LOCUS       NM_005026               5412 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase
            catalytic subunit delta (PIK3CD), transcript variant 1, mRNA.
ACCESSION   NM_005026
VERSION     NM_005026.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5412)
  AUTHORS   Orellana,H., Yan,J., Paul,A., Tokita,M., Ding,Y., Ghosh,R.,
            Lewis,K.L., Davis,J., Jamal,L., Jodarski,C., Similuk,M.,
            Saucier,N., Zhu,Z., Wang,Y., Wu,S., Ruggieri,J., Su,H.C., Uzel,G.,
            Nahas,S., Cooper,M. and Walkiewicz,M.A.
  TITLE     Case report: Deep sequencing and long-read genome sequencing refine
            prior genetic analyses in families with apparent gonadal mosaicism
            in PIK3CD-related activated PI3K delta syndrome
  JOURNAL   Front Immunol 15, 1451212 (2024)
   PUBMED   39253077
  REMARK    GeneRIF: Case report: Deep sequencing and long-read genome
            sequencing refine prior genetic analyses in families with apparent
            gonadal mosaicism in PIK3CD-related activated PI3K delta syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5412)
  AUTHORS   Fu,X.L., He,F.T., Li,M.H., Fu,C.Y. and Chen,J.Z.
  TITLE     circZNF532 promotes endothelial-to-mesenchymal transition in
            diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD
  JOURNAL   Endocr J 71 (7), 675-686 (2024)
   PUBMED   38811189
  REMARK    GeneRIF: circZNF532 promotes endothelial-to-mesenchymal transition
            in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD.
REFERENCE   3  (bases 1 to 5412)
  AUTHORS   Liu,D., Yan,B., Yin,Y., Chen,F., Guo,C., Li,Q., Liu,J., Pu,L.,
            Wu,W. and Luo,J.
  TITLE     PI3Kdelta Mediates Fibrosis by Patient-Derived Vitreous
  JOURNAL   Lab Invest 104 (4), 102026 (2024)
   PUBMED   38307209
  REMARK    GeneRIF: PI3Kdelta Mediates Fibrosis by Patient-Derived Vitreous.
REFERENCE   4  (bases 1 to 5412)
  AUTHORS   Wang,J., Zhao,X., Wang,Q., Zheng,X., Simayi,D., Zhao,J., Yang,P.,
            Mao,Q. and Xia,H.
  TITLE     FAM76B regulates PI3K/Akt/NF-kappaB-mediated M1 macrophage
            polarization by influencing the stability of PIK3CD mRNA
  JOURNAL   Cell Mol Life Sci 81 (1), 107 (2024)
   PUBMED   38421448
  REMARK    GeneRIF: FAM76B regulates PI3K/Akt/NF-kappaB-mediated M1 macrophage
            polarization by influencing the stability of PIK3CD mRNA.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5412)
  AUTHORS   Li,Z., Liu,J., Wang,P., Zhang,B., He,G. and Yang,L.
  TITLE     The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in non-small
            cell lung cancer progression and chemoresistance by mediating
            autophagy
  JOURNAL   Funct Integr Genomics 24 (2), 33 (2024)
   PUBMED   38363382
  REMARK    GeneRIF: The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in
            non-small cell lung cancer progression and chemoresistance by
            mediating autophagy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5412)
  AUTHORS   Borgatti,P., Zauli,G., Cantley,L.C. and Capitani,S.
  TITLE     Extracellular HIV-1 Tat protein induces a rapid and selective
            activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta
            isoforms in PC12 cells
  JOURNAL   Biochem Biophys Res Commun 242 (2), 332-337 (1998)
   PUBMED   9446795
REFERENCE   7  (bases 1 to 5412)
  AUTHORS   Borgatti,P., Zauli,G., Colamussi,M.L., Gibellini,D., Previati,M.,
            Cantley,L.L. and Capitani,S.
  TITLE     Extracellular HIV-1 Tat protein activates phosphatidylinositol 3-
            and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells
  JOURNAL   Eur J Immunol 27 (11), 2805-2811 (1997)
   PUBMED   9394803
REFERENCE   8  (bases 1 to 5412)
  AUTHORS   Chantry,D., Vojtek,A., Kashishian,A., Holtzman,D.A., Wood,C.,
            Gray,P.W., Cooper,J.A. and Hoekstra,M.F.
  TITLE     p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit
            that associates with p85 and is expressed predominantly in
            leukocytes
  JOURNAL   J Biol Chem 272 (31), 19236-19241 (1997)
   PUBMED   9235916
REFERENCE   9  (bases 1 to 5412)
  AUTHORS   Vanhaesebroeck,B., Welham,M.J., Kotani,K., Stein,R., Warne,P.H.,
            Zvelebil,M.J., Higashi,K., Volinia,S., Downward,J. and
            Waterfield,M.D.
  TITLE     P110delta, a novel phosphoinositide 3-kinase in leukocytes
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4330-4335 (1997)
   PUBMED   9113989
REFERENCE   10 (bases 1 to 5412)
  AUTHORS   Milani,D., Mazzoni,M., Borgatti,P., Zauli,G., Cantley,L. and
            Capitani,S.
  TITLE     Extracellular human immunodeficiency virus type-1 Tat protein
            activates phosphatidylinositol 3-kinase in PC12 neuronal cells
  JOURNAL   J Biol Chem 271 (38), 22961-22964 (1996)
   PUBMED   8798481
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314191.1, BC030263.1,
            U86453.1, BC132919.1, Y10055.2, BC150297.1, W30913.1, CA427830.1
            and AL691449.21.
            
            On May 17, 2019 this sequence version replaced NM_005026.4.
            
            Summary: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol
            lipids and are involved in the immune response. The protein encoded
            by this gene is a class I PI3K found primarily in leukocytes. Like
            other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the
            encoded protein binds p85 adapter proteins and GTP-bound RAS.
            However, unlike the other class I PI3Ks, this protein
            phosphorylates itself, not p85 protein.[provided by RefSeq, Jul
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.17736.1, AK314191.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377346.9/ ENSP00000366563.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AK314191.1         1-55
            56-72               BC030263.1         27-43
            73-966              U86453.1           59-952
            967-3747            BC132919.1         880-3660
            3748-3881           Y10055.2           3735-3868
            3882-4120           U86453.1           3868-4106
            4121-5214           BC150297.1         4068-5161
            5215-5217           U86453.1           5206-5208
            5218-5218           W30913.1           272-272
            5219-5223           CA427830.1         10-14               c
            5224-5412           AL691449.21        95727-95915
FEATURES             Location/Qualifiers
     source          1..5412
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..5412
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase
                     catalytic subunit delta"
                     /db_xref="GeneID:5293"
                     /db_xref="HGNC:HGNC:8977"
                     /db_xref="MIM:602839"
     exon            1..72
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            73..177
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            178..350
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            351..579
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            580..809
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            810..989
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1139
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1229
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1451
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1548
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1679
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1730
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1898
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2020
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2164
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2264
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2443
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2556
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2635
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2803
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2927
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3073
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3206
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..5412
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5208
                     /gene="PIK3CD"
                     /gene_synonym="APDS; IMD14; IMD14A; IMD14B; p110D;
                     P110DELTA; PI3K; ROCHIS"
                     /note="major polyA site"
ORIGIN      
        1 actcgcgccc agcgcagtcg ctccgagcgg ccgcgagcag agccgcccag ccctgccagc
       61 tgcgccggga cgataaggag tcaggccagg gcgggatgac actcattgat tctaaagcat
      121 ctttaatctg ccaggcggag ggggctttgc tggtctttct tggactattc cagagaggac
      181 aactgtcatc tgggaagtaa caacgcagga tgccccctgg ggtggactgc cccatggaat
      241 tctggaccaa ggaggagaat cagagcgttg tggttgactt cctgctgccc acaggggtct
      301 acctgaactt ccctgtgtcc cgcaatgcca acctcagcac catcaagcag ctgctgtggc
      361 accgcgccca gtatgagccg ctcttccaca tgctcagtgg ccccgaggcc tatgtgttca
      421 cctgcatcaa ccagacagcg gagcagcaag agctggagga cgagcaacgg cgtctgtgtg
      481 acgtgcagcc cttcctgccc gtcctgcgcc tggtggcccg tgagggcgac cgcgtgaaga
      541 agctcatcaa ctcacagatc agcctcctca tcggcaaagg cctccacgag tttgactcct
      601 tgtgcgaccc agaagtgaac gactttcgcg ccaagatgtg ccaattctgc gaggaggcgg
      661 ccgcccgccg gcagcagctg ggctgggagg cctggctgca gtacagtttc cccctgcagc
      721 tggagccctc ggctcaaacc tgggggcctg gtaccctgcg gctcccgaac cgggcccttc
      781 tggtcaacgt taagtttgag ggcagcgagg agagcttcac cttccaggtg tccaccaagg
      841 acgtgccgct ggcgctgatg gcctgtgccc tgcggaagaa ggccacagtg ttccggcagc
      901 cgctggtgga gcagccggaa gactacacgc tgcaggtgaa cggcaggcat gagtacctgt
      961 atggcagcta cccgctctgc cagttccagt acatctgcag ctgcctgcac agtgggttga
     1021 cccctcacct gaccatggtc cattcctcct ccatcctcgc catgcgggat gagcagagca
     1081 accctgcccc ccaggtccag aaaccgcgtg ccaaaccacc tcccattcct gcgaagaagc
     1141 cttcctctgt gtccctgtgg tccctggagc agccgttccg catcgagctc atccagggca
     1201 gcaaagtgaa cgccgacgag cggatgaagc tggtggtgca ggccgggctt ttccacggca
     1261 acgagatgct gtgcaagacg gtgtccagct cggaggtgag cgtgtgctcg gagcccgtgt
     1321 ggaagcagcg gctggagttc gacatcaaca tctgcgacct gccccgcatg gcccgtctct
     1381 gctttgcgct gtacgccgtg atcgagaaag ccaagaaggc tcgctccacc aagaagaagt
     1441 ccaagaaggc ggactgcccc attgcctggg ccaacctcat gctgtttgac tacaaggacc
     1501 agcttaagac cggggaacgc tgcctctaca tgtggccctc cgtcccagat gagaagggcg
     1561 agctgctgaa ccccacgggc actgtgcgca gtaaccccaa cacggatagc gccgctgccc
     1621 tgctcatctg cctgcccgag gtggccccgc accccgtgta ctaccccgcc ctggagaaga
     1681 tcttggagct ggggcgacac agcgagtgtg tgcatgtcac cgaggaggag cagctgcagc
     1741 tgcgggaaat cctggagcgg cgggggtctg gggagctgta tgagcacgag aaggacctgg
     1801 tgtggaagct gcggcatgaa gtccaggagc acttcccgga ggcgctagcc cggctgctgc
     1861 tggtcaccaa gtggaacaag catgaggatg tggcccagat gctctacctg ctgtgctcct
     1921 ggccggagct gcccgtcctg agcgccctgg agctgctaga cttcagcttc cccgattgcc
     1981 acgtaggctc cttcgccatc aagtcgctgc ggaaactgac ggacgatgag ctgttccagt
     2041 acctgctgca gctggtgcag gtgctcaagt acgagtccta cctggactgc gagctgacca
     2101 aattcctgct ggaccgggcc ctggccaacc gcaagatcgg ccacttcctt ttctggcacc
     2161 tccgctccga gatgcacgtg ccgtcggtgg ccctgcgctt cggcctcatc ctggaggcct
     2221 actgcagggg cagcacccac cacatgaagg tgctgatgaa gcagggggaa gcactgagca
     2281 aactgaaggc cctgaatgac ttcgtcaagc tgagctctca gaagaccccc aagccccaga
     2341 ccaaggagct gatgcacttg tgcatgcggc aggaggccta cctagaggcc ctctcccacc
     2401 tgcagtcccc actcgacccc agcaccctgc tggctgaagt ctgcgtggag cagtgcacct
     2461 tcatggactc caagatgaag cccctgtgga tcatgtacag caacgaggag gcaggcagcg
     2521 gcggcagcgt gggcatcatc tttaagaacg gggatgacct ccggcaggac atgctgaccc
     2581 tgcagatgat ccagctcatg gacgtcctgt ggaagcagga ggggctggac ctgaggatga
     2641 ccccctatgg ctgcctcccc accggggacc gcacaggcct cattgaggtg gtactccgtt
     2701 cagacaccat cgccaacatc caactcaaca agagcaacat ggcagccaca gccgccttca
     2761 acaaggatgc cctgctcaac tggctgaagt ccaagaaccc gggggaggcc ctggatcgag
     2821 ccattgagga gttcaccctc tcctgtgctg gctattgtgt ggccacatat gtgctgggca
     2881 ttggcgatcg gcacagcgac aacatcatga tccgagagag tgggcagctg ttccacattg
     2941 attttggcca ctttctgggg aatttcaaga ccaagtttgg aatcaaccgc gagcgtgtcc
     3001 cattcatcct cacctacgac tttgtccatg tgattcagca ggggaagact aataatagtg
     3061 agaaatttga acggttccgg ggctactgtg aaagggccta caccatcctg cggcgccacg
     3121 ggcttctctt cctccacctc tttgccctga tgcgggcggc aggcctgcct gagctcagct
     3181 gctccaaaga catccagtat ctcaaggact ccctggcact ggggaaaaca gaggaggagg
     3241 cactgaagca cttccgagtg aagtttaacg aagccctccg tgagagctgg aaaaccaaag
     3301 tgaactggct ggcccacaac gtgtccaaag acaacaggca gtagtggctc ctcccagccc
     3361 tgggcccaag aggaggcggc tgcgggtcgt ggggaccaag cacattggtc ctaaaggggc
     3421 tgaagagcct gaactgcacc taacgggaaa gaaccgacat ggctgccttt tgtttacact
     3481 ggttatttat ttatgacttg aaatagttta aggagctaaa cagccataaa cggaaacgcc
     3541 tccttcatgc agcggcggtg ctgggccccc cgaggctgca cctggctctc ggctgaggat
     3601 tgtcacccca agtcttccag ctggtggatc tgggcccagc aaagactgtt ctcctcccga
     3661 gggaaccttc ttcccaggcc tcccgccaga ctgcctgggt cctggcgcct ggcggtcacc
     3721 tggtgcctac tgtccgacag gatgccttga tcctcgtgcg acccaccctg tgtatcctcc
     3781 ctagactgag ttctggcagc tccccgaggc agccggggta ccctctagat tcagggatgc
     3841 ttgctctcca cttttcaagt gggtcttggg tacgagaatt ccctcatctt tctctactgt
     3901 aaagtgattt tgtttgcagg taagaaaata atagatgact caccacacct ctacggctgg
     3961 ggagatcagg cccagcccca taaaggagaa tctacgctgg tcctcaggac gtgttaaaga
     4021 gatctgggcc tcatgtagct caccccggtc acgcatgaag gcaaaagcag gtcagaagcg
     4081 aatactctgc cattatctca aaaatctttt tttttttttt gagatggggt cttcctctgt
     4141 tgcccaggct ggagtgcagt ggtgcaatct tggctcactg taacctccgc ctcccaggtt
     4201 caagtgattc ttctgcctca gcctcctgag tagctgggat tacaggtgtg caccaccgta
     4261 cccagctaat ttttgtattt tagtagagac gggggtttca ccatgttggc tgggctggtc
     4321 tcgaactcct gacctcaggt gatccacccg cctgagcctc ccaaagtgct gggattacag
     4381 gcatgagcca ccgcgcccgg cccactctgc cattgtctaa gccacctctg aaagcaggtt
     4441 ttaacaaaag gatgaggcca gaactcttcc agaaccatca cctttgggaa cctgctgtga
     4501 gagtgctgag gtaccagaag tgtgagaacg agggggcgtg ctgggatctt tctctctgac
     4561 tatacttagt ttgaaatggt gcaggcttag tcttaagcct ccaaaggcct ggatttgagc
     4621 agctttagaa atgcaggttc tagggcttct cccagccttc agaagccaac taactctgca
     4681 gatggggcta ggactgtggg cttttagcag cccacaggtg atcctaacat atcaggccat
     4741 ggactcagga cctgcccggt gatgctgttg atttctcaaa ggtcttccaa aactcaacag
     4801 agccagaagt agccgcccgc tcagcggctc aggtgccagc tctgttctga ttcaccaggg
     4861 gtccgtcagt agtcattgcc acccgcgggg cacctccctg gccacacgcc tgttcccagc
     4921 aagtgctgaa actcactaga ccgtctgcct gtttcgaaat ggggaaagcc gtgcgtgcgc
     4981 gttatttatt taagtgcgcc tgtgtgcgcg ggtgtgggag cacactttgc aaagccacag
     5041 cgtttctggt tttgggtgta cagtcttgtg tgcctggcga gaagaatatt ttctattttt
     5101 ttaagtcatt tcatgtttct gtctggggaa ggcaagttag ttaagtatca ctgatgtggg
     5161 ttgagaccag cactctgtga aaccttgaaa tgagaagtaa aggcagatga aaagaaagaa
     5221 aaagcctttt tatgttcttt tatgttctcg gctcaaaaag aaacaaggga gtgtaggttt
     5281 aaaaccaaaa caggagagaa gacaaacccc gctccggctg gagttagtta gaaccagaac
     5341 tttattgtag cggatacact ttctgaccta tcatgagtat acacatctgc gaagggaaac
     5401 cgcgcggcga ca
//
