LOCUS       NM_002644               4275 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens polymeric immunoglobulin receptor (PIGR), mRNA.
ACCESSION   NM_002644
VERSION     NM_002644.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4275)
  AUTHORS   Laprise,F., Arduini,A., Duguay,M., Pan,Q. and Liang,C.
  TITLE     SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor
            pIgR
  JOURNAL   Viruses 16 (7), 1008 (2024)
   PUBMED   39066171
  REMARK    GeneRIF: SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA
            Receptor pIgR.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4275)
  AUTHORS   Chae,J., Choi,J. and Chung,J.
  TITLE     Polymeric immunoglobulin receptor (pIgR) in cancer
  JOURNAL   J Cancer Res Clin Oncol 149 (19), 17683-17690 (2023)
   PUBMED   37897659
  REMARK    GeneRIF: Polymeric immunoglobulin receptor (pIgR) in cancer.
            Review article
REFERENCE   3  (bases 1 to 4275)
  AUTHORS   Asanprakit,W., Lobo,D.N., Eremin,O. and Bennett,A.J.
  TITLE     Expression of polymeric immunoglobulin receptor (PIGR) and the
            effect of PIGR overexpression on breast cancer cells
  JOURNAL   Sci Rep 13 (1), 16606 (2023)
   PUBMED   37789066
  REMARK    GeneRIF: Expression of polymeric immunoglobulin receptor (PIGR) and
            the effect of PIGR overexpression on breast cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4275)
  AUTHORS   Ram,A.K., Kanojia,R.P., Bhatia,A., Menon,P., Minz,R.W., Dhawan,V.,
            Arora,A. and Kumar,Y.
  TITLE     Polymeric immunoglobulin receptor and galectin-3-binding protein
            are raised in biliary atresia: Reveals a proteomic-based study
  JOURNAL   J Proteomics 287, 104974 (2023)
   PUBMED   37467891
  REMARK    GeneRIF: Polymeric immunoglobulin receptor and galectin-3-binding
            protein are raised in biliary atresia: Reveals a proteomic-based
            study.
REFERENCE   5  (bases 1 to 4275)
  AUTHORS   Li,Y., Shen,H., Zhang,R., Ji,C., Wang,Y., Su,C. and Xiao,J.
  TITLE     Immunoglobulin M perception by FcmuR
  JOURNAL   Nature 615 (7954), 907-912 (2023)
   PUBMED   36949194
REFERENCE   6  (bases 1 to 4275)
  AUTHORS   Krajci,P., Kvale,D., Tasken,K. and Brandtzaeg,P.
  TITLE     Molecular cloning and exon-intron mapping of the gene encoding
            human transmembrane secretory component (the poly-Ig receptor)
  JOURNAL   Eur J Immunol 22 (9), 2309-2315 (1992)
   PUBMED   1355431
  REMARK    Erratum:[Eur J Immunol 1993 Jan;23(1):311]
REFERENCE   7  (bases 1 to 4275)
  AUTHORS   Bakos,M.A., Kurosky,A. and Goldblum,R.M.
  TITLE     Characterization of a critical binding site for human polymeric Ig
            on secretory component
  JOURNAL   J Immunol 147 (10), 3419-3426 (1991)
   PUBMED   1940346
REFERENCE   8  (bases 1 to 4275)
  AUTHORS   Krajci,P., Grzeschik,K.H., Geurts van Kessel,A.H., Olaisen,B. and
            Brandtzaeg,P.
  TITLE     The human transmembrane secretory component (poly-Ig receptor):
            molecular cloning, restriction fragment length polymorphism and
            chromosomal sublocalization
  JOURNAL   Hum Genet 87 (6), 642-648 (1991)
   PUBMED   1682231
REFERENCE   9  (bases 1 to 4275)
  AUTHORS   Eiffert,H., Quentin,E., Wiederhold,M., Hillemeir,S., Decker,J.,
            Weber,M. and Hilschmann,N.
  TITLE     Determination of the molecular structure of the human free
            secretory component
  JOURNAL   Biol Chem Hoppe Seyler 372 (2), 119-128 (1991)
   PUBMED   1859628
REFERENCE   10 (bases 1 to 4275)
  AUTHORS   Krajci,P., Solberg,R., Sandberg,M., Oyen,O., Jahnsen,T. and
            Brandtzaeg,P.
  TITLE     Molecular cloning of the human transmembrane secretory component
            (poly-Ig receptor) and its mRNA expression in human tissues
  JOURNAL   Biochem Biophys Res Commun 158 (3), 783-789 (1989)
   PUBMED   2920039
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK225471.1 and AF272149.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002644.3.
            
            Summary: This gene is a member of the immunoglobulin superfamily.
            The encoded poly-Ig receptor binds polymeric immunoglobulin
            molecules at the basolateral surface of epithelial cells; the
            complex is then transported across the cell to be secreted at the
            apical surface. A significant association was found between
            immunoglobulin A nephropathy and several SNPs in this
            gene.[provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF272149.2, X73079.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356495.5/ ENSP00000348888.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AK225471.1         1-115
            116-4270            AF272149.2         112-4266
            4271-4275           AK225471.1         1341-1345
FEATURES             Location/Qualifiers
     source          1..4275
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..4275
                     /gene="PIGR"
                     /note="polymeric immunoglobulin receptor"
                     /db_xref="GeneID:5284"
                     /db_xref="HGNC:HGNC:8968"
                     /db_xref="MIM:173880"
     exon            1..131
                     /gene="PIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            132..227
                     /gene="PIGR"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..2479
                     /gene="PIGR"
                     /note="hepatocellular carcinoma associated protein TB6;
                     poly-Ig receptor"
                     /codon_start=1
                     /product="polymeric immunoglobulin receptor precursor"
                     /protein_id="NP_002635.2"
                     /db_xref="CCDS:CCDS1474.1"
                     /db_xref="GeneID:5284"
                     /db_xref="HGNC:HGNC:8968"
                     /db_xref="MIM:173880"
                     /translation="MLLFVLTCLLAVFPAISTKSPIFGPEEVNSVEGNSVSITCYYPP
                     TSVNRHTRKYWCRQGARGGCITLISSEGYVSSKYAGRANLTNFPENGTFVVNIAQLSQ
                     DDSGRYKCGLGINSRGLSFDVSLEVSQGPGLLNDTKVYTVDLGRTVTINCPFKTENAQ
                     KRKSLYKQIGLYPVLVIDSSGYVNPNYTGRIRLDIQGTGQLLFSVVINQLRLSDAGQY
                     LCQAGDDSNSNKKNADLQVLKPEPELVYEDLRGSVTFHCALGPEVANVAKFLCRQSSG
                     ENCDVVVNTLGKRAPAFEGRILLNPQDKDGSFSVVITGLRKEDAGRYLCGAHSDGQLQ
                     EGSPIQAWQLFVNEESTIPRSPTVVKGVAGGSVAVLCPYNRKESKSIKYWCLWEGAQN
                     GRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLTSRDAGFYWCLTNGDTLWR
                     TTVEIKIIEGEPNLKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKWNNTGCQALPS
                     QDEGPSKAFVNCDENSRLVSLTLNLVTRADEGWYWCGVKQGHFYGETAAVYVAVEERK
                     AAGSRDVSLAKADAAPDEKVLDSGFREIENKAIQDPRLFAEEKAVADTRDQADGSRAS
                     VDSGSSEEQGGSSRALVSTLVPLGLVLAVGAVAVGVARARHRKNVDRVSIRSYRTDIS
                     MSDFENSREFGANDNMGASSITQETSLGGKEEFVATTESTTETKEPKKAKRSSKEEAE
                     MAYKDFLLQSSTVAAEAQDGPQEA"
     exon            228..572
                     /gene="PIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            573..1229
                     /gene="PIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1562
                     /gene="PIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1889
                     /gene="PIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2070
                     /gene="PIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2192
                     /gene="PIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2324
                     /gene="PIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2383
                     /gene="PIGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..4275
                     /gene="PIGR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4252..4257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIGR"
                     /note="hexamer: ATTAAA"
     polyA_site      4275
                     /gene="PIGR"
                     /note="major polyA site"
ORIGIN      
        1 gagcagagtt tcagttttgg cagcagcgtc cagtgccctg ccagtagctc ctagagaggc
       61 aggggttacc aactggccag caggctgtgt ccctgaagtc agatcaacgg gagagaagga
      121 agtggctaaa acattgcaca ggagaagtcg gcctgagtgg tgcggcgctc gggacccacc
      181 agcaatgctg ctcttcgtgc tcacctgcct gctggcggtc ttcccagcca tctccacgaa
      241 gagtcccata tttggtcccg aggaggtgaa tagtgtggaa ggtaactcag tgtccatcac
      301 gtgctactac ccacccacct ctgtcaaccg gcacacccgg aagtactggt gccggcaggg
      361 agctagaggt ggctgcataa ccctcatctc ctcggagggc tacgtctcca gcaaatatgc
      421 aggcagggct aacctcacca acttcccgga gaacggcaca tttgtggtga acattgccca
      481 gctgagccag gatgactccg ggcgctacaa gtgtggcctg ggcatcaata gccgaggcct
      541 gtcctttgat gtcagcctgg aggtcagcca gggtcctggg ctcctaaatg acactaaagt
      601 ctacacagtg gacctgggca gaacggtgac catcaactgc cctttcaaga ctgagaatgc
      661 tcaaaagagg aagtccttgt acaagcagat aggcctgtac cctgtgctgg tcatcgactc
      721 cagtggttat gtaaatccca actatacagg aagaatacgc cttgatattc agggtactgg
      781 ccagttactg ttcagcgttg tcatcaacca actcaggctc agcgatgctg ggcagtatct
      841 ctgccaggct ggggatgatt ccaatagtaa taagaagaat gctgacctcc aagtgctaaa
      901 gcccgagccc gagctggttt atgaagacct gaggggctca gtgaccttcc actgtgccct
      961 gggccctgag gtggcaaacg tggccaaatt tctgtgccga cagagcagtg gggaaaactg
     1021 tgacgtggtc gtcaacaccc tggggaagag ggccccagcc tttgagggca ggatcctgct
     1081 caacccccag gacaaggatg gctcattcag tgtggtgatc acaggcctga ggaaggagga
     1141 tgcagggcgc tacctgtgtg gagcccattc ggatggtcag ctgcaggaag gctcgcctat
     1201 ccaggcctgg caactcttcg tcaatgagga gtccacgatt ccccgcagcc ccactgtggt
     1261 gaagggggtg gcaggaggct ctgtggccgt gctctgcccc tacaaccgta aggaaagcaa
     1321 aagcatcaag tactggtgtc tctgggaagg ggcccagaat ggccgctgcc ccctgctggt
     1381 ggacagcgag gggtgggtta aggcccagta cgagggccgc ctctccctgc tggaggagcc
     1441 aggcaacggc accttcactg tcatcctcaa ccagctcacc agccgggacg ccggcttcta
     1501 ctggtgtctg accaacggcg atactctctg gaggaccacc gtggagatca agattatcga
     1561 aggagaacca aacctcaagg taccagggaa tgtcacggct gtgctgggag agactctcaa
     1621 ggtcccctgt cactttccat gcaaattctc ctcgtacgag aaatactggt gcaagtggaa
     1681 taacacgggc tgccaggccc tgcccagcca agacgaaggc cccagcaagg ccttcgtgaa
     1741 ctgtgacgag aacagccggc ttgtctccct gaccctgaac ctggtgacca gggctgatga
     1801 gggctggtac tggtgtggag tgaagcaggg ccacttctat ggagagactg cagccgtcta
     1861 tgtggcagtt gaagagagga aggcagcggg gtcccgcgat gtcagcctag cgaaggcaga
     1921 cgctgctcct gatgagaagg tgctagactc tggttttcgg gagattgaga acaaagccat
     1981 tcaggatccc aggctttttg cagaggaaaa ggcggtggca gatacaagag atcaagccga
     2041 tgggagcaga gcatctgtgg attccggcag ctctgaggaa caaggtggaa gctccagagc
     2101 gctggtctcc accctggtgc ccctgggcct ggtgctggca gtgggagccg tggctgtggg
     2161 ggtggccaga gcccggcaca ggaagaacgt cgaccgagtt tcaatcagaa gctacaggac
     2221 agacattagc atgtcagact tcgagaactc cagggaattt ggagccaatg acaacatggg
     2281 agcctcttcg atcactcagg agacatccct cggaggaaaa gaagagtttg ttgccaccac
     2341 tgagagcacc acagagacca aagaacccaa gaaggcaaaa aggtcatcca aggaggaagc
     2401 cgagatggcc tacaaagact tcctgctcca gtccagcacc gtggccgccg aggcccagga
     2461 cggcccccag gaagcctaga cggtgtcgcc gcctgctccc tgcacccatg acaatcacct
     2521 tcagaatcat gtcgatcctg gggccctcag ctcctgggga ccccactccc tgctctaaca
     2581 cctgcctagg tttttcctac tgtcctcaga ggcgtgctgg tcccctcctc agtgacatca
     2641 aagcctggcc taattgttcc tattggggat gagggtggca tgaggaggtc ccacttgcaa
     2701 cttctttctg ttgagagaac ctcaggtacg gagaagaata gaggtcctca tgggtccctt
     2761 gaaggaagag ggaccagggt gggagagctg attgcagaaa ggagagacgt gcagcgcccc
     2821 tctgcaccct tatcatggga tgtcaacaga atttttccct ccactccatc cctccctccc
     2881 gtccttcccc tcttcttctt tccttccatc aaaagatgta tttgaattca tactagaatt
     2941 caggtgcttt gctagatgct gtgacaggta tgccaccaac actgctcaca gcctttctga
     3001 ggacaccagt gaaagaagcc acagctcttc ttggcgtatt tatactcact gagtcttaac
     3061 ttttcaccag gggtgctcac ctctgcccct attgggagag gtcataaaat gtctcgagtc
     3121 ctaaggcctt aggggtcatg tatgatgagc atacacacag gtaattataa acccacattc
     3181 ttaccatttc acacataaga aaattgaggt ttggaagagt gaagcgtttt tctttttctt
     3241 tttttttttt gagacggagt ctctcactgt cgcccaggct ggagtgcagt ggcgcaatct
     3301 cggctcactg caacctccgc ctcccaggtt gacaccattc tcctgcctca ccctcccaag
     3361 tagctgggac tacaggcgcc tgccagcacg cctggctaat tttttgtatt tttagtagag
     3421 acagggtttc accgtgttag ccaggatggt ctcgatctcc tgacctcgtg atccgcctgc
     3481 ctctgcctcc caaagtgctg ggattacagg cgtgagccac cgcgtccggc ctcttttttt
     3541 cttttctttt ttttgagaca aagtctcact gtgtcaccca gactggaatg cagtgacaca
     3601 atctcggctc actgaaacct ctgccttcca ggttcaagct attctcatgc ctcagcctct
     3661 caagtagctg ggactacaga tgtgggccac catgtctggc taattttttt tttttttttt
     3721 tttttttgta gagacagggt ttcgccatgt tgacgagact ggtctcgaac tcctggcctc
     3781 aagtgatctg ccgcctcagc ttctcaaagt actgggatta tataggcatg agccactgag
     3841 cctggccctg aagcgttttt ctcaaaggcc ctcagtgaga taaattagat ttggcatctc
     3901 ctgtcctggg ccagggatct ctctacaaga gcccctgccc ctctgttgga ggcacagttt
     3961 tagaataagg aggaggaggg agaagagaaa atgtaaagga gggagatctt tcccaggccg
     4021 caccatttct gtcactcaca tggacccaag ataaaagaat ggccaaaccc tcacaacccc
     4081 tgatgtttga agagttccaa gttgaaggga aacaaagaag tgtttgatgg tgccagagag
     4141 gggctgctct ccagaaagct aaaatttaat ttcttttttc ctctgagttc tgtacttcaa
     4201 ccagcctaca agctggcact tgctaacaaa tcagaaatat gacaattaat gattaaagac
     4261 tgtgattgcc accaa
//
