LOCUS       NM_017916               1197 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens PIH1 domain containing 1 (PIH1D1), mRNA.
ACCESSION   NM_017916
VERSION     NM_017916.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1197)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1197)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1197)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1197)
  AUTHORS   Cloutier,P., Poitras,C., Faubert,D., Bouchard,A., Blanchette,M.,
            Gauthier,M.S. and Coulombe,B.
  TITLE     Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of
            the PAQosome
  JOURNAL   J Proteome Res 19 (1), 18-27 (2020)
   PUBMED   31738558
REFERENCE   5  (bases 1 to 1197)
  AUTHORS   Henri,J., Chagot,M.E., Bourguet,M., Abel,Y., Terral,G., Maurizy,C.,
            Aigueperse,C., Georgescauld,F., Vandermoere,F., Saint-Fort,R.,
            Behm-Ansmant,I., Charpentier,B., Pradet-Balade,B., Verheggen,C.,
            Bertrand,E., Meyer,P., Cianferani,S., Manival,X. and Quinternet,M.
  TITLE     Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the
            HSP90 Co-chaperone R2TP Complex
  JOURNAL   Structure 26 (9), 1196-1209 (2018)
   PUBMED   30033218
  REMARK    GeneRIF: An RPAP3:PIH1D1 sub-complex is found demonstrating the
            need for a 34-residue insertion, specific of RPAP3 isoform 1, for
            the tight binding of PIH1D1.
REFERENCE   6  (bases 1 to 1197)
  AUTHORS   Horejsi,Z., Takai,H., Adelman,C.A., Collis,S.J., Flynn,H.,
            Maslen,S., Skehel,J.M., de Lange,T. and Boulton,S.J.
  TITLE     CK2 phospho-dependent binding of R2TP complex to TEL2 is essential
            for mTOR and SMG1 stability
  JOURNAL   Mol Cell 39 (6), 839-850 (2010)
   PUBMED   20864032
REFERENCE   7  (bases 1 to 1197)
  AUTHORS   Zhai,N., Zhang,Y. and Shen,Y.F.
  TITLE     [Effect of PIH1D1 on the degradation of its binding protein SNF5]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 31 (6), 756-759 (2009)
   PUBMED   20078948
  REMARK    GeneRIF: PIH1D1 may stabilize SNF5 by attenuating its proteasome
            degradation pathway.
REFERENCE   8  (bases 1 to 1197)
  AUTHORS   Cloutier,P., Al-Khoury,R., Lavallee-Adam,M., Faubert,D., Jiang,H.,
            Poitras,C., Bouchard,A., Forget,D., Blanchette,M. and Coulombe,B.
  TITLE     High-resolution mapping of the protein interaction network for the
            human transcription machinery and affinity purification of RNA
            polymerase II-associated complexes
  JOURNAL   Methods 48 (4), 381-386 (2009)
   PUBMED   19450687
  REMARK    GeneRIF: Is part of an RNA polymerase II-associated complex with
            possible chaperone activity.
REFERENCE   9  (bases 1 to 1197)
  AUTHORS   McKeegan,K.S., Debieux,C.M., Boulon,S., Bertrand,E. and
            Watkins,N.J.
  TITLE     A dynamic scaffold of pre-snoRNP factors facilitates human box C/D
            snoRNP assembly
  JOURNAL   Mol Cell Biol 27 (19), 6782-6793 (2007)
   PUBMED   17636026
REFERENCE   10 (bases 1 to 1197)
  AUTHORS   Gonzales,F.A., Zanchin,N.I., Luz,J.S. and Oliveira,C.C.
  TITLE     Characterization of Saccharomyces cerevisiae Nop17p, a novel
            Nop58p-interacting protein that is involved in Pre-rRNA processing
  JOURNAL   J Mol Biol 346 (2), 437-455 (2005)
   PUBMED   15670595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC385084.1, AK000650.1 and AA018444.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017916.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.410159.1,
                                           SRR5189655.215037.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262265.10/ ENSP00000262265.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DC385084.1         45-48
            5-1196              AK000650.1         1-1192
            1197-1197           AA018444.1         16-16               c
FEATURES             Location/Qualifiers
     source          1..1197
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1197
                     /gene="PIH1D1"
                     /gene_synonym="DNAAF14; MOT48; NOP17; Pih1"
                     /note="PIH1 domain containing 1"
                     /db_xref="GeneID:55011"
                     /db_xref="HGNC:HGNC:26075"
                     /db_xref="MIM:611480"
     exon            1..330
                     /gene="PIH1D1"
                     /gene_synonym="DNAAF14; MOT48; NOP17; Pih1"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1113
                     /gene="PIH1D1"
                     /gene_synonym="DNAAF14; MOT48; NOP17; Pih1"
                     /note="nucleolar protein 17 homolog; dynein axonemal
                     assembly factor 14"
                     /codon_start=1
                     /product="PIH1 domain-containing protein 1"
                     /protein_id="NP_060386.1"
                     /db_xref="CCDS:CCDS12765.1"
                     /db_xref="GeneID:55011"
                     /db_xref="HGNC:HGNC:26075"
                     /db_xref="MIM:611480"
                     /translation="MANPKLLGMGLSEAEAIGADSARFEELLLQASKELQQAQTTRPE
                     STQIQPQPGFCIKTNSSEGKVFINICHSPSIPPPADVTEEELLQMLEEDQAGFRIPMS
                     LGEPHAELDAKGQGCTAYDVAVNSDFYRRMQNSDFLRELVITIAREGLEDKYNLQLNP
                     EWRMMKNRPFMGSISQQNIRSEQRPRIQELGDLYTPAPGRAESGPEKPHLNLWLEAPD
                     LLLAEVDLPKLDGALGLSLEIGENRLVMGGPQQLYHLDAYIPLQINSHESKAAFHRKR
                     KQLMVAMPLLPVPS"
     exon            331..397
                     /gene="PIH1D1"
                     /gene_synonym="DNAAF14; MOT48; NOP17; Pih1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..577
                     /gene="PIH1D1"
                     /gene_synonym="DNAAF14; MOT48; NOP17; Pih1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..639
                     /gene="PIH1D1"
                     /gene_synonym="DNAAF14; MOT48; NOP17; Pih1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..721
                     /gene="PIH1D1"
                     /gene_synonym="DNAAF14; MOT48; NOP17; Pih1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..851
                     /gene="PIH1D1"
                     /gene_synonym="DNAAF14; MOT48; NOP17; Pih1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..927
                     /gene="PIH1D1"
                     /gene_synonym="DNAAF14; MOT48; NOP17; Pih1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1071
                     /gene="PIH1D1"
                     /gene_synonym="DNAAF14; MOT48; NOP17; Pih1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1197
                     /gene="PIH1D1"
                     /gene_synonym="DNAAF14; MOT48; NOP17; Pih1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1177..1182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIH1D1"
                     /gene_synonym="DNAAF14; MOT48; NOP17; Pih1"
                     /note="hexamer: AATAAA"
     polyA_site      1197
                     /gene="PIH1D1"
                     /gene_synonym="DNAAF14; MOT48; NOP17; Pih1"
                     /note="major polyA site"
ORIGIN      
        1 gtttacagtt cggcacgtag gacggagggt agtgcgtcta gagacacata ttccccacgg
       61 atttgacgat ggtgttcggt cttgaatgga aatgtagtct taggccagtc ttaggttttt
      121 gaacaggata gtaggtatcc ggagtcgatt gagggccaga gcaggcactg gggttcggat
      181 cctgggcaaa gtttcccacg ttgagggtct cgaggacgcc tagatctctt tcccagggcc
      241 atggcgaacc cgaagctgct gggaatgggg ctaagcgagg cggaggcgat cggtgctgat
      301 tcggcgcgat ttgaggagct gctgctgcag gcctcgaagg agctccagca agcccagaca
      361 accagaccag aatcgacaca aatccagcct cagcctggtt tctgcataaa gaccaactcc
      421 tcggaaggga aggttttcat caacatctgc cactccccct ctatccctcc tcccgccgac
      481 gtgaccgagg aggagctgct tcagatgcta gaggaggacc aagctgggtt tcgcatcccc
      541 atgagtctgg gagagcctca tgcagaactg gatgcaaaag gccagggatg taccgcctac
      601 gacgtagctg tcaacagcga cttctaccgg aggatgcaga acagcgattt cttgcgggag
      661 ctcgtgatca ccatcgccag ggagggcctt gaggacaaat acaacttgca gctgaatccg
      721 gaatggcgca tgatgaagaa ccggccattc atgggctcca tctcgcagca gaacatccgc
      781 tcggagcagc gtcctcggat ccaggagctg ggggacctgt acacgcccgc ccccgggaga
      841 gctgagtcag ggcctgaaaa gcctcacctg aacctgtggc tggaagcccc cgacctcctc
      901 ttggccgaag ttgacctccc caaactggat ggagccctgg ggctgtcgct ggagatcggg
      961 gagaaccgcc tggtgatggg gggcccccag cagctgtatc atctagacgc ttatatcccg
     1021 ctgcagatca actctcatga gagcaaggca gccttccacc ggaagagaaa gcaattaatg
     1081 gtggccatgc cgcttctgcc ggtgccttct tgatcagggt gtctccttgt gcttctgaga
     1141 tgtggagaag aggctgctgg cttccctaaa agttgaaata aaagattttt gcctttg
//
