LOCUS       NM_001308421             944 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens PIGB opposite strand 1 (PIGBOS1), transcript variant
            1, mRNA.
ACCESSION   NM_001308421
VERSION     NM_001308421.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 944)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 944)
  AUTHORS   Chu,Q., Martinez,T.F., Novak,S.W., Donaldson,C.J., Tan,D.,
            Vaughan,J.M., Chang,T., Diedrich,J.K., Andrade,L., Kim,A.,
            Zhang,T., Manor,U. and Saghatelian,A.
  TITLE     Regulation of the ER stress response by a mitochondrial
            microprotein
  JOURNAL   Nat Commun 10 (1), 4883 (2019)
   PUBMED   31653868
  REMARK    GeneRIF: PIGBOS regulates the unfolded protein response (UPR).
            PIGBOS localizes to the mitochondrial outer membrane where it
            interacts with the ER protein CLCC1 at ER-mitochondria contact
            sites. Functional studies reveal that the loss of PIGBOS leads to
            heightened UPR and increased cell death.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 944)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB593170.1, HY126324.1, BQ434443.1 and CA420894.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001308421.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein. This
            protein is conserved in mammals but has not been
            functionally-validated.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL574059.3, AL550078.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000436697.3/ ENSP00000484893.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AB593170.1         72-103
            33-504              HY126324.1         1-472
            505-717             BQ434443.1         452-664
            718-944             CA420894.1         17-243              c
FEATURES             Location/Qualifiers
     source          1..944
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..944
                     /gene="PIGBOS1"
                     /gene_synonym="HP06981"
                     /note="PIGB opposite strand 1"
                     /db_xref="GeneID:101928527"
                     /db_xref="HGNC:HGNC:50696"
                     /db_xref="MIM:618809"
     exon            1..260
                     /gene="PIGBOS1"
                     /gene_synonym="HP06981"
                     /inference="alignment:Splign:2.1.0"
     exon            261..944
                     /gene="PIGBOS1"
                     /gene_synonym="HP06981"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..500
                     /gene="PIGBOS1"
                     /gene_synonym="HP06981"
                     /note="PIGB opposite strand protein 1"
                     /codon_start=1
                     /product="protein PIGBOS1"
                     /protein_id="NP_001295350.1"
                     /db_xref="CCDS:CCDS81884.1"
                     /db_xref="GeneID:101928527"
                     /db_xref="HGNC:HGNC:50696"
                     /db_xref="MIM:618809"
                     /translation="MFRRLTFAQLLFATVLGIAGGVYIFQPVFEQYAKDQKELKEKMQ
                     LVQESEEKKS"
     regulatory      913..918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIGBOS1"
                     /gene_synonym="HP06981"
                     /note="hexamer: AATAAA"
     polyA_site      944
                     /gene="PIGBOS1"
                     /gene_synonym="HP06981"
                     /note="major polyA site"
ORIGIN      
        1 gtagctccca cccgacgtgg tggcctcctt gcggtttcct ttcgccgttt ccgaaccgag
       61 ggattgctac tcgcctttgg cttggcggtc tctgtgctcg ggggtccgaa aactgctgga
      121 aggcccccgg tctctggagg ggagcaggcg gtagcgagtt tagtgacgtg gagcaggcgc
      181 agaacagtcg gaggtacctg agtggttatt aaaaacggta acggtaattg tagacgtcag
      241 tgttggtgtt aacatttcag atttgaagag atttcctggg tgtggagtgt gactttccaa
      301 aaccagcttt tccttgagct gtatttgttg cagcaatgtt taggagattg acttttgcac
      361 aactgctttt tgccactgtc cttggaattg ctggaggagt atatattttt caaccagtat
      421 ttgaacagta tgccaaagat cagaaggaat taaaagaaaa gatgcagttg gtacaagaat
      481 cagaagagaa gaaaagttaa tactacatgg agttaggcct ggcgcagtgg ctcacgcctg
      541 taatcccagc actttgggag gccgaggcgg gtggatcagg tggtcaggag ttcaagacca
      601 gcctgaccaa catggtgaaa ccctgtctct actgaaaata caaaaatcag ccaggcttgg
      661 tggcatgcgc ctgtaatccc agctacttgg gaggctgagg caggagcatc acttgaacct
      721 gggaggcaga ggtggcagtg agtcaagatc acgctgctgc actccagcct gggtgacaga
      781 gcgagactcc atctaaaaaa acaaaaagca aaaaaaccca caaatacctc atggagatga
      841 actgtaataa ttgcttaaag ttccatttaa ttatgttaac tctaatctag caaaaacata
      901 gatgtactta aaaataaatc atggataatg attttttaac ctaa
//
