location/Qualifiers
     source          1..2075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..2075
                     /gene="PIM2"
                     /note="Pim-2 proto-oncogene, serine/threonine kinase"
                     /db_xref="GeneID:11040"
                     /db_xref="HGNC:HGNC:8987"
                     /db_xref="MIM:300295"
     exon            1..251
                     /gene="PIM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1126
                     /gene="PIM2"
                     /EC_number="2.7.11.1"
                     /note="proto-oncogene Pim-2 (serine threonine kinase);
                     pim-2 oncogene; pim-2h"
                     /codon_start=1
                     /product="serine/threonine-protein kinase pim-2"
                     /protein_id="NP_006866.2"
                     /db_xref="CCDS:CCDS14312.1"
                     /db_xref="GeneID:11040"
                     /db_xref="HGNC:HGNC:8987"
                     /db_xref="MIM:300295"
                     /translation="MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFG
                     TVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRL
                     LDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVV
                     HRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALP
                     ATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPS
                     LEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP"
     exon            252..361
                     /gene="PIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            362..412
                     /gene="PIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..785
                     /gene="PIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..962
                     /gene="PIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..2075
                     /gene="PIM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2054..2059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIM2"
                     /note="hexamer: AATAAA"
     polyA_site      2075
                     /gene="PIM2"
                     /note="major polyA site"
ORIGIN      
        1 agtagcattg gggctggcgc gcgcggcgaa tctcaacgct gcgccgtctg cgggcgcttc
       61 cgggccacca gtttctctgc tttccaccct ggcgcccccc agccctggct ccccagctgc
      121 gctgccccgg gcgtccacgc cctgcgggct tagcgggttc agtgggctca atctgcgcag
      181 cgccacctcc atgttgacca agcctctaca ggggcctccc gcgccccccg ggacccccac
      241 gccgccgcca ggaggcaagg atcgggaagc gttcgaggcc gagtatcgac tcggccccct
      301 cctgggtaag gggggctttg gcaccgtctt cgcaggacac cgcctcacag atcgactcca
      361 ggtggccatc aaagtgattc cccggaatcg tgtgctgggc tggtccccct tgtcagactc
      421 agtcacatgc ccactcgaag tcgcactgct atggaaagtg ggtgcaggtg gtgggcaccc
      481 tggcgtgatc cgcctgcttg actggtttga gacacaggag ggcttcatgc tggtcctcga
      541 gcggcctttg cccgcccagg atctctttga ctatatcaca gagaagggcc cactgggtga
      601 aggcccaagc cgctgcttct ttggccaagt agtggcagcc atccagcact gccattcccg
      661 tggagttgtc catcgtgaca tcaaggatga gaacatcctg atagacctac gccgtggctg
      721 tgccaaactc attgattttg gttctggtgc cctgcttcat gatgaaccct acactgactt
      781 tgatgggaca agggtgtaca gccccccaga gtggatctct cgacaccagt accatgcact
      841 cccggccact gtctggtcac tgggcatcct cctctatgac atggtgtgtg gggacattcc
      901 ctttgagagg gaccaggaga ttctggaagc tgagctccac ttcccagccc atgtctcccc
      961 agactgctgt gccctaatcc gccggtgcct ggcccccaaa ccttcttccc gaccctcact
     1021 ggaagagatc ctgctggacc cctggatgca aacaccagcc gaggatgtac ccctcaaccc
     1081 ctccaaagga ggccctgccc ctttggcctg gtccttgcta ccctaagcct ggcctggcct
     1141 ggcctggccc ccaatggtca gaagagccat cccatggcca tgtcacaggg atagatggac
     1201 atttgttgac ttggttttac aggtcattac cagtcattaa agtccagtat tactaaggta
     1261 agggattgag gatcaggggt tagaagacat aaaccaagtc tgcccagttc ccttcccaat
     1321 cctacaaagg agccttcctc ccagaacctg tggtccctga ttctggaggg ggaacttctt
     1381 gcttctcatt ttgctaagga agtttatttt ggtgaagttg ttcccattct gagccccggg
     1441 actcttattc tgatgatgtg tcaccccaca ttggcacctc ctactaccac cacacaaact
     1501 tagttcatat gctcttactt gggcaagggt gctttccttc caatacccca gtagctttta
     1561 ttttagtaaa gggacccttt cccctagcct agggtcccat attgggtcaa gctgcttacc
     1621 tgcctcagcc caggattctt tattctgggg gaggtaatgc cctgttgtta ccccaaggct
     1681 tctttttttt tttttttttt ttgggtgagg ggaccctact ctgttatccc aagtgctctt
     1741 attctggtga gaagaacctt acttccataa tttgggaagg aatggaagat ggacaccacc
     1801 ggacaccacc agacactagg atgggatgga tggttttttg ggggatgggc taggggaaat
     1861 aaggcttgct gtttgttctc ctggggcgct ccctccaact tttgcagatt cttgcaacct
     1921 cctcctgagc cgggattgtc caattactaa aatgtaaata atcacgtatt gtggggaggg
     1981 gagttccaag tgtgccctcc tctcttctcc tgcctggatt atttaaaaag ccatgtgtgg
     2041 aaacccacta tttaataaaa gtaatagaat cagaa
//
