LOCUS       NM_004570               4864 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens phosphatidylinositol-4-phosphate 3-kinase catalytic
            subunit type 2 gamma (PIK3C2G), transcript variant 3, mRNA.
ACCESSION   NM_004570
VERSION     NM_004570.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4864)
  AUTHORS   Koch,P.A., Dornan,G.L., Hessenberger,M. and Haucke,V.
  TITLE     The molecular mechanisms mediating class II PI 3-kinase function in
            cell physiology
  JOURNAL   FEBS J 288 (24), 7025-7042 (2021)
   PUBMED   33387369
  REMARK    GeneRIF: The molecular mechanisms mediating class II PI 3-kinase
            function in cell physiology.
            Review article
REFERENCE   2  (bases 1 to 4864)
  AUTHORS   Yoshioka,K.
  TITLE     Class II phosphatidylinositol 3-kinase isoforms in vesicular
            trafficking
  JOURNAL   Biochem Soc Trans 49 (2), 893-901 (2021)
   PUBMED   33666217
  REMARK    GeneRIF: Class II phosphatidylinositol 3-kinase isoforms in
            vesicular trafficking.
            Review article
REFERENCE   3  (bases 1 to 4864)
  AUTHORS   Freitag,A., Prajwal,P., Shymanets,A., Harteneck,C., Nurnberg,B.,
            Schachtele,C., Kubbutat,M., Totzke,F. and Laufer,S.A.
  TITLE     Development of first lead structures for phosphoinositide
            3-kinase-C2gamma inhibitors
  JOURNAL   J Med Chem 58 (1), 212-221 (2015)
   PUBMED   24983663
  REMARK    GeneRIF: Data indicate substituents of benzensulfonamide and
            pyrazine as phosphoinositide 3-kinase-C2gamma (PI3K-C2GAMMA)
            inhibitors.
REFERENCE   4  (bases 1 to 4864)
  AUTHORS   Wang,Q., Xiang,B., Deng,W., Wu,J., Li,M., Ma,X., Wang,Y., Jiang,L.,
            McAlonan,G., Chua,S.E., Sham,P.C., Hu,X. and Li,T.
  TITLE     Genome-wide association analysis with gray matter volume as a
            quantitative phenotype in first-episode treatment-naive patients
            with schizophrenia
  JOURNAL   PLoS One 8 (9), e75083 (2013)
   PUBMED   24086445
  REMARK    Erratum:[PLoS One. 2015 Apr 07;10(4):e0122945. doi:
            10.1371/journal.pone.0122945.. PMID: 25848962]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4864)
  AUTHORS   Shia,W.C., Ku,T.H., Tsao,Y.M., Hsia,C.H., Chang,Y.M., Huang,C.H.,
            Chung,Y.C., Hsu,S.L., Liang,K.W. and Hsu,F.R.
  TITLE     Genetic copy number variants in myocardial infarction patients with
            hyperlipidemia
  JOURNAL   BMC Genomics 12 Suppl 3 (Suppl 3), S23 (2011)
   PUBMED   22369086
REFERENCE   6  (bases 1 to 4864)
  AUTHORS   Ono,F., Nakagawa,T., Saito,S., Owada,Y., Sakagami,H., Goto,K.,
            Suzuki,M., Matsuno,S. and Kondo,H.
  TITLE     A novel class II phosphoinositide 3-kinase predominantly expressed
            in the liver and its enhanced expression during liver regeneration
  JOURNAL   J Biol Chem 273 (13), 7731-7736 (1998)
   PUBMED   9516481
REFERENCE   7  (bases 1 to 4864)
  AUTHORS   Misawa,H., Ohtsubo,M., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.
            and Yoshimura,A.
  TITLE     Cloning and characterization of a novel class II phosphoinositide
            3-kinase containing C2 domain
  JOURNAL   Biochem Biophys Res Commun 244 (2), 531-539 (1998)
   PUBMED   9514948
REFERENCE   8  (bases 1 to 4864)
  AUTHORS   Borgatti,P., Zauli,G., Cantley,L.C. and Capitani,S.
  TITLE     Extracellular HIV-1 Tat protein induces a rapid and selective
            activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta
            isoforms in PC12 cells
  JOURNAL   Biochem Biophys Res Commun 242 (2), 332-337 (1998)
   PUBMED   9446795
REFERENCE   9  (bases 1 to 4864)
  AUTHORS   Borgatti,P., Zauli,G., Colamussi,M.L., Gibellini,D., Previati,M.,
            Cantley,L.L. and Capitani,S.
  TITLE     Extracellular HIV-1 Tat protein activates phosphatidylinositol 3-
            and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells
  JOURNAL   Eur J Immunol 27 (11), 2805-2811 (1997)
   PUBMED   9394803
REFERENCE   10 (bases 1 to 4864)
  AUTHORS   Milani,D., Mazzoni,M., Borgatti,P., Zauli,G., Cantley,L. and
            Capitani,S.
  TITLE     Extracellular human immunodeficiency virus type-1 Tat protein
            activates phosphatidylinositol 3-kinase in PC12 neuronal cells
  JOURNAL   J Biol Chem 271 (38), 22961-22964 (1996)
   PUBMED   8798481
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087240.17, AC092851.9,
            KF455618.1, AC087236.11 and AC091815.7.
            
            On Aug 13, 2020 this sequence version replaced NM_004570.5.
            
            Summary: The protein encoded by this gene belongs to the
            phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in
            signaling pathways involved in cell proliferation, oncogenic
            transformation, cell survival, cell migration, and intracellular
            protein trafficking. This protein contains a lipid kinase catalytic
            domain as well as a C-terminal C2 domain, a characteristic of class
            II PI3-kinases. C2 domains act as calcium-dependent phospholipid
            binding motifs that mediate translocation of proteins to membranes,
            and may also mediate protein-protein interactions. This gene may
            play a role in several diseases, including type II diabetes.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (3) lacks an in-frame exon in the
            central coding region, compared to variant 1. The encoded isoform
            (3) is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ000008.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC087240.17        114483-114542
            61-816              AC087240.17        134969-135724
            817-899             AC087240.17        139812-139894
            900-1057            AC087240.17        143820-143977
            1058-1172           AC087240.17        146866-146980
            1173-1275           AC087240.17        166927-167029
            1276-1346           AC087240.17        173927-173997
            1347-1410           AC087240.17        178000-178063
            1411-1533           AC087240.17        191391-191513
            1534-1567           AC087240.17        196292-196325
            1568-1582           AC092851.9         36532-36546
            1583-1763           KF455618.1         1-181
            1764-1895           AC092851.9         61071-61202
            1896-2010           AC092851.9         71657-71771
            2011-2141           AC092851.9         81013-81143
            2142-2330           AC092851.9         89550-89738
            2331-2424           AC092851.9         110832-110925
            2425-2519           AC092851.9         113836-113930
            2520-2700           AC087236.11        34796-34976
            2701-2808           AC087236.11        37798-37905
            2809-2901           AC087236.11        42409-42501
            2902-3031           AC087236.11        43966-44095
            3032-3168           AC087236.11        49628-49764
            3169-3338           AC087236.11        51639-51808
            3339-3495           AC091815.7         25491-25647
            3496-3605           AC091815.7         33658-33767
            3606-3795           AC091815.7         50038-50227
            3796-3917           AC091815.7         50712-50833
            3918-4026           AC091815.7         54284-54392
            4027-4102           AC091815.7         81829-81904
            4103-4197           AC091815.7         96870-96964
            4198-4323           AC091815.7         127764-127889
            4324-4864           AC091815.7         135211-135751
FEATURES             Location/Qualifiers
     source          1..4864
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..4864
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /note="phosphatidylinositol-4-phosphate 3-kinase catalytic
                     subunit type 2 gamma"
                     /db_xref="GeneID:5288"
                     /db_xref="HGNC:HGNC:8973"
                     /db_xref="MIM:609001"
     exon            1..60
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            61..816
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..4476
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /EC_number="2.7.1.137"
                     /EC_number="2.7.1.154"
                     /note="isoform 3 is encoded by transcript variant 3;
                     PTDINS-3-kinase C2 gamma; phosphatidylinositol-4-phosphate
                     3-kinase C2 domain-containing subunit gamma;
                     phosphatidylinositol-4-phosphate 3-kinase C2
                     domain-containing gamma polypeptide;
                     phosphoinositide-3-kinase, class 2, gamma polypeptide;
                     phosphatidylinositol 3-kinase C2 domain-containing subunit
                     gamma"
                     /codon_start=1
                     /product="phosphatidylinositol 3-kinase C2
                     domain-containing subunit gamma isoform 3"
                     /protein_id="NP_004561.3"
                     /db_xref="CCDS:CCDS44839.1"
                     /db_xref="GeneID:5288"
                     /db_xref="HGNC:HGNC:8973"
                     /db_xref="MIM:609001"
                     /translation="MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVSLGFDQIV
                     DEISGKIPHYESEIDENTFFVPTAPKWDSTGHSLNEAHQISLNEFTSKSRELSWHQVS
                     KAPAIGFSPSVLPKPQNTNKECSWGSPIGKHHGADDSRFSILAPSFTSLDKINLEKEL
                     ENENHNYHIGFESSIPPTNSSFSSDFMPKEENKRSGHVNIVEPSLMLLKGSLQPGMWE
                     STWQKNIESIGCSIQLVEVPQSSNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTT
                     AFPYQLFSKTKFNIHIFIDNSTQPLHFMPCANYLVKDLIAEILHFCTNDQLLPKDHIL
                     SVCGSEEFLQNDHCLGSHKMFQKDKSVIQLHLQKSREAPGKLSRKHEEDHSQFYLNQL
                     LEFMHIWKVSRQCLLTLIRKYDFHLKYLLKTQENVYNIIEEVKKICSVLGCVETKQIT
                     DAVNELSLILQRKGENFYQSSETSAKGLIEKVTTELSTSIYQLINVYCNSFYADFQPV
                     NVPRCTSYLNPGLPSHLSFTVYAAHNIPETWVHRINFPLEIKSLPRESMLTVKLFGIA
                     CATNNANLLAWTCLPLFPKEKSILGSMLFSMTLQSEPPVEMITPGVWDVSQPSPVTLQ
                     IDFPATGWEYMKPDSEENRSNLEEPLKECIKHIARLSQKQTPLLLSEEKKRYLWFYRF
                     YCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPLEALGLLTSSFPDQEIRKV
                     AVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKN
                     AENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGDIGERVKSASDHQRQEV
                     LKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANPMGK
                     NISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPD
                     AVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILG
                     VCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKN
                     PQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDT
                     DLEATSHFTKKIKESLECFPVKLNNLIHTLAQMSAISPAKSTSQTFPQESCLLSTTRS
                     IERATILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPEFP
                     HWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQTVEESSPVY
                     LGEKFPDKKPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRR
                     RKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEK
                     WYPLGNSII"
     exon            817..899
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1057
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1172
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1275
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1346
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1410
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1533
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1567
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1763
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1895
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2010
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2141
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2330
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2424
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2519
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2700
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2808
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2901
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3031
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3168
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3338
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3495
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3496..3605
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3795
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3796..3917
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3918..4026
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4027..4102
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4103..4197
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4198..4323
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4324..4864
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4717..4722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /note="hexamer: AATAAA"
     polyA_site      4739
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
     regulatory      4744..4749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /note="hexamer: AATATA"
     polyA_site      4761
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
     regulatory      4841..4846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /note="hexamer: AATAAA"
     polyA_site      4864
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /note="major polyA site"
ORIGIN      
        1 gtatttgact cttgaaaaga aatgagatcg tgtttcattt caggaagata tatgcgtcag
       61 gaaaatttct atcttctttt gtattatcaa ggagatattt ggagcagagt caaccctctc
      121 agttacataa aataaaaaat ggcatattct tggcaaacgg atccaaatcc taatgaatca
      181 cacgaaaagc agtatgaaca ccaagaattt ctctttgtaa atcaacccca ttcttctagc
      241 caagtcagtc tgggttttga tcagatagta gatgagatca gtggcaaaat tccacactac
      301 gagagtgaaa ttgatgaaaa cacctttttt gtgcccactg caccaaaatg ggactcaaca
      361 gggcattcat taaatgaagc acaccaaata tccttgaatg aattcacttc taaaagccgt
      421 gaactctcct ggcatcaagt tagcaaagca ccagcaattg gttttagtcc ttctgtgtta
      481 ccaaaacctc aaaatacgaa taaagaatgc tcctggggaa gccccatagg aaaacatcat
      541 ggtgctgatg attccagatt cagtatttta gctccatcat tcacaagttt ggataaaatt
      601 aatctagaga aagaattaga aaatgaaaat cataactacc atataggatt tgaaagtagc
      661 attcctccaa caaattcatc cttctcaagt gacttcatgc cgaaagaaga gaataaaagg
      721 agtggacatg tgaacattgt ggaaccatct ttgatgcttt tgaaaggctc tcttcaaccc
      781 ggaatgtggg aaagtacatg gcagaagaat atagagtcaa taggttgttc cattcagcta
      841 gtggaagtac ctcaaagcag caatacgagt ctggcctctt tttgcaacaa agtaaaaaaa
      901 atcagagaaa gatatcatgc agctgatgtt aatttcaatt ctgggaagat ctggagcact
      961 actacagcat ttccgtatca gctcttttct aagaccaagt ttaatataca tatttttatt
     1021 gataactcaa cacaacctct tcattttatg ccatgtgcta attatcttgt caaagatcta
     1081 attgcagaaa ttctgcattt ttgcacaaat gaccagctac tccccaaaga tcatattcta
     1141 agtgtatgtg gctctgaaga atttttacaa aacgaccact gtttggggag ccacaaaatg
     1201 tttcaaaaag ataaatctgt tattcagctc cacctgcaga aaagtaggga agctccagga
     1261 aagctatctc gaaagcatga agaggaccac agtcagtttt atctgaatca acttctagaa
     1321 tttatgcata tttggaaagt atccagacaa tgtctcttaa cactcatcag aaaatatgac
     1381 ttccacctga aatacctatt gaaaacccag gaaaacgtgt ataatattat tgaagaagtt
     1441 aaaaaaatat gcagtgttct agggtgtgtg gaaaccaaac aaattacaga tgcagtaaat
     1501 gaactaagtc taattcttca gagaaaagga gagaattttt atcaaagttc agagacttca
     1561 gcaaaaggct tgatagagaa ggtaacaact gaactatcca catccatcta ccagctaatc
     1621 aatgtctact gtaacagctt ttatgcagat tttcagcctg taaatgtacc tagatgcact
     1681 tcctatctaa atcccgggct tccttcccac ctcagcttca cagtgtatgc agcacacaac
     1741 attccagaaa cctgggtgca caggatcaat tttccccttg aaataaagtc acttccaagg
     1801 gaatccatgc tcactgtaaa actgtttggg attgcctgtg caaccaacaa tgcaaattta
     1861 ctggcgtgga cttgtcttcc actgtttcca aaagaaaaat ccattctcgg gtctatgctg
     1921 ttcagcatga cattacagag tgagcctccc gtagaaatga taactccagg agtgtgggat
     1981 gtaagtcagc catccccggt gaccctgcag attgattttc cagctactgg gtgggagtat
     2041 atgaaacctg attctgaaga gaatagaagt aatcttgaag agccactaaa ggagtgtata
     2101 aaacatattg ccagactttc acagaaacag actcccctac tactctctga agaaaagaaa
     2161 agatatttat ggttttatcg cttctactgc aataatgaaa actgctccct tcctttagtc
     2221 ctgggtagtg cccctggatg ggatgaaagg actgtttcag aaatgcatac cattttgaga
     2281 agatggacat tttctcaacc tttagaggct cttgggcttt tgacttccag ttttccagat
     2341 caagaaattc gtaaagtggc agttcaacaa ttagacaacc tcttgaatga tgaactactg
     2401 gaatatctcc cacagctagt tcaggctgtc aagtttgaat ggaaccttga gagtccttta
     2461 gtgcaacttc tactccaccg ctccttgcag agcatccagg ttgcccatcg tctttactgg
     2521 ctgctaaaaa atgcagaaaa tgaagcttat tttaaaagct ggtatcagaa gctactagct
     2581 gctctccaat tctgtgcagg taaagccttg aatgatgagt tttccaagga gcagaaactt
     2641 atcaaaattc tgggagatat tggggaaaga gtcaagtctg ccagtgacca tcaaagacag
     2701 gaggtactga agaaagaaat tggcagacta gaagagttct ttcaagatgt aaatacttgt
     2761 catcttcctc tgaaccctgc cctatgtata aaagggattg atcacgatgc atgttcatat
     2821 tttacatcta atgctttgcc attgaagatt actttcatca atgctaatcc gatgggcaaa
     2881 aacatcagca ttatttttaa ggctggagat gatcttcgtc aggatatgct tgttctgcag
     2941 cttattcaag tgatggacaa tatttggctg caggaaggct tggatatgca aatgatcatt
     3001 tatagatgtc tatccacagg aaaagaccaa ggattggtgc agatggtacc tgatgctgtg
     3061 accctagcaa agattcatcg ccattctgga ctgataggac cattgaaaga aaatacaatt
     3121 aaaaagtggt tcagtcagca caaccactta aaggcagatt atgaaaaggc cttgaggaac
     3181 tttttctact cctgtgctgg ctggtgtgtg gtaacattca tcctgggagt atgtgaccgt
     3241 cacaatgata atatcatgct gacaaagtcg ggccacatgt ttcatattga ctttggaaaa
     3301 ttcttaggtc atgcacaaac atttggaggg ataaaaaggg accgagctcc tttcattttt
     3361 acttcagaga tggaatactt tattacagag ggtgggaaaa acccacagca ttttcaagat
     3421 tttgtggaac tttgctgtcg tgcttataat attatcagaa agcacagcca actgctcttg
     3481 aacctgctgg aaatgatgct gtatgcagga ctgcctgagc taagtggaat tcaagacctg
     3541 aaatatgtgt ataataatct tcgtccacaa gacacagacc tggaagcaac aagtcatttt
     3601 accaagaaaa taaaggaaag tctggagtgt ttccctgtta aattgaataa cttgatccac
     3661 acacttgcac aaatgtcagc cataagccct gccaaatcta cttcacagac ttttcctcag
     3721 gaatcctgtt tgctgagtac aactaggtcg attgaaagag caacaatttt agggttcagc
     3781 aagaaatcca gtaatctgta tctgatccag gtgacacaca gcaacaacga aacaagcctg
     3841 acagaaaaat catttgagca gttttcaaaa cttcacagcc aacttcagaa gcagtttgca
     3901 tcactgactc tcccagagtt tcctcattgg tggcacctac cttttacaaa ttcagatcac
     3961 agaagattca gagatctaaa tcattacatg gaacagatat taaatgtatc acatgaagtt
     4021 acaaacagtg attgtgtact tagctttttc ctctctgagg ctgtgcaaca aacagttgaa
     4081 gaatcatcac ctgtgtacct aggtgagaag tttccagaca agaagcctaa ggtgcagtta
     4141 gtcatatcct acgaggatgt gaagctgacc atactagtga aacacatgaa aaacattcat
     4201 ctcccagatg gctctgcgcc cagtgcacat gttgaatttt atcttttacc atatcccagt
     4261 gaagttcgta ggaggaaaac aaaatctgtt ccaaaatgta cggaccccac ttacaatgaa
     4321 attgtagtat atgatgaagt cacagagctc caaggacatg tcttaatgct tattgtgaag
     4381 agtaaaactg tatttgtggg agcaattaac atccgactct gtagtgtccc actcgataaa
     4441 gaaaaatggt atccattagg aaacagtata atttgaccat tgctatgaac atatgcatta
     4501 ttcattaact acttgtattt ttttcacttc tgggcctctg aatcacataa gtaaggcatc
     4561 tttgttgtca aagacagcac agggtattaa ggacacagaa aaaaaatcag aattagtctt
     4621 ttgtgttgtt tattttctac ctgtgctttc attgtttttt cataatcttt tctccttcag
     4681 tggagtactg attgcatgaa atttgatgtg taaaataata aaagaccttt attaaatcat
     4741 tttaatatat tttaaattaa acataggttt acatttgttt taattgtgtg cctacagtta
     4801 aaagcagtat ttttaatgta ttttataaga aagacaatca aataaacctc atcaattaat
     4861 tcaa
//
