LOCUS       NM_001328648            4878 bp    mRNA    linear   PRI 30-APR-2024
DEFINITION  Homo sapiens phosphoinositide-3-kinase regulatory subunit 3
            (PIK3R3), transcript variant 6, mRNA.
ACCESSION   NM_001328648
VERSION     NM_001328648.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4878)
  AUTHORS   Qian,W., Mei,K., Zhu,L., Chu,Y., Lv,J. and Yun,C.
  TITLE     Circ_0044235 regulates the development of osteoarthritis by the
            modulation of miR-375/PIK3R3 axis
  JOURNAL   J Orthop Surg Res 19 (1), 241 (2024)
   PUBMED   38622668
  REMARK    GeneRIF: Circ_0044235 regulates the development of osteoarthritis
            by the modulation of miR-375/PIK3R3 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4878)
  AUTHORS   Lee,H., Zhuang,L. and Gan,B.
  TITLE     VHL governs m6A modification and PIK3R3 mRNA stability in clear
            cell renal cell carcinomas
  JOURNAL   J Clin Invest 134 (8), e179560 (2024)
   PUBMED   38618953
  REMARK    GeneRIF: VHL governs m6A modification and PIK3R3 mRNA stability in
            clear cell renal cell carcinomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4878)
  AUTHORS   Li,Z., Dai,R., Chen,M., Huang,L., Zhu,K., Li,M., Zhu,W., Li,Y.,
            Xie,N., Li,J., Wang,L., Lan,F. and Cao,C.M.
  TITLE     p55gamma degrades RIP3 via MG53 to suppress ischaemia-induced
            myocardial necroptosis and mediates cardioprotection of
            preconditioning
  JOURNAL   Cardiovasc Res 119 (14), 2421-2440 (2023)
   PUBMED   37527538
  REMARK    GeneRIF: p55gamma degrades RIP3 via MG53 to suppress
            ischaemia-induced myocardial necroptosis and mediates
            cardioprotection of preconditioning.
REFERENCE   4  (bases 1 to 4878)
  AUTHORS   Lin,W., Wang,K., Mo,J., Wang,L., Song,Z., Jiang,H., Wang,C. and
            Jin,C.
  TITLE     PIK3R3 is upregulated in liver cancer and activates Akt signaling
            to control cancer growth by regulation of CDKN1C and SMC1A
  JOURNAL   Cancer Med 12 (13), 14413-14425 (2023)
   PUBMED   37212524
  REMARK    GeneRIF: PIK3R3 is upregulated in liver cancer and activates Akt
            signaling to control cancer growth by regulation of CDKN1C and
            SMC1A.
REFERENCE   5  (bases 1 to 4878)
  AUTHORS   Wang,B., Min,W., Zhang,W., Liu,Q., Guo,X., Zhan,J., Lei,M., Zan,Y.,
            Ma,Q. and Ma,H.
  TITLE     PIK3R3 Missense and NOTCH2 Synonymous Single Nucleotide
            Polymorphisms Are Associated with Liver Cancer
  JOURNAL   Dig Dis 41 (3), 458-467 (2023)
   PUBMED   36535266
  REMARK    GeneRIF: PIK3R3 Missense and NOTCH2 Synonymous Single Nucleotide
            Polymorphisms Are Associated with Liver Cancer.
REFERENCE   6  (bases 1 to 4878)
  AUTHORS   Dey,B.R., Furlanetto,R.W. and Nissley,S.P.
  TITLE     Cloning of human p55 gamma, a regulatory subunit of
            phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen
            with the insulin-like growth factor-I receptor
  JOURNAL   Gene 209 (1-2), 175-183 (1998)
   PUBMED   9524259
  REMARK    Erratum:[Gene 1998 May 28;212(1):155]
REFERENCE   7  (bases 1 to 4878)
  AUTHORS   Mothe,I., Delahaye,L., Filloux,C., Pons,S., White,M.F. and Van
            Obberghen,E.
  TITLE     Interaction of wild type and dominant-negative p55PIK regulatory
            subunit of phosphatidylinositol 3-kinase with insulin-like growth
            factor-1 signaling proteins
  JOURNAL   Mol Endocrinol 11 (13), 1911-1923 (1997)
   PUBMED   9415396
REFERENCE   8  (bases 1 to 4878)
  AUTHORS   Takahashi-Tezuka,M., Hibi,M., Fujitani,Y., Fukada,T., Yamaguchi,T.
            and Hirano,T.
  TITLE     Tec tyrosine kinase links the cytokine receptors to PI-3 kinase
            probably through JAK
  JOURNAL   Oncogene 14 (19), 2273-2282 (1997)
   PUBMED   9178903
REFERENCE   9  (bases 1 to 4878)
  AUTHORS   Tuscano,J.M., Engel,P., Tedder,T.F., Agarwal,A. and Kehrl,J.H.
  TITLE     Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl
            inositol-3 kinase in signal transduction via the human B lymphocyte
            antigen CD22
  JOURNAL   Eur J Immunol 26 (6), 1246-1252 (1996)
   PUBMED   8647200
REFERENCE   10 (bases 1 to 4878)
  AUTHORS   Pons,S., Asano,T., Glasheen,E., Miralpeix,M., Zhang,Y.,
            Fisher,T.L., Myers,M.G. Jr., Sun,X.J. and White,M.F.
  TITLE     The structure and function of p55PIK reveal a new regulatory
            subunit for phosphatidylinositol 3-kinase
  JOURNAL   Mol Cell Biol 15 (8), 4453-4465 (1995)
   PUBMED   7542745
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL672043.15 and AL358075.10.
            
            Summary: Phosphatidylinositol 3-kinase (PI3K) phosphorylates
            phosphatidylinositol and similar compounds, which then serve as
            second messengers in growth signaling pathways. PI3K is composed of
            a catalytic and a regulatory subunit. The protein encoded by this
            gene represents a regulatory subunit of PI3K. The encoded protein
            contains two SH2 domains through which it binds activated protein
            tyrosine kinases to regulate their activity. [provided by RefSeq,
            Jun 2016].
            
            Transcript Variant: This variant (6) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (5) is
            shorter at the N-terminus compared to isoform 1. Variants 6, 7, 8,
            and 9 all encode the same isoform (5).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.942.1,
                                           SRR1803614.230418.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AL672043.15        30618-30682         c
            66-174              AL358075.10        65470-65578
            175-273             AL358075.10        68607-68705
            274-454             AL358075.10        79129-79309
            455-580             AL358075.10        80041-80166
            581-723             AL358075.10        84149-84291
            724-900             AL358075.10        90249-90425
            901-975             AL358075.10        99595-99669
            976-1146            AL358075.10        100132-100302
            1147-4878           AL358075.10        102349-106080
FEATURES             Location/Qualifiers
     source          1..4878
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..4878
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /note="phosphoinositide-3-kinase regulatory subunit 3"
                     /db_xref="GeneID:8503"
                     /db_xref="HGNC:HGNC:8981"
                     /db_xref="MIM:606076"
     exon            1..65
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            66..174
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1345
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /note="isoform 5 is encoded by transcript variant 6;
                     phosphatidylinositol 3-kinase, regulatory subunit,
                     polypeptide 3 (p55, gamma); PI3-kinase subunit p55-gamma;
                     PI3K regulatory subunit gamma; PI3-kinase regulatory
                     subunit gamma; ptdIns-3-kinase regulatory subunit
                     p55-gamma; phosphatidylinositol 3-kinase 55 kDa regulatory
                     subunit gamma; phosphoinositide-3-kinase, regulatory
                     subunit 3 (gamma)"
                     /codon_start=1
                     /product="phosphatidylinositol 3-kinase regulatory subunit
                     gamma isoform 5"
                     /protein_id="NP_001315577.1"
                     /db_xref="GeneID:8503"
                     /db_xref="HGNC:HGNC:8981"
                     /db_xref="MIM:606076"
                     /translation="MTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFL
                     VRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLA
                     QYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTR
                     TSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDK
                     LKSRLGEIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKG
                     VRQKRLNVWLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDG
                     AFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTS
                     LVQHNDSLNVRLAYPVHAQMPSLCR"
     exon            175..273
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            274..454
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            455..580
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            581..723
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            724..900
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            901..975
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1146
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..4878
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4855..4860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /note="hexamer: AATAAA"
     polyA_site      4878
                     /gene="PIK3R3"
                     /gene_synonym="p55; p55-GAMMA; p55PIK"
                     /note="major polyA site"
ORIGIN      
        1 aacatggaga agggtgagat tctgagaaag gcatactacc ttcggccctt caaccattct
       61 ctgagctctt ccaccaaagc cacctaagcc aatgacttca gcagttccaa atggaatgaa
      121 ggacagttct gtttctcttc aggatgcaga atggtactgg ggggatattt caagggagga
      181 ggtaaatgac aaattgcggg atatgccaga tgggaccttc ttggtccgag atgcctcaac
      241 aaaaatgcag ggagattata ctttgacttt gcggaaggga ggcaataata agttaataaa
      301 gatctatcac cgggatggta aatatggctt ttctgatcct ctgacattta attccgtggt
      361 ggagctcatt aaccactatc accatgaatc tcttgctcag tacaatccca aacttgatgt
      421 gaagctgatg tacccagtgt ccagatacca acaggatcag ttggtaaaag aagataatat
      481 tgatgcagta ggtaaaaaac tgcaagaata ccactctcag tatcaggaga agagtaaaga
      541 gtatgatagg ctgtatgaag aatatactag aacatcccag gaaatacaga tgaagaggac
      601 tgcaatagaa gcttttaatg aaacaattaa aatatttgaa gagcagtgtc acacacaaga
      661 acaacatagc aaagaatata ttgagcgatt tcgcagagag gggaatgaaa aggagattga
      721 acgaattatg atgaattatg ataaattgaa atcacgtctg ggtgagattc atgatagcaa
      781 aatgcgtcta gagcaggatt tgaagaatca agctttggac aaccgagaaa tagataaaaa
      841 aatgaatagc atcaaacctg acctgatcca gctgcgaaag atccgagatc aacaccttgt
      901 atggctcaat cacaaaggag tgagacagaa acgcctgaat gtctggctgg gaattaagaa
      961 tgaggatgct gatgagaact attttatcaa tgaggaagat gaaaacctgc cccattatga
     1021 tgagaaaacc tggtttgttg aggatatcaa tcgagtacaa gcagaggact tgctttatgg
     1081 gaaacctgat ggtgcattct taattcgtga gagtagcaag aaaggatgct atgcttgctc
     1141 tgtggtggcc gatggggaag tgaagcactg tgtgatctac agcactgctc ggggctatgg
     1201 ctttgcagag ccctacaacc tgtacagctc tctgaaggag ctagtgctcc attaccagca
     1261 gacatccttg gttcagcaca acgactccct caacgtcagg cttgcctacc ctgttcatgc
     1321 acagatgccc tcgctttgca gataaagagg aagtgggaag agaggtggtt ctctggcatt
     1381 tttttctaca gtttttatta gactacgatg agggcattct ttctacatag actgcttgtt
     1441 ttgcacaaga agtgattttg tgaatgtgaa gtggagaggc cgagcagcag ccggccggga
     1501 tgggggcatt agaggcctga ggttctctag gactcagcca tgccgctgca ctgacatact
     1561 aagctggaag cagatgtttt ttttgaaagt ctgtttcatt ggggtttttg ttttgtttag
     1621 ccagacaccc tcaacagaat attaggcttg atggttatag cgggtggggt tgtatttgga
     1681 agcctctgaa gagaccatgt ctttttaaaa tctaactctt gagagtgcag caggggcatg
     1741 gctctgctgg gagttgtgtt ttgctttggc agtctctctt ccccccacga agaaggctgt
     1801 ttaggttttg tgatagaatg ggatttgatg aaaaagacaa ccaaaggaaa atggggaggc
     1861 ttgggatttc atttaaataa tctaagccaa gatgataaaa aaaaccttca actgaaggta
     1921 ttttgtttct taccaacata atttaggctt cagcatctca ccagcccctc cctctgaaga
     1981 agtattatgt tcagaagcca acaaaacagt ttgttgccag accaatgttt gatgggaaaa
     2041 cgtggcactc atagttgaat gtatacttct gtaccaaaac ttgaacataa aaagactaga
     2101 atttgtgagt tttagcaaac gctaaaattg atcactgtaa ctaacccctt ctgtccttcc
     2161 tgcctgtttc tctgagatga ggaatagcat tctttttgtg gggatggtga gctttgaatc
     2221 ataaaatgaa gttggtgctt gtatggtgtt tccttagcct aaagaatgat ctgttgtttg
     2281 aaacctttgt aacttgtttg tatgagtaaa gaaaaggtgc aatgcagtgc ttttagatgg
     2341 cttgatatac caaataacaa tatagaacaa cattattata tgtgcttccc caagtttaaa
     2401 ggccctgcag aaatagtaaa catggtttaa tttcccttca tttccccctc ctttgctgga
     2461 tggggttttg ggagctatag gttgctaagg aggggagtca gattgtggtc aggtgcctca
     2521 gtaaatcaca gacccagggg ccctgtggtc cagggtgaga gtcacaccac attacacatg
     2581 tgcttccata cagtggtttc tgaagctttt gcagggagag aagatggctt agtgtttaga
     2641 ctgttagtag aagccatctg gaagcttttc tctttgcctt tttttgtgat cctgccatta
     2701 aggctatgtg cagtctgccc tcctgctcca gtggccttga ttttaggcca ggaatcttct
     2761 gctccatgtg gcttaagcct tccagctgag tgaagctagg caaatggagt gggggcaggc
     2821 atctattcct gcccccatca tgccccacac ccatcagtca acactcattt gacaaataga
     2881 gtccagctgc ctctgagcca atcctgggac cataataggc tcagagtgag tcagctgttt
     2941 gaacccaaag ctgtgcagtc aggcaccctg gctgagctag agaagccagt acctgcatct
     3001 tggtttataa ggcttacagc taggaaagct ctagttctgg gggtgaaaga aaaatattag
     3061 tttacctgag cacttatttc catgacaggg tctaaaatat ggaccatgat gtagacacag
     3121 atttttaatt ttggaaaaac ctccagttac tagtgacgag gatagaaagg gaagtgcttc
     3181 tctttggctt tttcttggtt acactgcagt ttcaggattg ggtgagacag agacaaatga
     3241 acccccctct aaagtcattt aactaatagc cagcacatcc cttccccaaa ctgtcaattg
     3301 aaatcttaac tgaaagtttt actgaataat accaagctaa ttgctgttgg gcacacctgg
     3361 atggctttgc acctggtgtt gaacctgctg aagcaggtgg atgctcaaga ttacgtgcaa
     3421 ggaatccctc ccatctggta ctaaaatttc agtgtgttct gagtgtcttt taaaccaaaa
     3481 tggaaataca gatacagggc tgtagtattc agtaatgtgt ctgctccttg ttgggcagac
     3541 accagcggtg tgcagggaga gaccaagtac catctttatc tacacttggg ctggcttgtg
     3601 gagaagggct gctttttttc agtcctacat tccttcattt tttttttcat tcttgaattc
     3661 attgttttgt gggatctaag acccaggggt catttgagag gtttgacagt atcttttctg
     3721 accagttgcc acatgacttg cttgaccctg agcctgtgga aatggcatag ggaccagtct
     3781 actacccact gggcctggtg tgtagagggg gagagggtag caaggtgctt ctctacgccc
     3841 atgacttggg agcaggtctt ggcctccttc atgagagtct agtgccatgt cctgtcccat
     3901 gatctggacc ctgggactgt cttggcatct taactgcagt ttcaatgagg cagagggcaa
     3961 agagagacca agatcagagg ggttcattat acccctggct agagaaccca gctactgaca
     4021 tgcaagcagc ttggggctgg ctggacacag gtactaggcc cattgtttcc aggtgaagct
     4081 ttcatcacag aacagtgttg tctccacctg gccttagatg gcacgccatg attcgggcct
     4141 ggatagactg cctgcgtcct taccactgat ctggccaaga atgaggccct cccaacactt
     4201 tcactccctc tccaagcctt gatgggacct ccacttattt aggcctcatg tgctttgaag
     4261 aagctttgag agccaatgtg tcttccacgg gtctcttttt tgctacaagt aatcagcccc
     4321 atgtgttctc ttaaactgag aattgcacct gggcaattcc tgttttctaa ggtggtctct
     4381 gctgctattt aacaacccag agtaggcctc tgtgaggctt cagtggcctc agaaaccaga
     4441 gggtccagat agggggcctg cttgggccct ctgctgccaa ctgctcaaac ctgctttagc
     4501 tccagccact tgtggcaaac aacctcgttt ccttacaaat tccagcatgt gactttggtg
     4561 ccgttacttg tgaaaaatct attctgttgt ctttgatgtg tccaagaaaa ttcgtgtagt
     4621 ttacgtaaaa atatctgact cacaagaaag ccaactgtat gtcttgtgat gggacagttc
     4681 ataatgtagt tgctagacca ctttacaaat tgttcttgtc accagatgtg ttcagacatt
     4741 gctgtgcaat tgttggggag ggtaggggga aaggcgagag gagatactta ttggtctttt
     4801 tgtttaatac cttccccaag aggggacagt ctggccaact tgctccagta atgcaataaa
     4861 gacattgcaa taaagtaa
//
