LOCUS       NM_003629               5596 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens phosphoinositide-3-kinase regulatory subunit 3
            (PIK3R3), transcript variant 1, mRNA.
ACCESSION   NM_003629
VERSION     NM_003629.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5596)
  AUTHORS   Qian,W., Mei,K., Zhu,L., Chu,Y., Lv,J. and Yun,C.
  TITLE     Circ_0044235 regulates the development of osteoarthritis by the
            modulation of miR-375/PIK3R3 axis
  JOURNAL   J Orthop Surg Res 19 (1), 241 (2024)
   PUBMED   38622668
  REMARK    GeneRIF: Circ_0044235 regulates the development of osteoarthritis
            by the modulation of miR-375/PIK3R3 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5596)
  AUTHORS   Lee,H., Zhuang,L. and Gan,B.
  TITLE     VHL governs m6A modification and PIK3R3 mRNA stability in clear
            cell renal cell carcinomas
  JOURNAL   J Clin Invest 134 (8), e179560 (2024)
   PUBMED   38618953
  REMARK    GeneRIF: VHL governs m6A modification and PIK3R3 mRNA stability in
            clear cell renal cell carcinomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5596)
  AUTHORS   Li,Z., Dai,R., Chen,M., Huang,L., Zhu,K., Li,M., Zhu,W., Li,Y.,
            Xie,N., Li,J., Wang,L., Lan,F. and Cao,C.M.
  TITLE     p55gamma degrades RIP3 via MG53 to suppress ischaemia-induced
            myocardial necroptosis and mediates cardioprotection of
            preconditioning
  JOURNAL   Cardiovasc Res 119 (14), 2421-2440 (2023)
   PUBMED   37527538
  REMARK    GeneRIF: p55gamma degrades RIP3 via MG53 to suppress
            ischaemia-induced myocardial necroptosis and mediates
            cardioprotection of preconditioning.
REFERENCE   4  (bases 1 to 5596)
  AUTHORS   Lin,W., Wang,K., Mo,J., Wang,L., Song,Z., Jiang,H., Wang,C. and
            Jin,C.
  TITLE     PIK3R3 is upregulated in liver cancer and activates Akt signaling
            to control cancer growth by regulation of CDKN1C and SMC1A
  JOURNAL   Cancer Med 12 (13), 14413-14425 (2023)
   PUBMED   37212524
  REMARK    GeneRIF: PIK3R3 is upregulated in liver cancer and activates Akt
            signaling to control cancer growth by regulation of CDKN1C and
            SMC1A.
REFERENCE   5  (bases 1 to 5596)
  AUTHORS   Wang,B., Min,W., Zhang,W., Liu,Q., Guo,X., Zhan,J., Lei,M., Zan,Y.,
            Ma,Q. and Ma,H.
  TITLE     PIK3R3 Missense and NOTCH2 Synonymous Single Nucleotide
            Polymorphisms Are Associated with Liver Cancer
  JOURNAL   Dig Dis 41 (3), 458-467 (2023)
   PUBMED   36535266
  REMARK    GeneRIF: PIK3R3 Missense and NOTCH2 Synonymous Single Nucleotide
            Polymorphisms Are Associated with Liver Cancer.
REFERENCE   6  (bases 1 to 5596)
  AUTHORS   Dey,B.R., Furlanetto,R.W. and Nissley,S.P.
  TITLE     Cloning of human p55 gamma, a regulatory subunit of
            phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen
            with the insulin-like growth factor-I receptor
  JOURNAL   Gene 209 (1-2), 175-183 (1998)
   PUBMED   9524259
  REMARK    Erratum:[Gene 1998 May 28;212(1):155]
REFERENCE   7  (bases 1 to 5596)
  AUTHORS   Mothe,I., Delahaye,L., Filloux,C., Pons,S., White,M.F. and Van
            Obberghen,E.
  TITLE     Interaction of wild type and dominant-negative p55PIK regulatory
            subunit of phosphatidylinositol 3-kinase with insulin-like growth
            factor-1 signaling proteins
  JOURNAL   Mol Endocrinol 11 (13), 1911-1923 (1997)
   PUBMED   9415396
REFERENCE   8  (bases 1 to 5596)
  AUTHORS   Takahashi-Tezuka,M., Hibi,M., Fujitani,Y., Fukada,T., Yamaguchi,T.
            and Hirano,T.
  TITLE     Tec tyrosine kinase links the cytokine receptors to PI-3 kinase
            probably through JAK
  JOURNAL   Oncogene 14 (19), 2273-2282 (1997)
   PUBMED   9178903
REFERENCE   9  (bases 1 to 5596)
  AUTHORS   Tuscano,J.M., Engel,P., Tedder,T.F., Agarwal,A. and Kehrl,J.H.
  TITLE     Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl
            inositol-3 kinase in signal transduction via the human B lymphocyte
            antigen CD22
  JOURNAL   Eur J Immunol 26 (6), 1246-1252 (1996)
   PUBMED   8647200
REFERENCE   10 (bases 1 to 5596)
  AUTHORS   Pons,S., Asano,T., Glasheen,E., Miralpeix,M., Zhang,Y.,
            Fisher,T.L., Myers,M.G. Jr., Sun,X.J. and White,M.F.
  TITLE     The structure and function of p55PIK reveal a new regulatory
            subunit for phosphatidylinositol 3-kinase
  JOURNAL   Mol Cell Biol 15 (8), 4453-4465 (1995)
   PUBMED   7542745
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC021622.1, BC094768.1 and
            U90907.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003629.3.
            
            Summary: Phosphatidylinositol 3-kinase (PI3K) phosphorylates
            phosphatidylinositol and similar compounds, which then serve as
            second messengers in growth signaling pathways. PI3K is composed of
            a catalytic and a regulatory subunit. The protein encoded by this
            gene represents a regulatory subunit of PI3K. The encoded protein
            contains two SH2 domains through which it binds activated protein
            tyrosine kinases to regulate their activity. [provided by RefSeq,
            Jun 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749649.1, BC021622.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262741.10/ ENSP00000262741.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1618              BC021622.1         14-1631
            1619-1864           BC094768.1         1078-1323
            1865-4272           BC021622.1         1878-4285
            4273-5596           U90907.1           334-1657
FEATURES             Location/Qualifiers
     source          1..5596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..5596
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /note="phosphoinositide-3-kinase regulatory subunit 3"
                     /db_xref="GeneID:8503"
                     /db_xref="HGNC:HGNC:8981"
                     /db_xref="MIM:606076"
     exon            1..783
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     CDS             678..2063
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol 3-kinase, regulatory subunit,
                     polypeptide 3 (p55, gamma); PI3-kinase subunit p55-gamma;
                     PI3K regulatory subunit gamma; PI3-kinase regulatory
                     subunit gamma; ptdIns-3-kinase regulatory subunit
                     p55-gamma; phosphatidylinositol 3-kinase 55 kDa regulatory
                     subunit gamma; phosphoinositide-3-kinase, regulatory
                     subunit 3 (gamma)"
                     /codon_start=1
                     /product="phosphatidylinositol 3-kinase regulatory subunit
                     gamma isoform 1"
                     /protein_id="NP_003620.3"
                     /db_xref="CCDS:CCDS529.1"
                     /db_xref="GeneID:8503"
                     /db_xref="HGNC:HGNC:8981"
                     /db_xref="MIM:606076"
                     /translation="MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKP
                     MTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTL
                     TLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPV
                     SRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEA
                     FNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMR
                     LEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKN
                     EDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYA
                     CSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAY
                     PVHAQMPSLCR"
     exon            784..892
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            893..991
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1172
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1298
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1441
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1618
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1693
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1864
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..5596
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5573..5578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /note="hexamer: AATAAA"
     polyA_site      5596
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /note="major polyA site"
ORIGIN      
        1 gggcagagct tgagggcagt tggtgcggtc gggttggttc ttacaccccg gcgggagcgc
       61 ccagacaagc cgagctgact ggacttctcc ggccggcccc attcccgagg ctgcggcagc
      121 ttcggttccg agaccgaccg gagaggagcc cgagtcccgg cctctggggg attcgctctc
      181 tgcagaccag tgggaccccg aaacttgaac gcaatctcca gccccctttt ttgccttcct
      241 ttgtcacttg cccgggtttc tcccaacgtg ttcttttttt tcctcttcat tctccctcct
      301 tcgaaggaca caaaagtggc ttccgcggaa agatttggag gcggtgggag cttttctccc
      361 cggagagcga ctgtgtagaa aggatttttg ggaagccgct ttttaacacc tctgctctcc
      421 gtcccccaag cctctgtgta atcctctgag gagaaaagcc catagcttga aagttcgggg
      481 gcattttgtt gtgttctgta ggagagaggg ggaggaccct gttcgggtag tttggccgga
      541 ctggtactgg ccgttggaaa acccgaagta catttccgtg tggaactttt gcagatatat
      601 atttttagat ttttaaatac cagataaaaa atatatgcct tctatatatc tcctggcgac
      661 ctgcccctga cagcgcgatg tacaatacgg tgtggagtat ggaccgcgat gacgcagact
      721 ggagggaggt gatgatgccc tattcgacag aactgatatt ttatattgaa atggatcctc
      781 cagctcttcc accaaagcca cctaagccaa tgacttcagc agttccaaat ggaatgaagg
      841 acagttctgt ttctcttcag gatgcagaat ggtactgggg ggatatttca agggaggagg
      901 taaatgacaa attgcgggat atgccagatg ggaccttctt ggtccgagat gcctcaacaa
      961 aaatgcaggg agattatact ttgactttgc ggaagggagg caataataag ttaataaaga
     1021 tctatcaccg ggatggtaaa tatggctttt ctgatcctct gacatttaat tccgtggtgg
     1081 agctcattaa ccactatcac catgaatctc ttgctcagta caatcccaaa cttgatgtga
     1141 agctgatgta cccagtgtcc agataccaac aggatcagtt ggtaaaagaa gataatattg
     1201 atgcagtagg taaaaaactg caagaatacc actctcagta tcaggagaag agtaaagagt
     1261 atgataggct gtatgaagaa tatactagaa catcccagga aatacagatg aagaggactg
     1321 caatagaagc ttttaatgaa acaattaaaa tatttgaaga gcagtgtcac acacaagaac
     1381 aacatagcaa agaatatatt gagcgatttc gcagagaggg gaatgaaaag gagattgaac
     1441 gaattatgat gaattatgat aaattgaaat cacgtctggg tgagattcat gatagcaaaa
     1501 tgcgtctaga gcaggatttg aagaatcaag ctttggacaa ccgagaaata gataaaaaaa
     1561 tgaatagcat caaacctgac ctgatccagc tgcgaaagat ccgagatcaa caccttgtat
     1621 ggctcaatca caaaggagtg agacagaaac gcctgaatgt ctggctggga attaagaatg
     1681 aggatgctga tgagaactat tttatcaatg aggaagatga aaacctgccc cattatgatg
     1741 agaaaacctg gtttgttgag gatatcaatc gagtacaagc agaggacttg ctttatggga
     1801 aacctgatgg tgcattctta attcgtgaga gtagcaagaa aggatgctat gcttgctctg
     1861 tggtggccga tggggaagtg aagcactgtg tgatctacag cactgctcgg ggctatggct
     1921 ttgcagagcc ctacaacctg tacagctctc tgaaggagct agtgctccat taccagcaga
     1981 catccttggt tcagcacaac gactccctca acgtcaggct tgcctaccct gttcatgcac
     2041 agatgccctc gctttgcaga taaagaggaa gtgggaagag aggtggttct ctggcatttt
     2101 tttctacagt ttttattaga ctacgatgag ggcattcttt ctacatagac tgcttgtttt
     2161 gcacaagaag tgattttgtg aatgtgaagt ggagaggccg agcagcagcc ggccgggatg
     2221 ggggcattag aggcctgagg ttctctagga ctcagccatg ccgctgcact gacatactaa
     2281 gctggaagca gatgtttttt ttgaaagtct gtttcattgg ggtttttgtt ttgtttagcc
     2341 agacaccctc aacagaatat taggcttgat ggttatagcg ggtggggttg tatttggaag
     2401 cctctgaaga gaccatgtct ttttaaaatc taactcttga gagtgcagca ggggcatggc
     2461 tctgctggga gttgtgtttt gctttggcag tctctcttcc ccccacgaag aaggctgttt
     2521 aggttttgtg atagaatggg atttgatgaa aaagacaacc aaaggaaaat ggggaggctt
     2581 gggatttcat ttaaataatc taagccaaga tgataaaaaa aaccttcaac tgaaggtatt
     2641 ttgtttctta ccaacataat ttaggcttca gcatctcacc agcccctccc tctgaagaag
     2701 tattatgttc agaagccaac aaaacagttt gttgccagac caatgtttga tgggaaaacg
     2761 tggcactcat agttgaatgt atacttctgt accaaaactt gaacataaaa agactagaat
     2821 ttgtgagttt tagcaaacgc taaaattgat cactgtaact aaccccttct gtccttcctg
     2881 cctgtttctc tgagatgagg aatagcattc tttttgtggg gatggtgagc tttgaatcat
     2941 aaaatgaagt tggtgcttgt atggtgtttc cttagcctaa agaatgatct gttgtttgaa
     3001 acctttgtaa cttgtttgta tgagtaaaga aaaggtgcaa tgcagtgctt ttagatggct
     3061 tgatatacca aataacaata tagaacaaca ttattatatg tgcttcccca agtttaaagg
     3121 ccctgcagaa atagtaaaca tggtttaatt tcccttcatt tccccctcct ttgctggatg
     3181 gggttttggg agctataggt tgctaaggag gggagtcaga ttgtggtcag gtgcctcagt
     3241 aaatcacaga cccaggggcc ctgtggtcca gggtgagagt cacaccacat tacacatgtg
     3301 cttccataca gtggtttctg aagcttttgc agggagagaa gatggcttag tgtttagact
     3361 gttagtagaa gccatctgga agcttttctc tttgcctttt tttgtgatcc tgccattaag
     3421 gctatgtgca gtctgccctc ctgctccagt ggccttgatt ttaggccagg aatcttctgc
     3481 tccatgtggc ttaagccttc cagctgagtg aagctaggca aatggagtgg gggcaggcat
     3541 ctattcctgc ccccatcatg ccccacaccc atcagtcaac actcatttga caaatagagt
     3601 ccagctgcct ctgagccaat cctgggacca taataggctc agagtgagtc agctgtttga
     3661 acccaaagct gtgcagtcag gcaccctggc tgagctagag aagccagtac ctgcatcttg
     3721 gtttataagg cttacagcta ggaaagctct agttctgggg gtgaaagaaa aatattagtt
     3781 tacctgagca cttatttcca tgacagggtc taaaatatgg accatgatgt agacacagat
     3841 ttttaatttt ggaaaaacct ccagttacta gtgacgagga tagaaaggga agtgcttctc
     3901 tttggctttt tcttggttac actgcagttt caggattggg tgagacagag acaaatgaac
     3961 ccccctctaa agtcatttaa ctaatagcca gcacatccct tccccaaact gtcaattgaa
     4021 atcttaactg aaagttttac tgaataatac caagctaatt gctgttgggc acacctggat
     4081 ggctttgcac ctggtgttga acctgctgaa gcaggtggat gctcaagatt acgtgcaagg
     4141 aatccctccc atctggtact aaaatttcag tgtgttctga gtgtctttta aaccaaaatg
     4201 gaaatacaga tacagggctg tagtattcag taatgtgtct gctccttgtt gggcagacac
     4261 cagcggtgtg cagggagaga ccaagtacca tctttatcta cacttgggct ggcttgtgga
     4321 gaagggctgc tttttttcag tcctacattc cttcattttt tttttcattc ttgaattcat
     4381 tgttttgtgg gatctaagac ccaggggtca tttgagaggt ttgacagtat cttttctgac
     4441 cagttgccac atgacttgct tgaccctgag cctgtggaaa tggcataggg accagtctac
     4501 tacccactgg gcctggtgtg tagaggggga gagggtagca aggtgcttct ctacgcccat
     4561 gacttgggag caggtcttgg cctccttcat gagagtctag tgccatgtcc tgtcccatga
     4621 tctggaccct gggactgtct tggcatctta actgcagttt caatgaggca gagggcaaag
     4681 agagaccaag atcagagggg ttcattatac ccctggctag agaacccagc tactgacatg
     4741 caagcagctt ggggctggct ggacacaggt actaggccca ttgtttccag gtgaagcttt
     4801 catcacagaa cagtgttgtc tccacctggc cttagatggc acgccatgat tcgggcctgg
     4861 atagactgcc tgcgtcctta ccactgatct ggccaagaat gaggccctcc caacactttc
     4921 actccctctc caagccttga tgggacctcc acttatttag gcctcatgtg ctttgaagaa
     4981 gctttgagag ccaatgtgtc ttccacgggt ctcttttttg ctacaagtaa tcagccccat
     5041 gtgttctctt aaactgagaa ttgcacctgg gcaattcctg ttttctaagg tggtctctgc
     5101 tgctatttaa caacccagag taggcctctg tgaggcttca gtggcctcag aaaccagagg
     5161 gtccagatag ggggcctgct tgggccctct gctgccaact gctcaaacct gctttagctc
     5221 cagccacttg tggcaaacaa cctcgtttcc ttacaaattc cagcatgtga ctttggtgcc
     5281 gttacttgtg aaaaatctat tctgttgtct ttgatgtgtc caagaaaatt cgtgtagttt
     5341 acgtaaaaat atctgactca caagaaagcc aactgtatgt cttgtgatgg gacagttcat
     5401 aatgtagttg ctagaccact ttacaaattg ttcttgtcac cagatgtgtt cagacattgc
     5461 tgtgcaattg ttggggaggg tagggggaaa ggcgagagga gatacttatt ggtctttttg
     5521 tttaatacct tccccaagag gggacagtct ggccaacttg ctccagtaat gcaataaaga
     5581 cattgcaata aagtaa
//
