LOCUS       NM_001010855            3053 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens phosphoinositide-3-kinase regulatory subunit 6
            (PIK3R6), transcript variant 1, mRNA.
ACCESSION   NM_001010855 XM_375404
VERSION     NM_001010855.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3053)
  AUTHORS   Yang,J., Zhong,X., Gao,X., Xie,W., Chen,Y., Liao,Y. and Zhang,P.
  TITLE     Knockdown of PIK3R6 impedes the onset and advancement of clear cell
            renal cell carcinoma
  JOURNAL   Cell Adh Migr 18 (1), 1-12 (2024)
   PUBMED   38831518
  REMARK    GeneRIF: Knockdown of PIK3R6 impedes the onset and advancement of
            clear cell renal cell carcinoma.
REFERENCE   2  (bases 1 to 3053)
  AUTHORS   Du,Y., Zhao,W., Han,H., Ren,L., Ding,M. and Wang,Y.
  TITLE     PIK3R6 Promotes Angiogenesis in Hepatocellular carcinoma by
            Activating STAT3 Signaling Pathway
  JOURNAL   Altern Ther Health Med 29 (8), 704-709 (2023)
   PUBMED   37708538
  REMARK    GeneRIF: PIK3R6 Promotes Angiogenesis in Hepatocellular carcinoma
            by Activating STAT3 Signaling Pathway.
REFERENCE   3  (bases 1 to 3053)
  AUTHORS   Liu,Y.J., Cui,L.L., Liu,Z.S., Jia,R.Y., Ding,Y.X. and Xu,L.Z.
  TITLE     RBBP6 aggravates the progression of ovarian cancer by targeting
            PIK3R6
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (20), 10366-10374 (2020)
   PUBMED   33155192
  REMARK    GeneRIF: RBBP6 aggravates the progression of ovarian cancer by
            targeting PIK3R6.
REFERENCE   4  (bases 1 to 3053)
  AUTHORS   Nurnberg,B. and Beer-Hammer,S.
  TITLE     Function, Regulation and Biological Roles of PI3Kgamma Variants
  JOURNAL   Biomolecules 9 (9), 427 (2019)
   PUBMED   31480354
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3053)
  AUTHORS   Turvey,M.E., Klingler-Hoffmann,M., Hoffmann,P. and McColl,S.R.
  TITLE     p84 forms a negative regulatory complex with p110gamma to control
            PI3Kgamma signalling during cell migration
  JOURNAL   Immunol Cell Biol 93 (8), 735-743 (2015)
   PUBMED   25753393
  REMARK    GeneRIF: Our findings suggest that p84 binding to p110gamma may
            represent a novel negative feedback signal that terminates
            PI3Kgamma activity.
REFERENCE   6  (bases 1 to 3053)
  AUTHORS   Suire,S., Coadwell,J., Ferguson,G.J., Davidson,K., Hawkins,P. and
            Stephens,L.
  TITLE     p84, a new Gbetagamma-activated regulatory subunit of the type IB
            phosphoinositide 3-kinase p110gamma
  JOURNAL   Curr Biol 15 (6), 566-570 (2005)
   PUBMED   15797027
REFERENCE   7  (bases 1 to 3053)
  AUTHORS   Brock,C., Schaefer,M., Reusch,H.P., Czupalla,C., Michalke,M.,
            Spicher,K., Schultz,G. and Nurnberg,B.
  TITLE     Roles of G beta gamma in membrane recruitment and activation of
            p110 gamma/p101 phosphoinositide 3-kinase gamma
  JOURNAL   J Cell Biol 160 (1), 89-99 (2003)
   PUBMED   12507995
REFERENCE   8  (bases 1 to 3053)
  AUTHORS   Jiang,K., Zhong,B., Gilvary,D.L., Corliss,B.C., Hong-Geller,E.,
            Wei,S. and Djeu,J.Y.
  TITLE     Pivotal role of phosphoinositide-3 kinase in regulation of
            cytotoxicity in natural killer cells
  JOURNAL   Nat Immunol 1 (5), 419-425 (2000)
   PUBMED   11062502
  REMARK    Erratum:[Nat Immunol 2000 Dec;1(6):541]
REFERENCE   9  (bases 1 to 3053)
  AUTHORS   Krugmann,S., Hawkins,P.T., Pryer,N. and Braselmann,S.
  TITLE     Characterizing the interactions between the two subunits of the
            p101/p110gamma phosphoinositide 3-kinase and their role in the
            activation of this enzyme by G beta gamma subunits
  JOURNAL   J Biol Chem 274 (24), 17152-17158 (1999)
   PUBMED   10358071
REFERENCE   10 (bases 1 to 3053)
  AUTHORS   Stoyanov,B., Volinia,S., Hanck,T., Rubio,I., Loubtchenkov,M.,
            Malek,D., Stoyanova,S., Vanhaesebroeck,B., Dhand,R., Nurnberg,B. et
            al.
  TITLE     Cloning and characterization of a G protein-activated human
            phosphoinositide-3 kinase
  JOURNAL   Science 269 (5224), 690-693 (1995)
   PUBMED   7624799
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC003695.1, KF573668.1 and
            AC009451.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 6, 2019 this sequence version replaced NM_001010855.3.
            
            Summary: Phosphoinositide 3-kinase gamma is a lipid kinase that
            produces the lipid second messenger phosphatidylinositol
            3,4,5-trisphosphate. The kinase is composed of a catalytic subunit
            and one of several regulatory subunits, and is chiefly activated by
            G protein-coupled receptors. This gene encodes a regulatory
            subunit, and is distantly related to the phosphoinositide-3-kinase,
            regulatory subunit 5 gene which is located adjacent to this gene on
            chromosome 7. The orthologous protein in the mouse binds to both
            the catalytic subunit and to G(beta/gamma), and mediates activation
            of the kinase subunit downstream of G protein-coupled receptors.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.125362.1,
                                           SRR1803617.172743.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619866.5/ ENSP00000480157.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC003695.1         51453-51598
            147-250             AC003695.1         69242-69345
            251-334             AC003695.1         79430-79513
            335-426             AC003695.1         80472-80563
            427-495             AC003695.1         81256-81324
            496-628             AC003695.1         82204-82336
            629-698             AC003695.1         82511-82580
            699-882             AC003695.1         83671-83854
            883-1039            AC003695.1         86082-86238
            1040-1126           AC003695.1         89335-89421
            1127-1550           AC003695.1         90137-90560
            1551-1629           AC003695.1         90937-91015
            1630-1752           AC003695.1         91833-91955
            1753-1863           AC003695.1         95630-95740
            1864-1954           AC003695.1         96041-96131
            1955-2025           AC003695.1         96470-96540
            2026-2116           KF573668.1         103-193
            2117-2232           AC009451.21        2043-2158
            2233-2345           AC009451.21        17088-17200
            2346-3053           AC009451.21        17812-18519
FEATURES             Location/Qualifiers
     source          1..3053
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..3053
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /note="phosphoinositide-3-kinase regulatory subunit 6"
                     /db_xref="GeneID:146850"
                     /db_xref="HGNC:HGNC:27101"
                     /db_xref="MIM:611462"
     exon            1..146
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            147..250
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..2502
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PI3Kgamma adapter protein of 87 kDa; p87 phosphoinositide
                     3-kinase gamma (PI3Kg) adapter protein; p84 PI3K adapter
                     protein"
                     /codon_start=1
                     /product="phosphoinositide 3-kinase regulatory subunit 6
                     isoform 1"
                     /protein_id="NP_001010855.1"
                     /db_xref="CCDS:CCDS73985.1"
                     /db_xref="GeneID:146850"
                     /db_xref="HGNC:HGNC:27101"
                     /db_xref="MIM:611462"
                     /translation="MESSDVELDLQRSVQAVLRELSTQAPALQSNQGMWRWSLHKKVE
                     RDPGKSPVLVRILLRELEKAESQDLRHVIIPLLHTVMYVLTKATGITEELYQRIYAFC
                     TRLLTLPTPYCTVALDCAIRLKTEMAVPGTLYQRMVIAEQNLTNELYPYQERVFLFVD
                     PELVSASVCSALLLEIEAAQAQQTPETCMRHVVSHALQAALGEACHAGALHRKLQASP
                     RRTLEHYFHAVVAALEQMASEASPSREGHVERLEEIYCSLLGPAAGRCGGDLVQERPP
                     SIPLPSPYITFHLWTGEEQLWKELVLFLRPRSQLRLSADLEVLDLQGLRPDRELARVS
                     VLSTDSGIERDLPTGADELPAPGSPEMERAGLQRKGGIKKRAWPLDFLMPGSWDGPPG
                     LHRRTGRPSGDGEMLPGVSRLHTARVLVLGDDRMLGRLAQAYHRLRKRETQKFCLTPR
                     LSLQLYYIPVLAPEKPAASRQPELGELATFLGRVDPWYQSNVNTLCPAIHKLAEMPPS
                     LDTSRTVDPFILDVITYYIRMGTQPIYFQIYTVKIFFSDLSQDPTEDIFLIELKVKIQ
                     DSKFPKDGFSPRRRGVAEGPGAELSLCYQKALLSHRPREVTVSLRATGLILKAIPASD
                     TEVSGSSHCPLPAAPVTDHTCLNVNVTEVVKSSNLAGKSFSTVTNTFRTNNIQIQSRD
                     QRLLTLSLDKDDQRTFRDVVRFEVAPCPEPCSGAQKSKAPWLNLHGQQEVEAIKAKPK
                     PLLMPINTFSGIVQ"
     exon            251..334
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            335..426
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            427..495
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            496..628
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            629..698
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            699..882
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1039
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1126
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1550
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1629
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1752
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1863
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1954
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2025
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2116
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2232
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2345
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..3053
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3017..3022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /note="hexamer: AATAAA"
     polyA_site      3053
                     /gene="PIK3R6"
                     /gene_synonym="C17orf38; HsT41028; p84 PIKAP; p87(PIKAP);
                     p87PIKAP"
                     /note="major polyA site"
ORIGIN      
        1 gcagatctga agagcacagt caagaccaca gacacccgtg gaggctcccc caagacatct
       61 gcttctctgg gactggggac ctcgctcagg accgtgggga gttggctgaa ggacttgggg
      121 agcccagaag ctgccaccga accaagaacc acctctgtgc agaaaagcaa ccaccttgtt
      181 ctctattctg ctgcccgaga caaccacatc ctcctcctcc tacacccaaa ggctcccatg
      241 gagagctcag atgtggagct ggacctccag aggagcgtgc aggctgtgct ccgggagctc
      301 agcacccagg cccctgccct gcagagcaac caaggcatgt ggaggtggtc cctgcacaag
      361 aaggtcgagc gagatcccgg taagagccca gtgctggtcc gcattcttct cagagaactg
      421 gagaaggcgg aaagccagga cctccggcat gtcatcattc ccttgctgca cactgtaatg
      481 tacgtgctca ccaaggccac aggaatcaca gaagagctct accagagaat ctatgccttt
      541 tgcacaaggt tactgaccct gcccaccccc tactgcacag tcgccttgga ctgcgcgata
      601 aggctgaaaa cggagatggc tgtcccaggg acactgtacc aaaggatggt cattgccgaa
      661 cagaacttga cgaatgagct gtatccctac caggagagag tgttcctctt cgtggatcct
      721 gagctggtgt ctgcgtctgt gtgcagtgct ctgctactgg agatcgaggc ggcccaggcg
      781 cagcagacac cagagacctg catgcgccac gtggtctccc acgccctgca ggcggctctg
      841 ggggaggcct gtcacgcagg cgctctgcac aggaagctgc aggccagccc tcgccgcacc
      901 ctggagcact atttccacgc cgtggtggcc gccttggagc agatggccag cgaggccagc
      961 ccgagccggg agggacacgt agagaggctg gaggagattt actgctcgct gctgggtccc
     1021 gcggcggggc gctgcggtgg tgaccttgtc caagagcggc caccaagcat tcccctgccc
     1081 agcccctaca tcaccttcca cttgtggacc ggtgaggagc agctctggaa ggaactggtg
     1141 ctcttcctcc gcccaagatc ccagctgcgc ctcagtgctg acttggaggt cttggatctg
     1201 cagggcctcc ggccggaccg ggagttggcc cgggtttctg tgctgtccac tgacagcggc
     1261 attgagcggg accttcccac gggggctgat gagctgcctg cacccggcag ccctgagatg
     1321 gagcgagccg ggctgcagcg caaagggggc atcaagaagc gtgcatggcc cctggacttc
     1381 ttgatgcctg gcagctggga cgggccccca gggctgcacc ggaggacagg ccggcccagt
     1441 ggggatgggg aaatgctgcc cggcgtgtcc cggctgcaca cagcccgggt acttgtgctc
     1501 ggagatgaca ggatgctggg gcgcctggcc caggcctacc acagactcag gaaacgggag
     1561 acccagaagt tctgcctcac tcccagactc agcctgcagc tctactacat ccccgtgctg
     1621 gcgcctgaga agcctgcagc atccaggcag ccggagctgg gagagctggc tacgttcctg
     1681 ggccgcgtag acccgtggta ccagagcaac gtcaacacgc tgtgccccgc catccacaag
     1741 ctggctgaga tgcctccttc cctggacaca tcccggactg tggacccctt catcctagac
     1801 gtcatcacct actacatccg catgggcacc caacccatct atttccagat ctacacagtc
     1861 aagatctttt tcagtgacct gagccaagac cctactgagg acattttcct cattgaactg
     1921 aaggtgaaga tccaagattc taaattcccc aaagatggct tttcacccag gaggagaggc
     1981 gtggctgagg gcccaggggc agagctctcc ctatgctacc agaaggcctt gcttagccac
     2041 cggccccgag aggtcaccgt ttccctgcgg gccactgggc tgatcctgaa ggccattcca
     2101 gccagcgaca cagaagtttc agggtctagc cattgccccc tgcctgctgc tcctgtcaca
     2161 gaccacacat gtctgaatgt caacgtgaca gaggttgtca agtcctccaa cttggcggga
     2221 aagtccttct ctacagtgac caacaccttc aggacgaaca atatccagat ccagagccgg
     2281 gaccagaggc tgctgacact gtcgctggac aaggacgatc aacgcacttt cagggatgtg
     2341 gtcagattcg aggttgctcc ctgcccagaa ccatgttctg gggcccagaa gtccaaggca
     2401 ccgtggctca atttgcatgg gcaacaggag gtggaagcaa tcaaagccaa gcccaagccc
     2461 cttctgatgc ccatcaacac attctctggt attgtccagt gagcctgcag ggacagcagg
     2521 cccaggagga aggatacact accccaccaa ctccaaacac tcacaccaac agccagagca
     2581 aggcccggct ccacacggca gctttggcct tgaccaggag ccagcgagtg cctgggagca
     2641 cagggagcct accctgggga ctgtgatgag gaagggccca catggaggtc tacggatggc
     2701 ccaggcaatg ctgtcgctgc ttgagaacat acacaccaag cccagcttct catacaaatg
     2761 tctactcctt catttagctt caattcccac ttctcccact gtcctctccc acccaagctc
     2821 cccatccagc ccttaaaacc agggttaaag ctgctgtctt ggccagagcc ctgtggccta
     2881 ggggaaaatt ggaagcaagg aacagcaaca gcaccacctc cctcccaagt ctcttccctt
     2941 cccactctca ggccactgcc cacctcactc agcccaggca ggtgtctcta tcaggtgaga
     3001 gaaaaatgtc agactcaata aatgtacact gaagtctttc tgctttcatc tca
//
