LOCUS       NM_025163               2688 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens phosphatidylinositol glycan anchor biosynthesis class
            Z (PIGZ), mRNA.
ACCESSION   NM_025163
VERSION     NM_025163.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2688)
  AUTHORS   Taron,B.W., Colussi,P.A., Wiedman,J.M., Orlean,P. and Taron,C.H.
  TITLE     Human Smp3p adds a fourth mannose to yeast and human
            glycosylphosphatidylinositol precursors in vivo
  JOURNAL   J Biol Chem 279 (34), 36083-36092 (2004)
   PUBMED   15208306
REFERENCE   2  (bases 1 to 2688)
  AUTHORS   Eisenhaber,B., Maurer-Stroh,S., Novatchkova,M., Schneider,G. and
            Eisenhaber,F.
  TITLE     Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and
            post-translational transfer to proteins
  JOURNAL   Bioessays 25 (4), 367-385 (2003)
   PUBMED   12655644
  REMARK    Review article
REFERENCE   3  (bases 1 to 2688)
  AUTHORS   Oriol,R., Martinez-Duncker,I., Chantret,I., Mollicone,R. and
            Codogno,P.
  TITLE     Common origin and evolution of glycosyltransferases using
            Dol-P-monosaccharides as donor substrate
  JOURNAL   Mol Biol Evol 19 (9), 1451-1463 (2002)
   PUBMED   12200473
REFERENCE   4  (bases 1 to 2688)
  AUTHORS   Grimme,S.J., Westfall,B.A., Wiedman,J.M., Taron,C.H. and Orlean,P.
  TITLE     The essential Smp3 protein is required for addition of the
            side-branching fourth mannose during assembly of yeast
            glycosylphosphatidylinositols
  JOURNAL   J Biol Chem 276 (29), 27731-27739 (2001)
   PUBMED   11356840
  REMARK    GeneRIF: publication also discusses human SMP3
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK022830.1, AK296867.1,
            BC018804.1, BG760692.1 and BX493581.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025163.3.
            
            Summary: The glycosylphosphatidylinositol (GPI) anchor is a
            glycolipid found on many blood cells that serves to anchor proteins
            to the cell surface. This gene encodes a protein that is localized
            to the endoplasmic reticulum, and is involved in GPI anchor
            biosynthesis. As shown for the yeast homolog, which is a member of
            a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent
            mannosyltransferases, this protein can also add a side-branching
            fourth mannose to GPI precursors during the assembly of GPI
            anchors. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022830.1, SRR1660805.108837.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412723.6/ ENSP00000413405.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-941               AK022830.1         1-941
            942-998             AK296867.1         582-638
            999-1035            BC018804.1         918-954
            1036-1036           BG760692.1         933-933
            1037-1165           AK022830.1         1037-1165
            1166-1206           BX493581.1         477-517
            1207-2687           AK022830.1         1207-2687
            2688-2688           BC018804.1         2607-2607
FEATURES             Location/Qualifiers
     source          1..2688
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..2688
                     /gene="PIGZ"
                     /gene_synonym="GPI-MT-IV; PIG-Z; SMP3"
                     /note="phosphatidylinositol glycan anchor biosynthesis
                     class Z"
                     /db_xref="GeneID:80235"
                     /db_xref="HGNC:HGNC:30596"
                     /db_xref="MIM:611671"
     exon            1..147
                     /gene="PIGZ"
                     /gene_synonym="GPI-MT-IV; PIG-Z; SMP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1887
                     /gene="PIGZ"
                     /gene_synonym="GPI-MT-IV; PIG-Z; SMP3"
                     /note="phosphatidylinositol glycan, class Z; SMP3
                     mannosyltransferase; GPI mannosyltransferase IV;
                     phosphatidylinositol-glycan biosynthesis class Z protein;
                     dol-P-Man dependent GPI mannosyltransferase"
                     /codon_start=1
                     /product="GPI mannosyltransferase 4"
                     /protein_id="NP_079439.2"
                     /db_xref="CCDS:CCDS3324.1"
                     /db_xref="GeneID:80235"
                     /db_xref="HGNC:HGNC:30596"
                     /db_xref="MIM:611671"
                     /translation="MQICGSSVASVAAGTSFQVLGPVCWQQLDLKMAVRVLWGGLSLL
                     RVLWCLLPQTGYVHPDEFFQSPEVMAEDILGVQAARPWEFYPSSSCRSVLFPLLISGS
                     TFWLLRLWEELGPWPGLVSGYALLVGPRLLLTALSFALDGAVYHLAPPMGADRWNALA
                     LLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEPAPGPRWRSWLLGG
                     IVAAGFFNRPTFLAFAVVPLYLWGTRGATNPGLKSLTREALVLLPGAALTAAVFVATD
                     SWYFSSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVLHAQAL
                     QAAWQRLQVGLQASAQMGLLRALGARSLLSSPRSYLLLLYFMPLALLSAFSHQEARFL
                     IPLLVPLVLLCSPQTQPVPWKGTVVLFNALGALLFGCLHQGGLVPGLEYLEQVVHAPV
                     LPSTPTHYTLLFTHTYMPPRHLLHLPGLGAPVEVVDMGGTEDWALCQTLKSFTRQPAC
                     QVAGGPWLCRLFVVTPGTTRRAVEKCSFPFKNETLLFPHLTLEDPPALSSLLSGAWRD
                     HLSLHIVELGEET"
     exon            148..358
                     /gene="PIGZ"
                     /gene_synonym="GPI-MT-IV; PIG-Z; SMP3"
                     /inference="alignment:Splign:2.1.0"
     exon            359..2688
                     /gene="PIGZ"
                     /gene_synonym="GPI-MT-IV; PIG-Z; SMP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2670..2675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIGZ"
                     /gene_synonym="GPI-MT-IV; PIG-Z; SMP3"
                     /note="hexamer: AATATA"
     polyA_site      2688
                     /gene="PIGZ"
                     /gene_synonym="GPI-MT-IV; PIG-Z; SMP3"
                     /note="major polyA site"
ORIGIN      
        1 agtctccgcg ctgctgaggc gcgcccggcc gctcccacgg cctcccctcc gccctgcggt
       61 cccgccgcct ccggggcctc ctgggaccct ggccctcgcc gggcaggacg ccgccagcgc
      121 tgaaggcgca gcccggaggc cgcgcggatg cagatctgtg gatccagcgt agcatctgta
      181 gcagctggga catcattcca ggttttgggc ccggtgtgtt ggcaacaact ggatctgaag
      241 atggcagtca gggtgctttg gggtggtctc agcctgctcc gagtgctgtg gtgtctcctt
      301 ccgcagacgg gctatgtgca cccagatgag ttcttccagt cccctgaggt gatggcagag
      361 gacatcctgg gcgttcaggc cgcgcggccc tgggagtttt accccagcag ctcctgccgc
      421 tcggtgctct tccccctgct gatctctggt tccaccttct ggctgctcag gctctgggag
      481 gagctggggc cgtggcctgg cctggtgagc ggctatgcgc tgctggtggg gcctcgactc
      541 ctcctcactg ccctttcctt tgctctggac ggggccgtgt accacctggc cccgccgatg
      601 ggggcggatc gctggaacgc cctggccctg ctgtctggtt cctacgtcac cctggtcttc
      661 tacacaagga ccttctccaa caccattgag ggactcctct tcacgtggct gctggtgctg
      721 gtatcctccc atgtaacgtg gggccctaca cgcaaggagc cggcgccggg tccacggtgg
      781 cgcagctggc ttcttggagg cattgtggct gctggcttct tcaaccggcc cacctttctg
      841 gcctttgctg tggtccccct ctacctctgg ggcactcgtg gagccacaaa ccctggtttg
      901 aagtctctga cccgggaggc cctggtgctg ctccctgggg cagccctcac agcagcggtg
      961 tttgtggcca cggacagctg gtatttctcc agccccgcta catccaggaa ccttgtcctg
     1021 acacctgtca acttcttgca ctacaacctg aatccccaaa acctggcgag acatggcacg
     1081 cacgcgcggc tcactcacct ggcagtcaac ggcttcctgc tcttcggggt gctgcatgcc
     1141 caggccctgc aggctgcgtg gcaacggctg caagtcggcc tccaggcctc tgcacaaatg
     1201 ggcctcctga gggcactggg tgcccggagc ctgctgtcca gccccaggtc ctatctcctt
     1261 ctcctctact tcatgcctct ggccctgcta tctgccttta gccaccagga ggctcggttc
     1321 ctgattcccc tcctggtccc cctggtcctg ctttgtagtc cacagacgca gcctgtgcct
     1381 tggaagggca ctgtggtcct cttcaacgcc ctcggtgccc tcctcttcgg ctgcctgcat
     1441 caggggggcc tggtgcctgg cctggagtac ctggagcagg tggtccatgc ccctgtgctc
     1501 ccaagcacac ccacccacta cacactcctc ttcactcaca cctacatgcc cccccggcac
     1561 ctcctacacc tcccaggcct gggggcacca gtggaggtgg tggacatggg ggggactgag
     1621 gactgggccc tgtgccaaac cctgaaaagc ttcaccagac aaccagcctg ccaagtggct
     1681 ggtgggccat ggctctgccg cctctttgtg gtaacccctg gcaccaccag gcgtgccgtg
     1741 gagaagtgca gcttcccctt caagaatgaa acacttttat ttccccatct gaccctggag
     1801 gatccaccag ccctgtcctc cttgctgagt ggggcttgga gggaccacct cagtcttcac
     1861 attgtggagc tgggggaaga aacctgacaa tatgacagag cacccactgc ccaagactca
     1921 gccatagaag atgccgcccc accttctact tgggtagctg ggctgggacg ctgggacagg
     1981 accccgtcct ccttcatgac tcccactgct gcctctcctg ggcatggctg ttagctgttc
     2041 tgccttctgg gtgagctggc actcttctcc ctgagaccaa agatttgacc tgtcggtctt
     2101 gatgtcaagg tccccaaaga ccaggttaag tgacgacacc tgtctgttcc tgccctgttg
     2161 cttccagcca ctgtgatgtt tgaaatatgt gatagtacct ggttgtgaaa aaagacaatg
     2221 aactgctagt gacattcctc aatgacctct cccaaacctc ccatgatgcc ttacccttgc
     2281 tgtcatgaca accctctggc ttcctaagac ccatctgcct atcgaaatat gtgcaagtca
     2341 gtgagacgaa gtatagagaa caggtggccc agatccaggg gacccaactt ctggcccctt
     2401 ggtctgtcac ctcctcgctg tgtgatcttg agaaagctcc ttccactcac ccaccccact
     2461 tcccagtctg ttgggatcag aggaactttg aggtgtctgc cggctaacat tgtgtcattc
     2521 ctggagtcca cagtacacgt cccctgcctc aacaggcaca gctctcacaa agctcttcaa
     2581 gcatggaagt gggagttgtg ttgtacttca tggcactctg atgcctgctg tctcagtgtt
     2641 tggttattat gcaaacaagt aatgtttgaa atatataata gcactgga
//
