LOCUS       NM_001142864            8089 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens piezo type mechanosensitive ion channel component 1
            (Er blood group) (PIEZO1), mRNA.
ACCESSION   NM_001142864 NM_014745 XM_001714313 XM_001714598 XM_001717096
VERSION     NM_001142864.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8089)
  AUTHORS   Xiao,B.
  TITLE     Mechanisms of mechanotransduction and physiological roles of PIEZO
            channels
  JOURNAL   Nat Rev Mol Cell Biol 25 (11), 886-903 (2024)
   PUBMED   39251883
  REMARK    GeneRIF: Mechanisms of mechanotransduction and physiological roles
            of PIEZO channels.
            Review article
REFERENCE   2  (bases 1 to 8089)
  AUTHORS   Ezzo,M., Spindler,K., Wang,J.B., Lee,D., Pecoraro,G., Cowen,J.,
            Pakshir,P. and Hinz,B.
  TITLE     Acute contact with profibrotic macrophages mechanically activates
            fibroblasts via alphavbeta3 integrin-mediated engagement of Piezo1
  JOURNAL   Sci Adv 10 (43), eadp4726 (2024)
   PUBMED   39441936
  REMARK    GeneRIF: Acute contact with profibrotic macrophages mechanically
            activates fibroblasts via alphavbeta3 integrin-mediated engagement
            of Piezo1.
REFERENCE   3  (bases 1 to 8089)
  AUTHORS   Zheng,M., Yao,Y., Borkar,N.A., Thompson,M.A., Zhang,E., Drake,L.Y.,
            Ye,X., Vogel,E.R., Pabelick,C.M. and Prakash,Y.S.
  TITLE     Piezo channels modulate human lung fibroblast function
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 327 (4), L547-L556 (2024)
   PUBMED   39189800
  REMARK    GeneRIF: Piezo channels modulate human lung fibroblast function.
REFERENCE   4  (bases 1 to 8089)
  AUTHORS   Hwang,S.M., Song,J.M., Choi,J.J., Jung,Y., Park,C.K. and Kim,Y.H.
  TITLE     Functional Role of Piezo1 in the Human Eosinophil Cell Line
            AML14.3D10: Implications for the Immune and Sensory Nervous Systems
  JOURNAL   Biomolecules 14 (9), 1157 (2024)
   PUBMED   39334923
  REMARK    GeneRIF: Functional Role of Piezo1 in the Human Eosinophil Cell
            Line AML14.3D10: Implications for the Immune and Sensory Nervous
            Systems.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8089)
  AUTHORS   Bagriantsev,S.N., Gracheva,E.O. and Gallagher,P.G.
  TITLE     Piezo proteins: regulators of mechanosensation and other cellular
            processes
  JOURNAL   J Biol Chem 289 (46), 31673-31681 (2014)
   PUBMED   25305018
  REMARK    Review article
REFERENCE   6  (bases 1 to 8089)
  AUTHORS   Nagase,T., Yamakawa,H., Tadokoro,S., Nakajima,D., Inoue,S.,
            Yamaguchi,K., Itokawa,Y., Kikuno,R.F., Koga,H. and Ohara,O.
  TITLE     Exploration of human ORFeome: high-throughput preparation of ORF
            clones and efficient characterization of their protein products
  JOURNAL   DNA Res 15 (3), 137-149 (2008)
   PUBMED   18316326
REFERENCE   7  (bases 1 to 8089)
  AUTHORS   Shim,J.W., Cho,K.S., Choi,Y.D., Park,Y.W., Lee,D.W., Han,W.S.,
            Shim,S.I., Kim,H.J. and Cho,N.H.
  TITLE     Diagnostic algorithm for papillary urothelial tumors in the urinary
            bladder
  JOURNAL   Virchows Arch 452 (4), 353-362 (2008)
   PUBMED   18311491
  REMARK    GeneRIF: The MIB index was strongly correlated with disease
            progression in papillary urothelial neoplasms in the urinary
            bladder.
REFERENCE   8  (bases 1 to 8089)
  AUTHORS   Satoh,K., Hata,M., Takahara,S., Tsuzaki,H., Yokota,H., Akatsu,H.,
            Yamamoto,T., Kosaka,K. and Yamada,T.
  TITLE     A novel membrane protein, encoded by the gene covering KIAA0233, is
            transcriptionally induced in senile plaque-associated astrocytes
  JOURNAL   Brain Res 1108 (1), 19-27 (2006)
   PUBMED   16854388
REFERENCE   9  (bases 1 to 8089)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   10 (bases 1 to 8089)
  AUTHORS   Carella,M., Stewart,G., Ajetunmobi,J.F., Perrotta,S.,
            Grootenboer,S., Tchernia,G., Delaunay,J., Totaro,A., Zelante,L.,
            Gasparini,P. and Iolascon,A.
  TITLE     Genomewide search for dehydrated hereditary stomatocytosis
            (hereditary xerocytosis): mapping of locus to chromosome 16
            (16q23-qter)
  JOURNAL   Am J Hum Genet 63 (3), 810-816 (1998)
   PUBMED   9718354
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY165228.1, CN280966.1,
            DR731297.1, AC138028.1, DV080374.1, DV080349.1, AA682915.1,
            AB161230.1 and BU633404.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 11, 2018 this sequence version replaced NM_001142864.3.
            
            Summary: The protein encoded by this gene is a
            mechanically-activated ion channel that links mechanical forces to
            biological signals. The encoded protein contains 36 transmembrane
            domains and functions as a homotetramer. Defects in this gene have
            been associated with dehydrated hereditary stomatocytosis.
            [provided by RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.11341.1,
                                           SRR11853559.12919.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301015.14/ ENSP00000301015.9
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               HY165228.1         1-161
            162-406             CN280966.1         153-397
            407-420             HY165228.1         408-421
            421-503             DR731297.1         1-83
            504-504             AC138028.1         36344-36344
            505-636             DR731297.1         85-216
            637-637             AC138028.1         37117-37117
            638-816             DR731297.1         218-396
            817-1004            DV080374.1         180-367             c
            1005-1005           AC138028.1         40353-40353
            1006-1302           DV080349.1         145-441
            1303-1327           AC138028.1         40891-40915
            1328-1374           AA682915.1         21-67
            1375-1384           AC138028.1         41044-41053
            1385-1435           AA682915.1         76-126
            1436-1436           AC138028.1         41105-41105
            1437-1473           AA682915.1         128-164
            1474-1475           AC138028.1         41962-41963
            1476-1629           AA682915.1         167-320
            1630-4269           AB161230.1         81-2720
            4270-4270           AC138028.1         53040-53040
            4271-5793           AB161230.1         2722-4244
            5794-5794           AC138028.1         57383-57383
            5795-6825           AB161230.1         4246-5276
            6826-6826           AC138028.1         61566-61566
            6827-7314           AB161230.1         5278-5765
            7315-7315           AC138028.1         62411-62411
            7316-7822           AB161230.1         5767-6273
            7823-8023           BU633404.1         85-285              c
            8024-8089           BU633404.1         18-83               c
FEATURES             Location/Qualifiers
     source          1..8089
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..8089
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /note="piezo type mechanosensitive ion channel component 1
                     (Er blood group)"
                     /db_xref="GeneID:9780"
                     /db_xref="HGNC:HGNC:28993"
                     /db_xref="MIM:611184"
     exon            1..320
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..7822
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /note="membrane protein induced by beta-amyloid treatment;
                     family with sequence similarity 38, member A"
                     /codon_start=1
                     /product="piezo-type mechanosensitive ion channel
                     component 1"
                     /protein_id="NP_001136336.2"
                     /db_xref="CCDS:CCDS54058.1"
                     /db_xref="GeneID:9780"
                     /db_xref="HGNC:HGNC:28993"
                     /db_xref="MIM:611184"
                     /translation="MEPHVLGAVLYWLLLPCALLAACLLRFSGLSLVYLLFLLLLPWF
                     PGPTRCGLQGHTGRLLRALLGLSLLFLVAHLALQICLHIVPRLDQLLGPSCSRWETLS
                     RHIGVTRLDLKDIPNAIRLVAPDLGILVVSSVCLGICGRLARNTRQSPHPRELDDDER
                     DVDASPTAGLQEAATLAPTRRSRLAARFRVTAHWLLVAAGRVLAVTLLALAGIAHPSA
                     LSSVYLLLFLALCTWWACHFPISTRGFSRLCVAVGCFGAGHLICLYCYQMPLAQALLP
                     PAGIWARVLGLKDFVGPTNCSSPHALVLNTGLDWPVYASPGVLLLLCYATASLRKLRA
                     YRPSGQRKEAAKGYEARELELAELDQWPQERESDQHVVPTAPDTEADNCIVHELTGQS
                     SVLRRPVRPKRAEPREASPLHSLGHLIMDQSYVCALIAMMVWSITYHSWLTFVLLLWA
                     CLIWTVRSRHQLAMLCSPCILLYGMTLCCLRYVWAMDLRPELPTTLGPVSLRQLGLEH
                     TRYPCLDLGAMLLYTLTFWLLLRQFVKEKLLKWAESPAALTEVTVADTEPTRTQTLLQ
                     SLGELVKGVYAKYWIYVCAGMFIVVSFAGRLVVYKIVYMFLFLLCLTLFQVYYSLWRK
                     LLKAFWWLVVAYTMLVLIAVYTFQFQDFPAYWRNLTGFTDEQLGDLGLEQFSVSELFS
                     SILVPGFFLLACILQLHYFHRPFMQLTDMEHVSLPGTRLPRWAHRQDAVSGTPLLREE
                     QQEHQQQQQEEEEEEEDSRDEGLGVATPHQATQVPEGAAKWGLVAERLLELAAGFSDV
                     LSRVQVFLRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMASC
                     LSTVWTCVIIVCKMLYQLKVVNPQEYSSNCTEPFPNSTNLLPTEISQSLLYRGPVDPA
                     NWFGVRKGFPNLGYIQNHLQVLLLLVFEAIVYRRQEHYRRQHQLAPLPAQAVFASGTR
                     QQLDQDLLGCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFLVTLHGCWLVAILTRRH
                     RQAIARLWPNYCLFLALFLLYQYLLCLGMPPALCIDYPWRWSRAVPMNSALIKWLYLP
                     DFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAGVNTDRLEPLRGEPNPVP
                     NFIHCRSYLDMLKVAVFRYLFWLVLVVVFVTGATRISIFGLGYLLACFYLLLFGTALL
                     QRDTRARLVLWDCLILYNVTVIISKNMLSLLACVFVEQMQTGFCWVIQLFSLVCTVKG
                     YYDPKEMMDRDQDCLLPVEEAGIIWDSVCFFFLLLQRRVFLSHYYLHVRADLQATALL
                     ASRGFALYNAANLKSIDFHRRIEEKSLAQLKRQMERIRAKQEKHRQGRVDRSRPQDTL
                     GPKDPGLEPGPDSPGGSSPPRRQWWRPWLDHATVIHSGDYFLFESDSEEEEEAVPEDP
                     RPSAQSAFQLAYQAWVTNAQAVLRRRQQEQEQARQEQAGQLPTGGGPSQEVEPAEGPE
                     EAAAGRSHVVQRVLSTAQFLWMLGQALVDELTRWLQEFTRHHGTMSDVLRAERYLLTQ
                     ELLQGGEVHRGVLDQLYTSQAEATLPGPTEAPNAPSTVSSGLGAEEPLSSMTDDMGSP
                     LSTGYHTRSGSEEAVTDPGEREAGASLYQGLMRTASELLLDRRLRIPELEEAELFAEG
                     QGRALRLLRAVYQCVAAHSELLCYFIIILNHMVTASAGSLVLPVLVFLWAMLSIPRPS
                     KRFWMTAIVFTEIAVVVKYLFQFGFFPWNSHVVLRRYENKPYFPPRILGLEKTDGYIK
                     YDLVQLMALFFHRSQLLCYGLWDHEEDSPSKEHDKSGEEEQGAEEGPGVPAATTEDHI
                     QVEARVGPTDGTPEPQVELRPRDTRRISLRFRRRKKEGPARKGAAAIEAEDREEEEGE
                     EEKEAPTGREKRPSRSGGRVRAAGRRLQGFCLSLAQGTYRPLRRFFHDILHTKYRAAT
                     DVYALMFLADVVDFIIIIFGFWAFGKHSAATDITSSLSDDQVPEAFLVMLLIQFSTMV
                     VDRALYLRKTVLGKLAFQVALVLAIHLWMFFILPAVTERMFNQNVVAQLWYFVKCIYF
                     ALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLS
                     LSSWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFP
                     LLFMSLVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIIPFTAQAYEELSRQFD
                     PQPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKRELYNGTADITLRFTWN
                     FQRDLAKGGTVEYANEKHMLALAPNSTARRQLASLLEGTSDQSVVIPNLFPKYIRAPN
                     GPEANPVKQLQPNEEADYLGVRIQLRREQGAGATGFLEWWVIELQECRTDCNLLPMVI
                     FSDKVSPPSLGFLAGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKL
                     CQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTREKE"
     exon            321..416
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            417..539
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            540..582
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            583..721
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            722..890
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1104
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1276
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1363
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1451
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1552
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1813
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1925
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2104
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2253
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2436
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2585
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2743
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2920
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3046
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3247
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3452
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3557
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3711
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..3955
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..4052
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4224
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4314
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            4315..4418
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            4419..4490
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            4491..4591
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            4592..4694
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            4695..4751
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            4752..4924
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            4925..5031
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            5032..5211
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            5212..5470
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            5471..5659
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            5660..5924
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            5925..6057
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            6058..6205
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            6206..6420
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            6421..6579
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            6580..6727
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            6728..6916
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            6917..7009
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            7010..7182
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            7183..7305
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            7306..7385
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            7386..7572
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            7573..8089
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8052..8057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /note="hexamer: ATTAAA"
     polyA_site      8060
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
     polyA_site      8081
                     /gene="PIEZO1"
                     /gene_synonym="DHS; ER; FAM38A; LMPH3; LMPHM6; Mib"
                     /note="major polyA site"
ORIGIN      
        1 gggagccgcc gtccggccca gctcggcccc agtgagccga gcgctgcgct ccgccgaggg
       61 gcagggcggt cgcctgagcg agcgcgggcc cgggacgtcg gcaccggcgg ggcggccgaa
      121 ggagaaggag gaagaggaga aggcggcgcg cgggtccccg cgggtcagcc atggcgcgcc
      181 ggccccgggg cccccgcacc gccccatagc gccgcggcgt ccgctcggtc tgggccgggc
      241 cctgggccct ccagccatgg agccgcacgt gctcggcgcg gtcctgtact ggctgctgct
      301 gccctgcgcg ctgctggctg cctgcctgct ccgcttcagc ggactctcgc tggtctacct
      361 gctcttcctg ctgctgctgc cctggttccc cggccccacc cgatgcggcc tccaaggtca
      421 cacaggccgc ctcctgcggg cattgctggg cctcagcctg ctcttcctgg tggcccatct
      481 cgccctccag atctgcctgc atattgtgcc ccgcctggac cagctcctgg gacccagctg
      541 cagccgctgg gagaccctct cgcgacacat aggggtcaca aggctggacc tgaaggacat
      601 ccccaacgcc atccggctgg tggcccctga cctgggcatc ttggtggtct cctctgtctg
      661 cctcggcatc tgcgggcgcc ttgcaaggaa cacccggcag agcccacatc cacgggagct
      721 ggatgatgat gagagggatg tggatgccag cccgacggca gggctgcagg aagcagcaac
      781 gctggcccct acacggaggt cacggctggc cgctcgtttc cgagtcacgg cccactggct
      841 gctggtggcg gctgggcggg tcctggccgt aacactgctt gcactggcag gcatcgccca
      901 cccctcggcc ctctccagtg tctacctgct gctcttcctg gccctctgca cctggtgggc
      961 ctgccacttt cccatcagca ctcggggctt cagcagactc tgcgtcgcgg tggggtgctt
     1021 cggcgccggc catctcatct gcctctactg ctaccagatg cccttggcac aggctctgct
     1081 cccgcctgcc ggcatctggg ctagggtgct gggtctcaag gacttcgtgg gtcccaccaa
     1141 ctgctccagc ccccacgcgc tggtcctcaa caccggcctg gactggcctg tgtatgccag
     1201 ccccggcgtc ctcctgctgc tgtgctacgc cacggcctct ctgcgcaagc tccgcgcgta
     1261 ccgcccctcc ggccagagga aggaggcggc aaaggggtat gaggctcggg agctggagct
     1321 agcagagctg gaccagtggc cccaggaacg ggagtctgac cagcacgtgg tgcccacagc
     1381 acccgacacc gaggctgata actgcatcgt gcacgagctg accggccaga gctccgtcct
     1441 gcggcggcct gtgcggccca agcgggctga gcccagggag gcgtctccgc tccacagcct
     1501 gggccacctc atcatggacc agagctatgt gtgcgcgctc attgccatga tggtatggag
     1561 catcacctac cacagctggc tgaccttcgt actgctgctc tgggcctgcc tcatctggac
     1621 ggtgcgcagc cgccaccaac tggccatgct gtgctcgccc tgcatcctgc tgtatgggat
     1681 gacgctgtgc tgcctacgct acgtgtgggc catggacctg cgccctgagc tgcccaccac
     1741 cctgggcccc gtcagcctgc gccagctggg gctggagcac acccgctacc cctgtctgga
     1801 ccttggtgcc atgttgctct acaccctgac cttctggctc ctgctgcgcc agtttgtgaa
     1861 agagaagctg ctgaagtggg cagagtctcc agctgcgctg acggaggtca ccgtggcaga
     1921 cacagagccc acgcggacgc agacgctgtt gcagagcctg ggggagctgg tgaagggcgt
     1981 gtacgccaag tactggatct atgtgtgtgc tggcatgttc atcgtggtca gcttcgccgg
     2041 ccgcctcgtg gtctacaaga ttgtctacat gttcctcttc ctgctctgcc tcaccctctt
     2101 ccaggtctac tacagcctgt ggcggaagct gctcaaggcc ttctggtggc tcgtggtggc
     2161 ctacaccatg ctggtcctca tcgccgtcta caccttccag ttccaggact tccctgccta
     2221 ctggcgcaac ctcactggct tcaccgacga gcagctgggg gacctgggcc tggagcagtt
     2281 cagcgtgtcc gagctcttct ccagcatcct ggtgcccggc ttcttcctcc tggcctgcat
     2341 cctgcagctg cactacttcc acaggccctt catgcagctc accgacatgg agcacgtgtc
     2401 cctgcctggc acgcgcctcc cgcgctgggc tcacaggcag gatgcagtga gtgggacccc
     2461 actgctgcgg gaggagcagc aggagcatca gcagcagcag caggaggagg aggaggagga
     2521 ggaggactcc agggacgagg ggctgggcgt ggccactccc caccaggcca cgcaggtgcc
     2581 tgaaggggca gccaagtggg gcctggtggc tgagcggctg ctggagctgg cagccggctt
     2641 ctcggacgtc ctctcacgcg tgcaggtgtt cctgcggcgg ctgctggagc ttcacgtttt
     2701 caagctggtg gccctgtaca ccgtctgggt ggccctgaag gaggtgtcgg tgatgaacct
     2761 gctgctggtg gtgctgtggg ccttcgccct gccctaccca cgcttccggc ccatggcctc
     2821 ctgcctgtcc accgtgtgga cctgcgtcat catcgtgtgt aagatgctgt accagctcaa
     2881 ggttgtcaac ccccaggagt attccagcaa ctgcaccgag cccttcccca acagcaccaa
     2941 cttgctgccc acggagatca gccagtccct gctgtaccgg gggcccgtgg accctgccaa
     3001 ctggtttggg gtgcggaaag ggttccccaa cctgggctac atccagaacc acctgcaagt
     3061 gctgctgctg ctggtattcg aggccatcgt gtaccggcgc caggagcact accgccggca
     3121 gcaccagctg gccccgctgc ctgcccaggc cgtgtttgcc agcggcaccc gccagcagct
     3181 ggaccaggat ctgctcggct gcctcaagta cttcatcaac ttcttcttct acaaattcgg
     3241 gctggagatc tgcttcctga tggccgtgaa cgtgatcggg cagcgcatga actttctggt
     3301 gaccctgcac ggttgctggc tggtggccat cctcacccgc aggcaccgcc aggccattgc
     3361 ccgcctctgg cccaactact gcctcttcct ggcgctgttc ctgctgtacc agtacctgct
     3421 gtgcctgggg atgcccccgg ccctgtgcat tgattatccc tggcgctgga gccgggccgt
     3481 ccccatgaac tccgcactca tcaagtggct gtacctgcct gatttcttcc gggcccccaa
     3541 ctccaccaac ctcatcagcg actttctcct gctgctgtgc gcctcccagc agtggcaggt
     3601 gttctcagct gagcgcacag aggagtggca gcgcatggct ggcgtcaaca ccgaccgcct
     3661 ggagccgctg cggggggagc ccaaccccgt gcccaacttt atccactgca ggtcctacct
     3721 tgacatgctg aaggtggccg tcttccgata cctgttctgg ctggtgctgg tggtggtgtt
     3781 tgtcacgggg gccacccgca tcagcatctt cgggctgggc tacctgctgg cctgcttcta
     3841 cctgctgctc ttcggcacgg ccctgctgca gagggacaca cgggcccgcc tcgtgctgtg
     3901 ggactgcctc attctgtaca acgtcaccgt catcatctcc aagaacatgc tgtcgctcct
     3961 ggcctgcgtc ttcgtggagc agatgcagac cggcttctgc tgggtcatcc agctcttcag
     4021 ccttgtatgc accgtcaagg gctactatga ccccaaggag atgatggaca gagaccagga
     4081 ctgcctgctg cctgtggagg aggctggcat catctgggac agcgtctgct tcttcttcct
     4141 gctgctgcag cgccgcgtct tccttagcca ttactacctg cacgtcaggg ccgacctcca
     4201 ggccaccgcc ctgctagcct ccaggggctt cgccctctac aacgctgcca acctcaagag
     4261 cattgacttt caccgcagga tagaggagaa gtccctggcc cagctgaaaa gacagatgga
     4321 gcgtatccgt gccaagcagg agaagcacag gcagggccgg gtggaccgca gtcgccccca
     4381 ggacaccctg ggccccaagg accccggcct ggagccaggg cccgacagtc cagggggctc
     4441 ctccccgcca cggaggcagt ggtggcggcc ctggctggac cacgccacag tcatccactc
     4501 cggggactac ttcctgtttg agtccgacag tgaggaagag gaggaggctg ttcctgaaga
     4561 cccgaggccg tcggcacaga gtgccttcca gctggcgtac caggcatggg tgaccaacgc
     4621 ccaggcggtg ctgaggcggc ggcagcagga gcaggagcag gcaaggcagg aacaggcagg
     4681 acagctaccc acaggaggtg gtcccagcca ggaggtggag ccagcagagg gccccgagga
     4741 ggcagcggca ggccggagcc atgtggtgca gagggtgctg agcacggcgc agttcctgtg
     4801 gatgctgggg caggcgctag tggatgagct gacacgctgg ctgcaggagt tcacccggca
     4861 ccacggcacc atgagcgacg tgctgcgggc agagcgctac ctcctcacac aggagctcct
     4921 gcagggcggc gaagtgcaca ggggcgtgct ggatcagctg tacacaagcc aggccgaggc
     4981 cacgctgcca ggccccaccg aggcccccaa tgccccaagc accgtgtcca gtgggctggg
     5041 cgcggaggag ccactcagca gcatgacaga cgacatgggc agccccctga gcaccggcta
     5101 ccacacgcgc agtggcagtg aggaggcagt caccgacccc ggggagcgtg aggctggtgc
     5161 ctctctgtac cagggactga tgcggacggc cagcgagctg ctcctggaca ggcgcctgcg
     5221 catcccagag ctggaggagg cagagctgtt tgcggagggg cagggccggg cgctgcggct
     5281 gctgcgggcc gtgtaccagt gtgtggccgc ccactcggag ctgctctgct acttcatcat
     5341 catcctcaac cacatggtca cggcctccgc cggctcgctg gtgctgcccg tgctcgtctt
     5401 cctgtgggcc atgctgtcga tcccgaggcc cagcaagcgc ttctggatga cggccatcgt
     5461 cttcaccgag atcgcggtgg tcgtcaagta cctgttccag tttgggttct tcccctggaa
     5521 cagccacgtg gtgctgcggc gctacgagaa caagccctac ttcccgcccc gcatcctggg
     5581 cctggagaag actgacggct acatcaagta cgacctggtg cagctcatgg cccttttctt
     5641 ccaccgctcc cagctgctgt gctatggcct ctgggaccat gaggaggact caccatccaa
     5701 ggagcatgac aagagcggcg aggaggagca gggagccgag gaggggccag gggtgcctgc
     5761 ggccaccacc gaagaccaca ttcaggtgga agccagggtc ggacccacgg acgggacccc
     5821 agaaccccaa gtggagctca ggccccgtga tacgaggcgc atcagtctac gttttagaag
     5881 aaggaagaag gagggcccag cacggaaagg agcggcagcc atcgaagctg aggacaggga
     5941 ggaagaagag ggggaggaag agaaagaggc ccccacgggg agagagaaga ggccaagccg
     6001 ctctggagga agagtaaggg cggccgggcg gcggctgcag ggcttctgcc tgtccctggc
     6061 ccagggcaca tatcggccgc tacggcgctt cttccacgac atcctgcaca ccaagtaccg
     6121 cgcagccacc gacgtctatg ccctcatgtt cctggctgat gttgtcgact tcatcatcat
     6181 catttttggc ttctgggcct ttgggaagca ctcggcggcc acagacatca cgtcctccct
     6241 atcagacgac caggtacccg aggctttcct ggtcatgctg ctgatccagt tcagtaccat
     6301 ggtggttgac cgcgccctct acctgcgcaa gaccgtgctg ggcaagctgg ccttccaggt
     6361 ggcgctggtg ctggccatcc acctatggat gttcttcatc ctgcccgccg tcactgagag
     6421 gatgttcaac cagaatgtgg tggcccagct ctggtacttc gtgaagtgca tctacttcgc
     6481 cctgtccgcc taccagatcc gctgcggcta ccccacccgc atcctcggca acttcctcac
     6541 caagaagtac aatcatctca acctcttcct cttccagggg ttccggctgg tgccgttcct
     6601 ggtggagctg cgggcagtga tggactgggt gtggacggac accacgctgt ccctgtccag
     6661 ctggatgtgt gtggaggaca tctatgccaa catcttcatc atcaaatgca gccgagagac
     6721 agagaagaaa tacccgcagc ccaaagggca gaagaagaag aagatcgtca agtacggcat
     6781 gggtggcctc atcatcctct tcctcatcgc catcatctgg ttcccactgc tcttcatgtc
     6841 gctggtgcgc tccgtggttg gggttgtcaa ccagcccatc gatgtcaccg tcaccctgaa
     6901 gctgggcggc tatgagccgc tgttcaccat gagcgcccag cagccgtcca tcatcccctt
     6961 cacggcccag gcctatgagg agctgtcccg gcagtttgac ccccagccgc tggccatgca
     7021 gttcatcagc cagtacagcc ctgaggacat cgtcacggcg cagattgagg gcagctccgg
     7081 ggcgctgtgg cgcatcagtc cccccagccg tgcccagatg aagcgggagc tctacaacgg
     7141 cacggccgac atcaccctgc gcttcacctg gaacttccag agggacctgg cgaagggagg
     7201 cactgtggag tatgccaacg agaagcacat gctggccctg gcccccaaca gcactgcacg
     7261 gcggcagctg gccagcctgc tcgagggcac ctcggaccag tctgtggtca tccctaatct
     7321 cttccccaag tacatccgtg cccccaacgg gcccgaagcc aaccctgtga agcagctgca
     7381 gcccaatgag gaggccgact acctcggcgt gcgtatccag ctgcggaggg agcagggtgc
     7441 gggggccacc ggcttcctcg aatggtgggt catcgagctg caggagtgcc ggaccgactg
     7501 caacctgctg cccatggtca ttttcagtga caaggtcagc ccaccgagcc tcggcttcct
     7561 ggctggctac ggcatcatgg ggctgtacgt gtccatcgtg ctggtcatcg gcaagttcgt
     7621 gcgcggattc ttcagcgaga tctcgcactc cattatgttc gaggagctgc cgtgcgtgga
     7681 ccgcatcctc aagctctgcc aggacatctt cctggtgcgg gagactcggg agctggagct
     7741 ggaggaggag ttgtacgcca agctcatctt cctctaccgc tcaccggaga ccatgatcaa
     7801 gtggactcgt gagaaggagt aggagctgct gctggcgccc gagagggaag gagccggcct
     7861 gctgggcagc gtggccacaa ggggcggcac tcctcaggcc gggggagcca ctgccccgtc
     7921 caaggccgcc agctgtgatg catcctcccg gcctgcctga gccctgatgc tgctgtcaga
     7981 gaaggacact gcgtccccac ggcctgcgtg gcgctgccgt cccccacgtg tactgtagag
     8041 tttttttttt aattaaaaaa tgttttattt atacaaatgg acaatcaga
//
