LOCUS       NM_001282426            7059 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase
            catalytic subunit gamma (PIK3CG), transcript variant 2, mRNA.
ACCESSION   NM_001282426 XM_005250441
VERSION     NM_001282426.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7059)
  AUTHORS   Gu,H., Chen,C., Hou,Z.S., He,X.D., Xie,S., Ni,J., Qian,C.,
            Cheng,X., Jiang,T., Yang,C., Roberts,T.M., Zheng,J., Varner,J.A.,
            Armstrong,S.A. and Zhao,J.J.
  TITLE     PI3Kgamma maintains the self-renewal of acute myeloid leukemia stem
            cells by regulating the pentose phosphate pathway
  JOURNAL   Blood 143 (19), 1965-1979 (2024)
   PUBMED   38271660
  REMARK    GeneRIF: PI3Kgamma maintains the self-renewal of acute myeloid
            leukemia stem cells by regulating the pentose phosphate pathway.
REFERENCE   2  (bases 1 to 7059)
  AUTHORS   Sun,Y., Stenson,K., Mohan,M.L., Gupta,M.K., Wanner,N., Asosingh,K.,
            Erzurum,S. and Naga Prasad,S.V.
  TITLE     Hypoxia Sensing of beta-Adrenergic Receptor Is Regulated by
            Endosomal PI3Kgamma
  JOURNAL   Circ Res 132 (6), 690-703 (2023)
   PUBMED   36779349
  REMARK    GeneRIF: Hypoxia Sensing of beta-Adrenergic Receptor Is Regulated
            by Endosomal PI3Kgamma.
REFERENCE   3  (bases 1 to 7059)
  AUTHORS   Jung,I., Lee,H.W., Roh,M.S., Lee,J.S., Kim,K., Kim,K., Kim,T.G. and
            Nam,H.Y.
  TITLE     High expression of the phosphoinositide 3-kinase p11gamma isoform
            can predict poor prognosis of non-small cell lung cancer
  JOURNAL   Histol Histopathol 37 (12), 1177-1184 (2022)
   PUBMED   35673779
  REMARK    GeneRIF: High expression of the phosphoinositide 3-kinase p11gamma
            isoform can predict poor prognosis of non-small cell lung cancer.
REFERENCE   4  (bases 1 to 7059)
  AUTHORS   Silva,M.C., Fuzo,C.A., Marques Paiva,I., Lopes Bibo,N., Tavares de
            Oliveira,M., da Silva Soares,H.A., Chevillard,C., Kalil,J.,
            Cunha-Neto,E., Cunha,T.M. and Silva,J.S.
  TITLE     Synonymous mutation rs1129293 is associated with PIK3CG expression
            and PI3Kgamma activation in patients with chronic Chagas
            cardiomyopathy
  JOURNAL   Immunobiology 227 (5), 152242 (2022)
   PUBMED   35870262
  REMARK    GeneRIF: Synonymous mutation rs1129293 is associated with PIK3CG
            expression and PI3Kgamma activation in patients with chronic Chagas
            cardiomyopathy.
REFERENCE   5  (bases 1 to 7059)
  AUTHORS   Klaus,F.L., Kirsch,C., Muller,J.P., Huber,O. and Reiche,J.
  TITLE     PI3Kgamma is a novel regulator of TNFalpha signaling in the human
            colon cell line HT29/B6
  JOURNAL   Ann N Y Acad Sci 1515 (1), 196-207 (2022)
   PUBMED   35725890
  REMARK    GeneRIF: PI3Kgamma is a novel regulator of TNFalpha signaling in
            the human colon cell line HT29/B6.
REFERENCE   6  (bases 1 to 7059)
  AUTHORS   Borgatti,P., Zauli,G., Colamussi,M.L., Gibellini,D., Previati,M.,
            Cantley,L.L. and Capitani,S.
  TITLE     Extracellular HIV-1 Tat protein activates phosphatidylinositol 3-
            and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells
  JOURNAL   Eur J Immunol 27 (11), 2805-2811 (1997)
   PUBMED   9394803
REFERENCE   7  (bases 1 to 7059)
  AUTHORS   Milani,D., Mazzoni,M., Borgatti,P., Zauli,G., Cantley,L. and
            Capitani,S.
  TITLE     Extracellular human immunodeficiency virus type-1 Tat protein
            activates phosphatidylinositol 3-kinase in PC12 neuronal cells
  JOURNAL   J Biol Chem 271 (38), 22961-22964 (1996)
   PUBMED   8798481
REFERENCE   8  (bases 1 to 7059)
  AUTHORS   Stoyanov,B., Volinia,S., Hanck,T., Rubio,I., Loubtchenkov,M.,
            Malek,D., Stoyanova,S., Vanhaesebroeck,B., Dhand,R., Nurnberg,B. et
            al.
  TITLE     Cloning and characterization of a G protein-activated human
            phosphoinositide-3 kinase
  JOURNAL   Science 269 (5224), 690-693 (1995)
   PUBMED   7624799
REFERENCE   9  (bases 1 to 7059)
  AUTHORS   Blume-Jensen,P., Ronnstrand,L., Gout,I., Waterfield,M.D. and
            Heldin,C.H.
  TITLE     Modulation of Kit/stem cell factor receptor-induced signaling by
            protein kinase C
  JOURNAL   J Biol Chem 269 (34), 21793-21802 (1994)
   PUBMED   7520444
REFERENCE   10 (bases 1 to 7059)
  AUTHORS   Dhand,R., Hiles,I., Panayotou,G., Roche,S., Fry,M.J., Gout,I.,
            Totty,N.F., Truong,O., Vicendo,P., Yonezawa,K. et al.
  TITLE     PI 3-kinase is a dual specificity enzyme: autoregulation by an
            intrinsic protein-serine kinase activity
  JOURNAL   EMBO J 13 (3), 522-533 (1994)
   PUBMED   8313897
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292684.1, BX648341.1,
            X83368.1, BC035683.1, AC005018.2 and AA810265.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001282426.1.
            
            Summary: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol
            lipids and are involved in the immune response. The protein encoded
            by this gene is a class I catalytic subunit of PI3K. Like other
            class I catalytic subunits (p110-alpha p110-beta, and p110-delta),
            the encoded protein binds a p85 regulatory subunit to form PI3K.
            This gene is located in a commonly deleted segment of chromosome 7
            previously identified in myeloid leukemias. Several transcript
            variants encoding the same protein have been found for this gene.
            [provided by RefSeq, Jun 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.154592.1, BX648341.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000496166.6/ ENSP00000419260.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AK292684.1         5-71
            68-211              BX648341.1         55-198
            212-241             X83368.1           378-407
            242-1128            BC035683.1         138-1024
            1129-1138           AC005018.2         17505-17514
            1139-2181           BC035683.1         1035-2077
            2182-4290           X83368.1           2345-4453
            4291-7049           AC005018.2         55184-57942
            7050-7057           AA810265.1         9-16                c
            7058-7059           AC005018.2         57951-57952
FEATURES             Location/Qualifiers
     source          1..7059
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..7059
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase
                     catalytic subunit gamma"
                     /db_xref="GeneID:5294"
                     /db_xref="HGNC:HGNC:8978"
                     /db_xref="MIM:601232"
     exon            1..145
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /inference="alignment:Splign:2.1.0"
     exon            146..2152
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..3466
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /EC_number="2.7.1.137"
                     /EC_number="2.7.1.154"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.1.153"
                     /note="phosphatidylinositol 3-kinase catalytic 110-kD
                     gamma; phosphatidylinositol 3 kinase gamma, p110 gamma;
                     phosphoinositide-3-kinase gamma catalytic subunit;
                     1-phosphatidylinositol 3-kinase; PI3-kinase subunit gamma;
                     ptdIns-3-kinase subunit gamma; ptdIns-3-kinase subunit
                     p110-gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase
                     110 kDa catalytic subunit gamma; serine/threonine protein
                     kinase PIK3CG"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit gamma isoform"
                     /protein_id="NP_001269355.1"
                     /db_xref="CCDS:CCDS5739.1"
                     /db_xref="GeneID:5294"
                     /db_xref="HGNC:HGNC:8978"
                     /db_xref="MIM:601232"
                     /translation="MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVL
                     PTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQK
                     KGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGY
                     DVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANN
                     CIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCG
                     RDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTG
                     YHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
                     VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESP
                     SSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNP
                     DKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNP
                     LTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDV
                     GLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLL
                     KRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIE
                     MLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAI
                     EKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWE
                     TESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEK
                     SPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNY
                     KSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIIL
                     FSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFL
                     HLVLGIKQGEKHSA"
     exon            2153..2218
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2444
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2548
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2695
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2786
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2917
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3029
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3187
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..7059
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3877..3882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /note="hexamer: AAGAAA"
     polyA_site      3900
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /note="major polyA site"
     regulatory      6962..6967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /note="hexamer: AATAAA"
     polyA_site      6985
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /note="major polyA site"
     regulatory      7030..7035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
                     /note="hexamer: AATAAA"
     polyA_site      7059
                     /gene="PIK3CG"
                     /gene_synonym="IMD97; p110gamma; p120-PI3K; PI3CG; PI3K;
                     PI3Kgamma; PIK3"
ORIGIN      
        1 gcaacacttc ctctgcatct ggatatgaag ggagccccag aaaagcggaa gaatttagac
       61 gcacactggg taggtttgaa tttgttttgt tttcaaaaat taaacaaatg atccttcagc
      121 atcatcgcct ccgctgcttt atcaggtcgc atagggcatg gagctggaga actataaaca
      181 gcccgtggtg ctgagagagg acaactgccg aaggcgccgg aggatgaagc cgcgcagtgc
      241 tgcggccagc ctgtcctcca tggagctcat ccccatcgag ttcgtgctgc ccaccagcca
      301 gcgcaaatgc aagagccccg aaacggcgct gctgcacgtg gccggccacg gcaacgtgga
      361 gcagatgaag gcccaggtgt ggctgcgagc gctggagacc agcgtggcgg cggacttcta
      421 ccaccggctg ggaccgcatc acttcctcct gctctatcag aagaaggggc agtggtacga
      481 gatctacgac aagtaccagg tggtgcagac tctggactgc ctgcgctact ggaaggccac
      541 gcaccggagc ccgggccaga tccacctggt gcagcggcac ccgccctccg aggagtccca
      601 agccttccag cggcagctca cggcgctgat tggctatgac gtcactgacg tcagcaacgt
      661 gcacgacgat gagctggagt tcacgcgccg tggcttggtg accccgcgca tggcggaggt
      721 ggccagccgc gaccccaagc tctacgccat gcacccgtgg gtgacgtcca agcccctccc
      781 ggagtacctg tggaagaaga ttgccaacaa ctgcatcttc atcgtcattc accgcagcac
      841 caccagccag accattaagg tctcacccga cgacaccccc ggcgccatcc tgcagagctt
      901 cttcaccaag atggccaaga agaaatctct gatggatatt cccgaaagcc aaagcgaaca
      961 ggattttgtg ctgcgcgtct gtggccggga tgagtacctg gtgggcgaaa cgcccatcaa
     1021 aaacttccag tgggtgaggc actgcctcaa gaacggagaa gagattcacg tggtactgga
     1081 cacgcctcca gacccggccc tagacgaggt gaggaaggaa gagtggccac tggtggatga
     1141 ctgcacggga gtcaccggct accatgagca gcttaccatc cacggcaagg accacgagag
     1201 tgtgttcacc gtgtccctgt gggactgcga ccgcaagttc agggtcaaga tcagaggcat
     1261 tgatatcccc gtcctgcctc ggaacaccga cctcacagtt tttgtagagg caaacatcca
     1321 gcatgggcaa caagtccttt gccaaaggag aaccagcccc aaacccttca cagaggaggt
     1381 gctgtggaat gtgtggcttg agttcagtat caaaatcaaa gacttgccca aaggggctct
     1441 actgaacctc cagatctact gcggtaaagc tccagcactg tccagcaagg cctctgcaga
     1501 gtcccccagt tctgagtcca agggcaaagt tcagcttctc tattatgtga acctgctgct
     1561 gatagaccac cgtttcctcc tgcgccgtgg agaatacgtc ctccacatgt ggcagatatc
     1621 tgggaaggga gaagaccaag gaagcttcaa tgctgacaaa ctcacgtctg caactaaccc
     1681 agacaaggag aactcaatgt ccatctccat tcttctggac aattactgcc acccgatagc
     1741 cctgcctaag catcagccca cccctgaccc ggaaggggac cgggttcgag cagaaatgcc
     1801 caaccagctt cgcaagcaat tggaggcgat catagccact gatccactta accctctcac
     1861 agcagaggac aaagaattgc tctggcattt tagatacgaa agccttaagc acccaaaagc
     1921 atatcctaag ctatttagtt cagtgaaatg gggacagcaa gaaattgtgg ccaaaacata
     1981 ccaattgttg gccagaaggg aagtctggga tcaaagtgct ttggatgttg ggttaacaat
     2041 gcagctcctg gactgcaact tctcagatga aaatgtaaga gccattgcag ttcagaaact
     2101 ggagagcttg gaggacgatg atgttctgca ttaccttcta caattggtcc aggctgtgaa
     2161 atttgaacca taccatgata gcgcccttgc cagatttctg ctgaagcgtg gtttaagaaa
     2221 caaaagaatt ggtcactttt tgttttggtt cttgagaagt gagatagccc agtccagaca
     2281 ctatcagcag aggttcgctg tgattctgga agcctatctg aggggctgtg gcacagccat
     2341 gctgcacgac tttacccaac aagtccaagt aatcgagatg ttacaaaaag tcacccttga
     2401 tattaaatcg ctctctgctg aaaagtatga cgtcagttcc caagttattt cacaacttaa
     2461 acaaaagctt gaaaacctgc agaattctca actccccgaa agctttagag ttccatatga
     2521 tcctggactg aaagcaggag cgctggcaat tgaaaaatgt aaagtaatgg cctccaagaa
     2581 aaaaccacta tggcttgagt ttaaatgtgc cgatcctaca gccctatcaa atgaaacaat
     2641 tggaattatc tttaaacatg gtgatgatct gcgccaagac atgcttattt tacagattct
     2701 acgaatcatg gagtctattt gggagactga atctttggat ctatgcctcc tgccatatgg
     2761 ttgcatttca actggtgaca aaataggaat gatcgagatt gtgaaagacg ccacgacaat
     2821 tgccaaaatt cagcaaagca cagtgggcaa cacgggagca tttaaagatg aagtcctgaa
     2881 tcactggctc aaagaaaaat cccctactga agaaaagttt caggcagcag tggagagatt
     2941 tgtttattcc tgtgcaggct actgtgtggc aacctttgtt cttggaatag gcgacagaca
     3001 caatgacaat attatgatca ccgagacagg aaacctattt catattgact tcgggcacat
     3061 tcttgggaat tacaaaagtt tcctgggcat taataaagag agagtgccat ttgtgctaac
     3121 ccctgacttc ctctttgtga tgggaacttc tggaaagaag acaagcccac acttccagaa
     3181 atttcaggac atctgtgtta aggcttatct agcccttcgt catcacacaa acctactgat
     3241 catcctgttc tccatgatgc tgatgacagg aatgccccag ttaacaagca aagaagacat
     3301 tgaatatatc cgggatgccc tcacagtggg gaaaaatgag gaggatgcta aaaagtattt
     3361 tcttgatcag atcgaagttt gcagagacaa aggatggact gtgcagttta attggtttct
     3421 acatcttgtt cttggcatca aacaaggaga gaaacattca gcctaatact ttaggctaga
     3481 atcaaaaaca agttagtgtt ctatggttta aattagcata gcaatcatcg aacttggatt
     3541 tcaaatgcaa tagacattgt gaaagctggc atttcagaag tatagctctt ttcctacctg
     3601 aactcttccc tggagaaaag atgttggcat tgctgattgt ttggttaagc aatgtccagt
     3661 gctaggatta tttgcaggtt tggttttttc tcatttgtct gtggcattgg agaatattct
     3721 cggtttaaac agactaatga cttccttatt gtccctgata ttttgactat cttactattg
     3781 agtgcttctg gaaattcttt ggaataattg atgacatcta ttttcatctg ggtttagtct
     3841 caattttggt tatctttgtg ttcctcaagc tctttaaaga aaaagatgta atcgttgtaa
     3901 cctttgtctc attccttaaa tgatgcttcc aaacatctcc ttagtgtctg caggtgttag
     3961 tggtgtgcta aaagcaagga aagcgagtta gtcttttcag tgtcttttgc aattcaattc
     4021 ttttgtcatg tataactgag acacacaaac acagcaggag aaatctaaac cgttgtgcct
     4081 tgaccttcct ctgctggtct tgttccaggg ttatgaatat gaaaaaatag agatgagact
     4141 ttttgtgtca actctgtcca caagagtgag ttatctagta tgattagtat agctttctcc
     4201 agcatggcag caggaagtaa ctacagggcc tcttttatgc ctgacatttc ttcccttcct
     4261 ttttccctgc ctcccttttt catcaattgc gatgctccca caactcttta cagacttgtg
     4321 aaatcttcaa gaacaccttt actctataac tcaaaaatta gttgaaaaat aattacttct
     4381 caaggattat tagaatctta ggtacttatt tgtaaagatg tttagtgact tttttttcaa
     4441 gtatcttatt aaaggaggca ttctagaaaa tatgaattag tttccaaatg ccttaatttt
     4501 aaactttggc ctgaacagtt ttttcttttt cttaatggaa gaagatattt aatatcttaa
     4561 aaatattcca agttaggaag aacactactt gccttatcca tttcccattt aaaggacttt
     4621 taaactttga cacatccttc agatttcctg aaaataattg aaatatctta ctttaaaaat
     4681 attttcatct ctgaaatatc tcgttattta ttggaggtat tgtttaacct tagagagacc
     4741 attaaattat ttataaaata ttttgtaatt acctgtagct aatacattac atagaaaaaa
     4801 actatgttaa cagtgtctct gtttaagtat aatcagatat aaatatatac ttaatttttt
     4861 aattttaaaa atagatacct gtttgacttt gaggtagtcc agaccttttc tttttttttt
     4921 tttttttaat gtgtgcaaaa gcccaaaggt tcctaagcct ggctgcaaag aagaatcaac
     4981 agggacactt tttaaaaaca ctcttatcag cctgggcaac acagtgagac tccatctctt
     5041 aaaaaaaaaa ttagctgggt atagtggtat gtgcctgtag tcccaggtac tcaggaggct
     5101 gaggcaggag gattgcctga gcccaggagg tggaaactgc agagagtcat gatcatgtcc
     5161 ttacactcca gcctggataa cagagcgaga ccctgtctca aaaaaataaa ataaaaaata
     5221 aaaacaccct tgcctgcgct ccattcccag gttataattt aattactgtg ggatgagacc
     5281 cagacatcaa tatttttcta gattcttcag gtgattctaa ttcacagcca gagttggaag
     5341 ccctgcgtgg cctttgaagg tctagatgat tcttcttcct tgccctttga gcttttcccc
     5401 atctcacagg tatctagaaa aaaactcctc ttctttggca acctgtcctt ttaaaatcac
     5461 actctaccca cctgtacaga agaccatgcc ctataatgaa atgtttattc ctatctataa
     5521 atggaggata aacattttgt ggcacttctg gaccaactat tccctactat tcttttgaag
     5581 aaaggcagga agagtacttt ctaattcaga agaggatgtt ttcactattc tgataaacaa
     5641 tagccaagtt cagaccttgt acagattctt tttatttgaa ttgctgaaat aatttattga
     5701 tgatgaaaaa aagattagag aggaatacat ttatatttag cttattggca catgtgcata
     5761 catatttcct cttcaaatga accagttctt tcatttcatt atgctaatat atatatataa
     5821 catatatatg ctaatatata tataacatat atatgctaat atatatatat cacacatata
     5881 tatcacagtt ttatatatat atatgtatgt gtgtgtgtat atatatatat atatatcaca
     5941 gttgggcttg attcttccgt attccaaaga gcataatttc agttctatag acttatagat
     6001 aaataaaaat catctttgtg ggcttccttc ctttactgtt cgcagtgaat tacatgacga
     6061 acaacttcta tacctttgaa aatgttctag aactagaatc atcctgctac tgggaactac
     6121 ccacagctct atcttcaatg ccaggtgaaa acacagatca caagtcagat gaatcaggcc
     6181 aaagcaactt ttatgtatat ctaggactgg cgacataatt tgcagagccc agtgaacagt
     6241 gaaaatgcag tcccatcatt caaaaattat taagaaattc gagatggcaa cagcagttgt
     6301 cacaccaagc acagtgccct tctgagcatg aggctctgtg tgactgcatg ggtccatgag
     6361 accagcactg tgtgggtctg aatgatggct ttggtgttca gtttagcaca cgcggtctac
     6421 cacgtctgca tgagtggtaa atgtagtgcc tgggtcaaaa tgttccttct gttcaaatcg
     6481 aaatacctca tctctatggc tctatggctg tacattagga cctagaacag tggcccattg
     6541 ctcttagact ggaaccatgt ccactaaaat aaacctaagc agatgttgta gacctagccc
     6601 cacaggactg catttagctg cttcagtgac actttgatga aagtatggag aagtggagac
     6661 attatagata aaatatatca attcccagag aaaactcttg acttaaaaac ttaactgtag
     6721 taaatatatc tttttcaggt gatgaattat ttttttaaaa aaggttacat ataggaattc
     6781 tgcagtataa tttggaggct attagtgcta tattaatgga aattaattat tttttaagta
     6841 agtccaaaaa ataatctaga aagtaagttt ccagagcaaa tctgacctag catttggtat
     6901 gctaggctct gcttttcatg attttgaaat aaatcataat tagacttaac aatatggaga
     6961 aaataaactt gtatttttaa gtgttctgtt ggcttatttt ctgtttcatc caactcaata
     7021 attctgataa ataaatttgg ttctagtttg gtgcttgtc
//
