LOCUS       NM_001042616            1311 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens phosphatidylinositol glycan anchor biosynthesis class
            Y (PIGY), mRNA.
ACCESSION   NM_001042616
VERSION     NM_001042616.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1311)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1311)
  AUTHORS   Ilkovski,B., Pagnamenta,A.T., O'Grady,G.L., Kinoshita,T.,
            Howard,M.F., Lek,M., Thomas,B., Turner,A., Christodoulou,J.,
            Sillence,D., Knight,S.J., Popitsch,N., Keays,D.A., Anzilotti,C.,
            Goriely,A., Waddell,L.B., Brilot,F., North,K.N., Kanzawa,N.,
            Macarthur,D.G., Taylor,J.C., Kini,U., Murakami,Y. and Clarke,N.F.
  TITLE     Mutations in PIGY: expanding the phenotype of inherited
            glycosylphosphatidylinositol deficiencies
  JOURNAL   Hum Mol Genet 24 (21), 6146-6159 (2015)
   PUBMED   26293662
REFERENCE   3  (bases 1 to 1311)
  AUTHORS   Lee,H.J., Woo,H.G., Greenwood,T.A., Kripke,D.F. and Kelsoe,J.R.
  TITLE     A genome-wide association study of seasonal pattern mania
            identifies NF1A as a possible susceptibility gene for bipolar
            disorder
  JOURNAL   J Affect Disord 145 (2), 200-207 (2013)
   PUBMED   22925353
REFERENCE   4  (bases 1 to 1311)
  AUTHORS   Hu,R., Mukhina,G.L., Lee,S.H., Jones,R.J., Englund,P.T., Brown,P.,
            Sharkis,S.J., Buckley,J.T. and Brodsky,R.A.
  TITLE     Silencing of genes required for glycosylphosphatidylinositol anchor
            biosynthesis in Burkitt lymphoma
  JOURNAL   Exp Hematol 37 (4), 423-434 (2009)
   PUBMED   19302917
REFERENCE   5  (bases 1 to 1311)
  AUTHORS   Murakami,Y., Siripanyaphinyo,U., Hong,Y., Tashima,Y., Maeda,Y. and
            Kinoshita,T.
  TITLE     The initial enzyme for glycosylphosphatidylinositol biosynthesis
            requires PIG-Y, a seventh component
  JOURNAL   Mol Biol Cell 16 (11), 5236-5246 (2005)
   PUBMED   16162815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI548853.1, AB206972.1 and
            DB519150.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 9, 2020 this sequence version replaced NM_001042616.2.
            
            Summary: The protein encoded by this gene is part of the
            GPI-N-acetylglucosaminyltransferase (GIP-GnT) complex which
            initiates the biosynthesis of glycosylphosphatidylinositol (GPI).
            GPI is synthesized in the endoplasmic reticulum and serves as an
            anchor for many surface proteins. Proteins containing GPI anchors
            can have an important role in cell-cell interactions. The
            transcript for this gene is bicistronic. The downstream open
            reading frame encodes this GPI-GnT complex protein, while the
            upstream open reading frame encodes a protein with unknown
            function, as represented by GeneID:100996939. [provided by RefSeq,
            Aug 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB206972.1, BC007876.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            bicistronic transcript             :: PMID: 16162815
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000527353.2/
                                                  ENSP00000432688.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BI548853.1         31-33
            4-1307              AB206972.1         1-1304
            1308-1311           DB519150.1         464-467
FEATURES             Location/Qualifiers
     source          1..1311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..1311
                     /gene="PIGY"
                     /gene_synonym="HPMRS6; PIG-Y"
                     /note="phosphatidylinositol glycan anchor biosynthesis
                     class Y"
                     /db_xref="GeneID:84992"
                     /db_xref="HGNC:HGNC:28213"
                     /db_xref="MIM:610662"
     exon            1..279
                     /gene="PIGY"
                     /gene_synonym="HPMRS6; PIG-Y"
                     /inference="alignment:Splign:2.1.0"
     exon            280..1311
                     /gene="PIGY"
                     /gene_synonym="HPMRS6; PIG-Y"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..735
                     /gene="PIGY"
                     /gene_synonym="HPMRS6; PIG-Y"
                     /note="phosphatidylinositol-glycan biosynthesis class Y
                     protein"
                     /codon_start=1
                     /product="phosphatidylinositol
                     N-acetylglucosaminyltransferase subunit Y"
                     /protein_id="NP_001036081.1"
                     /db_xref="CCDS:CCDS54778.1"
                     /db_xref="GeneID:84992"
                     /db_xref="HGNC:HGNC:28213"
                     /db_xref="MIM:610662"
                     /translation="MFLSLPTLTVLIPLVSLAGLFYSASVEENFPQGCTSTASLCFYS
                     LLLPITIPVYVFFHLWTWMGIKLFRHN"
     regulatory      1277..1282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIGY"
                     /gene_synonym="HPMRS6; PIG-Y"
                     /note="hexamer: AATAAA"
     polyA_site      1311
                     /gene="PIGY"
                     /gene_synonym="HPMRS6; PIG-Y"
                     /note="major polyA site"
ORIGIN      
        1 ctggacgaac gggaagccgg gagctcggcc acgggtggcg aggctgcggt gaggcctggt
       61 ctccggctgc cagaccatgc tgagtggagc acgctgcagg ctcgcctcag cgctgcgggg
      121 aacgcgcgcg ccgccgtccg cggtcgcccg taggtgcctg cacgcgtcgg ggtcgcggcc
      181 tttggccgac cggggcaaga agactgagga gccgccccgc gacttcgatc cggcgctgct
      241 ggagttcctg gtgtgcccgc tctccaagaa gccgctcaga tatgaagcat caacaaacga
      301 attgattaat gaagagttgg gaatagctta tccaatcatt gatgggatcc ctaatatgat
      361 accacaggca gctaggatga cacgtcaaag taagaagcaa gaagaagtgg agcagcgcta
      421 gttcataatt taaaaaaatt aaaaaaacgc aacagccaac ttttcttaat accatatacc
      481 ttttaaaaca cagtggcagg taataagtgg aagagaagaa tgtttctgtc tcttcctacg
      541 ttgactgttc ttattccact ggtttcttta gcaggactgt tctactcagc ctctgtggaa
      601 gaaaacttcc cacagggctg cactagcaca gccagccttt gcttttacag cctgctcttg
      661 cctattacca taccagtgta tgtattcttc cacctttgga cttggatggg tattaaactc
      721 ttcaggcata attgatgcaa ctagagtcaa tatgctgtat atattaatga tagctcttgg
      781 gcatcgatct ctgaaagctc aaatggatgg aatttagttt gcgggaaaga ggctttgctt
      841 tgcgcatatc aggcttagga ctgtgggagg cttaagttgc agatgcttct tttattgtac
      901 tcttgttctg cccttgtttt ttgaaggctc tgacttataa ctgctgtatc agaagaaaca
      961 ttttgacagt gtcttggttg gagatgaaca tccctaattg acatgtgatg actatttctt
     1021 attccattca tctaagagtc attgaaattt tgttttgctt gtttgtttag cttcaaggtc
     1081 tttggtaaag tcacatgtta aggatgactg aaataattcc aaaggagtga tgttggaata
     1141 gtccctctaa gggagagaaa tgcatttgaa cgaatgtgat ataaaaccac ataatcaaat
     1201 agaaacttca tgtacttaca aaaactgagt ttgtaaaatt accttcattt ctttgacatt
     1261 aaatgcttat attagcaata aacatgttga cactttccta taaaaaataa a
//
