LOCUS       NM_001100818            2557 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens phosphotyrosine interaction domain containing 1
            (PID1), transcript variant 2, mRNA.
ACCESSION   NM_001100818
VERSION     NM_001100818.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2557)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2557)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2557)
  AUTHORS   Mu,Q., Zhu,J., Si,Y., Chen,X., Duan,G., Sun,S., Fang,G., Zeng,Y.
            and Yang,N.
  TITLE     Overexpression of PID1 reduces high density lipoprotein level and
            functionality in swine
  JOURNAL   IUBMB Life 71 (12), 1946-1951 (2019)
   PUBMED   31339628
  REMARK    GeneRIF: PID1 reduces serum HDL-Cholesterol levels.
REFERENCE   4  (bases 1 to 2557)
  AUTHORS   Fischer,A.W., Albers,K., Krott,L.M., Hoffzimmer,B., Heine,M.,
            Schmale,H., Scheja,L., Gordts,P.L.S.M. and Heeren,J.
  TITLE     The adaptor protein PID1 regulates receptor-dependent endocytosis
            of postprandial triglyceride-rich lipoproteins
  JOURNAL   Mol Metab 16, 88-99 (2018)
   PUBMED   30100244
  REMARK    GeneRIF: By acting as an insulin-dependent retention adaptor, PID1
            serves as a regulator of LRP1 function controlling the disposal of
            postprandial lipoproteins.
REFERENCE   5  (bases 1 to 2557)
  AUTHORS   Erdreich-Epstein,A., Robison,N., Ren,X., Zhou,H., Xu,J.,
            Davidson,T.B., Schur,M., Gilles,F.H., Ji,L., Malvar,J.,
            Shackleford,G.M., Margol,A.S., Krieger,M.D., Judkins,A.R.,
            Jones,D.T., Pfister,S.M., Kool,M., Sposto,R. and Asgharzadeh,S.
  TITLE     PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain
            tumors and gliomas
  JOURNAL   Clin Cancer Res 20 (4), 827-836 (2014)
   PUBMED   24300787
  REMARK    GeneRIF: Overall survival and radiation-free progression-free
            survival were longer in medulloblastoma patients whose tumors had
            higher PID1 mRNA levels.
            Erratum:[Clin Cancer Res. 2015 Sep 15;21(18):4243. doi:
            10.1158/1078-0432.CCR-15-1523.. Asgharazadeh, Shahab [corrected to
            Asgharzadeh, Shahab]. PMID: 26374075]
REFERENCE   6  (bases 1 to 2557)
  AUTHORS   Yu,Z. and Guo,X.
  TITLE     NYGGF4 as a new therapeutic target for obesity-associated insulin
            resistance
  JOURNAL   Med Hypotheses 78 (4), 432-434 (2012)
   PUBMED   22284633
  REMARK    GeneRIF: NYGGF4 acts directly on the IRS1/PI3K/AKT insulin pathway
            to reduce glucose uptake and transport, impairs mitochondrial
            function and causes insulin resistance, and thus may be a useful
            therapeutic target for obesity-associated insulin resistance.
REFERENCE   7  (bases 1 to 2557)
  AUTHORS   Zhao,Y., Zhang,C., Chen,X., Gao,C., Ji,C., Chen,F., Zhu,C., Zhu,J.,
            Wang,J., Qian,L. and Guo,X.
  TITLE     Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in
            3T3-L1 adipocytes
  JOURNAL   Mol Cell Biochem 340 (1-2), 41-48 (2010)
   PUBMED   20165904
  REMARK    GeneRIF: Overexpression of NYGGF4 caused mitochondrial dysfunction
            in adipocytes, which might be responsible for the development of
            NYGGF4-induced insulin resistance.
REFERENCE   8  (bases 1 to 2557)
  AUTHORS   Zhang,C.M., Chen,X.H., Wang,B., Liu,F., Chi,X., Tong,M.L., Ni,Y.H.,
            Chen,R.H. and Guo,X.R.
  TITLE     Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1
            adipocytes via attenuated phosphorylation of IRS-1 and Akt
  JOURNAL   Acta Pharmacol Sin 30 (1), 120-124 (2009)
   PUBMED   19079291
  REMARK    GeneRIF: Data show that NYGGF4 regulates the functions of IRS-1 and
            Akt, decreases GLUT4 translocation and reduces glucose uptake in
            response to insulin.
REFERENCE   9  (bases 1 to 2557)
  AUTHORS   Caratu,G., Allegra,D., Bimonte,M., Schiattarella,G.G.,
            D'Ambrosio,C., Scaloni,A., Napolitano,M., Russo,T. and Zambrano,N.
  TITLE     Identification of the ligands of protein interaction domains
            through a functional approach
  JOURNAL   Mol Cell Proteomics 6 (2), 333-345 (2007)
   PUBMED   17124247
  REMARK    GeneRIF: Q7Z2X4 protein (PID1) identified as a cytosolic ligand of
            LRP1 in a trimeric complex with Cubilin. Q7Z2X4 named PCLI1
            (PTB-containing, Cubilin and LRP1 Interacting protein 1)
REFERENCE   10 (bases 1 to 2557)
  AUTHORS   Wang,B., Zhang,M., Ni,Y.H., Liu,F., Fan,H.Q., Fei,L., Pan,X.Q.,
            Guo,M., Chen,R.H. and Guo,X.R.
  TITLE     Identification and characterization of NYGGF4, a novel gene
            containing a phosphotyrosine-binding (PTB) domain that stimulates
            3T3-L1 preadipocytes proliferation
  JOURNAL   Gene 379, 132-140 (2006)
   PUBMED   16815647
  REMARK    GeneRIF: A novel gene named NYGGF4, which was expressed at a higher
            level in obese subjects, was isolated and characterized and could
            play a role in cell growth and adipogenesis process
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB474424.1, AB075874.1 and BU727693.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001100818.1.
            
            Transcript Variant: This variant (2) lacks an alternate segment in
            the 5' coding region and uses an upstream start codon, compared to
            variant 1. Isoform 2 has a shorter and distinct N-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096636.1, SRR14038195.1286202.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392055.8/ ENSP00000375908.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               DB474424.1         55-328
            275-2537            AB075874.1         195-2457
            2538-2557           BU727693.1         16-35               c
FEATURES             Location/Qualifiers
     source          1..2557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.3"
     gene            1..2557
                     /gene="PID1"
                     /gene_synonym="HMFN2073; NYGGF4; P-CLI1; PCLI1"
                     /note="phosphotyrosine interaction domain containing 1"
                     /db_xref="GeneID:55022"
                     /db_xref="HGNC:HGNC:26084"
                     /db_xref="MIM:612930"
     exon            1..274
                     /gene="PID1"
                     /gene_synonym="HMFN2073; NYGGF4; P-CLI1; PCLI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..898
                     /gene="PID1"
                     /gene_synonym="HMFN2073; NYGGF4; P-CLI1; PCLI1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     PTB-containing, cubilin and LRP1-interacting protein;
                     phosphotyrosine interaction domain-containing protein 1"
                     /codon_start=1
                     /product="PTB-containing, cubilin and LRP1-interacting
                     protein isoform 2"
                     /protein_id="NP_001094288.1"
                     /db_xref="CCDS:CCDS42830.1"
                     /db_xref="GeneID:55022"
                     /db_xref="HGNC:HGNC:26084"
                     /db_xref="MIM:612930"
                     /translation="MWQPATERLQHFQTMLKSKLNVLTLKKEPLPAVIFHEPEAIELC
                     TTTPLMKTRTHSGCKVTYLGKVSTTGMQFLSGCTEKPVIELWKKHTLAREDVFPANAL
                     LEIRPFQVWLHHLDHKGEATVHMDTFQVARIAYCTADHNVSPNIFAWVYREINDDLSY
                     QMDCHAVECESKLEAKKLAHAMMEAFRKTFHSMKSDGRIHSNSSSEEVSQELESDDG"
     exon            275..421
                     /gene="PID1"
                     /gene_synonym="HMFN2073; NYGGF4; P-CLI1; PCLI1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..2557
                     /gene="PID1"
                     /gene_synonym="HMFN2073; NYGGF4; P-CLI1; PCLI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2516..2521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PID1"
                     /gene_synonym="HMFN2073; NYGGF4; P-CLI1; PCLI1"
                     /note="hexamer: AATAAA"
     polyA_site      2557
                     /gene="PID1"
                     /gene_synonym="HMFN2073; NYGGF4; P-CLI1; PCLI1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcctct cgcagctgcg ccaggacagc cggcgcgcgg ccgtgcccac aagttgccgg
       61 cagctgagcg ccgcgcctcc tcctgctcgc agccccctac gcccacccgg cggcggtggc
      121 cagcgccagg acgcacatcc cgcggacacc gaccccagat gtaaagcggg accccagccc
      181 ctcgcccccc ggcgcgatcg acagtctcgc cagcgtctcc tctgccaaaa cccagggctg
      241 gaagatgtgg cagccggcca cggagcgcct gcagcacttt cagaccatgc tgaagtctaa
      301 attgaatgtc ttaacactga aaaaggaacc tctcccagcg gtcatcttcc atgagccgga
      361 ggccattgag ctgtgcacga ccacaccgct gatgaagaca aggactcaca gtggctgcaa
      421 ggttacctac ctgggcaaag tctccaccac tggcatgcag tttttgtcag gctgcacaga
      481 aaagccagtc attgagctct ggaagaagca cacgctagcc cgagaggatg tctttccggc
      541 caatgccctc ctggaaatcc ggccattcca agtttggctc catcatctcg accacaaagg
      601 ggaggccaca gtgcacatgg ataccttcca ggtggcccgc atcgcctact gcaccgccga
      661 ccacaacgtg agccccaaca tcttcgcctg ggtctacagg gagatcaatg atgacctgtc
      721 ctaccagatg gactgccacg ccgtggagtg cgagagcaag ctcgaggcca agaaactggc
      781 ccacgccatg atggaggcct tcaggaagac tttccacagt atgaagagcg acgggcggat
      841 ccacagcaac agctcctccg aagaggtttc ccaggaattg gaatccgatg atggctgaat
      901 gaacttgaga cgcttcagca aaggcagcat tggtcacgga gttcaaggga atagatgagt
      961 aagcaacgtt tcaaatttgg gatgaaaaga ctgccaaact attggctgac caaggttttt
     1021 aaattcagaa gagcaattct aaatctaaag aaatgtatca ttaaagtaat tacgttacat
     1081 tgaaacctgc tgctgctgtg actgtgagga gggtgggagt gtggatgggg aggaaggttc
     1141 taggctctct tatttttctc atttcccaat gcctctctgt gggagagctc catgccagtt
     1201 ttcaccacgc tcaggcaaat actctgcagc tgttattgga tgggccattc cgatctgcct
     1261 tatgaaattc cacaagaatg ttaggggcac ctatgggatc tctagtgggg tgggcagggt
     1321 gctgatgggg acgctggccg cagggaggaa ggaacatctc gggagggccc tctgttcctc
     1381 tcccacggca gatgccctcc tctgtatgca aatcagcaca gcctttattg agctttacaa
     1441 ctaacaacct gatagttggc agttaattca cagttacaga taatgctttt atttacataa
     1501 atataccaag tagtaccctc ttattgtatt cacttcatct attttcttag aatacttgca
     1561 attactaatg accccttccc tttccctcct gctgccctgt ccaccctctt tccccttcta
     1621 acatccttag agggatgaaa tctcagcata tgttgcagga caccaaaagg aagaaaacaa
     1681 tcaagcaaat aaaataaaca gtcaaacaaa ccaggagttt aaaacaacaa ccccaacaac
     1741 agaagccttg gcaaagagga ataagtgatc agcaagtgaa cacactctat gtcaactctc
     1801 cttttatcca gctgagattt atggtaactt atttaattaa tggtcctgtc tgatgcatcc
     1861 ttgatggcaa gcttcaaatc tgatttggta tcaccgagga aaccttgccc ccatcactca
     1921 gcattgcact tagatacaga atgagttaga taaacttggc ttgtctagag acccatgtca
     1981 tcttaaccta aagggaaatc ttattgcgtt atcataaaat tgatgatatc ttagggtcag
     2041 aattgccctt tttttttatt ttgaatggga agttctcact aaaacaatcc tgagatttct
     2101 taatttcatg gttctttaaa tattataaac acagagtcaa catagaatga aattgtattt
     2161 gttaaaatac acacattgga ggacaagagc agatgactac ttttcgaagt aatgctgctc
     2221 cttcctaaaa gtctgttttc aatcctggta atattagggg cactgcggca cctaagaagc
     2281 cttaaatgag agctaatcca atctagagag cgatggtgtc agcatttcgg tctgcatatc
     2341 tgtgtgtccg tatctgcgtt tgtgtgcgtg tacgtgtgcc cctgtgtgtg ggcccagttt
     2401 tcaggcatgt agaataagca tggagtcata ttgaggagga ctcacttctt gaagatatgc
     2461 ttgttgcttt acaacatatg taagctattc tttagcataa atgcattcat tctttaataa
     2521 aaatatgttt gcattaataa agctgaggag tttcata
//
