LOCUS       NM_002643               1294 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens phosphatidylinositol glycan anchor biosynthesis class
            F (PIGF), transcript variant 1, mRNA.
ACCESSION   NM_002643
VERSION     NM_002643.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1294)
  AUTHORS   Darmochwal-Kolarz,D. and Chara,A.
  TITLE     The Association of IL-17 and PlGF/sENG Ratio in Pre-Eclampsia and
            Adverse Pregnancy Outcomes
  JOURNAL   Int J Environ Res Public Health 20 (1), 768 (2022)
   PUBMED   36613090
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1294)
  AUTHORS   Martinez-Varea,A., Martinez-Saez,C., Domenech,J., Desco-Blay,J.,
            Monfort-Pitarch,S., Hueso,M. and Diago-Almela,V.
  TITLE     sFlt-1/PlGF Ratio at 24 Weeks Gestation in Twin Pregnancies as a
            Predictor of Preeclampsia or Fetal Growth Restriction
  JOURNAL   Fetal Diagn Ther 49 (4), 206-214 (2022)
   PUBMED   35609518
REFERENCE   3  (bases 1 to 1294)
  AUTHORS   Oshovskyy,V., Arbuzova,S., Nikolenko,M. and Mylytsya,K.
  TITLE     PREGNANCY OUTCOMES IN WOMEN WITH EXTREMELY HIGH SFLT-1/PIGF RATIO:
            CASE SERIES
  JOURNAL   Wiad Lek 75 (1), 141-143 (2022)
   PUBMED   35092264
REFERENCE   4  (bases 1 to 1294)
  AUTHORS   Salian,S., Benkerroum,H., Nguyen,T.T.M., Nampoothiri,S.,
            Kinoshita,T., Felix,T.M., Stewart,F., Sisodiya,S.M., Murakami,Y.
            and Campeau,P.M.
  TITLE     PIGF deficiency causes a phenotype overlapping with DOORS syndrome
  JOURNAL   Hum Genet 140 (6), 879-884 (2021)
   PUBMED   33386993
  REMARK    GeneRIF: PIGF deficiency causes a phenotype overlapping with DOORS
            syndrome.
REFERENCE   5  (bases 1 to 1294)
  AUTHORS   Yang,S.H., Wang,X.L., Cai,J. and Wang,S.H.
  TITLE     Diagnostic Value of Circulating PIGF in Combination with Flt-1 in
            Early Cervical Cancer
  JOURNAL   Curr Med Sci 40 (5), 973-978 (2020)
   PUBMED   33123910
REFERENCE   6  (bases 1 to 1294)
  AUTHORS   Kinoshita,T. and Inoue,N.
  TITLE     Dissecting and manipulating the pathway for
            glycosylphos-phatidylinositol-anchor biosynthesis
  JOURNAL   Curr Opin Chem Biol 4 (6), 632-638 (2000)
   PUBMED   11102867
  REMARK    Review article
REFERENCE   7  (bases 1 to 1294)
  AUTHORS   Hong,Y., Maeda,Y., Watanabe,R., Inoue,N., Ohishi,K. and
            Kinoshita,T.
  TITLE     Requirement of PIG-F and PIG-O for transferring phosphoethanolamine
            to the third mannose in glycosylphosphatidylinositol
  JOURNAL   J Biol Chem 275 (27), 20911-20919 (2000)
   PUBMED   10781593
REFERENCE   8  (bases 1 to 1294)
  AUTHORS   Ohishi,K., Inoue,N., Endo,Y., Fujita,T., Takeda,J. and Kinoshita,T.
  TITLE     Structure and chromosomal localization of the GPI-anchor synthesis
            gene PIGF and its pseudogene psi PIGF
  JOURNAL   Genomics 29 (3), 804-807 (1995)
   PUBMED   8575782
REFERENCE   9  (bases 1 to 1294)
  AUTHORS   Kinoshita,T., Takahashi,M., Inoue,N., Miyata,T. and Takeda,J.
  TITLE     Expression cloning of genes for GPI-anchor biosynthesis
  JOURNAL   Braz J Med Biol Res 27 (2), 127-132 (1994)
   PUBMED   8081220
REFERENCE   10 (bases 1 to 1294)
  AUTHORS   Inoue,N., Kinoshita,T., Orii,T. and Takeda,J.
  TITLE     Cloning of a human gene, PIG-F, a component of
            glycosylphosphatidylinositol anchor biosynthesis, by a novel
            expression cloning strategy
  JOURNAL   J Biol Chem 268 (10), 6882-6885 (1993)
   PUBMED   8463218
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018682.4 and BC029408.1.
            
            On May 17, 2019 this sequence version replaced NM_002643.3.
            
            Summary: This gene encodes a protein involved in
            glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The
            GPI-anchor, a glycolipid containing three mannose molecules in its
            core backbone, is found on many blood cells where it serves to
            anchor proteins to the cell surface. The encoded protein and
            another GPI synthesis protein, PIGO, function in the transfer of
            ethanolaminephosphate to the third mannose in GPI. Alternatively
            spliced transcript variants encoding different isoforms have been
            described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.439290.1,
                                           SRR1163657.60128.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281382.11/ ENSP00000281382.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC018682.4         151363-151434       c
            73-321              AC018682.4         149330-149578       c
            322-413             AC018682.4         148087-148178       c
            414-530             AC018682.4         146621-146737       c
            531-639             AC018682.4         126868-126976       c
            640-955             AC018682.4         115669-115984       c
            956-957             BC029408.1         980-981
            958-1294            AC018682.4         115330-115666       c
FEATURES             Location/Qualifiers
     source          1..1294
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     gene            1..1294
                     /gene="PIGF"
                     /gene_synonym="OORS"
                     /note="phosphatidylinositol glycan anchor biosynthesis
                     class F"
                     /db_xref="GeneID:5281"
                     /db_xref="HGNC:HGNC:8962"
                     /db_xref="MIM:600153"
     exon            1..72
                     /gene="PIGF"
                     /gene_synonym="OORS"
                     /inference="alignment:Splign:2.1.0"
     exon            73..321
                     /gene="PIGF"
                     /gene_synonym="OORS"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..753
                     /gene="PIGF"
                     /gene_synonym="OORS"
                     /EC_number="2.7.8.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol-glycan biosynthesis class F protein;
                     PIG-F; GPI11 homolog"
                     /codon_start=1
                     /product="phosphatidylinositol-glycan biosynthesis class F
                     protein isoform 1"
                     /protein_id="NP_002634.1"
                     /db_xref="CCDS:CCDS1827.1"
                     /db_xref="GeneID:5281"
                     /db_xref="HGNC:HGNC:8962"
                     /db_xref="MIM:600153"
                     /translation="MKDNDIKRLLYTHLLCIFSIILSVFIPSLFLENFSILETHLTWL
                     CICSGFVTAVNLVLYLVVKPNTSSKRSSLSHKVTGFLKCCIYFLMSCFSFHVIFVLYG
                     APLIELALETFLFAVILSTFTTVPCLCLLGPNLKAWLRVFSRNGVTSIWENSLQITTI
                     SSFVGAWLGALPIPLDWERPWQVWPISCTLGATFGYVAGLVISPLWIYWNRKQLTYKN
                     N"
     exon            322..413
                     /gene="PIGF"
                     /gene_synonym="OORS"
                     /inference="alignment:Splign:2.1.0"
     exon            414..530
                     /gene="PIGF"
                     /gene_synonym="OORS"
                     /inference="alignment:Splign:2.1.0"
     exon            531..639
                     /gene="PIGF"
                     /gene_synonym="OORS"
                     /inference="alignment:Splign:2.1.0"
     exon            640..1294
                     /gene="PIGF"
                     /gene_synonym="OORS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggccgcc cgtcgtacct gatggtagga ggcagtagtt ccccgcttcc cttccgcggg
       61 agggagagtt agctagccat ccaagaaaac accatgaaag ataacgatat caagagacta
      121 ctgtataccc atcttttatg catattttca attatcctaa gtgtcttcat tccatcactc
      181 ttcttggaga acttctcaat attggaaaca cacttgacat ggttgtgcat ctgttctggt
      241 tttgtaactg ctgtcaatct agtactatat ttagtagtga aaccaaatac atcctctaaa
      301 agaagttcat tatcacacaa ggtaactgga tttttgaaat gctgtatcta ctttcttatg
      361 tcttgtttct cctttcatgt aatttttgtt ctgtatggag caccactgat agagttggca
      421 ttggaaacat ttttatttgc agttattttg tctactttta ctactgtgcc ttgcttatgt
      481 ttgttaggac caaacctcaa agcatggcta agagtgttca gtagaaatgg agttacatcc
      541 atatgggaga atagtctcca gatcactaca atttctagct ttgtaggagc atggcttgga
      601 gcacttccta ttccactgga ttgggaaaga ccatggcagg tatggcccat ctcctgtacg
      661 cttggagcga cctttggcta cgtggctggc cttgttattt caccactctg gatatactgg
      721 aatagaaagc aacttacata caagaacaat taactggagc aaagggagat atttctttgt
      781 gcagattctg taagggctgg gcagaaatgt gtatggtcaa agccaagcag ttccatttac
      841 agctctgttt tttacgtagt tacaacatga tgtgattgta gctttttaaa ctatgaaacc
      901 cctgagagat tgtaccttct agttgaaata aagtatttat aatagattgt ggcttcagat
      961 gctgcttact gcttcttaaa cctttaagga acattcttaa tacactttat agaattctga
     1021 ggacaggttt tgttttcttt caagttttga actgcttcat tacctataaa aggtctgggt
     1081 atagctgtag catttcattt gctttctgag agaaatggac agtttccttg gccactgaag
     1141 atgtttctca cgtaattaaa caacagttta tacatcttga tcctattctt ttttttacag
     1201 tgtgtttctt tggagttaaa atggctatga tagcctcatc aaaaacagtc ttcaatccct
     1261 tctgggttaa agctgaacat tccacatagc agca
//
