LOCUS       NM_152309               4800 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens phosphoinositide-3-kinase adaptor protein 1 (PIK3AP1),
            mRNA.
ACCESSION   NM_152309
VERSION     NM_152309.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4800)
  AUTHORS   Li,J., Zhang,Z., Hu,J., Wan,X., Huang,W., Zhang,H. and Jiang,N.
  TITLE     MiR-1246 regulates the PI3K/AKT signaling pathway by targeting
            PIK3AP1 and inhibits thyroid cancer cell proliferation and tumor
            growth
  JOURNAL   Mol Cell Biochem 477 (3), 649-661 (2022)
   PUBMED   34870753
  REMARK    GeneRIF: MiR-1246 regulates the PI3K/AKT signaling pathway by
            targeting PIK3AP1 and inhibits thyroid cancer cell proliferation
            and tumor growth.
REFERENCE   2  (bases 1 to 4800)
  AUTHORS   Tong,W. and Zhang,H.
  TITLE     Overexpression of long non-coding RNA WT1-AS or silencing of
            PIK3AP1 are inhibitory to cervical cancer progression
  JOURNAL   Cell Cycle 20 (24), 2583-2596 (2021)
   PUBMED   34839795
  REMARK    GeneRIF: Overexpression of long non-coding RNA WT1-AS or silencing
            of PIK3AP1 are inhibitory to cervical cancer progression.
REFERENCE   3  (bases 1 to 4800)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4800)
  AUTHORS   Lovsin,E., Kovac,J., Tesovnik,T., Toplak,N., Perko,D., Rozmaric,T.,
            Debeljak,M. and Avcin,T.
  TITLE     PIK3AP1 and SPON2 Genes Are Differentially Methylated in Patients
            With Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis
            (PFAPA) Syndrome
  JOURNAL   Front Immunol 11, 1322 (2020)
   PUBMED   32793186
  REMARK    GeneRIF: PIK3AP1 and SPON2 Genes Are Differentially Methylated in
            Patients With Periodic Fever, Aphthous Stomatitis, Pharyngitis, and
            Adenitis (PFAPA) Syndrome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4800)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4800)
  AUTHORS   Koutros,S., Schumacher,F.R., Hayes,R.B., Ma,J., Huang,W.Y.,
            Albanes,D., Canzian,F., Chanock,S.J., Crawford,E.D., Diver,W.R.,
            Feigelson,H.S., Giovanucci,E., Haiman,C.A., Henderson,B.E.,
            Hunter,D.J., Kaaks,R., Kolonel,L.N., Kraft,P., Le Marchand,L.,
            Riboli,E., Siddiq,A., Stampfer,M.J., Stram,D.O., Thomas,G.,
            Travis,R.C., Thun,M.J., Yeager,M. and Berndt,S.I.
  TITLE     Pooled analysis of phosphatidylinositol 3-kinase pathway variants
            and risk of prostate cancer
  JOURNAL   Cancer Res 70 (6), 2389-2396 (2010)
   PUBMED   20197460
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 4800)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4800)
  AUTHORS   Maruoka,M., Suzuki,J., Kawata,S., Yoshida,K., Hirao,N., Sato,S.,
            Goff,S.P., Takeya,T., Tani,K. and Shishido,T.
  TITLE     Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl
            interactor 1-regulated substrate of Abl kinases
  JOURNAL   FEBS Lett 579 (14), 2986-2990 (2005)
   PUBMED   15893754
  REMARK    GeneRIF: Abi-1 promotes Abl-mediated BCAP phosphorylation and
            suggest that Abi-1 in general coordinates kinase-substrate
            interactions
REFERENCE   9  (bases 1 to 4800)
  AUTHORS   Okada,T., Maeda,A., Iwamatsu,A., Gotoh,K. and Kurosaki,T.
  TITLE     BCAP: the tyrosine kinase substrate that connects B cell receptor
            to phosphoinositide 3-kinase activation
  JOURNAL   Immunity 13 (6), 817-827 (2000)
   PUBMED   11163197
REFERENCE   10 (bases 1 to 4800)
  AUTHORS   Edwards,J.A., Sethi,P.K., Scoma,A.J., Bannerman,R.M. and
            Frohman,L.A.
  TITLE     A new familial syndrome characterized by pigmentary retinopathy,
            hypogonadism, mental retardation, nerve deafness and glucose
            intolerance
  JOURNAL   Am J Med 60 (1), 23-32 (1976)
   PUBMED   1251844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK125635.1, BX648550.1, AK092883.1, AK122584.1 and AI826732.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152309.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125635.1, BX648550.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339364.10/ ENSP00000339826.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AK125635.1         1-180
            181-366             BX648550.1         85-270
            367-1695            AK125635.1         367-1695
            1696-1892           BX648550.1         1600-1796
            1893-2295           AK092883.1         1424-1826
            2296-4123           AK122584.1         3133-4960
            4124-4658           BX648550.1         4028-4562
            4659-4800           AI826732.1         10-151              c
FEATURES             Location/Qualifiers
     source          1..4800
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..4800
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /note="phosphoinositide-3-kinase adaptor protein 1"
                     /db_xref="GeneID:118788"
                     /db_xref="HGNC:HGNC:30034"
                     /db_xref="MIM:607942"
     exon            1..133
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2538
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /note="B cell adaptor protein; B-cell adapter for
                     phosphoinositide 3-kinase; B-cell phosphoinositide
                     3-kinase adapter protein 1"
                     /codon_start=1
                     /product="phosphoinositide 3-kinase adapter protein 1"
                     /protein_id="NP_689522.2"
                     /db_xref="CCDS:CCDS31259.1"
                     /db_xref="GeneID:118788"
                     /db_xref="HGNC:HGNC:30034"
                     /db_xref="MIM:607942"
                     /translation="MAASGVPRGCDILIVYSPDAEEWCQYLQTLFLSSRQVRSQKILT
                     HRLGPEASFSAEDLSLFLSTRCVVVLLSAELVQHFHKPALLPLLQRAFHPPHRVVRLL
                     CGVRDSEEFLDFFPDWAHWQELTCDDEPETYVAAVKKAISEDSGCDSVTDTEPEDEKV
                     VSYSKQQNLPTVTSPGNLMVVQPDRIRCGAETTVYVIVRCKLDDRVATEAEFSPEDSP
                     SVRMEAKVENEYTISVKAPNLSSGNVSLKIYSGDLVVCETVISYYTDMEEIGNLLSNA
                     ANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFGINQLEEEDMMTNQRDE
                     ELPTLLHFAAKYGLKNLTALLLTCPGALQAYSVANKHGHYPNTIAEKHGFRDLRQFID
                     EYVETVDMLKSHIKEELMHGEEADAVYESMAHLSTDLLMKCSLNPGCDEDLYESMAAF
                     VPAATEDLYVEMLQASTSNPIPGDGFSRATKDSMIRKFLEGNSMGMTNLERDQCHLGQ
                     EEDVYHTVDDDEAFSVDLASRPPVPVPRPETTAPGAHQLPDNEPYIFKVFAEKSQERP
                     GNFYVSSESIRKGPPVRPWRDRPQSSIYDPFAGMKTPGQRQLITLQEQVKLGIVNVDE
                     AVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQREKQKSGKQTDLEITVPIRHS
                     QHLPAKVEFGVYESGPRKSVIPPRTELRRGDWKTDSTSSTASSTSNRSSTRSLLSVSS
                     GMEGDNEDNEVPEVTRSRSPGPPQVDGTPTMSLERPPRVPPRAASQRPPTRETFHPPP
                     PVPPRGR"
     exon            134..550
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            551..687
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            688..832
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            833..975
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1108
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1305
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1495
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1591
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1789
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1855
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..2061
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2134
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2290
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2361
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2480
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..4800
                     /gene="PIK3AP1"
                     /gene_synonym="BCAP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcggcgg ccggtcccgc gcggagcccg gcgcccctcc agcccgagcc aggacgccgc
       61 cggccccggt cccggccccg ggcacgcagc gagccaggga tgtgagcggc gccccgcggc
      121 atggcagcct caggggtgcc cagaggatgc gacatcctca tcgtctacag cccggatgcc
      181 gaggaatggt gccagtacct gcagaccctg ttcctgtcca gtcggcaggt ccgcagccag
      241 aagatactga ctcacaggct gggccccgag gcctccttct cggcagagga cctaagcctt
      301 ttcctcagca cccgctgtgt cgtggtgctg ctgtccgcgg agctggtgca gcacttccac
      361 aagcccgcct tgctgcccct gctgcagaga gctttccatc ctccgcaccg cgtggtcagg
      421 ctgctctgcg gcgtgcggga cagcgaggag ttcctagact tctttccaga ttgggcccat
      481 tggcaggagc tcacctgtga cgatgagcca gagacctacg tggcagctgt gaaaaaagcc
      541 atttccgaag attctggctg tgactcagtc actgacactg agcctgagga cgagaaggtt
      601 gtttcctact cgaagcagca gaacctgccg acggtgactt cacctgggaa cctgatggtg
      661 gtgcagccgg accgcattcg ctgtggggca gaaaccactg tctatgttat tgtgagatgt
      721 aagctggatg acagggtggc gacagaagca gagttttctc ctgaggattc tccctctgta
      781 aggatggaag ccaaggtgga gaatgagtac accatttcag tgaaggctcc caacctttca
      841 tctgggaacg tttctctgaa gatatattct ggagacttag tggtgtgtga aaccgttatc
      901 agctattata ctgacatgga agaaattggg aatttattgt ccaatgccgc gaatcctgtg
      961 gaattcatgt gtcaggcctt taaaattgtg ccctacaaca cagagaccct tgataaactg
     1021 ctaaccgaat ccctgaagaa caatatccct gcaagcggac tgcacctctt tggaatcaac
     1081 cagctggaag aagaagatat gatgacaaat cagagggatg aagagctgcc caccctgttg
     1141 cattttgctg cgaagtatgg actgaagaac ctcactgcct tgttgctcac ctgcccagga
     1201 gccctgcagg cgtacagcgt ggccaacaag catggccact accccaacac catcgctgag
     1261 aaacacggct tcagggacct gcggcagttc atcgacgagt atgtggaaac ggtggacatg
     1321 ctcaagagtc acattaaaga ggaactgatg cacggggagg aggctgatgc tgtgtacgag
     1381 tccatggccc acctttccac agacctgctt atgaaatgct cgctcaaccc cggctgtgac
     1441 gaggatctct atgagtccat ggctgccttt gtcccagctg ccactgaaga cctctatgtt
     1501 gaaatgcttc aggccagtac atctaaccca atccctggag atggtttctc tcgggccact
     1561 aaggactcta tgatccgcaa gtttttagaa ggcaacagca tgggaatgac caatctggag
     1621 agagatcagt gccatcttgg tcaggaagaa gatgtttatc acacggtgga tgacgatgag
     1681 gccttttctg tggacctggc cagcaggccc cctgtcccag tgcccagacc agagaccact
     1741 gctcctggtg ctcaccagct gcctgacaac gaaccataca tttttaaagt ttttgcagaa
     1801 aaaagtcaag agcggcctgg gaatttctac gtttcctcag agagcatcag gaaagggccg
     1861 cccgtcagac catggaggga caggccccag tcgagtatat atgacccttt tgcgggaatg
     1921 aaaacgccag gccagcggca gcttatcacc ctccaggagc aggtgaagct gggcattgtc
     1981 aacgtggatg aggctgtgct ccacttcaaa gagtggcagc tcaaccagaa gaaacgatcg
     2041 gagtcctttc gtttccagca ggaaaatctt aaacggctaa gagacagcat cacccgaaga
     2101 cagagagaga agcaaaaatc aggaaagcag acagacttgg agatcacggt cccaattcgg
     2161 cactcacagc acctgcctgc aaaagtggag tttggagtct atgagagtgg ccccaggaaa
     2221 agtgtcattc cccctaggac ggagctgaga cgaggagact ggaaaacaga cagcacctcc
     2281 agcacagcaa gtagcacaag taaccgctcc agcacccgga gcctcctcag tgtgagcagc
     2341 gggatggaag gggacaacga ggataatgaa gtccctgagg ttaccagaag tcgcagtcca
     2401 ggccccccac aagtggatgg gacacccacc atgtccctcg agagaccccc cagggtgcct
     2461 ccgagagctg cctcacagag gcctccgacc agggagacct tccatcctcc tccacctgtt
     2521 ccacccagag gacgctgatt ccacctccta aaacctgcct acttcaggac tttaagactc
     2581 acagtcttca gcctgttaat gatgtcttca tgttgagttt tatagcatga ctgttgacct
     2641 taagatccat tctcattgct gataatgctg cagccctgct ggtttgggct tgcctcgaag
     2701 attttattaa ggcacgaaga agtgaaaaac taagggcttc attcaccatc accaagtata
     2761 tcgaaccata tacttgtttg ccaaaaggat gaagacttaa tcgaaatact tacctctaat
     2821 ttgccatatc agaagcctaa aaagaatgat cataaatgta cttcaccagt gattttactg
     2881 aaatgcactt atattagtct ttatgtattt gctagttcag cctgatttct agaagaggtt
     2941 atagtgtgag acttgtagta ttcaagtaag ataagtgacc taattttaaa ataattcttc
     3001 tacttttctg tatattcagc agggtattta agtgctaggg ctggtcacac acaaccaact
     3061 gaaaaagact agagggatta gtacaaactc ctcttataca gaaggcaaat ctgaggttcc
     3121 acagaagtct ggaaccaaga ctattcagtt ggttaaataa agaggttagt ctagactggg
     3181 cctgctcatt ctaggtcacc acattttcca tctccaaata gccaggccct ctctccctca
     3241 agaaatgccc agatgtagaa attcatcagt gcctattggt cttccagaat tttccatctt
     3301 ccgtatctcc caggcatgag actaccaagt ttgtttgttt tctttccaat ttgggaattt
     3361 atacttcagt atggtttcaa cgcagttatg tttccagaga acatctagaa gtggctggaa
     3421 accagaagct ggggattcca gggaccccac ttagtgctct atttccttta taggttttat
     3481 ttctggtcat agagagagaa ggacctttga ctttttcttc gttgaggctt ctgaggagga
     3541 aaaacaaacc taaaatagaa atacagtcag cctttcaaat ccatgggttc tgtgtccgtg
     3601 gattcaacca accttggatc aaaaatattt gaaaaaaaat ctacaaagtt tcaaaaagca
     3661 aaacttgaat ttgctgcatg ccaagaagta tgttgaattc atgtaaatga agtgatgtgt
     3721 aggcattgta ttagatatta taagaaatct agaaatgatt taaagcatac aggaggatgt
     3781 gcataggtta tatgcaaata ctatgctatt ttatatatgg gacttgagca tttgtggatt
     3841 ttgatactgg gggatcctgg aaccaatccc ccatggatac caaagtacga ctgtagttat
     3901 ctatttttta catacttatt attaccacca tgctcagtaa gtccattttt gcatggaata
     3961 tggagcctta aaacatgtca tgaatttgga gtccctggca cataaatcta ccttcaaatc
     4021 agaggtcctt aatgatgcct aaacatacag taaaattaga atcagaaata cttctttaaa
     4081 aaatattcaa aatgtgtttg tttcccatgg gattattctc tatcccacac gaatgtaaaa
     4141 aaatccacat taatgatcca tttaagtata gttttattgg gtccttttct aatgattaaa
     4201 ggttctttct caatttcatt cctcagtcct gcaagtaagg actcatactg aagagtactg
     4261 aaacaaggac ttcttgtcag aaacagcttc tggaatcttg ggttttgttt ttgttttttg
     4321 acaaaataca ctattggcca tgtccatcac gagagtgttt gtagtaatta attaccttgt
     4381 acaggacctg gcacttagta gcattcttca aatgttccct cagtgatcct tttactctcc
     4441 ttgtcactta tttgggagaa ataggggcac gtgagataag aagaagaata attttgatgt
     4501 tggtatgctt gccctgttac ttatagacag tctttgtcat aggcaaactt gaatttgatt
     4561 taaaataggg ctgggaaaaa tattcaataa ctgtaagccc ccttttggat gccaaactta
     4621 gaattttgta cattctctga tgaacaagca tttagatcgt aacatggtaa agcctattac
     4681 cagccaatgt tgttagcatc tttgtatgca catcactgtt tgtgcaatat atgaatattt
     4741 tgttgcattg tattcttata taaaaataag tagaaaacat aaaattgaaa ttgctgatga
//
