LOCUS       NM_006346               3080 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens progesterone immunomodulatory binding factor 1
            (PIBF1), transcript variant 2, mRNA.
ACCESSION   NM_006346
VERSION     NM_006346.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3080)
  AUTHORS   Li,X., Ren,C., Huang,A., Zhao,Y., Wang,L., Shen,H., Gao,C.,
            Chen,B., Zhu,T., Xiong,J., Zhu,D., Huang,Y., Ding,J., Yuan,Z.,
            Ding,W. and Wang,H.
  TITLE     PIBF1 regulates multiple gene expression via impeding long-range
            chromatin interaction to drive the malignant transformation of
            HPV16 integration epithelial cells
  JOURNAL   J Adv Res 57, 163-180 (2024)
   PUBMED   37182685
  REMARK    GeneRIF: PIBF1 regulates multiple gene expression via impeding
            long-range chromatin interaction to drive the malignant
            transformation of HPV16 integration epithelial cells.
REFERENCE   2  (bases 1 to 3080)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    GeneRIF: PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3080)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   4  (bases 1 to 3080)
  AUTHORS   Kumar,D., Rains,A., Herranz-Perez,V., Lu,Q., Shi,X., Swaney,D.L.,
            Stevenson,E., Krogan,N.J., Huang,B., Westlake,C.,
            Garcia-Verdugo,J.M., Yoder,B.K. and Reiter,J.F.
  TITLE     A ciliopathy complex builds distal appendages to initiate
            ciliogenesis
  JOURNAL   J Cell Biol 220 (9) (2021)
   PUBMED   34241634
  REMARK    GeneRIF: A ciliopathy complex builds distal appendages to initiate
            ciliogenesis.
REFERENCE   5  (bases 1 to 3080)
  AUTHORS   Szekeres-Bartho,J., Csabai,T. and Gorgey,E.
  TITLE     Biologia futura: embryo-maternal communication via
            progesterone-induced blocking factor (PIBF) positive embryo-derived
            extracellular vesicles. Their role in maternal immunomodulation
  JOURNAL   Biol Futur 72 (1), 69-74 (2021)
   PUBMED   34554496
  REMARK    GeneRIF: Biologia futura: embryo-maternal communication via
            progesterone-induced blocking factor (PIBF) positive embryo-derived
            extracellular vesicles. Their role in maternal immunomodulation.
            Review article
REFERENCE   6  (bases 1 to 3080)
  AUTHORS   Check,J.H., Arwitz,M., Gross,J., Szekeres-Bartho,J. and Wu,C.H.
  TITLE     Evidence that the expression of progesterone-induced blocking
            factor by maternal T-lymphocytes is positively correlated with
            conception
  JOURNAL   Am J Reprod Immunol 38 (1), 6-8 (1997)
   PUBMED   9266004
REFERENCE   7  (bases 1 to 3080)
  AUTHORS   Check,J.H., Arwitz,M., Gross,J., Peymer,M. and Szekeres-Bartho,J.
  TITLE     Lymphocyte immunotherapy (LI) increases serum levels of
            progesterone induced blocking factor (PIBF)
  JOURNAL   Am J Reprod Immunol 37 (1), 17-20 (1997)
   PUBMED   9138449
REFERENCE   8  (bases 1 to 3080)
  AUTHORS   Szekeres-Bartho,J., Faust,Z. and Varga,P.
  TITLE     The expression of a progesterone-induced immunomodulatory protein
            in pregnancy lymphocytes
  JOURNAL   Am J Reprod Immunol 34 (6), 342-348 (1995)
   PUBMED   8607938
REFERENCE   9  (bases 1 to 3080)
  AUTHORS   Szekeres-Bartho,J., Varga,P. and Pejtsik,B.
  TITLE     ELISA test for the detection of an immunological blocking factor in
            human pregnancy serum
  JOURNAL   J Reprod Immunol 16 (1), 19-29 (1989)
   PUBMED   2600930
REFERENCE   10 (bases 1 to 3080)
  AUTHORS   Szekeres-Bartho,J., Kilar,F., Falkay,G., Csernus,V., Torok,A. and
            Pacsa,A.S.
  TITLE     The mechanism of the inhibitory effect of progesterone on
            lymphocyte cytotoxicity: I. Progesterone-treated lymphocytes
            release a substance inhibiting cytotoxicity and prostaglandin
            synthesis
  JOURNAL   Am J Reprod Immunol Microbiol 9 (1), 15-18 (1985)
   PUBMED   3863495
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391384.18 and AL354720.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_006346.3.
            
            Summary: This gene encodes a protein that is induced by the steroid
            hormone progesterone and plays a role in the maintenance of
            pregnancy. The encoded protein regulates multiple facets of the
            immune system to promote normal pregnancy including cytokine
            synthesis, natural killer (NK) cell activity, and arachidonic acid
            metabolism. Low serum levels of this protein have been associated
            with spontaneous pre-term labor in humans. This protein may promote
            the proliferation, migration and invasion of glioma. [provided by
            RefSeq, Mar 2017].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region compared to variant 1. The encoded
            isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.168550.1, AF330046.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326291.11/ ENSP00000317144.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AL391384.18        2425-2641
            218-516             AL391384.18        3715-4013
            517-617             AL391384.18        12739-12839
            618-816             AL391384.18        15651-15849
            817-936             AL391384.18        18199-18318
            937-1070            AL391384.18        42141-42274
            1071-1179           AL391384.18        47302-47410
            1180-1361           AL391384.18        48025-48206
            1362-1487           AL391384.18        55535-55660
            1488-1586           AL391384.18        74349-74447
            1587-1752           AL391384.18        114076-114241
            1753-1903           AL391384.18        128823-128973
            1904-1994           AL391384.18        137368-137458
            1995-2097           AL391384.18        151457-151559
            2098-2228           AL354720.14        30396-30526
            2229-2313           AL354720.14        38713-38797
            2314-2487           AL354720.14        63944-64117
            2488-3080           AL354720.14        80991-81583
FEATURES             Location/Qualifiers
     source          1..3080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q21.33-q22.1"
     gene            1..3080
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /note="progesterone immunomodulatory binding factor 1"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
     exon            1..217
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            218..516
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..2538
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /note="isoform 2 is encoded by transcript variant 2;
                     progesterone-induced-blocking factor 1; centrosomal
                     protein of 90 kDa"
                     /codon_start=1
                     /product="progesterone-induced-blocking factor 1 isoform
                     2"
                     /protein_id="NP_006337.2"
                     /db_xref="CCDS:CCDS31991.1"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
                     /translation="MSRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKV
                     RITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLL
                     TLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFE
                     LTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQ
                     LKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQ
                     EVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRC
                     AHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEI
                     DQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTE
                     SKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQAS
                     SEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANV
                     PTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQ
                     PYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHR
                     EELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIFTPKPTL
                     FTKKEAPEWSKKQKMKT"
     exon            517..617
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            618..816
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            817..936
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1070
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1179
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1361
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1487
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1586
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1752
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1903
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1994
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2097
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2228
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2313
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2487
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..3080
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2745..2750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /note="hexamer: AATATA"
     polyA_site      2766
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /note="major polyA site"
     regulatory      3035..3040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /note="hexamer: AATAAA"
     polyA_site      3080
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
ORIGIN      
        1 agagttgact tccggcggct tgtgggagtg ctggttctgt cctccttgcg ggtgcggaga
       61 tggttgtctt ggttacgggt cctaacggtc ccctgccttg aaatcccttg ttgagggcct
      121 gcaaccttgt gcttccgacc ggagacgcct ttggtccctc ggtgtctgca ctggctgctg
      181 gtcaaggctt cagtgtggag taattgacac tttcgagaat attaaaatca aattagagaa
      241 gaaaactgat ccataataat aaaaatgtct cgaaaaattt caaaggagtc aaaaaaagtg
      301 aacatctcta gttctctgga atctgaagat attagtttag aaacaacagt tcctacggat
      361 gatatttcct catcagaaga gcgagagggc aaagtcagaa tcaccaggca gctaattgaa
      421 cgaaaagaac tacttcataa tattcagtta ctaaaaattg agctatccca gaaaactatg
      481 atgatcgaca atttgaaagt ggattatctt acaaagattg aagaattgga ggagaaactt
      541 aatgatgcac ttcaccagaa gcagctacta acattgagat tagacaacca attggctttt
      601 caacagaaag atgccagcaa atatcaagaa ttaatgaaac aagaaatgga aaccattttg
      661 ttgagacaga aacaactaga agagacaaat cttcagctaa gagaaaaagc tggagatgtt
      721 cgtcgaaacc tgcgtgactt tgagttgaca gaagagcaat atattaaatt aaaagctttt
      781 cctgaagatc agctttctat tcctgaatat gtatctgttc gcttctatga gctagtgaat
      841 ccattaagaa aggaaatctg tgaactacaa gtgaaaaaga atatcctagc agaagaatta
      901 agtacaaaca aaaaccaact gaagcagctg acagagacat atgaggaaga tcgaaaaaac
      961 tactctgaag ttcaaattag atgtcaacgt ttggccttag aattagcaga cacaaaacag
     1021 ttaattcagc aaggtgacta ccgtcaagag aactatgata aagtcaagag tgaacgtgat
     1081 gcacttgaac aggaagtaat tgagcttagg agaaaacatg aaatacttga agcctctcac
     1141 atgattcaaa caaaagaacg aagtgaatta tcaaaagagg tagtcacctt agagcaaact
     1201 gttactttac tgcaaaagga taaagaatat cttaatcgcc aaaacatgga gcttagtgtt
     1261 cgctgtgctc atgaagagga tcgccttgaa agacttcaag ctcaactgga agaaagcaaa
     1321 aaggctagag aagagatgta tgaaaaatat gtagcatcca gagaccatta taaaacagaa
     1381 tatgaaaata aactacatga tgaactagaa caaatcagat tgaaaaccaa ccaagaaatt
     1441 gatcaacttc gaaatgcctc tagggaaatg tatgaacgag aaaacagaaa tctccgagaa
     1501 gcaagggata atgctgtggc tgaaaaggaa cgagcagtga tggctgaaaa ggatgcttta
     1561 gaaaaacacg atcagctctt agacaggtac agagaactac aacttagtac agaaagcaaa
     1621 gtaacagaat ttctccatca aagtaaatta aaatcttttg aaagtgagcg tgttcaactt
     1681 ctgcaagagg aaacagcaag aaatctcaca cagtgtcaat tggaatgtga aaaatatcag
     1741 aaaaaattgg aggttttaac caaagaattt tatagtctcc aagcctcttc tgaaaaacgc
     1801 attactgaac ttcaagcaca gaactcagag catcaagcaa ggctagacat ttatgagaaa
     1861 ctggaaaaag agcttgatga aataataatg caaactgcag aaattgaaaa tgaagatgag
     1921 gctgaaaggg ttcttttttc ctacggctat ggtgctaatg ttcccacaac agccaaaaga
     1981 cgactaaagc aaagtgttca cttggcaaga agagtgcttc aattagaaaa acaaaactcg
     2041 ctgattttaa aagatctgga acatcgaaag gaccaagtaa cacagctttc acaagagctt
     2101 gacagagcca attcgctatt aaaccagact caacagcctt acaggtatct cattgaatca
     2161 gtgcgtcaga gagattctaa gattgattca ctgacggaat ctattgcaca acttgagaaa
     2221 gatgtcagca acttaaataa agaaaagtca gctttactac agacgaagaa tcaaatggca
     2281 ttagatttag aacaacttct aaatcatcgt gaggaattgg cagcaatgaa acagattctc
     2341 gttaagatgc atagtaaaca ttctgagaac agcttacttc tcactaaaac agaaccaaaa
     2401 catgtgacag aaaatcagaa atcaaagact ttgaatgtgc ctaaagagca tgaagacaat
     2461 atatttacac ctaaaccaac actctttact aaaaaagaag cacctgagtg gtctaagaaa
     2521 caaaagatga agacctagtg ttttggatgg gaagcacctg tagaccatta tatactcctg
     2581 aagttctttt tctgatggaa aacaaaattc agcttaatcg tgtactcagc attttttaaa
     2641 taacaatgtt tatttgaact aatattaaat taacaaattc agtgtaatca aaatgtgtaa
     2701 agaacaatca atatacttta tttttttttc tattttataa aataaatata tatgctatgc
     2761 tttaaatttt ggagctttca taaatgttca atgcatttta agtgtgtggc ttataaatat
     2821 tttggtattt ttctatacta cgtaaattct gagtttaaat gtcatacaca aatactaaga
     2881 cactttgcat ttttaaaaat taagaatcat ttgtgaagtc cactacgagg tacttcaaaa
     2941 gcccagtaat ggtggtcaga taccatgtag atggatacag attgttgact cttttgaagt
     3001 tgtttttttc ttatatttta tattaccatt aaccaataaa atctggcaga aagtctgcta
     3061 ttccattggt aaagtgaaaa
//
