LOCUS       NM_178238               1324 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens paired immunoglobin like type 2 receptor beta (PILRB),
            transcript variant 2, mRNA.
ACCESSION   NM_178238
VERSION     NM_178238.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1324)
  AUTHORS   Wang,X., Liu,Y., Zhao,Q., Wang,X., Chen,X., Hou,L., Tian,S.,
            Peng,Z.M., Han,X.J., Wang,T., Zhang,Z., Tou,F.F., Huang,S., Rao,J.,
            Chen,L. and Zheng,Z.
  TITLE     PILRB potentiates the PI3K/AKT signaling pathway and reprograms
            cholesterol metabolism to drive gastric tumorigenesis and
            metastasis
  JOURNAL   Cell Death Dis 15 (9), 642 (2024)
   PUBMED   39227585
  REMARK    GeneRIF: PILRB potentiates the PI3K/AKT signaling pathway and
            reprograms cholesterol metabolism to drive gastric tumorigenesis
            and metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1324)
  AUTHORS   Kwan,J.J., Slavkovic,S., Piazza,M., Wang,D., Dieckmann,T.,
            Johnson,P.E., Wen,X.Y. and Donaldson,L.W.
  TITLE     HACS1 signaling adaptor protein recognizes a motif in the paired
            immunoglobulin receptor B cytoplasmic domain
  JOURNAL   Commun Biol 3 (1), 672 (2020)
   PUBMED   33188360
  REMARK    GeneRIF: HACS1 signaling adaptor protein recognizes a motif in the
            paired immunoglobulin receptor B cytoplasmic domain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1324)
  AUTHORS   Lu,Q., Lu,G., Qi,J., Wang,H., Xuan,Y., Wang,Q., Li,Y., Zhang,Y.,
            Zheng,C., Fan,Z., Yan,J. and Gao,G.F.
  TITLE     PILRalpha and PILRbeta have a siglec fold and provide the basis of
            binding to sialic acid
  JOURNAL   Proc Natl Acad Sci U S A 111 (22), 8221-8226 (2014)
   PUBMED   24843130
  REMARK    GeneRIF: PILRbeta differs from PILRalpha in one of the three
            residues (Y2, R95 and W108) on the surface of PILRalpha (L108),
            explaining its inability to engage gB.
REFERENCE   4  (bases 1 to 1324)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 1324)
  AUTHORS   Wilson,M.D., Cheung,J., Martindale,D.W., Scherer,S.W. and Koop,B.F.
  TITLE     Comparative analysis of the paired immunoglobulin-like receptor
            (PILR) locus in six mammalian genomes: duplication, conversion, and
            the birth of new genes
  JOURNAL   Physiol Genomics 27 (3), 201-218 (2006)
   PUBMED   16926269
REFERENCE   6  (bases 1 to 1324)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   7  (bases 1 to 1324)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   8  (bases 1 to 1324)
  AUTHORS   Fournier,N., Chalus,L., Durand,I., Garcia,E., Pin,J.J.,
            Churakova,T., Patel,S., Zlot,C., Gorman,D., Zurawski,S., Abrams,J.,
            Bates,E.E. and Garrone,P.
  TITLE     FDF03, a novel inhibitory receptor of the immunoglobulin
            superfamily, is expressed by human dendritic and myeloid cells
  JOURNAL   J Immunol 165 (3), 1197-1209 (2000)
   PUBMED   10903717
  REMARK    GeneRIF: Characterization of paired counterpart PILRA.
REFERENCE   9  (bases 1 to 1324)
  AUTHORS   Mousseau,D.D., Banville,D., L'Abbe,D., Bouchard,P. and Shen,S.H.
  TITLE     PILRalpha, a novel immunoreceptor tyrosine-based inhibitory
            motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation
            and is paired with the truncated counterpart PILRbeta
  JOURNAL   J Biol Chem 275 (6), 4467-4474 (2000)
   PUBMED   10660620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005071.2.
            
            On Jan 28, 2021 this sequence version replaced NM_178238.3.
            
            Summary: The paired immunoglobin-like type 2 receptors consist of
            highly related activating and inhibitory receptors that are
            involved in the regulation of many aspects of the immune system.
            The paired immunoglobulin-like receptor genes are located in a
            tandem head-to-tail orientation on chromosome 7. This gene encodes
            the activating member of the receptor pair and contains a truncated
            cytoplasmic tail relative to its inhibitory counterpart (PILRA),
            that has a long cytoplasmic tail with immunoreceptor tyrosine-based
            inhibitory (ITIM) motifs. This gene is thought to have arisen from
            a duplication of the inhibitory PILRA gene and evolved to acquire
            its activating function. [provided by RefSeq, Jun 2013].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ400845.1, AF161081.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000609309.3/ ENSP00000477365.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AC005071.2         155423-155672
            251-640             AC005071.2         155996-156385
            641-841             AC005071.2         156643-156843
            842-1324            AC005071.2         164655-165137
FEATURES             Location/Qualifiers
     source          1..1324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1324
                     /gene="PILRB"
                     /gene_synonym="FDFACT1; FDFACT2"
                     /note="paired immunoglobin like type 2 receptor beta"
                     /db_xref="GeneID:29990"
                     /db_xref="HGNC:HGNC:18297"
                     /db_xref="MIM:605342"
     exon            1..250
                     /gene="PILRB"
                     /gene_synonym="FDFACT1; FDFACT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..870
                     /gene="PILRB"
                     /gene_synonym="FDFACT1; FDFACT2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; paired immunoglobin-like receptor beta; paired
                     immunoglobulin-like receptor beta; cell surface receptor
                     FDFACT1; cell surface receptor FDFACT2; paired
                     immunoglobulin-like type 2 receptor beta; activating
                     receptor PILRbeta; activating receptor PILR-beta"
                     /codon_start=1
                     /product="paired immunoglobulin-like type 2 receptor beta
                     isoform 2 precursor"
                     /protein_id="NP_839956.1"
                     /db_xref="CCDS:CCDS43622.1"
                     /db_xref="GeneID:29990"
                     /db_xref="HGNC:HGNC:18297"
                     /db_xref="MIM:605342"
                     /translation="MGRPLLLPLLLLLQPPAFLQPGGSTGSGPSYLYGVTQPKHLSAS
                     MGGSVEIPFSFYYPWELAIVPNVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWT
                     EGQESGFLRISNLRKEDQSVYFCRVELDTRRSGRQQLQSIKGTKLTITQAVTTTTTWR
                     PSSTTTIAGLRVTESKGHSESWHLSLDTAIRVALAVAVLKTVILGLLCLLLLWWRRRK
                     GSRAPSSDF"
     exon            251..640
                     /gene="PILRB"
                     /gene_synonym="FDFACT1; FDFACT2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..841
                     /gene="PILRB"
                     /gene_synonym="FDFACT1; FDFACT2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1324
                     /gene="PILRB"
                     /gene_synonym="FDFACT1; FDFACT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1202..1207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PILRB"
                     /gene_synonym="FDFACT1; FDFACT2"
                     /note="hexamer: AATACA"
     polyA_site      1226
                     /gene="PILRB"
                     /gene_synonym="FDFACT1; FDFACT2"
                     /note="major polyA site"
     regulatory      1298..1303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PILRB"
                     /gene_synonym="FDFACT1; FDFACT2"
                     /note="hexamer: AATAAA"
     polyA_site      1324
                     /gene="PILRB"
                     /gene_synonym="FDFACT1; FDFACT2"
                     /note="major polyA site"
ORIGIN      
        1 aaaggaagtg ctggtcaccc tggaggtgta ctggtttggg gaaggtcccc ggcccccaca
       61 gccctctggg gagcctcacc ctggctctcc ccactcacct cagccctcag gcagcccctc
      121 cacagggccc ctctcctgcc tggacagctc tgctggtctc cccgtcccct ggagaagaac
      181 aaggccatgg gtcggcccct gctgctgccc ctgctgctcc tgctgcagcc gccagcattt
      241 ctgcagcctg gtggctccac aggatctggt ccaagctacc tttatggggt cactcaacca
      301 aaacacctct cagcctccat gggtggctct gtggaaatcc ccttctcctt ctattacccc
      361 tgggagttag ccatagttcc caacgtgaga atatcctgga gacggggcca cttccacggg
      421 cagtccttct acagcacaag gccgccttcc attcacaagg attatgtgaa ccggctcttt
      481 ctgaactgga cagagggtca ggagagcggc ttcctcagga tctcaaacct gcggaaggag
      541 gaccagtctg tgtatttctg ccgagtcgag ctggacaccc ggagatcagg gaggcagcag
      601 ttgcagtcca tcaaggggac caaactcacc atcacccagg ctgtcacaac caccaccacc
      661 tggaggccca gcagcacaac caccatagcc ggcctcaggg tcacagaaag caaagggcac
      721 tcagaatcat ggcacctaag tctggacact gccatcaggg ttgcattggc tgtcgctgtg
      781 ctcaaaactg tcattttggg actgctgtgc ctcctcctcc tgtggtggag gagaaggaaa
      841 ggtagcaggg cgccaagcag tgacttctga ccaacagagt gtggggagaa gggatgtgta
      901 ttagccccgg aggacgtgat gtgagacccg cttgtgagtc ctccacactc gttccccatt
      961 ggcaagatac atggagagca ccctgaggac ctttaaaagg caaagccgca aggcagaagg
     1021 aggctgggtc cctgaatcac cgactggagg agagttacct acaagagcct tcatccagga
     1081 gcatccacac tgcaatgata taggaatgag gtctgaactc cactgaatta aaccactggc
     1141 atttgggggc tgtttattat agcagtgcaa agagttcctt tatcctcccc aaggatggaa
     1201 aaatacaatt tattttgctt accatacacc ccttttctcc tcgtccacat tttccaatct
     1261 gtatggtggc tgtcttctat ggcagaaggt tttggggaat aaatagcgtg aaatgctgct
     1321 gaca
//
