LOCUS       NM_001288772            4987 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens phosphatidylinositol-4-phosphate 3-kinase catalytic
            subunit type 2 gamma (PIK3C2G), transcript variant 1, mRNA.
ACCESSION   NM_001288772
VERSION     NM_001288772.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4987)
  AUTHORS   Koch,P.A., Dornan,G.L., Hessenberger,M. and Haucke,V.
  TITLE     The molecular mechanisms mediating class II PI 3-kinase function in
            cell physiology
  JOURNAL   FEBS J 288 (24), 7025-7042 (2021)
   PUBMED   33387369
  REMARK    GeneRIF: The molecular mechanisms mediating class II PI 3-kinase
            function in cell physiology.
            Review article
REFERENCE   2  (bases 1 to 4987)
  AUTHORS   Yoshioka,K.
  TITLE     Class II phosphatidylinositol 3-kinase isoforms in vesicular
            trafficking
  JOURNAL   Biochem Soc Trans 49 (2), 893-901 (2021)
   PUBMED   33666217
  REMARK    GeneRIF: Class II phosphatidylinositol 3-kinase isoforms in
            vesicular trafficking.
            Review article
REFERENCE   3  (bases 1 to 4987)
  AUTHORS   Freitag,A., Prajwal,P., Shymanets,A., Harteneck,C., Nurnberg,B.,
            Schachtele,C., Kubbutat,M., Totzke,F. and Laufer,S.A.
  TITLE     Development of first lead structures for phosphoinositide
            3-kinase-C2gamma inhibitors
  JOURNAL   J Med Chem 58 (1), 212-221 (2015)
   PUBMED   24983663
  REMARK    GeneRIF: Data indicate substituents of benzensulfonamide and
            pyrazine as phosphoinositide 3-kinase-C2gamma (PI3K-C2GAMMA)
            inhibitors.
REFERENCE   4  (bases 1 to 4987)
  AUTHORS   Wang,Q., Xiang,B., Deng,W., Wu,J., Li,M., Ma,X., Wang,Y., Jiang,L.,
            McAlonan,G., Chua,S.E., Sham,P.C., Hu,X. and Li,T.
  TITLE     Genome-wide association analysis with gray matter volume as a
            quantitative phenotype in first-episode treatment-naive patients
            with schizophrenia
  JOURNAL   PLoS One 8 (9), e75083 (2013)
   PUBMED   24086445
  REMARK    Erratum:[PLoS One. 2015 Apr 07;10(4):e0122945. doi:
            10.1371/journal.pone.0122945.. PMID: 25848962]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4987)
  AUTHORS   Shia,W.C., Ku,T.H., Tsao,Y.M., Hsia,C.H., Chang,Y.M., Huang,C.H.,
            Chung,Y.C., Hsu,S.L., Liang,K.W. and Hsu,F.R.
  TITLE     Genetic copy number variants in myocardial infarction patients with
            hyperlipidemia
  JOURNAL   BMC Genomics 12 Suppl 3 (Suppl 3), S23 (2011)
   PUBMED   22369086
REFERENCE   6  (bases 1 to 4987)
  AUTHORS   Ono,F., Nakagawa,T., Saito,S., Owada,Y., Sakagami,H., Goto,K.,
            Suzuki,M., Matsuno,S. and Kondo,H.
  TITLE     A novel class II phosphoinositide 3-kinase predominantly expressed
            in the liver and its enhanced expression during liver regeneration
  JOURNAL   J Biol Chem 273 (13), 7731-7736 (1998)
   PUBMED   9516481
REFERENCE   7  (bases 1 to 4987)
  AUTHORS   Misawa,H., Ohtsubo,M., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.
            and Yoshimura,A.
  TITLE     Cloning and characterization of a novel class II phosphoinositide
            3-kinase containing C2 domain
  JOURNAL   Biochem Biophys Res Commun 244 (2), 531-539 (1998)
   PUBMED   9514948
REFERENCE   8  (bases 1 to 4987)
  AUTHORS   Borgatti,P., Zauli,G., Cantley,L.C. and Capitani,S.
  TITLE     Extracellular HIV-1 Tat protein induces a rapid and selective
            activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta
            isoforms in PC12 cells
  JOURNAL   Biochem Biophys Res Commun 242 (2), 332-337 (1998)
   PUBMED   9446795
REFERENCE   9  (bases 1 to 4987)
  AUTHORS   Borgatti,P., Zauli,G., Colamussi,M.L., Gibellini,D., Previati,M.,
            Cantley,L.L. and Capitani,S.
  TITLE     Extracellular HIV-1 Tat protein activates phosphatidylinositol 3-
            and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells
  JOURNAL   Eur J Immunol 27 (11), 2805-2811 (1997)
   PUBMED   9394803
REFERENCE   10 (bases 1 to 4987)
  AUTHORS   Milani,D., Mazzoni,M., Borgatti,P., Zauli,G., Cantley,L. and
            Capitani,S.
  TITLE     Extracellular human immunodeficiency virus type-1 Tat protein
            activates phosphatidylinositol 3-kinase in PC12 neuronal cells
  JOURNAL   J Biol Chem 271 (38), 22961-22964 (1996)
   PUBMED   8798481
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087240.17, AC092851.9,
            KF455618.1, AC087236.11 and AC091815.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 5, 2019 this sequence version replaced NM_001288772.1.
            
            Summary: The protein encoded by this gene belongs to the
            phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in
            signaling pathways involved in cell proliferation, oncogenic
            transformation, cell survival, cell migration, and intracellular
            protein trafficking. This protein contains a lipid kinase catalytic
            domain as well as a C-terminal C2 domain, a characteristic of class
            II PI3-kinases. C2 domains act as calcium-dependent phospholipid
            binding motifs that mediate translocation of proteins to membranes,
            and may also mediate protein-protein interactions. This gene may
            play a role in several diseases, including type II diabetes.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC144134.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2142586, SAMEA2145774 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000538779.6/ ENSP00000445381.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC087240.17        114483-114542
            61-816              AC087240.17        134969-135724
            817-899             AC087240.17        139812-139894
            900-1057            AC087240.17        143820-143977
            1058-1172           AC087240.17        146866-146980
            1173-1275           AC087240.17        166927-167029
            1276-1346           AC087240.17        173927-173997
            1347-1410           AC087240.17        178000-178063
            1411-1533           AC087240.17        191391-191513
            1534-1567           AC087240.17        196292-196325
            1568-1582           AC092851.9         36532-36546
            1583-1763           KF455618.1         1-181
            1764-1886           AC092851.9         52655-52777
            1887-2018           AC092851.9         61071-61202
            2019-2133           AC092851.9         71657-71771
            2134-2264           AC092851.9         81013-81143
            2265-2453           AC092851.9         89550-89738
            2454-2547           AC092851.9         110832-110925
            2548-2642           AC092851.9         113836-113930
            2643-2823           AC087236.11        34796-34976
            2824-2931           AC087236.11        37798-37905
            2932-3024           AC087236.11        42409-42501
            3025-3154           AC087236.11        43966-44095
            3155-3291           AC087236.11        49628-49764
            3292-3461           AC087236.11        51639-51808
            3462-3618           AC091815.7         25491-25647
            3619-3728           AC091815.7         33658-33767
            3729-3918           AC091815.7         50038-50227
            3919-4040           AC091815.7         50712-50833
            4041-4149           AC091815.7         54284-54392
            4150-4225           AC091815.7         81829-81904
            4226-4320           AC091815.7         96870-96964
            4321-4446           AC091815.7         127764-127889
            4447-4987           AC091815.7         135211-135751
FEATURES             Location/Qualifiers
     source          1..4987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..4987
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /note="phosphatidylinositol-4-phosphate 3-kinase catalytic
                     subunit type 2 gamma"
                     /db_xref="GeneID:5288"
                     /db_xref="HGNC:HGNC:8973"
                     /db_xref="MIM:609001"
     exon            1..60
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            61..816
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..4599
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /EC_number="2.7.1.137"
                     /EC_number="2.7.1.154"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PTDINS-3-kinase C2 gamma; phosphatidylinositol-4-phosphate
                     3-kinase C2 domain-containing subunit gamma;
                     phosphatidylinositol-4-phosphate 3-kinase C2
                     domain-containing gamma polypeptide;
                     phosphoinositide-3-kinase, class 2, gamma polypeptide;
                     phosphatidylinositol 3-kinase C2 domain-containing subunit
                     gamma"
                     /codon_start=1
                     /product="phosphatidylinositol 3-kinase C2
                     domain-containing subunit gamma isoform 1"
                     /protein_id="NP_001275701.1"
                     /db_xref="CCDS:CCDS73452.1"
                     /db_xref="GeneID:5288"
                     /db_xref="HGNC:HGNC:8973"
                     /db_xref="MIM:609001"
                     /translation="MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVSLGFDQIV
                     DEISGKIPHYESEIDENTFFVPTAPKWDSTGHSLNEAHQISLNEFTSKSRELSWHQVS
                     KAPAIGFSPSVLPKPQNTNKECSWGSPIGKHHGADDSRFSILAPSFTSLDKINLEKEL
                     ENENHNYHIGFESSIPPTNSSFSSDFMPKEENKRSGHVNIVEPSLMLLKGSLQPGMWE
                     STWQKNIESIGCSIQLVEVPQSSNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTT
                     AFPYQLFSKTKFNIHIFIDNSTQPLHFMPCANYLVKDLIAEILHFCTNDQLLPKDHIL
                     SVCGSEEFLQNDHCLGSHKMFQKDKSVIQLHLQKSREAPGKLSRKHEEDHSQFYLNQL
                     LEFMHIWKVSRQCLLTLIRKYDFHLKYLLKTQENVYNIIEEVKKICSVLGCVETKQIT
                     DAVNELSLILQRKGENFYQSSETSAKGLIEKVTTELSTSIYQLINVYCNSFYADFQPV
                     NVPRCTSYLNPGLPSHLSFTVYAAHNIPETWVHSYKAFSFTCWLTYAGKKLCQVRNYR
                     NIPDKKLFFFLVNWNETINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWTCLPLF
                     PKEKSILGSMLFSMTLQSEPPVEMITPGVWDVSQPSPVTLQIDFPATGWEYMKPDSEE
                     NRSNLEEPLKECIKHIARLSQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAP
                     GWDERTVSEMHTILRRWTFSQPLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYL
                     PQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAA
                     LQFCAGKALNDEFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQDVNT
                     CHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDML
                     VLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRHSGLIGPL
                     KENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHM
                     FHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNI
                     IRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESLE
                     CFPVKLNNLIHTLAQMSAISPAKSTSQTFPQESCLLSTTRSIERATILGFSKKSSNLY
                     LIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPEFPHWWHLPFTNSDHRRFRD
                     LNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQTVEESSPVYLGEKFPDKKPKVQLVIS
                     YEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEI
                     VVYDEVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKWYPLGNSII"
     exon            817..899
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1057
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1172
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1275
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1346
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1410
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1533
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1567
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1763
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1886
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2018
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2133
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2264
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2453
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2547
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2642
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2823
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2931
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3024
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3154
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3291
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3461
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3618
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..3728
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3729..3918
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            3919..4040
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4041..4149
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..4225
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4226..4320
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4321..4446
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            4447..4987
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4840..4845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /note="hexamer: AATAAA"
     polyA_site      4862
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
     regulatory      4867..4872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /note="hexamer: AATATA"
     polyA_site      4884
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
     regulatory      4964..4969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /note="hexamer: AATAAA"
     polyA_site      4987
                     /gene="PIK3C2G"
                     /gene_synonym="PI3K-C2-gamma; PI3K-C2GAMMA"
                     /note="major polyA site"
ORIGIN      
        1 gtatttgact cttgaaaaga aatgagatcg tgtttcattt caggaagata tatgcgtcag
       61 gaaaatttct atcttctttt gtattatcaa ggagatattt ggagcagagt caaccctctc
      121 agttacataa aataaaaaat ggcatattct tggcaaacgg atccaaatcc taatgaatca
      181 cacgaaaagc agtatgaaca ccaagaattt ctctttgtaa atcaacccca ttcttctagc
      241 caagtcagtc tgggttttga tcagatagta gatgagatca gtggcaaaat tccacactac
      301 gagagtgaaa ttgatgaaaa cacctttttt gtgcccactg caccaaaatg ggactcaaca
      361 gggcattcat taaatgaagc acaccaaata tccttgaatg aattcacttc taaaagccgt
      421 gaactctcct ggcatcaagt tagcaaagca ccagcaattg gttttagtcc ttctgtgtta
      481 ccaaaacctc aaaatacgaa taaagaatgc tcctggggaa gccccatagg aaaacatcat
      541 ggtgctgatg attccagatt cagtatttta gctccatcat tcacaagttt ggataaaatt
      601 aatctagaga aagaattaga aaatgaaaat cataactacc atataggatt tgaaagtagc
      661 attcctccaa caaattcatc cttctcaagt gacttcatgc cgaaagaaga gaataaaagg
      721 agtggacatg tgaacattgt ggaaccatct ttgatgcttt tgaaaggctc tcttcaaccc
      781 ggaatgtggg aaagtacatg gcagaagaat atagagtcaa taggttgttc cattcagcta
      841 gtggaagtac ctcaaagcag caatacgagt ctggcctctt tttgcaacaa agtaaaaaaa
      901 atcagagaaa gatatcatgc agctgatgtt aatttcaatt ctgggaagat ctggagcact
      961 actacagcat ttccgtatca gctcttttct aagaccaagt ttaatataca tatttttatt
     1021 gataactcaa cacaacctct tcattttatg ccatgtgcta attatcttgt caaagatcta
     1081 attgcagaaa ttctgcattt ttgcacaaat gaccagctac tccccaaaga tcatattcta
     1141 agtgtatgtg gctctgaaga atttttacaa aacgaccact gtttggggag ccacaaaatg
     1201 tttcaaaaag ataaatctgt tattcagctc cacctgcaga aaagtaggga agctccagga
     1261 aagctatctc gaaagcatga agaggaccac agtcagtttt atctgaatca acttctagaa
     1321 tttatgcata tttggaaagt atccagacaa tgtctcttaa cactcatcag aaaatatgac
     1381 ttccacctga aatacctatt gaaaacccag gaaaacgtgt ataatattat tgaagaagtt
     1441 aaaaaaatat gcagtgttct agggtgtgtg gaaaccaaac aaattacaga tgcagtaaat
     1501 gaactaagtc taattcttca gagaaaagga gagaattttt atcaaagttc agagacttca
     1561 gcaaaaggct tgatagagaa ggtaacaact gaactatcca catccatcta ccagctaatc
     1621 aatgtctact gtaacagctt ttatgcagat tttcagcctg taaatgtacc tagatgcact
     1681 tcctatctaa atcccgggct tccttcccac ctcagcttca cagtgtatgc agcacacaac
     1741 attccagaaa cctgggtgca cagctacaaa gcgttttctt ttacctgttg gcttacatat
     1801 gctggaaaga agctgtgcca agtgagaaac tacagaaata ttccagacaa gaaattattt
     1861 tttttcttgg tcaactggaa tgaaacgatc aattttcccc ttgaaataaa gtcacttcca
     1921 agggaatcca tgctcactgt aaaactgttt gggattgcct gtgcaaccaa caatgcaaat
     1981 ttactggcgt ggacttgtct tccactgttt ccaaaagaaa aatccattct cgggtctatg
     2041 ctgttcagca tgacattaca gagtgagcct cccgtagaaa tgataactcc aggagtgtgg
     2101 gatgtaagtc agccatcccc ggtgaccctg cagattgatt ttccagctac tgggtgggag
     2161 tatatgaaac ctgattctga agagaataga agtaatcttg aagagccact aaaggagtgt
     2221 ataaaacata ttgccagact ttcacagaaa cagactcccc tactactctc tgaagaaaag
     2281 aaaagatatt tatggtttta tcgcttctac tgcaataatg aaaactgctc ccttccttta
     2341 gtcctgggta gtgcccctgg atgggatgaa aggactgttt cagaaatgca taccattttg
     2401 agaagatgga cattttctca acctttagag gctcttgggc ttttgacttc cagttttcca
     2461 gatcaagaaa ttcgtaaagt ggcagttcaa caattagaca acctcttgaa tgatgaacta
     2521 ctggaatatc tcccacagct agttcaggct gtcaagtttg aatggaacct tgagagtcct
     2581 ttagtgcaac ttctactcca ccgctccttg cagagcatcc aggttgccca tcgtctttac
     2641 tggctgctaa aaaatgcaga aaatgaagct tattttaaaa gctggtatca gaagctacta
     2701 gctgctctcc aattctgtgc aggtaaagcc ttgaatgatg agttttccaa ggagcagaaa
     2761 cttatcaaaa ttctgggaga tattggggaa agagtcaagt ctgccagtga ccatcaaaga
     2821 caggaggtac tgaagaaaga aattggcaga ctagaagagt tctttcaaga tgtaaatact
     2881 tgtcatcttc ctctgaaccc tgccctatgt ataaaaggga ttgatcacga tgcatgttca
     2941 tattttacat ctaatgcttt gccattgaag attactttca tcaatgctaa tccgatgggc
     3001 aaaaacatca gcattatttt taaggctgga gatgatcttc gtcaggatat gcttgttctg
     3061 cagcttattc aagtgatgga caatatttgg ctgcaggaag gcttggatat gcaaatgatc
     3121 atttatagat gtctatccac aggaaaagac caaggattgg tgcagatggt acctgatgct
     3181 gtgaccctag caaagattca tcgccattct ggactgatag gaccattgaa agaaaataca
     3241 attaaaaagt ggttcagtca gcacaaccac ttaaaggcag attatgaaaa ggccttgagg
     3301 aactttttct actcctgtgc tggctggtgt gtggtaacat tcatcctggg agtatgtgac
     3361 cgtcacaatg ataatatcat gctgacaaag tcgggccaca tgtttcatat tgactttgga
     3421 aaattcttag gtcatgcaca aacatttgga gggataaaaa gggaccgagc tcctttcatt
     3481 tttacttcag agatggaata ctttattaca gagggtggga aaaacccaca gcattttcaa
     3541 gattttgtgg aactttgctg tcgtgcttat aatattatca gaaagcacag ccaactgctc
     3601 ttgaacctgc tggaaatgat gctgtatgca ggactgcctg agctaagtgg aattcaagac
     3661 ctgaaatatg tgtataataa tcttcgtcca caagacacag acctggaagc aacaagtcat
     3721 tttaccaaga aaataaagga aagtctggag tgtttccctg ttaaattgaa taacttgatc
     3781 cacacacttg cacaaatgtc agccataagc cctgccaaat ctacttcaca gacttttcct
     3841 caggaatcct gtttgctgag tacaactagg tcgattgaaa gagcaacaat tttagggttc
     3901 agcaagaaat ccagtaatct gtatctgatc caggtgacac acagcaacaa cgaaacaagc
     3961 ctgacagaaa aatcatttga gcagttttca aaacttcaca gccaacttca gaagcagttt
     4021 gcatcactga ctctcccaga gtttcctcat tggtggcacc taccttttac aaattcagat
     4081 cacagaagat tcagagatct aaatcattac atggaacaga tattaaatgt atcacatgaa
     4141 gttacaaaca gtgattgtgt acttagcttt ttcctctctg aggctgtgca acaaacagtt
     4201 gaagaatcat cacctgtgta cctaggtgag aagtttccag acaagaagcc taaggtgcag
     4261 ttagtcatat cctacgagga tgtgaagctg accatactag tgaaacacat gaaaaacatt
     4321 catctcccag atggctctgc gcccagtgca catgttgaat tttatctttt accatatccc
     4381 agtgaagttc gtaggaggaa aacaaaatct gttccaaaat gtacggaccc cacttacaat
     4441 gaaattgtag tatatgatga agtcacagag ctccaaggac atgtcttaat gcttattgtg
     4501 aagagtaaaa ctgtatttgt gggagcaatt aacatccgac tctgtagtgt cccactcgat
     4561 aaagaaaaat ggtatccatt aggaaacagt ataatttgac cattgctatg aacatatgca
     4621 ttattcatta actacttgta tttttttcac ttctgggcct ctgaatcaca taagtaaggc
     4681 atctttgttg tcaaagacag cacagggtat taaggacaca gaaaaaaaat cagaattagt
     4741 cttttgtgtt gtttattttc tacctgtgct ttcattgttt tttcataatc ttttctcctt
     4801 cagtggagta ctgattgcat gaaatttgat gtgtaaaata ataaaagacc tttattaaat
     4861 cattttaata tattttaaat taaacatagg tttacatttg ttttaattgt gtgcctacag
     4921 ttaaaagcag tatttttaat gtattttata agaaagacaa tcaaataaac ctcatcaatt
     4981 aattcaa
//
