LOCUS       XM_047437550            9093 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens phosphatidylinositol 3-kinase catalytic
            subunit type 3 (PIK3C3), transcript variant X2, mRNA.
ACCESSION   XM_047437550
VERSION     XM_047437550.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000018.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9093
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
     gene            1..9093
                     /gene="PIK3C3"
                     /gene_synonym="hVps34; Vps34; VPS34"
                     /note="phosphatidylinositol 3-kinase catalytic subunit
                     type 3; Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 3 mRNAs, 63 ESTs, 759 long SRA
                     reads, and 96% coverage of the annotated genomic feature
                     by RNAseq alignments, including 81 samples with support
                     for all annotated introns"
                     /db_xref="GeneID:5289"
                     /db_xref="HGNC:HGNC:8974"
                     /db_xref="MIM:602609"
     CDS             295..2400
                     /gene="PIK3C3"
                     /gene_synonym="hVps34; Vps34; VPS34"
                     /codon_start=1
                     /product="phosphatidylinositol 3-kinase catalytic subunit
                     type 3 isoform X2"
                     /protein_id="XP_047293506.1"
                     /db_xref="GeneID:5289"
                     /db_xref="HGNC:HGNC:8974"
                     /db_xref="MIM:602609"
                     /translation="MVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKE
                     YGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKP
                     NAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAK
                     QALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALK
                     YENFDDIKNGLEPTKKDSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKT
                     KEVPDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNV
                     MRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLG
                     DNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFK
                     HGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVL
                     DTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLT
                     KTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLR
                     RYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVH
                     ALFAAVVEQIHKFAQYWRK"
ORIGIN      
        1 tgaaagtctg gcctaatgta gaagcagatg gatcagaacc cacaaaaact cctggcagaa
       61 caagtagcac tctctcagaa gatcagatga gccgtcttgc caaggaacat taagccatca
      121 tgtaagaagt ccagctattc tgttggagtg accaagttga aaaaccactt ggagagggag
      181 cagcactgag aatacgtggg gaaagagagg ccctaccacc ctggtatccc ggctaagccc
      241 accctttatc accaaggtgt tagaaatctc accaaagctc atcgacaagg acacatggtg
      301 aaagtagatt ggctggatag attgacattt agagaaatag aaatgataaa tgagagtgaa
      361 aaacgaagtt ctaatttcat gtacctgatg gttgaatttc gatgtgtcaa gtgtgatgat
      421 aaggaatatg gtattgttta ttatgaaaag gacggtgatg aatcatctcc aattttaaca
      481 agttttgaat tagtgaaagt tcctgacccc cagatgtcta tggagaattt agttgagagc
      541 aaacaccaca agcttgcccg gagtttaaga agtggacctt ctgaccacga tctgaaaccc
      601 aatgctgcca cgagagatca gttaaatatt attgtgagtt atccaccaac caagcaactt
      661 acatatgaag aacaagatct tgtttggaag tttagatatt atcttacgaa tcaagaaaaa
      721 gccttgacaa aattcttgaa atgtgttaat tgggatctac ctcaagaggc caaacaggcc
      781 ttggaacttc tgggaaaatg gaagccgatg gatgtagagg actccttgga gctgttatcc
      841 tctcattaca ccaacccaac tgtgaggcgt tatgctgttg cccggttgcg acaggccgat
      901 gatgaggatt tgttgatgta cctattacaa ttggtccagg ctctcaaata tgaaaatttt
      961 gatgatataa agaatggatt ggaacctacc aagaaggata gtcagagttc agtgtcagaa
     1021 aatgtgtcaa attctggaat aaattctgca gaaatagata gctcccaaat tataaccagc
     1081 ccccttcctt cagtctcttc acctcctcct gcatcaaaaa caaaagaagt tccagatggc
     1141 gaaaatctgg aacaagatct ctgtaccttc ttgatatcga gagcctgcaa aaactcaaca
     1201 ctggctaatt atttatactg gtatgtgata gtggaatgtg aagatcaaga tactcagcag
     1261 agagatccaa agacccatga gatgtacttg aacgtaatga gaagattcag ccaagcattg
     1321 ttgaagggtg ataagtctgt cagagttatg cgttctttgc tggctgcaca acagacattt
     1381 gtagatcggt tggtgcatct aatgaaggca gtacaacgcg aaagtggaaa tcgtaagaaa
     1441 aagaatgaga gactacaggc attgcttgga gataatgaaa agatgaattt gtcagatgtg
     1501 gaacttatcc cgttgccttt agaaccccaa gtgaaaatta gaggaataat tccggaaaca
     1561 gctacactgt ttaaaagtgc ccttatgcct gcacagttgt tttttaagac ggaagatgga
     1621 ggcaaatatc cagttatatt taagcatgga gatgatttac gtcaagatca acttattctt
     1681 caaatcattt cactcatgga caagctgtta cggaaagaaa atctggactt gaaattgaca
     1741 ccttataagg tgttagccac cagtacaaaa catggcttca tgcagtttat ccagtcagtt
     1801 cctgtggctg aagttcttga tacagaggga agcattcaga acttttttag aaaatatgca
     1861 ccaagtgaga atgggccaaa tgggattagt gctgaggtca tggacactta cgttaaaagc
     1921 tgtgctggat attgcgtgat cacctatata cttggagttg gagacaggca cctggataac
     1981 cttttgctaa caaaaacagg caaactcttc cacatagact ttggatatat tttgggtcgg
     2041 gatccaaagc ctcttcctcc accaatgaag ctgaataaag aaatggtaga aggaatgggg
     2101 ggcacacaga gtgagcagta ccaagagttc cgtaaacagt gttacacggc tttcctccac
     2161 ctgcgaaggt attctaatct gattttgaac ttgttttcct tgatggttga tgcaaacatt
     2221 ccagatattg cacttgaacc agataaaact gtgaaaaagg ttcaggataa attccgctta
     2281 gacctgtcgg atgaagaggc tgtgcattac atgcagagtc tgattgatga gagtgtccat
     2341 gctctttttg ctgcagtggt ggaacagatt cacaagtttg cccagtactg gagaaaatga
     2401 aactgggatt gacccatcaa gatgcttggc tcaataagaa aaccacgtta ggagcaacct
     2461 ttgtatattg gagacttcag agtaaccagc aaggaagaga aatcttaatc ttcaagttac
     2521 catattttcc aaatattaca tggtacctga gttctgcttc cttggatgtc attgcttaaa
     2581 tatagtcttg aagggcttgt tttgaaatat tgtatatatt ttttcaaatg tatacattgt
     2641 taataaatta agaaatgaga aacattctta tttatgtaca tgttatgaga gttctggagg
     2701 aagtaatatg ttgaaatagt aaaacatttt agtttttgag tttaaaatgt tattttttcc
     2761 tcttatatct tcatatcagg acagcagtaa cctgaattta gattgtcaca gtttacaagt
     2821 ttttgtttgt tccttctttc ctctctcttc tcccactcac ttttgtgtgt tgtttgtttt
     2881 tgcctaattt acatgtttaa agttctactt aaaatttttc ttcaagtttt acatgtgatg
     2941 gctcattctt ctgcagttca agaattgctt atatttttag aagatactca ttttctctta
     3001 caaataatta attttttgta aactacagtt aatagttctt ctagcttgta agtgtgtaaa
     3061 gtagaatatg aaaatgtggc tatttagata actggccaaa aggtcatatg accaccagtt
     3121 ttagtattga gcataagata tttttacata ttcatgtaag acaatgtaaa ttgtctttct
     3181 gcaataaatt ttttggatgc aaatttagat ttcaaaagct ttttgatgtt ataaaggagt
     3241 tgaggaacaa aaagctcttt gaaatagctc acctagacct gttaatgtaa tatattcttt
     3301 ctgaattaag caaaattttt tttgtctttt aagactagaa ctaatccctc tagctttttt
     3361 actggaactt tggggaaaaa gaacaaatac aaatatacaa atgatatgaa caatatggta
     3421 ataatctttt gcaacttaat atgttacata gtcatatgac ttggtcttgg aagaaaaaga
     3481 attgttttgg tgctgaataa atattagaaa tcaagtgaca gagaagatga aggtaaaatt
     3541 gtggcacagt ttcagagaat gccgttaatg ataacgtgtt atttgtctca aattcttagc
     3601 cctgggcttg cctcttcaga gtggggttac cggcgagagg gcaagcatgt aattaagaga
     3661 cactctagag gcatatggaa tatagtttgt ataaaacata cctgctgatt agaaaaatgg
     3721 taaaaatgaa aatacctttg tacatcatct taagagagct tatatataaa ctaaatgggc
     3781 aggctccatc gtctaccttt ctttttcttt tcttcacatg tttatgtctt ttttgttatt
     3841 agtcagacat ttttagccct ctgtatgctc attcttgtag ttctatttct attgaaactt
     3901 cctccaaaac ttttctctga attacccttg ttgaaactga cctttcttcc gtgtgaactc
     3961 ctacacttgc atctcctatt tcaggatttg gcatactttt tctttaatgg gctaagaaag
     4021 taaatatctt cagctttggg gggcatatga tcccaatagc atcaacttaa ctctgctaac
     4081 tggaaggcaa aagtgtatca tcttactcgt ctttataaac tccacagcac tctgcataga
     4141 tatgaccatg tttataagga actcaataaa taattttgac acaaacatga aattctagaa
     4201 gggcagacac tgacaactag taaggaagtt gatcatgagt aactttgtat tcagtgccac
     4261 cttaacaaga attgtaaaga ggataaacct ttctaggaag gttgatgcgt gttgggtgag
     4321 gaaggagcat ctctcaggag ggtaaacagt agctgtggtt ttgctgagag attttggctg
     4381 tgagtgacaa gcctatatca aaaagaaaag tggcttatca atctcagttt ttattgctca
     4441 aagcaattct ttactcctat tttttccaaa ttccattgtt tttactcttt agagctctat
     4501 cctcagagtg tagtctgcat atttctttat tatcattgcc atgtgacttc tttggtgaca
     4561 agttcagtga tatttcaagc atgatgtttt gagtttgaga aatgtatttg tgaggacaca
     4621 tcactttaat taaaaaagtg tgagtactat ggtcattaag ttattcagag tgagatttct
     4681 gagaggagaa gagagaatgt agatggcagt tattgagagt ggggctatag gacaaaaaga
     4741 agaaaagtat ggttaacatt gccaaataaa gggtcataca gccttgcttt ttgctggagt
     4801 tagcaaaaat cattctccat atgatagttt tagatgttcc ccagctcatt tgtattattg
     4861 agttttcagc tgggtatata ttataataac agtcaacatg atgtaggggc tcagtattac
     4921 atggcagggc tatactaatt gcttcatatg ccttatctca ttattctgtg agatagaatt
     4981 gtctcctcat tttttagttg aaataactga agtttaaagc aattgaatca tctgcccaag
     5041 gataagctgc tggtgagagc agagttggga tttgaagtcg agttagaccc cagtgatcac
     5101 agtcttgacg attaaattct tccagctttc atttttcact gagataatgg tagtgatagt
     5161 actgacctct aatgtgtgca tttgtgggta tgtggtccat tcagctttaa tccccagaag
     5221 acaaggctta ttccttttct tatttttggt catgttttat ttttccattg cttttaacag
     5281 gattaccaaa ggcacactca gtagtcagta aacacatttc taggaaaggt gttgtgtcat
     5341 catgccacat attcatactt tccttgggtt ggaaaataga tcattcagta aaaacataca
     5401 ggaaaaatga atcttgccaa tgcaattgtt aacctacaac cataatatac cttaagtata
     5461 tttttgcaca taagtataac attgcgattt aaaacaataa accagattga gattctaagg
     5521 agcattttgt aagtaattac taatgtttat tttagagaga tcacacaact tcaaataaaa
     5581 actgacatag attgaacacc ttgagaataa actttagtgc caaatggaaa ataatttttt
     5641 acaagtaaat ttgaagaaca atgtgaactt tctataatta tatacagaaa atatactgat
     5701 ttgccaaaat gagtaatttt gatatattaa tatttcactt ataagaatgc ataccacctg
     5761 atccaggatg ggatccagga acagaaaaag aacattaggt aaaaatgaca gaaatctgaa
     5821 tatagtatag agtagctaaa aacaaaccaa aaaaaaaaaa aaaaaaaaag gaaaaacaga
     5881 ataagcctca gaagatagtg agcatcccac ctgggtgacc acttagagaa gctgaggtgg
     5941 gacccctgca tccgataagt ggctgcacta gaccacagga accagactcc actgtaagaa
     6001 ctagagtggg aatggacatg tcaaaacctc ctgggaacct tattaaatgt gcacattccc
     6061 aatccccact cctgagcagc caaatcaatc tgcaggtggg ccttgtgagt tttcccaggg
     6121 gattccgatg cctgctagat ttaaccagta gatgagatgt taagttatcc tgtagtccag
     6181 agattccaca ggccagtgtc agggaacagg ggccagggct gggaaggcat aagaacagaa
     6241 gataaatttg aggctctgtt acgctggtca tccaacccaa ccaggtatct cttgttatat
     6301 gctaacttca ttttcccttt cttgtccata gtgggaaaaa ataattttta actggctatg
     6361 tagttaaaaa acctaacaaa aagcactttt ctatataatg agtggtttat attaagaata
     6421 ggtacaatgt aaatactggt aagtgaaagt tcattttgtt cagtgctatg ggctggtaca
     6481 ttgcatttca acactagttt tttactttta tctaccctga gggtagataa cccatattcc
     6541 aaaatacagt attattttca tttgctgtaa cattttaaga aatatgtagt ttctaaaact
     6601 tcatatactt tatatggaat atgaacaact ttaatatgaa taaatagtct agaaaaaaat
     6661 ttaggaaaaa ttgccatgaa atcatgagct aagtcaatgg ttattttaaa ccacttaatt
     6721 ttgagactag tatttcatac agaaaaagct aatactgata tcacacacta attgtgtata
     6781 aaacactagg aatgtcaaaa tagaacataa gaaaatgagt ctagtggacc cactgcatag
     6841 tgtaactttg ggatgaattt aaaagaatat ttaagtcaca gtcaattttc tgttggtcta
     6901 attttaccaa ataaccccct aaataagaag tctgatttat ctaaaataga agttaacata
     6961 gcatcccagt attgccattc taaaactctg gcatgtaaat gggagaaatg gaaataagct
     7021 caaaatgggt agagtaaccc atttctgcat gaaccataga atttaactag aatttggctg
     7081 gctcatgcct gtaatgccag cactttggga ggccaaggca ggcagatcac ttgagcccag
     7141 gagtttgaga ccagcccggg caacatggtg aaactccatc tcttcaaaaa tatatatttg
     7201 tgtgtgtgtg tgtgtgtatg tgcgtgcaca aaaattagct gagtgtggtg gttcacactt
     7261 gtaatcacag ctacctggga ggctgaggca ggaggattgc ttgagcctgg gaggcagagg
     7321 ttgcagtgag ctgagattgc accattgcac tgcagcctgg gtaatagagc gagacaactc
     7381 tatctcaaaa aaaagaattt cactagaatt tatatcttca gtgtttgcat tagattgtca
     7441 ccagcactat ctgccttgtg actgtcagga ctaatcctta tatcatttat cttatgtcct
     7501 ttacctcagt ttatgtctgt caccacaaga aacccagacc tccctaatca taccatatgc
     7561 cctggtctta cccacataca gctcggtaca actgcatttc cccaaacctc agaactcctt
     7621 gggccatcac tgtcagagac atttgaacta gagcaactcc atcttgagta gggactgggt
     7681 ataatgaagc tgagacccac tgggctgcat tcccaggaag ttaggcattc ttagtcacag
     7741 gatgagatag gagattggct caagataagg tcacaaagac cttgctgata aaacagtctg
     7801 tggtaaagaa gccagccaaa acccaccaaa accaagacgg gaatgaaagt gacctccggt
     7861 catcctcact gctcattata cgctagttat aatgcattga catgctaaga gacactccca
     7921 ccagcaccat gacagtttac aaatgccata acaacatcag gaagttaccc tatatggtct
     7981 aaaaagggga ggaaccctca gttctgagaa tttccttgaa aattcatgaa taatccaccc
     8041 cttgtttagc atatgatcaa gaaataatca ttaaaaaata gccaaccagc agctcatgct
     8101 gctggtctgc ctatggagta gccatccttt ctttattaac ctgctttcac tttatggact
     8161 cccctgaatt cttctgcagg agatccaaga accctctctt ggagtcttaa ccaggatccc
     8221 tttccagtaa cttcagcagg atctgtgagt gccagtttcc ttctgtggtg caaaactagg
     8281 tgctaagtac actttttccc ccctttcctc tatttttaaa agaactttca gcccttttga
     8341 agtgggtaca ttgtctggag tacataccct ggggttcatt gttataggag aatttaggac
     8401 acagacacac gaggagttta ggagcagagg tttaataggt agaagagaag ggaaagagaa
     8461 acagcttcct ctatagatgt ctgcactgac accgtggctt taaggcatgg cccatgatgt
     8521 gtctccgagt ggaaaagact ggttggtggt gaatgcgcca aattttatag tccggtttga
     8581 ggaggtggtt tctgattggt tgcatcatgt atgacgtttg caaggtgcat gtggaaggct
     8641 ggtcgcccca ccctaatctt atgcaaatgg gctttccagt tgattgggtc catcttgtgt
     8701 aacacgtggc tggcagagaa gggaagatga agccaccatc ttgaaaatgt ctagtcctta
     8761 gtttctgctg gcattcaccc atgcaagctg ccagcttgtc tatgtctgca gctcaacttt
     8821 acaggctgct ctttgttagc aaatgatttg gagcttcttt tcattaaaga aaaaagcctt
     8881 accgaggact cccataccct tgctttctgc ttaagtgatt tcttcttaac tcctatgtca
     8941 attttataca gcatgaaata atgatgtatc tataaatgag cctttgcaag attaccattt
     9001 atcaaagaaa accagtgatg tttagttaac tgtttgtaaa aataaatggt tagtagaatg
     9061 tctaattcaa taaatgtttc ataaatgagt aaa
//
