LOCUS       NM_005027               3980 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens phosphoinositide-3-kinase regulatory subunit 2
            (PIK3R2), transcript variant 1, mRNA.
ACCESSION   NM_005027
VERSION     NM_005027.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3980)
  AUTHORS   Du,X., Cheng,C., Yang,Y., Fan,B., Wang,P., Xia,H., Ni,X., Liu,Q.,
            Lu,L. and Wei,L.
  TITLE     NSUN2 promotes lung adenocarcinoma progression through stabilizing
            PIK3R2 mRNA in an m5C-dependent manner
  JOURNAL   Mol Carcinog 63 (5), 962-976 (2024)
   PUBMED   38411298
  REMARK    GeneRIF: NSUN2 promotes lung adenocarcinoma progression through
            stabilizing PIK3R2 mRNA in an m[5]C-dependent manner.
REFERENCE   2  (bases 1 to 3980)
  AUTHORS   Liu,F., Wang,Y., Huang,D. and Sun,Y.
  TITLE     LncRNA HOTAIR regulates the PI3K/AKT pathway via the
            miR-126-3p/PIK3R2 axis to participate in synovial angiogenesis in
            rheumatoid arthritis
  JOURNAL   Immun Inflamm Dis 11 (10), e1064 (2023)
   PUBMED   37904709
  REMARK    GeneRIF: LncRNA HOTAIR regulates the PI3K/AKT pathway via the
            miR-126-3p/PIK3R2 axis to participate in synovial angiogenesis in
            rheumatoid arthritis.
REFERENCE   3  (bases 1 to 3980)
  AUTHORS   Wang,J., Cai,S., Xiong,Q., Weng,D., Wang,Q. and Ma,Z.
  TITLE     PIK3R2 predicts poor outcomes for patients with melanoma and
            contributes to the malignant progression via PI3K/AKT/NF-kappaB
            axis
  JOURNAL   Clin Transl Oncol 25 (5), 1402-1412 (2023)
   PUBMED   36528701
  REMARK    GeneRIF: PIK3R2 predicts poor outcomes for patients with melanoma
            and contributes to the malignant progression via PI3K/AKT/NF-kappaB
            axis.
REFERENCE   4  (bases 1 to 3980)
  AUTHORS   Zhang,Y., He,B., Zhang,D., Zhang,Y., Chen,C., Zhang,W., Yang,S.,
            Yao,M., Cui,G., Gu,J., Wang,T., Lin,Z., Fan,Y., Xiong,Z. and Hao,Y.
  TITLE     FAK-mediated phosphorylation at Y464 regulates p85beta nuclear
            translocation to promote tumorigenesis of ccRCC by repressing RB1
            expression
  JOURNAL   Cell Rep 42 (3), 112188 (2023)
   PUBMED   36857183
  REMARK    GeneRIF: FAK-mediated phosphorylation at Y464 regulates p85beta
            nuclear translocation to promote tumorigenesis of ccRCC by
            repressing RB1 expression.
REFERENCE   5  (bases 1 to 3980)
  AUTHORS   Dai,L.P., Xu,X.D., Yang,T.T., Yin,Z.H., Ye,Z.Z. and Wei,Y.Z.
  TITLE     SPTBN1 attenuates rheumatoid arthritis synovial cell proliferation,
            invasion, migration and inflammatory response by binding to PIK3R2
  JOURNAL   Immun Inflamm Dis 10 (12), e724 (2022)
   PUBMED   36444616
  REMARK    GeneRIF: SPTBN1 attenuates rheumatoid arthritis synovial cell
            proliferation, invasion, migration and inflammatory response by
            binding to PIK3R2.
REFERENCE   6  (bases 1 to 3980)
  AUTHORS   Truitt,K.E., Hicks,C.M. and Imboden,J.B.
  TITLE     Stimulation of CD28 triggers an association between CD28 and
            phosphatidylinositol 3-kinase in Jurkat T cells
  JOURNAL   J Exp Med 179 (3), 1071-1076 (1994)
   PUBMED   7509360
REFERENCE   7  (bases 1 to 3980)
  AUTHORS   Mirzaa,G.
  TITLE     MPPH Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27854409
REFERENCE   8  (bases 1 to 3980)
  AUTHORS   Gout,I., Dhand,R., Panayotou,G., Fry,M.J., Hiles,I., Otsu,M. and
            Waterfield,M.D.
  TITLE     Expression and characterization of the p85 subunit of the
            phosphatidylinositol 3-kinase complex and a related p85 beta
            protein by using the baculovirus expression system
  JOURNAL   Biochem J 288 (Pt 2) (Pt 2), 395-405 (1992)
   PUBMED   1334406
REFERENCE   9  (bases 1 to 3980)
  AUTHORS   Volinia,S., Patracchini,P., Otsu,M., Hiles,I., Gout,I.,
            Calzolari,E., Bernardi,F., Rooke,L. and Waterfield,M.D.
  TITLE     Chromosomal localization of human p85 alpha, a subunit of
            phosphatidylinositol 3-kinase, and its homologue p85 beta
  JOURNAL   Oncogene 7 (4), 789-793 (1992)
   PUBMED   1314371
REFERENCE   10 (bases 1 to 3980)
  AUTHORS   Carpenter,C.L., Duckworth,B.C., Auger,K.R., Cohen,B.,
            Schaffhausen,B.S. and Cantley,L.C.
  TITLE     Purification and characterization of phosphoinositide 3-kinase from
            rat liver
  JOURNAL   J Biol Chem 265 (32), 19704-19711 (1990)
   PUBMED   2174051
  REMARK    GeneRIF: This paper reports the first purification of a
            phosphoinositide 3-kinase and shows that the protein is a
            heterodimer of an 85 kd regulatory subunit that mediates binding to
            phosphorylated proteins and a 110 kd catalytic subunit.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007192.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005027.3.
            
            Summary: Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase
            that phosphorylates phosphatidylinositol and similar compounds,
            creating second messengers important in growth signaling pathways.
            PI3K functions as a heterodimer of a regulatory and a catalytic
            subunit. The protein encoded by this gene is a regulatory component
            of PI3K. Three transcript variants, one protein coding and the
            other two non-protein coding, have been found for this gene.
            [provided by RefSeq, Apr 2019].
            
            Transcript Variant: This variant (1) represents the protein-coding
            variant.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090249.1, BC070082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222254.13/ ENSP00000222254.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC007192.1         16888-17019
            133-877             AC007192.1         19182-19926
            878-970             AC007192.1         24196-24288
            971-1021            AC007192.1         24644-24694
            1022-1153           AC007192.1         24779-24910
            1154-1370           AC007192.1         25004-25220
            1371-1456           AC007192.1         25691-25776
            1457-1565           AC007192.1         25927-26035
            1566-1664           AC007192.1         26133-26231
            1665-1845           AC007192.1         26692-26872
            1846-1971           AC007192.1         26988-27113
            1972-2114           AC007192.1         29885-30027
            2115-2291           AC007192.1         30855-31031
            2292-2363           AC007192.1         32200-32271
            2364-2534           AC007192.1         32451-32621
            2535-3980           AC007192.1         32812-34257
FEATURES             Location/Qualifiers
     source          1..3980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..3980
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /note="phosphoinositide-3-kinase regulatory subunit 2"
                     /db_xref="GeneID:5296"
                     /db_xref="HGNC:HGNC:8980"
                     /db_xref="MIM:603157"
     exon            1..132
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            133..877
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             556..2742
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /note="phosphatidylinositol 3-kinase, regulatory subunit,
                     polypeptide 2 (p85 beta); PI3-kinase subunit p85-beta;
                     PI3K regulatory subunit beta; ptdIns-3-kinase regulatory
                     subunit p85-beta; phosphatidylinositol 3-kinase 85 kDa
                     regulatory subunit beta; phosphoinositide-3-kinase
                     regulatory subunit beta; phosphoinositide-3-kinase,
                     regulatory subunit 2 (beta)"
                     /codon_start=1
                     /product="phosphatidylinositol 3-kinase regulatory subunit
                     beta"
                     /protein_id="NP_005018.2"
                     /db_xref="CCDS:CCDS12371.1"
                     /db_xref="GeneID:5296"
                     /db_xref="HGNC:HGNC:8980"
                     /db_xref="MIM:603157"
                     /translation="MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVA
                     EGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRD
                     GAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLS
                     DVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHR
                     ALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPS
                     PDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGD
                     ISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEP
                     LTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYH
                     QQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLER
                     FRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPD
                     LMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYV
                     GKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEP
                     YNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR"
     exon            878..970
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1021
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1153
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1370
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1456
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1565
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1664
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1845
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1971
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2114
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2291
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2363
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2534
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..3980
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3963..3968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /note="hexamer: TATAAA"
     polyA_site      3980
                     /gene="PIK3R2"
                     /gene_synonym="MPPH; MPPH1; p85; p85-BETA; P85B; p85beta"
                     /note="major polyA site"
ORIGIN      
        1 aggccgctcg gaaccgtggc ggcggcggag gcggggatcc cgcggctgcg gcgacggtgg
       61 ccgcggtgga gccacggggc gggcttggct tggtgtgacg gcggctgcgg cggcggtggc
      121 ggccgcgacc aggtcggcgt cctcagctgg ccgagcatgg tggcagcctg cacccttggc
      181 tcccttgtct ggtgcagcca gcagagccgc cagccttggg cgcccatggc cctccgtgtg
      241 agggcgtgag cggcctgccc cagcctcacc tgctgatgga ggactcaatg gcccagtgac
      301 ctgacaccac accaccaact ccctcccacc agctgacgaa tggtggaccc agtgacgagt
      361 ggcccttgta agggtcatgg aataatttga agcgaggcat gagcggcccc tgtggtcgcc
      421 tgtgactgct ggagatagag gtcccagcac cccaagccaa cccagcggac cctcccagcc
      481 ctgcttcaac caatggggcc agtggggctc caagcagcca cctaaccatc cagaccccac
      541 cccactcacg cggccatggc gggccctgag ggcttccagt accgcgctct gtacccgttc
      601 cgccgggagc ggccggagga cctggagctg ctgcccggcg acgtgctggt agtgagccgg
      661 gcggccttgc aggcgctggg cgtggccgag ggtggcgagc gctgcccaca gagcgtgggc
      721 tggatgcccg gcctcaacga gcgcacacgg cagcgaggtg acttccctgg cacctatgtg
      781 gagttcctgg ggcccgtggc cctggcccgg cccggccctc gcccacgggg cccccgccca
      841 ctgcccgcca ggccccgtga tggggcccct gagccaggcc tcacactccc cgacttgccc
      901 gagcagttct ccccacctga tgtggctccc cctcttctgg tgaagcttgt ggaggccatt
      961 gaaaggacag ggctggacag cgaatctcac taccgcccgg agctgcccgc accgcgtaca
     1021 gactggtccc tgagcgacgt ggatcagtgg gacacggcag ccctggctga cggcattaag
     1081 agcttcctgc tggcactgcc cgcgccgctc gtgacccccg aggcctcggc cgaggcgcgc
     1141 cgggccctgc gggaggccgc ggggcccgtg gggccggcgc tggagccacc gacgctgccg
     1201 ctgcaccgcg cgctcacgct gcgcttcctg ctccagcacc tgggccgcgt ggccagccgc
     1261 gccccggccc tgggtcccgc ggtccgggcc ctgggcgcca cctttgggcc gctgctgctg
     1321 cgcgcgccgc cgccgccgtc ctcgccgccg ccagggggcg ctcccgacgg gagtgagccc
     1381 agccctgact tcccggcgct gctggtggag aagctgcttc aggaacactt ggaagagcag
     1441 gaggttgcgc ccccagcgct gccgcctaaa ccccccaagg caaagccggc ctccacagtc
     1501 ctggccaatg gagggagccc accctccctg caggatgctg agtggtactg gggggacatt
     1561 tcaagggagg aggtgaacga gaaactccgg gacactcccg atggcacctt cctagtccga
     1621 gatgcttcta gcaagatcca gggcgagtac acgctgaccc tcaggaaagg cgggaacaat
     1681 aagctgatca aggtcttcca ccgagatggg cactatggct tctcagagcc actcaccttc
     1741 tgctccgttg tggacctcat caatcactac cgccacgagt ctctggccca gtacaatgcc
     1801 aagctggaca cacggctcct ctaccctgtg tccaaatacc agcaggacca gattgtcaag
     1861 gaggacagcg tggaggcagt gggcgcccag cttaaggtct atcaccagca gtaccaggac
     1921 aagagccgcg agtatgacca gctttatgaa gagtacacac ggacctccca ggagctgcag
     1981 atgaagcgta ctgcaattga ggccttcaat gagactatca agatctttga agagcagggc
     2041 cagactcaag agaaatgcag caaggaatac ctggagcgct tccggcgtga gggcaacgag
     2101 aaagagatgc aaaggatcct gctgaactcc gagcggctca agtcccgcat tgccgagatc
     2161 catgagagcc gcacgaagct ggagcagcag ctgcgggccc aggcctcgga caacagagag
     2221 atcgacaagc gcatgaacag cctcaagccg gacctcatgc agctgcgcaa gatccgagac
     2281 cagtacctcg tgtggctcac ccagaaaggc gcccggcaga agaaaatcaa cgagtggctg
     2341 gggattaaaa atgagactga ggaccagtac gcactcatgg aggacgagga cgatctcccg
     2401 caccacgagg aacgcacttg gtacgtgggc aagatcaacc gcacgcaggc agaggagatg
     2461 ctgagtggca agcgggatgg caccttcctc atccgcgaga gcagccagcg gggctgctac
     2521 gcctgctccg tggtagtgga cggcgacacc aagcactgcg tcatctaccg cacggccacc
     2581 ggcttcggct tcgcggagcc ctacaacctg tacgggtcgc tgaaggagct ggtgctgcac
     2641 taccagcacg cctcgctggt gcagcacaac gacgcgctca ccgtcaccct ggcgcaccca
     2701 gtgcgcgccc cgggccccgg cccgccgcct gccgcccgct gagcaccgag gacccgcccc
     2761 aagcagagcc gcccctgggc ccgtctgcgc cggaggctgc ggcggcggga gccacggacc
     2821 agaccagcca catccagggg tcctcatttc tccggctctg gctcttgttt ggggttctct
     2881 caccctcttt ctctttcctt ccctccccca ttctccagat ctccctctgt ctccttttct
     2941 ctgtctttct tggcccctgt ctctctccat gttgggggtc ctaactcccc caccccatat
     3001 ctacgtgtcc tccgggcatt gccctctcca tggctctggt caccctgacc ctctgccctg
     3061 cccaccgcag gtcccccggg gtcccggaag ccccttctgg ctgcacctgc catgtttaca
     3121 gagggcccct gggctgcgcg gccccagcct gggcaccctg atttttaagc catagacctg
     3181 gggtcagggc aggaaggaac ttcactctgc tgcttccgag aacctcggcc gtgacattcg
     3241 gggccgggcg ggacccgccc cacagactcc aacttcccct ccaaaccccg aagtgaaacc
     3301 cgccaccggg ttacccccac aagggggccg ctgcgagaag ttcacccacc cccgaaaaaa
     3361 taattaaact cgcaggccag gcacggtggc tcatgcctgt aatcccagca ctttgggagg
     3421 ccaagacggg cggatctttt gaggtcggga gttggaggcc agcctggcca aaatggcaaa
     3481 accccgcatc tactaaaata caaaaattag ccgggcgtgg tggcggccgc ctgtaatccc
     3541 agctacttgg gaggctgagg cgtgagaatc tcttgaaccc aggagatgga ggttgcagtg
     3601 agcagagatc gtgccactgc actccagcct gggtaacaga gggagactcc tccgtctcaa
     3661 aaaaataaat aaataaactt gtgagctggc cccaacccct cctaggaatc acagctcccc
     3721 gtactggtgc cgccgcagtg gccaagttgc gacactgccc acggcccctc cctctgatgc
     3781 agattcaggg cttctcttcg atcatgttgg gttttgattc tgtttttcct tgactgcaaa
     3841 accctctttc ctctcctctt ttgggacaag agccctggtt ttctacgctg cccttggcca
     3901 ccacactgcc tgccccacga gctgggaggc aggttttgta cggtacgttg ttattgatat
     3961 gatataaaac atcaaacgtc
//
