LOCUS       NM_001048265             675 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens piercer of microtubule wall 1 (PIERCE1), transcript
            variant 1, mRNA.
ACCESSION   NM_001048265
VERSION     NM_001048265.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 675)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   2  (bases 1 to 675)
  AUTHORS   Gui,M., Farley,H., Anujan,P., Anderson,J.R., Maxwell,D.W.,
            Whitchurch,J.B., Botsch,J.J., Qiu,T., Meleppattu,S., Singh,S.K.,
            Zhang,Q., Thompson,J., Lucas,J.S., Bingle,C.D., Norris,D.P., Roy,S.
            and Brown,A.
  TITLE     De novo identification of mammalian ciliary motility proteins using
            cryo-EM
  JOURNAL   Cell 184 (23), 5791-5806 (2021)
   PUBMED   34715025
REFERENCE   3  (bases 1 to 675)
  AUTHORS   Kim,H.J., Lee,S.E., Na,H., Roe,J.S., Roh,J.I. and Lee,H.W.
  TITLE     Divergence of the PIERCE1 expression between mice and humans as a
            p53 target gene
  JOURNAL   PLoS One 15 (8), e0236881 (2020)
   PUBMED   32745107
  REMARK    GeneRIF: Divergence of the PIERCE1 expression between mice and
            humans as a p53 target gene.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 675)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 675)
  AUTHORS   Zhang,C., Chang,C., Zhao,W., Gao,H., Wang,Q., Li,D., Zhang,F.,
            Zhang,S. and Xu,C.
  TITLE     The novel protein C9orf116 promotes rat liver cell line BRL-3A
            proliferation
  JOURNAL   PLoS One 12 (7), e0180607 (2017)
   PUBMED   28749992
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 675)
  AUTHORS   Sung,Y.H., Baek,I.J., Kim,Y.H., Gho,Y.S., Oh,S.P., Lee,Y.J. and
            Lee,H.W.
  TITLE     PIERCE1 is critical for specification of left-right asymmetry in
            mice
  JOURNAL   Sci Rep 6, 27932 (2016)
   PUBMED   27305836
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 675)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR003074.1, AY927868.1 and AI367252.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001048265.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU634102.1, SRR3476690.380146.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158569 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429260.7/ ENSP00000395281.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DR003074.1         130-147
            19-429              AY927868.1         1-411
            430-675             AI367252.1         13-258              c
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..675
                     /gene="PIERCE1"
                     /gene_synonym="C9orf116; RbEST47"
                     /note="piercer of microtubule wall 1"
                     /db_xref="GeneID:138162"
                     /db_xref="HGNC:HGNC:28435"
                     /db_xref="MIM:614502"
     exon            1..161
                     /gene="PIERCE1"
                     /gene_synonym="C9orf116; RbEST47"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..429
                     /gene="PIERCE1"
                     /gene_synonym="C9orf116; RbEST47"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pierce 1; UPF0691 protein C9orf116; p53-induced expression
                     in RB-null cells protein 1; p53-induced expression 1 in
                     Rba^'/a^' cells; p53-induced expression 1 in Rb-/- cells;
                     piercer of microtubule wall 1 protein"
                     /codon_start=1
                     /product="piercer of microtubule wall 1 protein isoform 1"
                     /protein_id="NP_001041730.1"
                     /db_xref="CCDS:CCDS43899.1"
                     /db_xref="GeneID:138162"
                     /db_xref="HGNC:HGNC:28435"
                     /db_xref="MIM:614502"
                     /translation="MAEECPRACAEPVAPKATAPPERTSDYYRVSADLPGRFNNPGWF
                     RGYRTQKAVSVYRTSNQAYGSRAPTVHEMPKVFYPNSNKFSQQLAAGGMFRNNTLNVY
                     LEKSIVTGPDNCITSCDRLNFHPSYNINRPSICD"
     exon            162..240
                     /gene="PIERCE1"
                     /gene_synonym="C9orf116; RbEST47"
                     /inference="alignment:Splign:2.1.0"
     exon            241..675
                     /gene="PIERCE1"
                     /gene_synonym="C9orf116; RbEST47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      652..657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIERCE1"
                     /gene_synonym="C9orf116; RbEST47"
                     /note="hexamer: ATTAAA"
     polyA_site      675
                     /gene="PIERCE1"
                     /gene_synonym="C9orf116; RbEST47"
                     /note="major polyA site"
ORIGIN      
        1 gcttctcctc caggcacaat ggctgaggaa tgccccagag cgtgcgcgga gcctgtggcg
       61 cccaaggcca cggccccgcc ggagaggacc agcgactact accgcgtgag cgcggacctg
      121 ccgggcaggt tcaacaaccc ggggtggttc cggggctaca ggacccagaa ggctgtctcc
      181 gtgtacagga ccagtaacca ggcttacggg agcagagccc ccaccgtgca cgagatgcct
      241 aaagtatttt atccaaattc gaataaattt tcccaacaac ttgcagcggg tggaatgttc
      301 cggaacaata ctctcaatgt ttacctggag aaaagcatcg tgactggccc cgataactgc
      361 atcacctcct gtgaccggct caacttccac cccagttaca acatcaacag gccatccatc
      421 tgcgattgag gggctggaaa ctccctctag gagtcctctg accccagggc ctcctggaaa
      481 atcatcatcc ctcatcaccc acagtcgccc gattgtgacg gcacagactg cgctgccttc
      541 cctgaaaata ttattcgtct gcggagtagg aaaatatgca aacggggccg tgaagtcctg
      601 ccatttcaca tctaataagt acatgggaaa gatgctaatg gttgactttg cattaaaaac
      661 gttgtcacat cctga
//
